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At least 523 records · Page 29

Exploration Clinical Decision Support System: Medical Data Architecture

The Exploration Clinical Decision Support (ECDS) System project is intended to enhance the Exploration Medical Capability (ExMC) Element for extended duration, deep-space mission planning in HRP. A major development guideline is the Risk of "Adverse Health Outcomes & Decrements in Performance due to Limitations of In-flight Medical Conditions". ECDS attempts to mitigate that Risk by providing crew-specific health information, actionable insight, crew guidance and advice based on computational algorithmic analysis. The availability of inflight health diagnostic computational methods has been identified as an essential capability for human exploration missions. Inflight electronic health data sources are often heterogeneous, and thus may be isolated or not examined as an aggregate whole. The ECDS System objective provides both a data architecture that collects and manages disparate health data, and an active knowledge system that analyzes health evidence to deliver case-specific advice. A single, cohesive space-ready decision support capability that considers all exploration clinical measurements is not commercially available at present. Hence, this Task is a newly coordinated development effort by which ECDS and its supporting data infrastructure will demonstrate the feasibility of intelligent data mining and predictive modeling as a biomedical diagnostic support mechanism on manned exploration missions. The initial step towards ground and flight demonstrations has been the research and development of both image and clinical text-based computer-aided patient diagnosis. Human anatomical images displaying abnormal/pathological features have been annotated using controlled terminology templates, marked-up, and then stored in compliance with the AIM standard. These images have been filtered and disease characterized based on machine learning of semantic and quantitative feature vectors. The next phase will evaluate disease treatment response via quantitative linear dimension biomarkers that enable image content-based retrieval and criteria assessment. In addition, a data mining engine (DME) is applied to cross-sectional adult surveys for predicting occurrence of renal calculi, ranked by statistical significance of demographics and specific food ingestion. In addition to this precursor space flight algorithm training, the DME will utilize a feature-engineering capability for unstructured clinical text classification health discovery. The ECDS backbone is a proposed multi-tier modular architecture providing data messaging protocols, storage, management and real-time patient data access. Technology demonstrations and success metrics will be finalized in FY16.

Biomedical support↗

Deleterious Effects of Simulated Spaceflight on Bone and Microvasculature in Adult Mice

Long-term spaceflight leads to extensive changes in the musculoskeletal system attributable, in part, to unloading during microgravity exposure. Additionally, irradiation at doses similar to that of a solar flare or a round-trip sojourn to Mars may cause significant depletion of stem/progenitor cell pools throughout the body as well as inflammation associated with prompt skeletal-tissue degradation. Previously, we demonstrated that irradiation leads to rapid bone loss, which can be mitigated in the short term by injection of a potent antioxidant (-lipoic acid). Furthermore, simulated weightlessness in adult mice adversely affects skeletal responses to low linear energy transfer (LET) radiation (137Cs). Here, we hypothesized that simulated weightlessness exacerbates the adverse effects of simulated space radiation (including both protons and 56Fe ions) by adversely affecting skeletal structure and functions as well as associated vasculature. Furthermore, we hypothesized that an antioxidant cocktail, which has been shown to be protective in other tissues, mitigates space radiation induced bone loss.

Shirazi-Fard, Y.↗

Multidisciplinary Design Optimization and Cruise Mach Number Study of Truss-Braced Wing Aircraft

