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At least 523 records · Page 29

Mountain-Top-to-Mountain-Top Optical Link Demonstration

A mountain-top-to-mountain-top optical communications demonstration was conducted between the JPL Table Mountain Facility (TMF), Wrightwood, California, and Strawberry Peak (SP), Lake Arrowhead, California, during the months of August and September of 2000. The link was nearly horizontal at an altitude of 2 km and spanned a range of 46.8 km. A 780-nm multibeam beacon broadcast from TMF was received by the JPL Optical Communications Demonstrator (OCD) located at SP. The received beacon was utilized as a pointing reference to retransmit an 852-nm communications laser beam, modulated at 400 Mb/s by a PN7 pseudo-random bit stream (PRBS) sequence. The long atmospheric path resulted in atmospheric-turbulence-induced angle-of-arrival fluctuations of the beacon at the OCD aperture. A .ne-steering control loop was used to track the resulting beacon centroid motion and update the pointing of the communications laser beam transmitted from SP to TMF. Fried parameters, or r0, inferred from focal spot sizes received at SP were 4 to 5 cm whereas, using the spot sizes received at TMF, they were 2 to 3 cm. In both cases, theory predicts larger r0 values. The predicted angle-of-arrival fluctuations compare well with measured rms displacements exhibited by the focal spots at either end of the link. An uncompensated error of ~1.1 rad in the x-axis and ~2 rad in the y-axis was obtained using centroid data logged by the OCD. Average bit-error rates of 10-5 were recorded for extended periods of time. An atmospheric coherence length r0 of 3 to 5 cm was inferred using the focal-plane spot size measured on the CCD tracking sensor and compared to a predicted value of 5 to 7 cm using reasonable atmospheric models. The irradiance bounds required for the CCD tracking sensor to perform centroiding was found to range from 2000 to 3000 integrated pixel counts, although a more reliable range was 600 to 3000, indicating a dynamic range of 6 to 11 dB. The motion of the spot on the focal plane was also recorded and yielded rms angle-of-arrival-induced focal-plane displacement of 9 to 11 m, compared to a predicted value of 7.8 to 11 m. The irradiance measurements made with the OCD clearly indicate that best tracking performance is obtained when the mean received signal is 2000 to 2200 counts. The best tracking performance resulted in an rms uncompensated error of 1.1 rad. The uncompensated error appeared to increase with either an increase or decrease in mean beacon-signal level. The rms uncompensated error determined by deriving the beacon displacement power spectral density from the beacon centroid-versustime data and the rejection function of the control loop yielded a higher value of 3.4 rad.

Biswas, A.↗

Retrospective Analysis of Clinical Performance of an Estonian Speech Recognition System for Radiology: Effects of Different Acoustic and Language Models

The aim of this study was to analyze retrospectively the influence of different acoustic and language models in order to determine the most important effects to the clinical performance of an Estonian language-based non-commercial radiology-oriented automatic speech recognition (ASR) system. An ASR system was developed for Estonian language in radiology domain by utilizing open-source software components (Kaldi toolkit, Thrax). The ASR system was trained with the real radiology text reports and dictations collected during development phases. The final version of the ASR system was tested by 11 radiologists who dictated 219 reports in total, in spontaneous manner in a real clinical environment. The audio files collected in the final phase were used to measure the performance of different versions of the ASR system retrospectively. ASR system versions were evaluated by word error rate (WER) for each speaker and modality and by WER difference for the first and the last version of the ASR system. Total average WER for the final version throughout all material was improved from 18.4% of the first version (v1) to 5.8% of the last (v8) version which corresponds to relative improvement of 68.5%. WER improvement was strongly related to modality and radiologist. In summary, the performance of the final ASR system version was close to optimal, delivering similar results to all modalities and being independent on user, the complexity of the radiology reports, user experience, and speech characteristics.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Q4 – A CubeSat Mission to Demonstrate Omnidirectional Optical Communications

