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NASA NTRS2011

Principles, Techniques, and Applications of Tissue Microfluidics

The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research. The proposed integration of microfluidic techniques and tissue slice samples is called tissue microfluidics because it molds the microfluidic architectures in accordance with each particular structure of each specific tissue sample. Thus, microfluidics can be built around the tissues, following the tissue structure, or alternatively, the microfluidics can be adapted to the specific geometry of particular tissues. By contrast, the traditional approach is that microfluidic devices are structured in accordance with engineering considerations, while the biological components in applied devices are forced to comply with these engineering presets. The proposed principles represent a paradigm shift in microfluidic technology in three important ways: Microfluidic devices are to be directly integrated with, onto, or around tissue samples, in contrast to the conventional method of off-chip sample extraction followed by sample insertion in microfluidic devices. Architectural and operational principles of microfluidic devices are to be subordinated to suit specific tissue structure and needs, in contrast to the conventional method of building devices according to fluidic function alone and without regard to tissue structure. Sample acquisition from tissue is to be performed on-chip and is to be integrated with the diagnostic measurement within the same device, in contrast to the conventional method of off-chip sample prep and subsequent insertion into a diagnostic device. A more advanced form of tissue integration with microfluidics is tissue encapsulation, wherein the sample is completely encapsulated within a microfluidic device, to allow for full surface access. The immediate applications of these approaches lie with diagnostics of tissue slices and biopsy samples e.g. for cancer but the approaches would also be very useful in comparative genomics and other areas of fundamental research involving heterogeneous tissue samples.

Wade, Lawrence A.↗

NASA NTRS1996

Development of a Micro-Fiber Nickel Electrode for Nickel-Hydrogen Cell

The development of a high specific energy battery is one of the objectives of the lightweight nickel-hydrogen (NiH2) program at the NASA Lewis Research Center. The approach has been to improve the nickel electrode by continuing combined in-house and contract efforts to develop a more efficient and lighter weight electrode for the nickel-hydrogen fuel cell. Small fiber diameter nickel plaques are used as conductive supports for the nickel hydroxide active material. These plaques are commercial products and have an advantage of increased surface area available for the deposition of active materials. Initial tests include activation and capacity measurements at different discharge levels followed by half-cell cycle testing at 80 percent depth-of-discharge in a low Earth orbit regime. The electrodes that pass the initial tests are life cycle tested in a boiler plate nickel-hydrogen cell before flightweight designs are built and tested.

Britton, Doris L.↗

NASA NTRS2004

Searching for Terrain Softening near Mercury's North Pole

In 1999, following the initial discovery of radar bright craters near both poles of Mercury measured the depth-todiameter (d/D) ratios of 170 impact craters in Mariner 10 images covering four different regions on Mercury s surface. Rapid softening of crater structure, indicated by lower d/D ratios, could indicate the possibility of subsurface water ice in Mercury's terrain originating from an internal source in the planet. Their study included 3 specific radar bright craters suggested to contain ice. They concluded that no terrain softening was apparent, and a rapidly emplaced exogenic water source was the most likely source for the proposed ice in these craters. Recent radar observations of the Mercurian North pole have pinpointed many additional radar bright areas with a resolution 10x better than previous radar measurements, and which correlate with craters imaged by Mariner 10. These craters are correlated with regions that are permanently shaded from direct sunlight, and are consistent with observations of clean water ice. We have expanded the initial study by Barlow et al. to include d/D measurements of 12 craters newly identified as radar bright at latitudes poleward of +80o. The radar reflectivity resemblances to Mars south polar cap and echoes from three icy Galilean satellites suggest that these craters too may have polar ice on Mercury. The effect of subsurface H20 on impact craters is a decrease in its d/D ratio, and softening of crater rims over a period of time. The study of Barlow et al., focused on determining the d/D ratios of 170 impact craters in the Borealis (north polar), Tolstoj (equatorial), Kuiper (equatorial), and Bach (south polar) quadrangles. This work focuses on the newly discovered radar bright craters, investigating their d/D ratios as an expansion of the earlier work..We compare our results to the statistical results from Barlow et al. here. With the upcoming Messenger spacecraft mission to Mercury, this is an especially timely study whose result could potentially help the Messenger team as they develop a mission strategy.