The Subsonic Ultra Green Aircraft Research (SUGAR) Phase III was led by Dr. Rakesh K. Kapania and Dr. Joseph A. Schetz at the Multidisciplinary Analysis and Design Center for Advanced Vehicles, Department of Aerospace and Ocean Engineering, Virginia Tech, Blacksburg VA. The research was performed from December 2014 to December 2015. Three major areas were investigated: Multidisciplinary Design Optimization (MDO) studies of truss braced wing (TBW) and strut braced wing (SBW) vehicles at cruise Mach numbers of 0.7 and 0.8 for a flight mission similar to current market single aisle configurations. The performance and the characteristics of the optimized vehicles were compared to the SUGAR Phase II TBW vehicle. These results were obtained without applying any of the extended transonic aerodynamic and aeroelastic tools that will be discussed later. It was found that the cruise Mach number has a large effect on the best “truss” configuration. At Mach 0.7, an SBW has a better fuel consumption and better take-off gross weight (TOGW). However, at Mach 0.8, the TBW is superior because the jury strut aids in satisfying the flutter constraint; Two-dimensional, steady, transonic aerodynamic analysis of the Boeing Airfoil J (BACJ) airfoil was performed for a range of thickness ratios, Mach numbers and lift coefficients. Reynolds-averaged Navier-Stokes (RANS) equations were solved to obtain the lift-curve slope, wave drag coefficient, the location of the center of pressure and to predict the separation at the trailing edge, which may lead to buffeting. One of the goals was to develop a database of lift-curve slope and the location of center of pressure, which could be used in a transonic aeroelastic analysis. Another goal was to compare the wave drag coefficients to those predicted by Lock’s fourth-power law and also to compare the transonic effects obtained from RANS simulations to those predicted by the Korn equations. A third goal was to develop a buffet boundary, which can be integrated into the MDO framework to prevent the optimized designs from probable buffeting; A state-space transonic aeroelastic analysis tool was developed, which can incorporate the nonlinear transonic effects in the unsteady aerodynamics but is yet computationally cheap when used within the VT MDO framework. The aeroelastic analysis uses Leishman- Beddoes (LB) indicial functions, which generated a state-space representation of the aeroelastic system. The indicial functions allow the incorporation of data for steady lift-curve slope and location of the center of pressure. Thus, the steady transonic effects are included, and the unsteady aerodynamic responses are a linearization about the steady results. The aeroelastic approach discretizes the wing into numerous strips, which results in a large eigenvalue problem as each strip has eight augmented aerodynamic states as per the LB theory. Thus, to reduce the computation expense, a reduced order model (ROM) was developed. The approach was validated using a few examples.

Kapania, Rakesh K.↗

Hawkeye Radiometric Calibration Methodology

Hawkeye is an ocean color instrument designed, manufactured and characterized at Cloud land Instruments, CA. It is a push broom instrument that has 8spectral bands similar to SeaWiFS and a spatial resolution of 120 m. Each spectral band has 1800 detectors (pixels) and all 14,000 detectors (pixels) need to be calibrated independently. This paper describes the preliminary design of on-orbit calibration method to correct for the instrument response's temperature sensitivity,scan angle dependency in radiometric sensitivity, relative spectral response (RSR),non linearity, and polarization sensitivity. We will provide a brief description on how each of the calibration parameters are used to address the instrument characteristics and how the calibration parameters are derived from instrument test data and use to retrieve ocean color products.

Lee, Shihyan↗

Oculometric Analysis of Saccadic Compensation for Visual Motion Processing Impairment due to Alcohol and Sleep Disruption

The Visuomotor Control Laboratory at Ames Research Center has developed a 5-minute ocular tracking test that computes 21 largely independent metrics of visuomotor performance, reflecting neural signal processing along a number of distinct pathways through cortex, brainstem, and cerebellum. Human sensorimotor performance is resilient to the challenges and stressors of many operational environments, in part, because overall performance is achieved through multiple parallel systems. Our multidimensional oculometrics allow us to examine impacts on these sub-components separately. To illustrate this, we contrasted the effects of two mild neural stressors, acute sleep-deprivation and low-dose alcohol. We have previously shown that, in both cases, oculometric analysis is a highly sensitive indicator of impairment. Here we quantified not only the observed impact on the performance of one sub-system, smooth pursuit, which uses high-level cortical processing of visual motion to track a moving object, but also the observed (partial) compensation by an evolutionarily older mid-brain and brainstem subsystem, saccades, which generates jumps in eye position to catch up with the target when smooth pursuit is inadequate. Specifically, we examined the dose-response (effect size vs. dose size) of the ground lost (pursuit deficit) and the ground recouped (saccadic compensation) across three separate studies – acute low-dose alcohol administration (16 subjects), acute sleep loss (12 subjects), and acute sleep loss with caffeine intervention (9 subjects). We computed the dose-response slopes using linear regression. The figure below shows that, in the case of acute sleep deprivation, the resulting slopes for ground lost and ground recouped (mean ± SE across subjects) were significantly different (paired t-test, t(11) = 5.17, p < 0.001), indicating poor saccadic compensation. However, when sleep loss was coupled with caffeine ingestion, ground lost was decreased and ground recouped increased such that the slopes were no longer different (t(8) = -0.05, p = 0.965). With alcohol, the two slopes were large albeit not significantly different (t(15) = 0.96, p = 0.351), indicating significant pursuit impairment but effective saccadic compensation. Our findings show that sleep deprivation and alcohol affect oculomotor performance differently. Low-dose alcohol effects appear predominantly cortical, with effective brainstem compensation. Sleep loss and circadian disruption however appears to affect both cortical and brainstem pathways with caffeine providing an effective countermeasure to both effects. Beyond the mere detection of impairment, our oculometric assessment allows us to characterize the nature of the deficit, to provide insight into the neural substrate, and to assess the effectiveness of countermeasures.