We are proposing a technology demonstration mission for JPL’s Inter-Satellite Optical Communicator (ISOC). The ISOC has the potential to enable up to 1 Gbps data rates over a distance up to 200 km in free space. Key features of the ISOC include full sky coverage and the ability to maintain multiple links simultaneously. The Q4 mission consists of (4) 6U CubeSats furnished with ISOCs to demonstrate high data rate communications among the spacecraft. More specifically, we seek to demonstrate the omnidirectionality of the ISOC by providing simultaneous optical links between one spacecraft and the other three. Q4 will be a demonstrator for small spacecraft swarm capabilities. Following a proposed deployment from the ISS, the CubeSats will utilize their onboard thrusters to enter their desired orbit. The orbit consists of one “leader” spacecraft in a circular orbit with a 400 km LEO altitude and three “follower” spacecraft in slightly elliptical orbits rotating azimuthally about the leader. The main mission will consist of three consecutive phases: First, the spacecraft will demonstrate pointing, acquisition, and tracking using newly developed protocols. Next, link establishment and different channel access methods (CDMA and TDMA) will be tested. Finally, Delay Tolerant Network protocols will be implemented to allow fast data sharing among the spacecraft. The distance between the communicating spacecraft will be increased as the mission progresses to characterize the link quality as a function of distance. All communications over the course of the mission will be recorded and analyzed on the ground using bit error rate as a metric for success. The current design for each the four Q4 CubeSats contains an XACT advanced ADCS system for precision beam pointing. Other components currently under consideration include MiPS cold gas thrusters for orbital maneuvering and gimbaled eHaWK 84W solar arrays. In this paper we present design considerations for the Q4 CubeSats, link budget calculations, results from preliminary mission analysis, and expected results.

Velazco, Jose E↗

Field Measurement and Analysis of Frequency and RoCoF for Low-Inertia Power Systems

The frequency measurement and rate of change of frequency (RoCoF) calculations are important for active power, frequency control, and frequency-related protection in power system operations. With the rapid decrease in inertia under modern power systems, however, multiple power variations introduced by variable renewable energy bring large RoCoF and introduce oscillations in frequency measurements. To shed light on this issue, this article proposes a frequency measurement and RoCoF analysis technology, as well as the sensitivity analysis for the real low-inertia power grid. First, a real-world event in an island power grid is analyzed as an example, and an event numerical model is estimated considering four uncertainties, including event RoCoF, oscillation magnitude, oscillation frequency, and underfrequency load-shedding threshold. Then, a sensitivity analysis is performed using the Sobol indices method and quasi-Monte Carlo simulations to identify the dominant uncertainties based on the event model. Here, the dominant uncertainties are compared to provide a guideline for the frequency estimation algorithm selection under different event cases. This algorithm is compared with an enhanced zero-crossing algorithm and gives a 3.41% better RoCoF error rate. Finally, an experiment is conducted using universal grid analyzers to validate the simulation results and the theoretical analysis.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Sequential programmable self-assembly: Role of cooperative interactions

Here, we propose a general strategy of “sequential programmable self-assembly” that enables a bottom-up design of arbitrary multi-particle architectures on nano- and microscales. We show that a naive realization of this scheme, based on the pairwise additive interactions between particles, has fundamental limitations that lead to a relatively high error rate. This can be overcome by using cooperative interparticle binding. The cooperativity is a well known feature of many biochemical processes, responsible, e.g., for signaling and regulations in living systems. Here we propose to utilize a similar strategy for high precision self-assembly, and show that DNA-mediated interactions provide a convenient platform for its implementation. In particular, we outline a specific design of a DNA-based complex which we call “DNA spider,” that acts as a smart interparticle linker and provides a built-in cooperativity of binding. We demonstrate versatility of the sequential self-assembly based on spider-functionalized particles by designing several mesostructures of increasing complexity and simulating their assembly process. This includes a number of finite and repeating structures, in particular, the so-called tetrahelix and its several derivatives. Due to its generality, this approach allows one to design and successfully self-assemble virtually any structure made of a “GEOMAG” magnetic construction toy, out of nanoparticles. According to our results, once the binding cooperativity is strong enough, the sequential self-assembly becomes essentially error-free.

