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All sourcesNASA NTRSDOE OSTI
DOE OSTI2021

The Hubble PanCET Program: Transit and Eclipse Spectroscopy of the Strongly Irradiated Giant Exoplanet WASP-76b

Ultra-hot Jupiters with equilibrium temperatures greater than 2000 K are uniquely interesting targets as they provide us crucial insights into how atmospheres behave under extreme conditions. This class of giant planets receives intense radiation from their host star and usually has strongly irradiated and highly inflated atmospheres. At such a high temperature, cloud formation is expected to be suppressed and thermal dissociation of water vapor could occur. We observed the ultra-hot Jupiter WASP-76b with seven transits and five eclipses using the Hubble Space Telescope and the Spitzer Space Telescope (Spitzer) for a comprehensive study of its atmospheric chemical and physical processes. We detected TiO and H{sub 2}O absorption in the optical and near-infrared transit spectrum. Additional absorption by a number of neutral and ionized heavy metals like Fe, Ni, Ti, and SiO help explain the short-wavelength transit spectrum. The secondary eclipse spectrum shows muted water feature but a strong CO emission feature in Spitzer’s 4.5 μm band indicating an inverted temperature pressure profile. We analyzed both the transit and eclipse spectra with a combination of self-consistent PHOENIX models and atmospheric retrieval. Both spectra were well fitted by the self-consistent PHOENIX forward atmosphere model in chemical and radiative equilibrium at solar metallicity, adding to the growing evidence that both TiO/VO and NUV heavy metals opacity are prominent NUV-optical opacity sources in the stratospheres of ultra-hot Jupiters.

47 OTHER INSTRUMENTATION↗
DOE OSTI2026

Data Release 1 of the Dark Energy Spectroscopic Instrument

In 2021 May the Dark Energy Spectroscopic Instrument (DESI) collaboration began a 5 yr spectroscopic redshift survey to produce a detailed map of the evolving three-dimensional structure of the Universe between z = 0 and z ≈ 4. DESI’s principal scientific objectives are to place precise constraints on the equation of state of dark energy, the gravitationally driven growth of large-scale structure, and the sum of the neutrino masses, and to explore the observational signatures of primordial inflation. We present DESI DR1, which consists of all data acquired during the first 13 months of the DESI main survey, as well as a uniform reprocessing of the DESI Survey Validation data, which were previously made public in the DESI Early Data Release. The DR1 main survey includes high-confidence redshifts for 18.7M objects, of which 13.1M are spectroscopically classified as galaxies, 1.6M as quasars, and 4M as stars, making DR1 the largest sample of extragalactic redshifts ever assembled. We summarize the DR1 observations, the spectroscopic data-reduction pipeline and data products, large-scale structure catalogs, value-added catalogs, and describe how to access and interact with the data. In addition to fulfilling its core cosmological objectives with unprecedented precision, we expect DR1 to enable a wide range of transformational astrophysical studies and discoveries.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2021

Electromagnetic Signatures from the Tidal Tail of a Black Hole—Neutron Star Merger

Black hole - neutron star (BH-NS) mergers are a major target for ground-based gravitational wave observatories. A merger can also produce an electromagnetic counterpart (a kilonova) if it ejects neutron-rich matter that assembles into heavy elements through r-process nucleosynthesis. We study the kilonova signatures of the unbound dynamical ejecta of a BH-NS merger. We take as our initial state the results from a numerical relativity simulation and then use a general relativistic hydrodynamics code to study the evolution of the ejecta with parameterized r-process heating models. The unbound dynamical ejecta is initially a flattened, directed tidal tail largely confined to a plane. Heating from the r-process inflates the ejecta into a more spherical shape and smooths its small-scale structure, though the ejecta retains its bulk directed motion. We calculate the electromagnetic signatures using a 3D radiative transfer code and a parameterized opacity model for lanthanide-rich matter. The light curve varies with viewing angle because of two effects: asphericity results in brighter emission for orientations with larger projected areas, while Doppler boosting results in brighter emission for viewing angles more aligned with the direction of bulk motion. For typical r-process heating rates, the peak bolometric luminosity varies by a factor of ~3 with orientation while the peak in the optical bands varies by ~3 magnitudes. The spectrum is blueshifted at viewing angles along the bulk motion, which increases the V-band peak magnitude to ~-14 despite the lanthanide-rich composition.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2021