pursuit↗

Artemis I Prelaunch Flight Readiness Analysis

The Prelaunch loads analysis traditionally captures the vehicle and Mobile Launcher (ML) loads associated with stacking in the Vehicle Assembly Building (VAB), rollout to the pad, and high-speed winds while out on the pad prior to liftoff. The following paper details the methodology used in this analysis for loads for the Artemis Flight Readiness assessment. This paper focuses on the stacking and assembly loads, the loads induced by fueling, and the load seen during rollout to the pad. Methods for integrating multiple structural models in dynamic simulations using interface forces, constraint modes, and residual vectors is discussed. Both linear and nonlinear responses are addressed. Simulation results are compared to measured data from the Dynamic Rollout Test (DRT) and Wet Dress Rehearsal (WDR).

SLS↗

Response control for fatigue testing of non-linear systems

A signal conditioner which ensures that peak and low values during vibration testing are not lost during nonlinear or asymmetric vibration testing on small structures is described. The trapped signals may be for acceleration, velocity, or displacement. The test signal is sent through an analog circuit to a multiplexer, which resets to zero each time a zero-line is crossed by another incoming signal. Peak positive and negative amplitude and frequency are retained and nonsymmetric responses are thus detected, rather than averaged out.

Gowdey, J. C.↗

A methodology for using nonlinear aerodynamics in aeroservoelastic analysis and design

A methodology is presented for using the Volterra-Wiener theory of nonlinear systems in aeroservoelastic (ASE) analyses and design. The theory is applied to the development of nonlinear aerodynamic response models that can be defined in state-space form and are, therefore, appropriate for use in modern control theory. The theory relies on the identification of nonlinear kernels that can be used to predict the response of a nonlinear system due to an arbitrary input. A numerical kernel identification technique, based on unit impulse responses, is presented and applied to a simple bilinear, single-input-single-output system. The linear kernel (unit impulse response) and the nonlinear second-order kernel of the system are numerically-identified and compared with the exact, analytically-defined linear and second-order kernels. This kernel identification technique is then applied to the CAP-TSD code for identification of the linear and second-order kernels of a NACA64A010 rectangular wing undergoing pitch at M = 0.5, M = 0.85 (transonic), and M = 0.93 (transonic). Results presented demonstrate the feasibility of this approach for use with nonlinear, unsteady aerodynamic responses.