77 NANOSCIENCE AND NANOTECHNOLOGY↗

Hardware Implementation of Serially Concatenated PPM Decoder

A prototype decoder for a serially concatenated pulse position modulation (SCPPM) code has been implemented in a field-programmable gate array (FPGA). At the time of this reporting, this is the first known hardware SCPPM decoder. The SCPPM coding scheme, conceived for free-space optical communications with both deep-space and terrestrial applications in mind, is an improvement of several dB over the conventional Reed-Solomon PPM scheme. The design of the FPGA SCPPM decoder is based on a turbo decoding algorithm that requires relatively low computational complexity while delivering error-rate performance within approximately 1 dB of channel capacity. The SCPPM encoder consists of an outer convolutional encoder, an interleaver, an accumulator, and an inner modulation encoder (more precisely, a mapping of bits to PPM symbols). Each code is describable by a trellis (a finite directed graph). The SCPPM decoder consists of an inner soft-in-soft-out (SISO) module, a de-interleaver, an outer SISO module, and an interleaver connected in a loop (see figure). Each SISO module applies the Bahl-Cocke-Jelinek-Raviv (BCJR) algorithm to compute a-posteriori bit log-likelihood ratios (LLRs) from apriori LLRs by traversing the code trellis in forward and backward directions. The SISO modules iteratively refine the LLRs by passing the estimates between one another much like the working of a turbine engine. Extrinsic information (the difference between the a-posteriori and a-priori LLRs) is exchanged rather than the a-posteriori LLRs to minimize undesired feedback. All computations are performed in the logarithmic domain, wherein multiplications are translated into additions, thereby reducing complexity and sensitivity to fixed-point implementation roundoff errors. To lower the required memory for storing channel likelihood data and the amounts of data transfer between the decoder and the receiver, one can discard the majority of channel likelihoods, using only the remainder in operation of the decoder. This is accomplished in the receiver by transmitting only a subset consisting of the likelihoods that correspond to time slots containing the largest numbers of observed photons during each PPM symbol period. The assumed number of observed photons in the remaining time slots is set to the mean of a noise slot. In low background noise, the selection of a small subset in this manner results in only negligible loss. Other features of the decoder design to reduce complexity and increase speed include (1) quantization of metrics in an efficient procedure chosen to incur no more than a small performance loss and (2) the use of the max-star function that allows sum of exponentials to be computed by simple operations that involve only an addition, a subtraction, and a table lookup. Another prominent feature of the design is a provision for access to interleaver and de-interleaver memory in a single clock cycle, eliminating the multiple clock-cycle latency characteristic of prior interleaver and de-interleaver designs.

Moision, Bruce↗

Efficient Routing of Quantum LDPC Codes on Programmable 2D Toric Architectures

Quantum low-density parity-check codes are promising candidates towards scalable fault-tolerant quantum computation. Among these, bivariate bicycle (BB) codes offer superior encoding rates and large code distance compared to surface codes. However, their requirement on long-range stabilizer measurements poses significant challenges for implementation on realistic hardware with limited connectivity, such as superconducting circuit platforms. In this work, we introduce a novel hardware-software co-design that leverages a programmable communication network architecture to address these limitations. Our approach utilizes a 2D toric network of oscillators as a flexible communication fabric linking qubits at each site. Such architecture significantly reduces the number of long-range couplers required from O ( n ) to O (√ n ). Dual-rail qubits, along with native gates including Swap-Wait-Swap gates and beamsplitter SWAPs, ensure that long-range two-qubit gates can be executed with high fidelity and low latency. To further enhance performance, our qubit layout and routing algorithm utilize symmetries of the codes and enable maximum parallelism for long-range two-qubit gates, maintaining a low syndrome extraction cycle duration and scalability over the code length. We perform circuit-level simulation with realistic noise modeling based on experimental hardware parameters, observing an logical error rate per logical qubit per cycle of 3.06% for [[18,4,4]] BB code, 2.6× less than the existing experimental result. These findings provide a practical roadmap and identify key technological advancements needed to achieve low-overhead fault-tolerant quantum computing at scale.