Two Year Cosmology Large Angular Scale Surveyor (CLASS) Observations: Long Timescale Stability Achieved with a Front-end Variable-delay Polarization Modulator at 40 GHz

The Cosmology Large Angular Scale Surveyor (CLASS) is a four-telescope array observing the largest angular scales (2≲ ℓ ≲ 200) of the cosmic microwave background (CMB) polarization. These scales encode information about reionization and inflation during the early universe. The instrument stability necessary to observe these angular scales from the ground is achieved through the use of a variable-delay polarization modulator as the first optical element in each of the CLASS telescopes. Here, we develop a demodulation scheme used to extract the polarization timestreams from the CLASS data and apply this method to selected data from the first 2 yr of observations by the 40 GHz CLASS telescope. These timestreams are used to measure the 1/f noise and temperature-to-polarization (T → P) leakage present in the CLASS data. We find a median knee frequency for the pair-differenced demodulated linear polarization of 15.12 mHz and a T → P leakage of <3.8 × 10 -4 (95% confidence) across the focal plane. We examine the sources of 1/f noise present in the data and find the component of 1/f due to atmospheric precipitable water vapor (PWV) has an amplitude of 203 ± 12 µK RJ $\sqrt{{s}}$ for 1 mm of PWV when evaluated at 10 mHz; accounting for ~17% of the 1/f noise in the central pixels of the focal plane. In conclusion, the low levels of T → P leakage and 1/f noise achieved through the use of a front-end polarization modulator are requirements for observing of the largest angular scales of the CMB polarization by the CLASS telescopes.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2021

Spectroscopic Confirmation of the Sixth Globular Cluster in the Fornax Dwarf Spheroidal Galaxy*

The Fornax dwarf spheroidal galaxy has an anomalous number of globular clusters, five, for its stellar mass. There is a longstanding debate about a potential sixth globular cluster (Fornax 6) that has recently been "rediscovered" in DECam imaging. We present new Magellan/M2FS spectroscopy of the Fornax 6 cluster and Fornax dSph. Combined with literature data we identify ~15–17 members of the Fornax 6 cluster, showing that this overdensity is indeed a star cluster and associated with the Fornax dSph. The cluster is significantly more metal-rich (mean metallicity of $\overline{[\mathrm{Fe}/{\rm{H}}]}$ = –0.71 ± 0.05) than the other five Fornax globular clusters (–2.5 < [Fe/H] < –1.4) and more metal-rich than the bulk of Fornax. We measure a velocity dispersion of ${5.6}_{-1.6}^{+2.0}\mathrm{km}\,{{\rm{s}}}^{-1}$ corresponding to an anomalously high mass-to-light of 15 < M/L < 258 at 90% confidence when calculated assuming equilibrium. Two stars inflate this dispersion and may be either Fornax field stars or as yet unresolved binary stars. Alternatively, the Fornax 6 cluster may be undergoing tidal disruption. Based on its metal-rich nature, the Fornax 6 cluster is likely younger than the other Fornax clusters, with an estimated age of ~2 Gyr when compared to stellar isochrones. The chemodynamics and star formation history of Fornax shows imprints of major events such as infall into the Milky Way, multiple pericenter passages, star formation bursts, and/or potential mergers or interactions. Any of these events may have triggered the formation of the Fornax 6 cluster.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2026