Cobian, P. S.↗

NASA NTRS2010

Terrain Hazard Detection and Avoidance During the Descent and Landing Phase of the Altair Mission

This paper describes some of the environmental challenges associated with landing a crewed or robotic vehicle at any certified location on the lunar surface (i.e. not a mountain peak, permanently dark crater floor or overly steep terrain), with a specific focus on how hazard detection technology may be incorporated to mitigate these challenges. For this discussion, the vehicle of interest is the Altair Lunar Lander, being the vehicle element of the NASA Constellation Program aimed at returning humans to the moon. Lunar environmental challenges for such global lunar access primarily involve terrain and lighting. These would include sizable rocks and slopes, which are more concentrated in highland areas; small craters, which are essentially everywhere independent of terrain type; and for polar regions, low-angle sunlight, which leaves significant terrain in shadow. To address these issues, as well as to provide for precision landing, the Autonomous Landing and Hazard Avoidance Technology (ALHAT) Project was charted by NASA Headquarters, and has since been making significant progress. The ALHAT team considered several sensors for real-time hazard detection, settling on the use of a Flash Lidar mounted to a high-speed gimbal, with computationally intense image processing and elevation interpretation software. The Altair Project has been working with the ALHAT team to understand the capabilities and limitations of their concept, and has incorporated much of the ALHAT hazard detection system into the Altair baseline design. This integration, along with open issues relating to computational performance, the need for system redundancy, and potential pilot interaction, will be explored further in this paper.

Strhan, Alan L.↗

NASA NTRS2017

Non-Axisymmetric Inflatable Pressure Structure (NAIPS) Full-Scale Pressure Test

Inflatable space structures have the potential to significantly reduce the required launch volume for large pressure vessels required for exploration applications including habitats, airlocks and tankage. In addition, mass savings can be achieved via the use of high specific strength softgoods materials, and the reduced design penalty from launching the structure in a densely packaged state. Large inclusions however, such as hatches, induce a high mass penalty at the interfaces with the softgoods and in the added rigid structure while reducing the packaging efficiency. A novel, Non-Axisymmetric Inflatable Pressure Structure (NAIPS) was designed and recently tested at NASA Langley Research Center to demonstrate an elongated inflatable architecture that could provide areas of low stress along a principal axis in the surface. These low stress zones will allow the integration of a flexible linear seal that substantially reduces the added mass and volume of a heritage rigid hatch structure. This paper describes the test of the first full-scale engineering demonstration unit (EDU) of the NAIPS geometry and a comparison of the results to finite element analysis.