Liu, Kun [Yale Univ., New Haven, CT (United States↗

Redefining the Practice of Peer Review Through Intelligent Automation Part 2: Data-Driven Peer Review Selection and Assignment

In conventional radiology peer review practice, a small number of exams (routinely 5% of the total volume) is randomly selected, which may significantly underestimate the true error rate within a given radiology practice. An alternative and preferable approach would be to create a data-driven model which mathematically quantifies a peer review risk score for each individual exam and uses this data to identify high risk exams and readers, and selectively target these exams for peer review. An analogous model can also be created to assist in the assignment of these peer review cases in keeping with specific priorities of the service provider. An additional option to enhance the peer review process would be to assign the peer review cases in a truly blinded fashion. In addition to eliminating traditional peer review bias, this approach has the potential to better define exam-specific standard of care, particularly when multiple readers participate in the peer review process.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Orbit Determination Error Analysis Results for the Triana Sun-Earth L2 Libration Point Mission

Using the NASA Goddard Space Flight Center's Orbit Determination Error Analysis System (ODEAS), orbit determination error analysis results are presented for all phases of the Triana Sun-Earth L1 libration point mission and for the science data collection phase of a future Sun-Earth L2 libration point mission. The Triana spacecraft was nominally to be released by the Space Shuttle in a low Earth orbit, and this analysis focuses on that scenario. From the release orbit a transfer trajectory insertion (TTI) maneuver performed using a solid stage would increase the velocity be approximately 3.1 km/sec sending Triana on a direct trajectory to its mission orbit. The Triana mission orbit is a Sun-Earth L1 Lissajous orbit with a Sun-Earth-vehicle (SEV) angle between 4.0 and 15.0 degrees, which would be achieved after a Lissajous orbit insertion (LOI) maneuver at approximately launch plus 6 months. Because Triana was to be launched by the Space Shuttle, TTI could potentially occur over a 16 orbit range from low Earth orbit. This analysis was performed assuming TTI was performed from a low Earth orbit with an inclination of 28.5 degrees and assuming support from a combination of three Deep Space Network (DSN) stations, Goldstone, Canberra, and Madrid and four commercial Universal Space Network (USN) stations, Alaska, Hawaii, Perth, and Santiago. These ground stations would provide coherent two-way range and range rate tracking data usable for orbit determination. Larger range and range rate errors were assumed for the USN stations. Nominally, DSN support would end at TTI+144 hours assuming there were no USN problems. Post-TTI coverage for a range of TTI longitudes for a given nominal trajectory case were analyzed. The orbit determination error analysis after the first correction maneuver would be generally applicable to any libration point mission utilizing a direct trajectory.

Marr, G.↗

An Approach to Dependence Assessment in Human Reliability Analysis: Application of Lag and Linger Effects

Dependence assessment refers to an approach used in human reliability analysis (HRA) to adjust a human error probability (HEP) for the following action by considering the impact of the preceding action. It has been known to significantly affect the overall results of probabilistic safety assessment (PSA). If the dependence assessment is not adequate, the result could be unconvincing for explaining the operator failures in the context of PSA. To date, several methods and some recent research have identified suggestions for treating dependence issues in HRA; however, these are still exclusively based on the intrinsic approach of the Technique for Human Error Rate Prediction (THERP), an HRA method. THERP inevitably has a challenge with the subjectivity of expert evaluation as well as the requirement for PSA and HRA expertise with resource-intensive and time-consuming processes. This paper suggests an approach to dependence assessment that could not only minimize the influence of expert judgment, but also saves time to perform the analysis with reasonable manpower. It modifies existing HRA methods with considering lag and linger effects to apply dependence effects for them. Based on a representative HRA method, i.e., Standardized Plant Analysis Risk - HRA (SPAR-H), guidance for how to apply lag and linger effects for the HRA method is suggested. Then, an investigation is carried out to compare quantification results of the revised HRA method with that of the original approach based on experimental data.