Simulation to a Newborn Supernova Remnant from a Low-mass Iron Core Star

Supernova remnant observations show a high degree of asymmetry, mixing, and inhomogeneity. These asymmetries are seeded during the early seconds of the explosion and are further enhanced and modified as the shock and ejecta move through the stellar progenitor and into the circumstellar medium. We present simulations of a 9.6 M⊙ zero-metallicity progenitor initialized after shock revival and evolved for several years when the ejecta is in the circumstellar medium. A suite of 1D and 2D simulations examines the effects of neutron-star wind and radioactive decay heating. In 1D, decay heating forms a low-density bubble that suppresses the reverse shock. While in 2D, the heating is localized to metal-rich pockets, inflating them and compressing the surrounding material into dense shells. In 3D, the neutron-star wind and decay heating modify the plume morphology, producing more large-scale structures. The extended plume morphology leads to an asymmetrical shock breakout. After breakout, the leading plumes cannot keep up with the shock front, resulting in deceleration and fragmentation by the reverse shock while retaining the large-scale asymmetry. The projected ejecta morphology and velocities are strongly viewing angle dependent. The relatively uniform metal-rich distribution does not resemble the strongly inhomogeneous ejecta structure of Cas A. The 160-isotope decay network shows that 24.4% of the radioactive heating comes from decay chains other than the canonical 56Ni chain. The low explosion energy, low 56Ni yield, and Ni/Fe ratio greater than unity suggest an observational signature similar to an electron capture supernova.

Neopane, Sudarshan [University of Tennessee (UT)]↗
DOE OSTI2022

On the Jet–Ejecta Interaction in 3D GRMHD Simulations of a Binary Neutron Star Merger Aftermath

Short γ-ray burst (sGRB) jets form in the aftermath of a neutron star merger, drill through disk winds and dynamical ejecta, and extend over four to five orders of magnitude in distance before breaking out of the ejecta. We present the first 3D general-relativistic magnetohydrodynamic sGRB simulations to span this enormous scale separation. They feature three possible outcomes: jet+cocoon, cocoon, and neither. Typical sGRB jets break out of the dynamical ejecta if (i) the bound ejecta's isotropic equivalent mass along the pole at the time of the BH formation is ≲10 -4 M ⊙ , setting a limit on the delay time between the merger and BH formation, otherwise, the jets perish inside the ejecta and leave the jet-inflated cocoon to power a low-luminosity sGRB; (ii) the postmerger remnant disk contains a strong large-scale vertical magnetic field, ≳1015 G; and (iii) if the jets are weak (≲10 50 erg), the ejecta's isotropic equivalent mass along the pole must be small (≲10 -2 M ⊙ ). Generally, the jet structure is shaped by the early interaction with disk winds rather than the dynamical ejecta. As long as our jets break out of the ejecta, they retain a significant magnetization (≲1), suggesting that magnetic reconnection is a fundamental property of sGRB emission. The angular structure of the outflow isotropic equivalent energy after breakout consistently features a flat core followed by a steep power-law distribution (slope ≳3), similar to hydrodynamic jets. In the cocoon-only outcome, the dynamical ejecta broadens the outflow angular distribution and flattens it (slope ~1.5).

Jets↗
DOE OSTI2022

Bridging the Bondi and Event Horizon Scales: 3D GRMHD Simulations Reveal X-shaped Radio Galaxy Morphology