Jones, Thomas C.↗

NASA NTRSDate not supplied

Quiet Spacecraft Cabin Ventilation Fan Development: Motivation and Context

It is important to control acoustical noise aboard crewed space vehicles and space habitats to provide a satisfactory environment for voice communications, alarm audibility, and restful sleep, and to minimize the risk for hearing loss and annoyance. As with most noise control efforts, it is best to control the noise at the source, and for spaceflight vehicles these are typically the fans associated with the Environmental Control and Life Support (ECLS) system. These include air ventilation fans, such as the main air conditioning fan (the ‘cabin fan’), intermodule ventilation (IMV) fans, air revitalization fans (for removal of carbon dioxide and trace contaminates), and thermal cooling fans. Thermal cooling pumps that circulate cooling fluid are another significant noise source in spaceflight vehicles, but these are outside of the scope of this paper. Throughout the history of crewed spaceflight, there have been issues with noise from ECLS ventilation fans. In the Apollo Command Module (CM) the crew would turn off the CM cabin fan once in orbit and use the backup suit-loop fan for ventilation because noise from the cabin fan interfered with communications and was an annoyance. On the Space Shuttle the ventilation system underwent significant redesign, including the addition of ventilation system mufflers, with resulting noise levels that were still too-high for long-duration missions. In the early years of International Space Station (ISS) operations, acoustical noise was one of the top two habitability issues, resulting in significant noise controls (along with significant cost and crew-time impacts) being implemented on-orbit on many fans, with significant noise reductions realized only after replacing noisy fans with fans of a quieter design, funded by the ISS Program. And, with the spaceflight vehicles and habitats currently being developed, there are again concerns with noise levels from ventilation fans. In the Orion vehicle, additional duct mufflers needed to be added to address the cabin fan noise. The Gateway’s Habitation and Logistics Outpost (HALO) module and low-Earth orbit (LEO) Freeflyer habitats are currently working to solve this problem. This will also be an issue for lunar and Mars spaceflight vehicles, space suits, and surface habitats. In an effort to address this problem, NASA is working to leverage the technology developed in its Aeronautics Research Mission Directorate (ARMD), specifically at the Glenn Research Center (GRC), to design highly efficient and quiet fans for reducing community noise levels from civilian aircraft. This technology was created over decades of research and development, and was proven to be effective at reducing aircraft noise levels. The current collaboration across NASA Centers, including HQ, GRC, and the Johnson Space Center (JSC) in this area is the first effort at re-purposing these tools, i.e. design codes and techniques, developed for high Reynolds number fans to spaceflight vehicle and habitat, low Reynolds number, fans. This paper will discuss the need for transfer of aeronautics fan design technology to spaceflight use. This paper will also discuss the potential benefits from this, which are significant, including 1) volume and mass savings from noise controls that are no longer as large or needed at all, 2) reduced system pressure loss from mufflers and silencers (that don’t need to be as restrictive) for better ventilation, 3) reduced power draw because of the reduced system pressure loss and the highly efficient fan design, and 4) satisfying spaceflight vehicle acoustic requirements to provide a safe and habitable acoustic environment for astronaut crewmembers. All of these benefits will be crucial for the successful development and operations of future spaceflight vehicles, space suits, and habitats.

Christopher S. Allen↗

NASA NTRS1975

Application of remote sensing to thermal pollution analysis

A comprehensive numerical model development program for near-field thermal plume discharge and far field general circulation in coastal regions is being carried on at the University of Miami Clean Energy Research Institute. The objective of the program is to develop a generalized, three-dimensional, predictive model for thermal pollution studies. Two regions of specific application of the model are the power plants sites at the Biscayne Bay and Hutchinson Island area along the Florida coastline. Remote sensing from aircraft as well as satellites are used in parallel with in situ measurements to provide information needed for the development and verification of the mathematical model. This paper describes the efforts that have been made to identify problems and limitations of the presently available satellite data and to develop methods for enhancing and enlarging thermal infrared displays for mesoscale sea surface temperature measurements.

Hiser, H. W.↗

NASA NTRS2003

Infrared Spectroscopy as a Chemical Fingerprinting Tool

Infrared (IR) spectroscopy is a powerful analytical tool in the chemical fingerprinting of materials. Any sample material that will interact with infrared light produces a spectrum and, although normally associated with organic materials, inorganic compounds may also be infrared active. The technique is rapid, reproducible and usually non-invasive to the sample. That it is non-invasive allows for additional characterization of the original material using other analytical techniques including thermal analysis and RAMAN spectroscopic techniques. With the appropriate accessories, the technique can be used to examine samples in liquid, solid or gas phase. Both aqueous and non-aqueous free-flowing solutions can be analyzed, as can viscous liquids such as heavy oils and greases. Solid samples of varying sizes and shapes may also be examined and with the addition of microscopic IR (microspectroscopy) capabilities, minute materials such as single fibers and threads may be analyzed. With the addition of appropriate software, microspectroscopy can be used for automated discrete point or compositional surface area mapping, with the latter providing a means to record changes in the chemical composition of a material surface over a defined area. Due to the ability to characterize gaseous samples, IR spectroscopy can also be coupled with thermal processes such as thermogravimetric (TG) analyses to provide both thermal and chemical data in a single run. In this configuration, solids (or liquids) heated in a TG analyzer undergo decomposition, with the evolving gases directed into the IR spectrometer. Thus, information is provided on the thermal properties of a material and the order in which its chemical constituents are broken down during incremental heating. Specific examples of these varied applications will be cited, with data interpretation and method limitations further discussed.