99 GENERAL AND MISCELLANEOUS↗

Characterization and thermometry of dissipatively stabilized steady states

In this work we study the properties of dissipatively stabilized steady states of noisy quantum algorithms, exploring the extent to which they can be well approximated as thermal distributions, and proposing methods to extract the effective temperature T. We study an algorithm called the relaxational quantum eigensolver (RQE), which is one of a family of algorithms that attempt to find ground states and balance error in noisy quantum devices. In RQE, we weakly couple a second register of auxiliary ‘shadow’ qubits to the primary system in Trotterized evolution, thus engineering an approximate zero-temperature bath by periodically resetting the auxiliary qubits during the algorithm’s runtime. Balancing the infinite temperature bath of random gate error, RQE returns states with an average energy equal to a constant fraction of the ground state. We probe the steady states of this algorithm for a range of base error rates, using several methods for estimating both T and deviations from thermal behavior. In particular, we both confirm that the steady states of these systems are often well-approximated by thermal distributions, and show that the same resources used for cooling can be adopted for thermometry, yielding a fairly reliable measure of the temperature. These methods could be readily implemented in near-term quantum hardware, and for stabilizing and probing Hamiltonians where simulating approximate thermal states is hard for classical computers.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Determination of a Generic Human Error Probability Distribution, Part 2: A Dynamic SPAR-H Example Application

Humans are an integral part of a nuclear power plant (NPP) from its construction, to its everyday maintenance and operation. In the nuclear industry there are many approaches to quantifying component reliability, which is called probability risk assessment (PRA). In PRA there are two considerations given to the quantification, static and dynamic. Static is quantified before or after an operation; and dynamic is time dependent, in that the probability changes as real time data are provided. In PRA, the importance of the components is calculated, but what of the importance of the human component? There are several methods for human reliability analysis (HRA), which include but are not limited to: THERP, ATHEANA, CREAM, SPAR-H, ASEP, and SLIM. Each of these methods aims to provide a more accurate and objective human error probability (HEP) quantification. Of the methods listed above, ASEP, THERP, and SPAR-H are all inextricably linked. The Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) method was generated to better generalize the Technique for Human Error Rate Prediction (THERP) and Accident Sequence Precursor (ASEP). THERP is mapped to specific scenario templates, and ASEP is a simplified screening method, while SPAR-H employs generalizations to describe the spectrum of human behavior while maintaining the same theoretical underpinnings. SPAR-H is a well-known and accepted HRA method that uses performance shaping factors (PSFs) to classify inputs to the human component. PSFs capture a wide variety of input data, including plant status, crew dynamics, task description, and psychological aspects of the human operator. Current efforts have been focused to further generalize SPAR-H in to a dynamic framework. These methods can fit into dynamic NPP simulations such as RAVEN / RELAP-7. In order to do this, a dynamic methodology is applied to model the human as would be applied to the components. This method is applied in part one in the accompanying paper.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Advanced technology for a satellite multichannel demultiplexer/demodulator

Satellite on-board processing is needed to efficiently service multiple users while at the same time minimizing earth station complexity. The processing satellite receives a wideband uplink at 30 GHz and down-converts it to a suitable intermediate frequency. A multichannel demultiplexer then separates the composite signal into discrete channels. Each channel is then demodulated by bulk demodulators, with the baseband signals routed to the downlink processor for retransmission to the receiving earth stations. This type of processing circumvents many of the difficulties associated with traditional bent-pipe repeater satellites. Uplink signal distortion and interference are not retransmitted on the downlink. Downlink power can be allocated in accordance with user needs, independent of uplink transmissions. This allows the uplink users to employ different data rates as well as different modulation and coding schemes. In addition, all downlink users have a common frequency standard and symbol clock on the satellite, which is useful for network synchronization in time division multiple access schemes. The purpose of this program is to demonstrate the concept of an optically implemented multichannel demultiplexer (MCD). A proof-of-concept (POC) model has been developed which has the ability to receive a 40 MHz wide composite signal consisting of up to 1000 40 kHz QPSK modulated channels and perform the demultiplexing process. In addition a set of special test equipment (STE) has been configured to evaluate the performance of the POC model. The optical MCD is realized as an acousto-optic spectrum analyzer utilizing the capability of Bragg cells to perform the required channelization. These Bragg cells receive an optical input from a laser source and an RF input (the signal). The Bragg interaction causes optical output diffractions at angles proportional to the RF input frequency. These discrete diffractions are optically detected and output to individual demodulators for baseband conversion. Optimization of the MCD design was conducted in order to achieve a compromise between two opposing sources of signal degradation: adjacent channel interference and intersymbol interference. The system was also optimized to allow simple, inexpensive ground stations communications with the MCD. These design goals led to the realization of a POC MCD which demonstrates the demultiplexing function with minimal signal degradation. Performance evaluation results using the STE equipment indicate that the dynamic range of the demultiplexer in the presence of adjacent and multiple channel loading is 40 - 50 dB. Measured bit error rate (BER) probabilities varied from the predicted theoretical results by one dB or less. The performance of the proof-of-concept model indicate that the development of a space qualified optically implemented MCD are feasible. The advantages to such an implementation include reduced size, weight and power and increased reliability when compared with electronic approaches. All of these factors are critical to on-board satellite processors. Further optimization can be conducted which trade ground station complexity and MCD performance to achieve desired system results.