X-shaped radio galaxies (XRGs) produce misaligned X-shaped jet pairs and make up ≲10% of radio galaxies. XRGs are thought to emerge in galaxies featuring a binary supermassive black hole (SMBH), SMBH merger, or large-scale ambient medium asymmetry. We demonstrate that XRG morphology can naturally form without such special, preexisting conditions. Our 3D general-relativistic magnetohydrodynamic (GRMHD) simulation for the first time follows magnetized rotating gas from outside the SMBH sphere of influence of radius RB to the SMBH of gravitational radius Rg at the largest scale separation, RB/Rg = 103, to date. Initially, our axisymmetric system of constant-density hot gas contains a weak vertical magnetic field and rotates in the equatorial plane of a rapidly spinning SMBH. We seed the gas with small-scale 2% level pressure perturbations. Infalling gas forms an accretion disk, and the SMBH launches relativistically magnetized collimated jets reaching well outside RB. Under the pressure of the infalling gas, the jets intermittently turn on and off, erratically wobble, and inflate pairs of cavities in different directions, resembling an X-shaped jet morphology. Synthetic X-ray images reveal multiple pairs of jet-powered shocks and cavities. Large-scale magnetic flux accumulates on the SMBH, becomes dynamically important, and leads to a magnetically arrested disk state. The SMBH accretes at 2% of the Bondi rate ($\dot{M}\simeq 2.4\times {10}^{-3}{M}_{\odot }\,{\mathrm{yr}}^{-1}$ for M87*) and launches twin jets at η = 150% efficiency. These jets are powerful enough (P jets ≃ 2 × 10 44 erg s -1 ) to escape along the SMBH spin axis and end the short-lived intermittent jet state, whose transient nature can account for the rarity of XRGs.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2023

The NANOGrav 15 yr Data Set: Search for Signals from New Physics

The 15 yr pulsar timing data set collected by the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) shows positive evidence for the presence of a low-frequency gravitational-wave (GW) background. In this paper, we investigate potential cosmological interpretations of this signal, specifically cosmic inflation, scalar-induced GWs, first-order phase transitions, cosmic strings, and domain walls. We find that, with the exception of stable cosmic strings of field theory origin, all these models can reproduce the observed signal. When compared to the standard interpretation in terms of inspiraling supermassive black hole binaries (SMBHBs), many cosmological models seem to provide a better fit resulting in Bayes factors in the range from 10 to 100. However, these results strongly depend on modeling assumptions about the cosmic SMBHB population and, at this stage, should not be regarded as evidence for new physics. Furthermore, we identify excluded parameter regions where the predicted GW signal from cosmological sources significantly exceeds the NANOGrav signal. These parameter constraints are independent of the origin of the NANOGrav signal and illustrate how pulsar timing data provide a new way to constrain the parameter space of these models. Finally, we search for deterministic signals produced by models of ultralight dark matter (ULDM) and dark matter substructures in the Milky Way. We find no evidence for either of these signals and thus report updated constraints on these models. In the case of ULDM, these constraints outperform torsion balance and atomic clock constraints for ULDM coupled to electrons, muons, or gluons.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2023

Jetted and Turbulent Stellar Deaths: New LVK-detectable Gravitational-wave Sources

Upcoming LIGO–Virgo–KAGRA (LVK) observing runs are expected to detect a variety of inspiralling gravitational-wave (GW) events that come from black hole and neutron star binary mergers. Detection of noninspiral GW sources is also anticipated. We report the discovery of a new class of noninspiral GW sources—the end states of massive stars—that can produce the brightest simulated stochastic GW burst signal in the LVK bands known to date, and could be detectable in LVK run A+. Some dying massive stars launch bipolar relativistic jets, which inflate a turbulent energetic bubble—cocoon—inside of the star. We simulate such a system using state-of-the-art 3D general relativistic magnetohydrodynamic simulations and show that these cocoons emit quasi-isotropic GW emission in the LVK band, ~10–100 Hz, over a characteristic jet activity timescale ~10–100 s. Our first-principles simulations show that jets exhibit a wobbling behavior, in which case cocoon-powered GWs might be detected already in LVK run A+, but it is more likely that these GWs will be detected by the third-generation GW detectors with an estimated rate of ~10 events yr –1 . The detection rate drops to ~1% of that value if all jets were to feature a traditional axisymmetric structure instead of a wobble. Accompanied by electromagnetic emission from the energetic core-collapse supernova and the cocoon, we predict that collapsars are powerful multimessenger events.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2023

Large-scale Evolution of Seconds-long Relativistic Jets from Black Hole–Neutron Star Mergers