Huff, Timothy L.↗

NASA NTRS2014

Lithium-Air Cell Development

Lithium-air (Li-air) primary batteries have a theoretical specific capacity of 11,400 Wh/kg, the highest of any common metal-air system. NASA is developing Li-air technology for a Mobile Oxygen Concentrator for Spacecraft Emergencies, an application which requires an extremely lightweight primary battery that can discharge over 24 hours continuously. Several vendors were funded through the NASA SBIR program to develop Li-air technology to fulfill the requirements of this application. New catalysts and carbon cathode structures were developed to enhance the oxygen reduction reaction and increase surface area to improve cell performance. Techniques to stabilize the lithium metal anode surface were explored. Experimental results for prototype laboratory cells are given. Projections are made for the performance of hypothetical cells constructed from the materials that were developed.

Lithium-air↗

NASA NTRS1980

Orbit transfer vehicle engine study, phase A extension. Volume 1: Executive summary

A 1980 state-of-the-art advanced expander engine was configured that delivers near-optimum payload-performance and exhibits the simplicity reliability, and life characteristics required of the OTV mission. Engine optimization studies indicate that the performance of the conventional expander cycle engine can be improved substantially through combustion chamber surface area enhancement, thermal enhancement, turbine regeneration, and power cycle efficiency enhancement procedures. The 20K lb. thrust staged combustion engine can be adapted to operate at extended periods in the 1 to 2K lb. thrust regime. The study results indicate that long-life, high performnce operation in the low thrust mode can be achieved with minimum modifications (kitting) of the engine. Although the main contribution to mission success and crew safety stems from propulsion system redundancy, significant reliability can be gained from engine component redundancy, specific engine design features ensuring safety and reliability, including an engine health monitoring system, and from a total program approach to safety and reliability, such as that presently applied to the space shuttle.

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NASA NTRS1988

Lunar landing and launch facilities and operations

A preliminary definition of a lunar landing and launch facility (LLLF or Complex 391) has been formulated. A Phase 3 lunar base is considered. Without specifying specific lunar base scenarios, three traffic levels are envisioned: 6, 12, and 24 landings/launches per year. A single, multipurpose vehicle for the lunar module is assumed. The design and specification of the vehicle and of the lunar base are outside the scope of this study. However, these two items will impact those items considered within the scope of this study because of interactions at the system boundaries. The scope of this study is graphically portrayed with the systems diagram. Based upon this diagram, nine major design items or areas are considered. These items are: (1) landing/launch site considerations; (2) structure, shelter, safety, and environmental needs; (3) landing/launch guidance, communications, and computing needs; (4) lunar module surface transport system; (5) heavy cargo unloading/loading systems; (6) personnel unloading/loading systems; (7) propellant unloading/loading systems; (8) vehicle storage; and (9) maintenance, repair, test and check-out requirements. Initially, a general, conceptual description of each of these items is given. Then, preliminary sizes, capacities, and other relevant design data for some of these items are identified. The Earth-Moon transportation infrastructure and the baseline lunar module design are summarized.

Source record↗

NASA NTRS2022

Sources, Transport and Visibility Impact of Ambient Submicrometer Particle Size Distributions in an Urban Area of Central Taiwan