Abramovitz, Irwin J.↗

Implementing computer-based procedures: thinking outside the paper margins - 236

In the past year there has been increased interest from the nuclear industry in adopting the use of electronic work packages and computer-based procedures (CBPs) in the field. The goal is to incorporate the use of technology in order to meet the Nuclear Promise requirements of reducing costs, and improving efficiency and decreasing human error rates in plant operations. Researchers, together with the nuclear industry, have been investigating the benefits of an electronic work package system and specifically CBPs would have over current paper-based procedure practices. There are several classifications of CBPs ranging from a straight copy of the paper-based procedure in PDF format to a more intelligent dynamic CBP. A CBP system offers a vast variety of potential improvements, such as context driven job aids, integrated human performance tools (e.g., place-keeping and correct component verification), and dynamic step presentation. However, the implementation of a CBP system does not automatically improve the quality of procedures. Utilities should review, standardize format and update current procedure content before transitioning to a computerized process. Implementation of a CBP system can be a time to break out of traditional procedure writing processes and create new processes and procedures that take advantage of the capabilities a CBP system. This paper summarizes INL research findings related to challenges with implementing a CBP system and provides suggestions to take into consideration. (authors)

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Blackcomb: Hardware-Software Co-design for Non-Volatile Memory in Exascale Systems