We present the first numerical simulations that track the evolution of a black hole–neutron star (BH–NS) merger from premerger to r ≳ 10 11 cm. The disk that forms after a merger of mass ratio q = 2 ejects massive disk winds (3–5 × 10 –2 M ⊙ ). We introduce various postmerger magnetic configurations and find that initial poloidal fields lead to jet launching shortly after the merger. The jet maintains a constant power due to the constancy of the large-scale BH magnetic flux until the disk becomes magnetically arrested (MAD), where the jet power falls off as L j ~ t –2 . All jets inevitably exhibit either excessive luminosity due to rapid MAD activation when the accretion rate is high or excessive duration due to delayed MAD activation compared to typical short gamma-ray bursts (sGRBs). This provides a natural explanation for long sGRBs such as GRB 211211A but also raises a fundamental challenge to our understanding of jet formation in binary mergers. One possible implication is the necessity of higher binary mass ratios or moderate BH spins to launch typical sGRB jets. For postmerger disks with a toroidal magnetic field, dynamo processes delay jet launching such that the jets break out of the disk winds after several seconds. We show for the first time that sGRB jets with initial magnetization σ0 > 100 retain significant magnetization (σ $\gg$ 1) at r > 10 10 cm, emphasizing the importance of magnetic processes in the prompt emission. The jet–wind interaction leads to a power-law angular energy distribution by inflating an energetic cocoon whose emission is studied in a companion paper.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2025

Magnetically Driven Neutron-rich Ejecta Unleashed: Global 3D Neutrino–General Relativistic Magnetohydrodynamic Simulations of Collapsars Probe the Conditions for r -process Nucleosynthesis

Abstract Collapsars—rapidly rotating stellar cores that form black holes—can power gamma-ray bursts and are proposed to be key contributors to the production of heavy elements in the Universe via the rapid neutron capture process ( r -process). Previous neutrino-transport collapsar simulations have been unable to unbind neutron-rich material from the disk. However, these simulations have not included sufficiently strong magnetic fields and the black hole (BH), both of which are essential for launching mass outflows. We present ν h-amr , a novel neutrino-transport general relativistic magnetohydrodynamic ( ν GRMHD) code, which we use to perform the first 3D global ν GRMHD collapsar simulations. We find a self-consistent formation of a weakly magnetized dense accretion disk, which has sufficient time to neutronize. Eventually, substantial magnetic flux accumulates near the BH, becomes dynamically important, leads to a magnetically arrested disk (MAD), and unbinds some of the neutron-rich material. However, the strong flux also hinders accretion, lowers density, and increases neutrino-cooling timescale, which prevents further disk neutronization. Typical collapsar progenitors with mass accretion rates, M ̇ ∼ 0.1 − 1 M ⊙ s - 1 , do not produce significant neutron-rich ( Y e < 0.25) ejecta. However, we find that MADs at higher mass accretion rates, M ̇ ≳ few M ⊙ s - 1 (e.g., for more centrally concentrated progenitors), can unbind M ej ≲ M ⊙ of neutron-rich ejecta. The outflows inflate a shocked cocoon that mixes with the infalling neutron-poor stellar gas and raises the final outflow Y e ; however, the final r -process yield may be determined earlier at the point of neutron capture freeze-out. Future work will explore under what conditions more typical collapsar engines become r -process factories.

Issa, Danat (ORCID:0009000524787631)↗
DOE OSTI2023

Light-duty Plug-in Electric Vehicles in China: Evolution, Competition, and Outlook