Silva, Walter A.↗

Sensorimotor integration in human postural control

It is generally accepted that human bipedal upright stance is achieved by feedback mechanisms that generate an appropriate corrective torque based on body-sway motion detected primarily by visual, vestibular, and proprioceptive sensory systems. Because orientation information from the various senses is not always available (eyes closed) or accurate (compliant support surface), the postural control system must somehow adjust to maintain stance in a wide variety of environmental conditions. This is the sensorimotor integration problem that we investigated by evoking anterior-posterior (AP) body sway using pseudorandom rotation of the visual surround and/or support surface (amplitudes 0.5-8 degrees ) in both normal subjects and subjects with severe bilateral vestibular loss (VL). AP rotation of body center-of-mass (COM) was measured in response to six conditions offering different combinations of available sensory information. Stimulus-response data were analyzed using spectral analysis to compute transfer functions and coherence functions over a frequency range from 0.017 to 2.23 Hz. Stimulus-response data were quite linear for any given condition and amplitude. However, overall behavior in normal subjects was nonlinear because gain decreased and phase functions sometimes changed with increasing stimulus amplitude. "Sensory channel reweighting" could account for this nonlinear behavior with subjects showing increasing reliance on vestibular cues as stimulus amplitudes increased. VL subjects could not perform this reweighting, and their stimulus-response behavior remained quite linear. Transfer function curve fits based on a simple feedback control model provided estimates of postural stiffness, damping, and feedback time delay. There were only small changes in these parameters with increasing visual stimulus amplitude. However, stiffness increased as much as 60% with increasing support surface amplitude. To maintain postural stability and avoid resonant behavior, an increase in stiffness should be accompanied by a corresponding increase in damping. Increased damping was achieved primarily by decreasing the apparent time delay of feedback control rather than by changing the damping coefficient (i.e., corrective torque related to body-sway velocity). In normal subjects, stiffness and damping were highly correlated with body mass and moment of inertia, with stiffness always about 1/3 larger than necessary to resist the destabilizing torque due to gravity. The stiffness parameter in some VL subjects was larger compared with normal subjects, suggesting that they may use increased stiffness to help compensate for their loss. Overall results show that the simple act of standing quietly depends on a remarkably complex sensorimotor control system.

NASA Discipline Neuroscience↗

A modal aeroelastic analysis scheme for turbomachinery blading

An aeroelastic analysis is developed which has general application to all types of axial-flow turbomachinery blades. The approach is based on linear modal analysis, where the blade's dynamic response is represented as a linear combination of contributions from each of its in-vacuum free vibrational modes. A compressible linearized unsteady potential theory is used to model the flow over the oscillating blades. The two-dimensional unsteady flow is evaluated along several stacked axisymmetric strips along the span of the airfoil. The unsteady pressures at the blade surface are integrated to result in the generalized force acting on the blade due to simple harmonic motions. The unsteady aerodynamic forces are coupled to the blade normal modes in the frequency domain using modal analysis. An iterative eigenvalue problem is solved to determine the stability of the blade when the unsteady aerodynamic forces are included in the analysis. The approach is demonstrated by applying it to a high-energy subsonic turbine blade from a rocket engine turbopump power turbine. The results indicate that this turbine could undergo flutter in an edgewise mode of vibration.

Smith, Todd E.↗

On transient rheology and glacial isostasy

The effect of transient creep on the inference of long-term mantle viscosity is investigated using theoretical predictions from self-gravitating, layered earth models with Maxwell, Burgers' body, and standard linear solid rheologies. The interaction between transient and steady-state rheologies is studied. The responses of the standard linear solid and Burgers' body models to transient creep in the entire mantle, and of the Burgers' body and Maxwell models to creep in the lower mantle are described. The models' responses are examined in terms of the surface displacement, free air gravity anomaly, wander of the rotation pole, and the secular variation of the degree 2 zonal coefficient of the earth's gravitational potential field. The data reveal that transient creep cannot operate throughout the entire mantle.

Yuen, David A.↗

A methodology for using nonlinear aerodynamics in aeroservoelastic analysis and design

A methodology is presented for using the Volterra-Wiener theory of nonlinear systems in aeroservoelastic (ASE) analyses and design. The theory is applied to the development of nonlinear aerodynamic response models that can be defined in state-space form and are, therefore, appropriate for use in modern control theory. The theory relies on the identification of nonlinear kernels that can be used to predict the response of a nonlinear system due to an arbitrary input. A numerical kernel identification technique, based on unit impulse responses, is presented and applied to a simple bilinear, single-input single-output (SISO) system. The linear kernel (unit impulse response) and the nonlinear second-order kernel of the system are numerically-identified and compared with the exact, analytically-defined and linear and second-order kernels. This kernel identification technique is then applied to the CAP-TSD (Computational Aeroelasticity Program-Transonic Small Disturbance) code for identification of the linear and second-order kernels of a NACA64A010 rectangular wing undergoing pitch at M = 0.5, M = 8.5 (transonic), and M = 0.93 (transonic). Results presented demonstrate the feasibility of this approach for use with nonlinear, unsteady aerodynamic responses.