Summary of technical results of Blackcomb Memory Devices We explored various different memory technologies (STTRAM, PCRAM, FeRAM, and ReRAM). The progress can be classified into three categories, below. Modeling and Tool Releases Various modeling tools have been developed over the last decade to help in the design of SRAM or DRAM-based memory hierarchies. To explore new design opportunities that NVM technologies can bring to the designers, we have developed similar high-level models for NVM, including PCRAMsim [Dong 2009], NVSim [Dong 2012], and NVMain [Poremba 2012]. NVSim is a circuit-level model for NVM performance, energy, and area estimation, which supports various NVM technologies, including STT-RAM, PCRAM, ReRAM, and legacy NAND Flash. NVSim is successfully validated against industrial NVM prototypes, and it is expected to help boost architecture-level NVM-related studies. On the other side, NVMain is a cycle accurate main memory simulator designed to simulate emerging nonvolatile memories at the architectural level. We have released these models as open source tools and provided contiguous support to them. We also proposed PS3-RAM, which is a fast, portable and scalable statistical STT-RAM reliability analysis model [Wen 2012]. Design Space Exploration and Optimization With the support of these models, we explore different device/circuit optimization techniques. For example, in [Niu 2012a] we studied the power reduction technique for the application of ECC scheme in ReRAM designs and proposed to use ECC code to relax the BER (Bit Error Rate) requirement of a single memory to improve the write energy consumption and latency for both 1T1R and cross-point ReRAM designs. In [Xu 2011], we proposed a methodology to design STT-RAM for different optimization goals such as read performance, write performance and write energy by leveraging the trade-off between write current and write time of MTJ. We also studied the tradeoffs in building a reliable crosspoint ReRAM array [Niu 2012b]. We have conducted an in depth analysis of the circuit and system level design implications of multi-layer cross-point Resistive RAM (MLCReRAM) from performance, power and reliability perspectives [Xu 2013]. The objective of this study is to understand the design trade-offs of this technology with respect to the MLC Phase Change Memory (MLCPCM).Our MLC ReRAM design at the circuit and system levels indicates that different resistance allocation schemes, programming strategies, peripheral designs, and material selections profoundly affect the area, latency, power, and reliability of MLC ReRAM. Based on this analysis, we conduct two case studies: first we compare MLC ReRAM design against MLC phase-change memory (PCM) and multi-layer cross-point ReRAM design, and point out why multi-level ReRAM is appealing; second we further explore the design space for MLC ReRAM. Architecture and Application We explored hybrid checkpointing using phase-change memory for future exascale systems [Dong 2011] and showed that the use of nonvolatile memory for local checkpointing significantly increases the number of faults covered by local checkpoints and reduces the probability of a global failure in the middle of a global checkpoint to less than 1%. We also proposed a technique called i2WAP to mitigate the write variations in NVM-based last-level cache for the improvement of the NVM lifetime [Wang 2013]. Our wear leveling technique attempts to work around the limitations of write endurance by arranging data access so that write operations can be distributed evenly across all the storage cells. During our intensive research on fault-tolerant NVM design, we found that ECC cannot effectively tolerate hard errors from limited write endurance and process imperfection. Therefore, we devised a novel Point and Discard (PAD) architecture in in [ 2012] as a hard-error-tolerant architecture for ReRAM-based Last Level Caches. PAD improves the lifetime of ReRAM caches by 1.6X-440X under different process variations without performance overhead in the system's early life. We have investigated the applicability of NVM for persistent memory design [Zhao 2013]. New byte addressable NVM enables fast persistent memory that allows in-memory persistent data objects to be updated with much higher throughput. Despite the significant improvement, the performance of these designs is only 50% of the native system with no persistence support, due to the logging or copy-on-write mechanisms used to update the persistent memory. A challenge in this approach is therefore how to efficiently enable atomic, consistent, and durable updates to ensure data persistence that survives application and/or system failures. We have designed a persistent memory system, called Klin, that can provide performance as close as that of the native system. The Klin design adopts a non-volatile cache and a non-volatile main memory for constructing a multi-versioned durable memory system, enabling atomic updates without logging or copy-on-write. Our evaluation shows that the proposed Kiln mechanism can achieve up to 2X of performance improvement to NVRAM-based persistent memory employing write-ahead logging. In addition, our design has numerous practical advantages: a simple and intuitive abstract interface, microarchitecture-level optimizations, fast recovery from failures, and no redundant writes to slow non-volatile storage media. The work was published in MICRO 2013 and received Best Paper Honorable Mentioned Award.

97 MATHEMATICS AND COMPUTING↗

Cigarettes vs. e-cigarettes: Passive exposure at home measured by means of airborne marker and biomarkers

Background: There is scarce evidence about passive exposure to the vapour released or exhaled from electronic cigarettes (e-cigarettes) under real conditions. The aim of this study is to characterise passive exposure to nicotine from e-cigarettes' vapour and conventional cigarettes' smoke at home among non-smokers under real-use conditions. Methods: We conducted an observational study with 54 non-smoker volunteers from different homes: 25 living at home with conventional smokers, 5 living with nicotine e-cigarette users, and 24 from control homes (not using conventional cigarettes neither e-cigarettes). We measured airborne nicotine at home and biomarkers (cotinine in saliva and urine). We calculated geometric mean (GM) and geometric standard deviations (GSD). We also performed ANOVA and Student's t tests for the log-transformed data. We used Bonferroni-corrected t-tests to control the family error rate for multiple comparisons at 5%. Results: The GMs of airborne nicotine were 0.74 μg/m{sup 3} (GSD=4.05) in the smokers’ homes, 0.13 μg/m{sup 3} (GSD=2.4) in the e-cigarettes users’ homes, and 0.02 μg/m{sup 3} (GSD=3.51) in the control homes. The GMs of salivary cotinine were 0.38 ng/ml (GSD=2.34) in the smokers’ homes, 0.19 ng/ml (GSD=2.17) in the e-cigarettes users’ homes, and 0.07 ng/ml (GSD=1.79) in the control homes. Salivary cotinine concentrations of the non-smokers exposed to e-cigarette's vapour at home (all exposed ≥2 h/day) were statistically significant different that those found in non-smokers exposed to second-hand smoke ≥2 h/day and in non-smokers from control homes. Conclusions: The airborne markers were statistically higher in conventional cigarette homes than in e-cigarettes homes (5.7 times higher). However, concentrations of both biomarkers among non-smokers exposed to conventional cigarettes and e-cigarettes’ vapour were statistically similar (only 2 and 1.4 times higher, respectively). The levels of airborne nicotine and cotinine concentrations in the homes with e-cigarette users were higher than control homes (differences statistically significant). Our results show that non-smokers passively exposed to e-cigarettes absorb nicotine. - Highlights: • This is the first study of e-cigarette exposure at home under real-use conditions. • Airborne nicotine in homes with smokers were 5.7 times higher than in e-cig homes. • Cotinine of non-smokers exposed to e-cig and conventional cigarettes was similar. • Airborne nicotine in homes with e-cig users was higher than control homes. • Cotinine of non-smokers exposed to e-cig users was higher than in those no exposed.