This study applied positive matrix factorization (PMF) to identify the sources of size-resolved submicrometer (10–1000 nm) particles and quantify their contributions to impaired visibility based on the particle number size distributions (PNSDs), aerosol light extinction (b p ), air pollutants (PM 10 , PM 2.5 , SO 2 , O 3 , and NO), and meteorological parameters (temperature, relative humidity, wind speed, wind direction, and ultraviolet index) measured hourly over an urban basin in central Taiwan between 2017 and 2021. The transport of source-specific PNSDs was evaluated with wind and back trajectory analyses. The PMF revealed six sources to the total particle number (TPN), surface (TPS), volume (TPV), and b p . Factor 1 (F1), the key contributor to TPN (35.0 %), represented nucleation (<25 nm) particles associated with fresh traffic emission and secondary new particle formation, which were transported from the west-southwest by stronger winds (>2.2 m s -1 ). F2 represented the large Aitken (50–100 nm) particles transported regionally via northerly winds, whereas F3 represented large accumulation (300–1000 nm) particles, which showed elevated concentrations under stagnant conditions (<1.1 m s −1 ). F4 represented small Aitken (25–50 nm) particles arising from the growth and transport of the nucleation particles (F1) via west-southwesterly winds. F5 represented large Aitken particles originating from combustion-related SO 2 sources and carried by west-northwesterly winds. F6 represented small accumulation (100–300 nm) particles emitted both by local sources and by the remote SO 2 sources found for F5. Overall, large accumulation particles (F3) played the greatest role in determining the TPV (66.4 %) and TPS (34.8 %), and their contribution to bp increased markedly from 17.3 % to 40.7 % as visibility decreased, indicating that TPV and TPS are better metrics than TPN for estimating b p . Furthermore, slow-moving air masses—and therefore stagnant conditions—facilitate the build-up of accumulation mode particles (F3 + F6), resulting in the poorest visibility.

source apportionment↗

NASA NTRS1974

Environmental observations of the Great Salt Lake Basin from ERTS-1

Some ERTS-1 observations of snowcover, turbidity variations in the major lakes, surface water area changes, land use features, and phenomena associated with industrial emissions are described. Turbidity patterns in the major water bodies can be observed that appear to be related to the general wind flow, or to lake circulation patterns, and the chemical or biological constituents in the water. Monthly, seasonal, and annual changes in surface water extent can be monitored and serve as indicators of water availability. Time and space variations in snowcover that are a function of exposure or time of year were observed in some regions. Specific measurements of snowline altitude during the major snowmelt period of 1973 were obtained. The existence and effect of industrial emission on vegetation were found to be detectable.

Smith, A. F.↗

NASA NTRS1984

Hybrid integrated optic modules for real-time signal processing

The most recent progress on four relatively new hybrid integrated optic device modules in LiNbO3 waveguides and one in YIG/GGG waveguide that are currently being studied are discussed. The five hybrid modules include a time-integrating acoustooptic correlator, a channel waveguide acoustooptic frequency shifter/modulator, an electrooptic channel waveguide total internal reflection moculator/switch, an electrooptic analog-to-digital converter using a Fabry-Perot modulator array, and a noncollinear magnetooptic modulator using magnetostatic surface waves. All of these devices possess the desirable characteristics of very large bandwidth (GHz or higher), very small substrate size along the optical path (typically 1.5 cm or less), single-mode optical propagation, and low drive power requirement. The devices utilize either acoustooptic, electrooptic or magnetooptic effects in planar or channel waveguides and, therefore, act as efficient interface devices between a light wave and temporal signals. Major areas of application lie in wideband multichannel optical real-time signal processing and communications. Some of the specific applications include spectral analysis and correlation of radio frequency (RF) signals, fiber-optic sensing, optical computing and multiport switching/routing, and analog-to-digital conversion of wide RF signals.

Tsai, C. S.↗

NASA NTRS1997

The Remote Sensing of Mineral Aerosols and their Impact on Phytoplankton Productivity

The overall objective of this experiment was to test the iron hypothesis does the addition of iron to nutrient rich surface waters enhance productivity? Our specific objectives in this experiment included sampling and studying the marine aerosol size and type (which are related to chemical reactivity) during the PlumEx cruise to determine the importance of local (Galapagos Islands) versus long-range sources of atmospheric material. Detailed results of single particle analysis of our samples are being prepared for publication in two papers. We collect aerosol samples and they have been analyzed for trace metals and other elements. We are mapped aerosol distribution and the desert source areas around the Arabian Sea region. We did record a clear relationship between the aerosol radiance and synoptic weather patterns with distinct signals over the ocean northwest and southwest of Australia. While the interpretation was limited an aerosol climatology pattern was presented.