China's plug-in electric vehicle (PEV) market with stocks at 7.8 million is the world's largest in 2021, and it accounts for half of the global PEV growth in 2021. The PEV market in China has dramatically evolved since the pandemic in 2020: over 20% of all new PEV sales are from China by mid-2022. Recent features of PEV market dynamics, consumer acceptance, policies, and infrastructure have important implications for both the global energy market and manufacturing stakeholders. From the perspective of demand pull-supply push, this study analyzes China's PEV industry with a market dynamics framework by reviewing sales, product and brand, infrastructure, and government policies from the last few years and outlooking the development of the new government’s 14th Five-Year Plan (2021-2025). From the demand side, small-sized sedans and compact sport utility vehicles with increased electric ranges are both popular for PEVs, and the electric range of over 60% of new battery electric vehicles in 2021 has been longer than 400 km. From the supply side, although foreign brands like Tesla are still competitive, the products by Chinese domestic automakers like BYD are becoming more attractive and cannibalizing the high-end market. However, the production capacity and cost of PEVs may be limited by the upstream of the supply chain – the battery manufacturing and supply chain inflation. In addition, it is also uncertain how much sales demand impacts will be caused by the potential global economic recession. The government firmly supports electrification and decarbonization of the vehicle industry by emphasizing the importance of the vehicle industry for promoting the greenhouse gas net zero by 2060. The dual-credit policy is regarded as the most critical regulation in a bid to restrain fuel consumption and promote PEV share. Still, the market is facing some technological obstacles, such as battery safety and driving range anxiety, before real prosperity. In addition, the Chinese electric vehicle market is seeing a trend toward the development of new technologies such as vehicle-to-X, autonomous driving, and connected vehicles.

Hao, Xu↗
DOE OSTI2025

Primordial Black Holes are 5D

We revisit well-established mechanisms for primordial black hole (PBH) production, namely inflation, phase transitions, and cosmic strings, in the context of the Dark Dimension Scenario, which is motivated by Swampland principles. Applying quantum gravity constraints, we demonstrate that any viable mechanism, barring exotic new physics at low energies, inevitably leads to the formation of five-dimensional PBHs. We further show that PBHs formed from cosmic strings can have lifetimes comparable to the age of the universe. We comment on the observational implications of this result, including a potential connection to the recent detection of a high-energy neutrino by KM3NeT, whose energy is intriguingly close to the five-dimensional Planck scale in the Dark Dimension Scenario.

Cosmology and Nongalactic Astrophysics (astro-ph.C↗
DOE OSTI2023

Calibrating radar wind profiler reflectivity factor using surface disdrometer observations

Abstract. This study uses surface disdrometer reflectivity factor estimates to calibrate the vertical and off-vertical pointing radar beams produced by an ultra high frequency (UHF) band radar wind profiler (RWP) deployed at the US Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) program Southern Great Plains (SGP) Central Facility in northern Oklahoma from April 2011 through July 2019. The methodology consists of five steps. First, the recorded Doppler velocity power spectra are adjusted to account for Nyquist velocity aliasing and coherent integration filtering effects. Second, the spectrum moments are calculated. The third step increases the signal-to-noise ratio (SNR) due to inflated noise power estimates during convective rain events that cause SNR to be biased low. The fourth step determines the RWP calibration constant for one radar beam (called the “reference” beam) by comparing uncalibrated RWP reflectivity factors at 500 m above the ground to 1 min resolution surface disdrometer reflectivity factors. The last step uses the calibrated reference beam reflectivity factor to calibrate the other radar beams during precipitation. There are two key findings. The RWP sensitivity decreased by approximately 3 to 4 dB yr−1 as the hardware aged. This drift was slow enough that the reference calibration constant can be estimated over 3-month intervals using episodic rain events. The calibrated moments are available on the DOE ARM data archive, and the Python processing code is available on public repositories.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2021