54 ENVIRONMENTAL SCIENCES↗

Grandparent Inference from Genetic Data: The Potential for Parentage-Based Tagging Programs to Identify Offspring of Hatchery Strays

Abstract Fisheries managers routinely use hatcheries to increase angling opportunity. Many hatcheries operate as segregated programs where hatchery-origin fish are not intended to spawn with natural-origin conspecifics in order to prevent potential negative effects on the natural-origin population. Currently available techniques to monitor the frequency with which hatchery-origin strays successfully spawn in the wild rely on either genetic differentiation between the hatchery- and natural-origin fish or extensive sampling of fish on the spawning grounds. We present a method to infer grandparent–grandchild trios by using only genotypes from two putative grandparents and one putative grandchild. We developed estimators of false-positive and false-negative error rates and showed that genetic panels containing 500–700 single-nucleotide polymorphisms or 200–300 microhaplotypes are expected to allow application of this technique for monitoring segregated hatchery programs. We discuss the ease with which this technique can be implemented by pre-existing parentage-based tagging programs and provide an R package that applies the method.

Delomas, Thomas A. (ORCID:000000015154759X)↗

Automatic Determination of the Need for Intravenous Contrast in Musculoskeletal MRI Examinations Using IBM Watson’s Natural Language Processing Algorithm

Magnetic resonance imaging (MRI) protocoling can be time- and resource-intensive, and protocols can often be suboptimal dependent upon the expertise or preferences of the protocoling radiologist. Providing a best-practice recommendation for an MRI protocol has the potential to improve efficiency and decrease the likelihood of a suboptimal or erroneous study. The goal of this study was to develop and validate a machine learning-based natural language classifier that can automatically assign the use of intravenous contrast for musculoskeletal MRI protocols based upon the free-text clinical indication of the study, thereby improving efficiency of the protocoling radiologist and potentially decreasing errors. We utilized a deep learning-based natural language classification system from IBM Watson, a question-answering supercomputer that gained fame after challenging the best human players on Jeopardy! in 2011. We compared this solution to a series of traditional machine learning-based natural language processing techniques that utilize a term-document frequency matrix. Each classifier was trained with 1240 MRI protocols plus their respective clinical indications and validated with a test set of 280. Ground truth of contrast assignment was obtained from the clinical record. For evaluation of inter-reader agreement, a blinded second reader radiologist analyzed all cases and determined contrast assignment based on only the free-text clinical indication. In the test set, Watson demonstrated overall accuracy of 83.2% when compared to the original protocol. This was similar to the overall accuracy of 80.2% achieved by an ensemble of eight traditional machine learning algorithms based on a term-document matrix. When compared to the second reader’s contrast assignment, Watson achieved 88.6% agreement. When evaluating only the subset of cases where the original protocol and second reader were concordant (n = 251), agreement climbed further to 90.0%. The classifier was relatively robust to spelling and grammatical errors, which were frequent. Implementation of this automated MR contrast determination system as a clinical decision support tool may save considerable time and effort of the radiologist while potentially decreasing error rates, and require no change in order entry or workflow.

62 RADIOLOGY AND NUCLEAR MEDICINE↗