Silva, Walter A.↗

Two-dimensional spatiotemporal coding of linear acceleration in vestibular nuclei neurons

Response properties of vertical (VC) and horizontal (HC) canal/otolith-convergent vestibular nuclei neurons were studied in decerebrate rats during stimulation with sinusoidal linear accelerations (0.2-1.4 Hz) along different directions in the head horizontal plane. A novel characteristic of the majority of tested neurons was the nonzero response often elicited during stimulation along the "null" direction (i.e., the direction perpendicular to the maximum sensitivity vector, Smax). The tuning ratio (Smin gain/Smax gain), a measure of the two-dimensional spatial sensitivity, depended on stimulus frequency. For most vestibular nuclei neurons, the tuning ratio was small at the lowest stimulus frequencies and progressively increased with frequency. Specifically, HC neurons were characterized by a flat Smax gain and an approximately 10-fold increase of Smin gain per frequency decade. Thus, these neurons encode linear acceleration when stimulated along their maximum sensitivity direction, and the rate of change of linear acceleration (jerk) when stimulated along their minimum sensitivity direction. While the Smax vectors were distributed throughout the horizontal plane, the Smin vectors were concentrated mainly ipsilaterally with respect to head acceleration and clustered around the naso-occipital head axis. The properties of VC neurons were distinctly different from those of HC cells. The majority of VC cells showed decreasing Smax gains and small, relatively flat, Smin gains as a function of frequency. The Smax vectors were distributed ipsilaterally relative to the induced (apparent) head tilt. In type I anterior or posterior VC neurons, Smax vectors were clustered around the projection of the respective ipsilateral canal plane onto the horizontal head plane. These distinct spatial and temporal properties of HC and VC neurons during linear acceleration are compatible with the spatiotemporal organization of the horizontal and the vertical/torsional ocular responses, respectively, elicited in the rat during linear translation in the horizontal head plane. In addition, the data suggest a spatially and temporally specific and selective otolith/canal convergence. We propose that the central otolith system is organized in canal coordinates such that there is a close alignment between the plane of angular acceleration (canal) sensitivity and the plane of linear acceleration (otolith) sensitivity in otolith/canal-convergent vestibular nuclei neurons.

NASA Discipline Neuroscience↗

Modeling and a correlation algorithm for spaceborne SAR signals

A mathematical model of a spaceborne synthetic aperture radar (SAR) response is presented. Thhe associated SAR system performance, in terms of the resolution capability, is also discussed. The analysis of spaceborne SAR target response indicates that the SAR correlation problem is a two-dimensional one with a linear shift-variant response function. A new digital processing algorithm is proposed here in order to realize an economical digital SAR correlation system. The proposed algorithm treats the two-dimensional correlation by a combination of frequency domain fast correlation in the azimuth dimension and a time-domain convolver type of operation in the range dimension. Finally, digitally correlated SEASAT satellite SAR imagery is used in an exemplary sense to validate the SAR response model and the new digital processing technique developed.

Wu, C.↗

The Local Stellar Velocity Field via Vector Spherical Harmonics

We analyze the local field of stellar tangential velocities for a sample of 42,339 nonbinary Hipparcos stars with accurate parallaxes, using a vector spherical harmonic formalism. We derive simple relations between the parameters of the classical linear model (Ogorodnikov-Milne) of the local systemic field and low-degree terms of the general vector harmonic decomposition. Taking advantage of these relationships, we determine the solar velocity with respect to the local stars of (V(sub X), V(sub Y), V(sub Z)) (10.5, 18.5, 7.3) +/- 0.1 km s(exp -1) not corrected for the asymmetric drift with respect to the local standard of rest. If only stars more distant than 100 pc are considered, the peculiar solar motion is (V(sub X), V(sub Y), V(sub Z)) (9.9, 15.6, 6.9) +/- 0.2 km s(exp -1). The adverse effects of harmonic leakage, which occurs between the reflex solar motion represented by the three electric vector harmonics in the velocity space and higher degree harmonics in the proper-motion space, are eliminated in our analysis by direct subtraction of the reflex solar velocity in its tangential components for each star. The Oort parameters determined by a straightforward least-squares adjustment in vector spherical harmonics are A=14.0 +/- 1.4, B=13.1 +/- 1.2, K=1.1 +/- 1.8, and C=2.9 +/- 1.4 km s(exp -1) kpc(exp -1). The physical meaning and the implications of these parameters are discussed in the framework of a general linear model of the velocity field. We find a few statistically significant higher degree harmonic terms that do not correspond to any parameters in the classical linear model. One of them, a third-degree electric harmonic, is tentatively explained as the response to a negative linear gradient of rotation velocity with distance from the Galactic plane, which we estimate at approximately -20 km s(exp -1) kpc(exp -1). A similar vertical gradient of rotation velocity has been detected for more distant stars representing the thick disk (z greater than 1 kpc), but here we surmise its existence in the thin disk at z less than 200 pc. The most unexpected and unexplained term within the Ogorodnikov-Milne model is the first-degree magnetic harmonic, representing a rigid rotation of the stellar field about the axis -Y pointing opposite to the direction of rotation. This harmonic comes out with a statistically robust coefficient of 6.2 +/- 0.9 km s(exp -1) kpc(exp -1) and is also present in the velocity field of more distant stars. The ensuing upward vertical motion of stars in the general direction of the Galactic center and the downward motion in the anticenter direction are opposite to the vector field expected from the stationary Galactic warp model.