Intense windstorms in the northeastern United States

Abstract. Windstorms are a major natural hazard in many countries. The objective of this study is to identify and characterize intense windstorms during the last 4 decades in the US Northeast and determine both the sources of cyclones responsible for these events and the manner in which those cyclones differ from the cyclone climatology. The windstorm detection is based on the spatial extent of locally extreme wind speeds at 100 m height from the ERA5 reanalysis database. During the top 10 windstorms, wind speeds exceed their local 99.9th percentile over at least one-third of land-based ERA5 grid cells in this high-population-density region of the USA. Maximum sustained wind speeds at 100 m during these windstorms range from 26 to over 43 ms−1, with wind speed return periods exceeding 6.5 to 106 years (considering the top 5 % of grid cells during each storm). Property damage associated with these storms, with inflation adjusted to January 2020, ranges from USD 24 million to over USD 29 billion. Two of these windstorms are linked to decaying tropical cyclones, three are Alberta clippers, and the remaining storms are Colorado lows. Two of the 10 re-intensified off the east coast, leading to development of nor'easters. These windstorms followed frequently observed cyclone tracks but exhibit maximum intensities as measured using 700 hPa relative vorticity and mean sea level pressure that is 5–10 times the mean values for cyclones that followed similar tracks over this 40-year period. The time evolution of wind speeds and concurrent precipitation for those windstorms that occurred after the year 2000 exhibit good agreement with in situ ground-based and remote sensing observations, plus storm damage reports, indicating that the ERA5 reanalysis data have a high degree of fidelity for large, damaging windstorms such as these. A larger pool of the top 50 largest windstorms exhibit evidence of only weak serial clustering, which is in contrast to the relatively strong serial clustering of windstorms in Europe.

58 GEOSCIENCES↗
DOE OSTI2021

Quantile-dependent expressivity of serum C-reactive protein concentrations in family sets

“Quantile-dependent expressivity” occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g., C-reactive protein, CRP) is high or low relative to its distribution. We have previously shown that the heritabilities ( h 2 ) of coffee and alcohol consumption, postprandial lipemia, lipoproteins, leptin, adiponectin, adiposity, and pulmonary function are quantile-specific. Whether CRP heritability is quantile-specific is currently unknown. Methods Serum CRP concentrations from 2,036 sibships and 6,144 offspring-parent pairs were analyzed from the Framingham Heart Study. Quantile-specific heritability from full-sib (β FS , h 2 ={(1 + 8r spouse β FS ) 0.5 - 1}/(2r spouse )) and offspring-parent regression slopes (β OP , h 2 = 2β OP /(1 + r spouse )) were estimated robustly by quantile regression with nonparametric significance determined from 1,000 bootstrap samples. Results Quantile-specific h 2 (±SE) increased with increasing percentiles of the offspring’s age- and sex-adjusted CRP distribution when estimated from β OP ( P trend = 0.0004): 0.02 ± 0.01 at the 10th, 0.04 ± 0.01 at the 25th, 0.10 ± 0.02 at the 50th, 0.20 ± 0.05 at the 75th, and 0.33 ± 0.10 at the 90th percentile, and when estimated from β FS ( P trend = 0.0008): 0.03±0.01 at the 10th, 0.06 ± 0.02 at the 25th, 0.14 ± 0.03 at the 50th, 0.24 ± 0.05 at the 75th, and 0.53 ± 0.21 at the 90th percentile. Conclusion Heritability of serum CRP concentration is quantile-specific, which may explain or contribute to the inflated CRP differences between CRP (rs1130864, rs1205, rs1800947, rs2794521, rs3091244), FGB (rs1800787), IL-6 (rs1800795, rs1800796), IL6R (rs8192284), TNF- α (rs1800629) and APOE genotypes following CABG surgery, stroke, TIA, curative esophagectomy, intensive periodontal therapy, or acute exercise; during acute coronary syndrome or Staphylococcus aureus bacteremia; or in patients with chronic rheumatoid arthritis, diabetes, peripheral arterial disease, ankylosing spondylitis, obesity or inflammatory bowel disease or who smoke.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

Soft buckling actuators

A soft actuator is described, including: a rotation center having a center of mass; a plurality of bucklable, elastic structural components each comprising a wall defining an axis along its longest dimension, the wall connected to the rotation center in a way that the axis is offset from the center of mass in a predetermined direction; and a plurality of cells each disposed between two adjacent bucklable, elastic structural components and configured for connection with a fluid inflation or deflation source; wherein upon the deflation of the cell, the bucklable, elastic structural components are configured to buckle in the predetermined direction. A soft actuating device including a plurality of the soft actuators and methods of actuation using the soft actuator or soft actuating device disclosed herein are also described.

42 ENGINEERING↗