Tindale, Neil W.↗

NASA NTRS2017

Evaluation of a Head-Worn Display System as an Equivalent Head-Up Display for Low Visibility Commercial Operations

Research, development, test, and evaluation of fight deck interface technologies is being conducted by the National Aeronautics and Space Administration (NASA) to proactively identify, develop, and mature tools, methods, and technologies for improving overall aircraft safety of new and legacy vehicles operating in the Next Generation Air Transportation System (NextGen). One specific area of research was the use of small Head-Worn Displays (HWDs) to serve as a possible equivalent to a Head-Up Display (HUD). A simulation experiment and a fight test were conducted to evaluate if the HWD can provide an equivalent level of performance to a HUD. For the simulation experiment, airline crews conducted simulated approach and landing, taxi, and departure operations during low visibility operations. In a follow-on fight test, highly experienced test pilots evaluated the same HWD during approach and surface operations. The results for both the simulation and fight tests showed that there were no statistical differences in the crews' performance in terms of approach, touchdown and takeoff; but, there are still technical hurdles to be overcome for complete display equivalence including, most notably, the end-to-end latency of the HWD system.

Arthur, Jarvis (Trey) J., III↗

NASA NTRS2008

Nanotip Carpets as Antireflection Surfaces

Carpet-like random arrays of metal-coated silicon nanotips have been shown to be effective as antireflection surfaces. Now undergoing development for incorporation into Sun sensors that would provide guidance for robotic exploratory vehicles on Mars, nanotip carpets of this type could also have many uses on Earth as antireflection surfaces in instruments that handle or detect ultraviolet, visible, or infrared light. In the original Sun-sensor application, what is required is an array of 50-micron-diameter apertures on what is otherwise an opaque, minimally reflective surface, as needed to implement a miniature multiple-pinhole camera. The process for fabrication of an antireflection nanotip carpet for this application (see Figure 1) includes, and goes somewhat beyond, the process described in A New Process for Fabricating Random Silicon Nanotips (NPO-40123), NASA Tech Briefs, Vol. 28, No. 1 (November 2004), page 62. In the first step, which is not part of the previously reported process, photolithography is performed to deposit etch masks to define the 50-micron apertures on a silicon substrate. In the second step, which is part of the previously reported process, the non-masked silicon area between the apertures is subjected to reactive ion etching (RIE) under a special combination of conditions that results in the growth of fluorine-based compounds in randomly distributed formations, known in the art as "polymer RIE grass," that have dimensions of the order of microns. The polymer RIE grass formations serve as microscopic etch masks during the next step, in which deep reactive ion etching (DRIE) is performed. What remains after DRIE is the carpet of nano - tips, which are high-aspect-ratio peaks, the tips of which have radii of the order of nanometers. Next, the nanotip array is evaporatively coated with Cr/Au to enhance the absorption of light (more specifically, infrared light in the Sun-sensor application). The photoresist etch masks protecting the apertures are then removed by dipping the substrate into acetone. Finally, for the Sun-sensor application, the back surface of the substrate is coated with a 57-nm-thick layer of Cr for attenuation of sunlight.

Bae, Youngsam↗

NASA NTRS1991

Automation and robotics for the Space Exploration Initiative: Results from Project Outreach

A total of 52 submissions were received in the Automation and Robotics (A&R) area during Project Outreach. About half of the submissions (24) contained concepts that were judged to have high utility for the Space Exploration Initiative (SEI) and were analyzed further by the robotics panel. These 24 submissions are analyzed here. Three types of robots were proposed in the high scoring submissions: structured task robots (STRs), teleoperated robots (TORs), and surface exploration robots. Several advanced TOR control interface technologies were proposed in the submissions. Many A&R concepts or potential standards were presented or alluded to by the submitters, but few specific technologies or systems were suggested.

Gonzales, D.↗