Galaxy↗

Effect of digitally computed drives on performance of continuous linear systems

The dependence of the Bode response upon digital sample rate for first and second order linear continuous systems driven by a digital computer is derived. Open loop lead compensation introduced within the digital computer in order to increase the system bandwidth is also examined in terms of derived Bode responses. This introduction of lead terms within the digital computer is shown to be effective at operating frequencies below the Nyquist frequency. In most practical applications, empirical determination of these lead coefficients appears to be a sufficient compensation method.

Parrish, R. V.↗

Assessing Reliability of NDE Flaw Detection Using Smaller Number of Demonstration Data Points

The paper provides an engineering analysis approach for assessing reliability of NDE flaw detection using smaller number of demonstration data points. It explores dependence of probability of detection (POD), probability of false positive (POF), on contrast-to-noise ratio, and net decision threshold-to-noise ratio in a simulated data; and draws some generically applicable inferences to devise the approach. ASTM nondestructive evaluation standards provide requirements on signal-to-noise ratio and/or contrast-to-noise ratio in order to provide reliable flaw detection and limit false positive calls. POD analysis of inspection test data results in an estimated flaw size, denoted by 𝑎90/95. This flaw size has 90% POD and minimum 95% confidence. POF is also estimated in the analysis. POD demonstration requires specimens with flaws of known size. In many situations, it is very expensive to produce the large number of flaws required for the POD analysis. In some situations, only real flaws can truly represent the flaws for demonstration. Real flaws of correct size and location in part configuration specimen may be difficult to produce, if not impossible. Here, an engineering analysis approach is devised using simulation to assess reliability of NDE technique when a limited number of flaws are available for demonstration. In this simulation, a technique is considered reliable, if it provides flaw detectability size equal to or better than the theoretical 𝑎90𝑡ℎ used in simulation and also provides a POF less than or equal to a chosen value. The paper uses simulated signal response versus flaw size data to devise the approach. Linear correlation is used between the signal response data and flaw size. POD software mh1823 uses generalized linear model (GLM) in POD analysis after transforming the flaw size and signal response, if needed, using logarithm. Therefore, this approach is in agreement with the linear signal correlation used in mh1823. Using the POD analysis of data, generic conditions on contrast-to-noise ratio and net decision threshold-to-noise ratio are derived for reliable flaw detection. In order to assess technique reliability using the engineering approach, signal response-to-flaw size correlation about the flaw size of concern is needed. In addition, measurement of noise is also needed. If the technique meets the above requirements, assumption of linear signal-to-flaw size correlation and conditions on noise, then the technique can be assessed using this analysis as it fits the underlying POD model used here. The approach is conservative and is designed to provide a larger flaw size compared to the POD approach. Such NDE technique assessment approach, although, not as rigorous as POD, can be cost effective if the larger flaw size can be tolerated. Typically, this is a situation for all quality control NDE inspections. Here, an NDE technique needs to be reliable and 𝑎90/95 is not estimated, but the assessed flaw size is assumed to be larger than the unknown a90 due to conservative factors or margins. Applicability of the approach for assessing reliability of flaw detection in x-ray radiography and 2D imaging in general is also explored.

Koshti, Ajay M.↗