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At least 523 records · Page 29
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NASA NTRS2002

Consequences of Coupled Electromagnetic-Gravitational Fields

In the late 1980s there was a flurry of activities involving the newly discovered high Tc superconductors in the development of new devices such as more efficient current transmission, transformers, generators, and motors. One such developmental project by Podkletnov in 1992 noted some small, anomalous gravitational behaviors. A following unpublished paper by Podkletnov 1995 provided data with larger effects using a larger (~ 25 cm) superconducting disk. Unfortunately this disk was extremely fragile and was broken beyond repair. To date, these experiments have not been successfully repeated because of the difficulties of producing stable, durable (and fired) superconducting disks. This problem with firing these disks has been solved by Li. What remains is to install the disk in "motor", at superconducting temperatures in the presence of appropriately tailored magnetic fields.

Larry Smalley↗
NASA NTRS2002

Hot HB Stars in Globular Clusters - Physical Parameters and Consequences for Theory. VI. The Second Parameter Pair M3 and M13

We present the results of spectroscopic analyses of hot horizontal branch (HB) stars in M13 and M3, which form a famous second parameter pair. From the spectra we derived - for the first time in M13 - atmospheric parameters (effective temperature and surface gravity) as well as abundances of helium, magnesium, and iron. Consistent with analyses of hot HB stars in other globular clusters we find evidence for helium depletion and iron enrichment in stars hotter than about 12,000 K in both M3 and M13. Accounting for the iron enrichment substantially improves the agreement with canonical evolutionary models, although the derived gravities and masses are still somewhat too low. This remaining discrepancy may be an indication that scaled-solar metal-rich model atmospheres do not adequately represent the highly non-solar abundance ratios found in blue HB stars with radiative levitation. We discuss the effects of an enhancement in the envelope helium abundance on the atmospheric parameters of the blue HB stars, as might be caused by deep mixing on the red giant branch or primordial pollution from an earlier generation of intermediate mass asymptotic giant branch stars.

Moehler, S.↗
NASA NTRS2002

Rootless Cones on Mars: A Consequence of Lava-Ground Ice Interaction

Fields of small cratered cones on Mars are interpreted to have formed by rootless eruptions due to explosive interaction of lava with ground ice contained within the regolith beneath the flow. Melting and vaporization of the ice, and subsequent explosive expansion of the vapour, act to excavate the lava and construct a rootless cone around the explosion site. Similar features are found in Iceland, where flowing lava encountered water-saturated substrates. The martian cones have basal diameters of c. 30-1000 m and are located predominantly in the northern volcanic plains. High-resolution Mars Orbiter Camera images offer significant improvements over Viking data for interpretation of cone origins. A new model of the dynamics of cone formation indicates that very modest amounts of water ice are required to initiate and sustain the explosive interactions that produced the observed features. This is consistent with the likely low availability of water ice in the martian regolith. The scarcity of impact craters on many of the host lava flows indicates very young ages, suggesting that ground ice was present as recently as less than 10 - l00 Ma, and may persist today. Rootless cones therefore act as a spatial and temporal probe of the distribution of ground ice on Mars, which is of key significance in understanding the evolution of the martian climate. The location of water in liquid or solid form is of great importance to future robotic and human exploration strategies, and to the search for extraterrestrial life.

Fagents, S. A.↗
NASA NTRS2003

Planetesimal Break-Up and the Feeding of Solids to the Satellite Disk: Consequences for the Formation Timescale and Composition of the Satellites of Jupiter and Saturn

In order to create a coherent scenario of satellite formation. the source of the solids (rock-metal and ice) that will eventually make up the satellites must be considered. While it is customary to use a solar composition mixture with a gas/solid mass ratio of about 100, at the tail end of the formation of the giant planet (when satellite formation is thought to have taken place) the fraction of solids entrained in the gas (particles with sizes lower than the decoupling size about 1 m for typical nebula parameters) is likely to be significantly lower than cosmic. In particular, in the core accretion model of giant planet formation one expects low dust and rubble content at late times due to particle coagulation leading to a collisional distribution of particle sizes with most of the mas residing in objects 1 km or larger, which are not coupled to the gas and whose dynamics must be followed independently. As a result, flow of gas into circumplanetary orbits is not sufficient to constrain the mas available to form satellites.

Mosqueira, I.↗
NASA NTRS2003

The Consequences of Alfven Waves and Parallel Potential Drops in the Auroral Zone

The goal of this research is to examine the causes of field-aligned plasma acceleration in the auroral zone using satellite data and numerical simulations. A primary question to be addressed is what causes the field-aligned acceleration of electrons (leading to precipitation) and ions (leading to upwelling ions) in the auroral zone. Data from the Fast Auroral SnapshoT (FAST) and Polar satellites is used when the two satellites are in approximate magnetic conjunction and are in the auroral region. FAST is at relatively low altitudes and samples plasma in the midst of the auroral acceleration region while Polar is at much higher altitudes and can measure plasmas and waves propagating towards the Earth. Polar can determine the sources of energy streaming earthward from the magnetotail, either in the form of field-aligned currents, electromagnetic waves or kinetic particle energy, that ultimately leads to the acceleration of plasma in the auroral zone. After identifying and examining several events, numerical simulations are run that bridges the spatial region between the two satellites. The code is a one-dimensional, long system length particle in cell simulation that has been developed to model the auroral region. A main goal of this research project is to include Alfven waves in the simulation to examine how these waves can accelerate plasma in the auroral zone.

Schriver, David↗
NASA NTRS2003

Hot HB Stars in Globular Clusters: Physical Parameters and Consequences for Theory: The Second Parameter Pair M 3 and M 13 - VI

We present the results of spectroscopic analyses of hot horizontal branch (HB) stars in M 13 and M 3, which form a famous "second parameter" pair. F rom the spectra and Stromgren photometry we derived - for the first time in M 13 - atmospheric parameters (effective temperature and surface gravity). For stars with Stromgren temperatures between 10,000 and 12,000 K we found excellent agreement between the atmospheric parameters derived from Stromgren photometry and those derived from Balmer line profile fits. However, for cooler stars there is a disagreement in the parameters derived by the two methods, for which we have no satisfactory explanation. Stars hotter than 12,000 K show evidence for helium depletion and iron enrichment, both in M 3 and M 13. Accounting for the iron enrichment substantially improves the agreement with canonical evolutionary models, although the derived gravities and masses are still somewhat too low. This remaining discrepancy may be an indication that scaled-solar metal-rich model atmospheres do not adequately represent the highly non-solar abundance ratios found in blue HB stars affected by diffusion. We discuss the effects of an enhancement in the envelope helium abundance on the atmospheric parameters of the blue HB stars, as might be caused by deep mixing on the red giant branch or primordial pollution from an earlier generation of intermediate mass asymptotic giant branch stars. Key words. Stars: atmospheres - Stars: evolution - Stars: horizontal branch - Globular clusters: individual: M 3 - Globular clusters: individual: M 13

Moehler, S.↗
NASA NTRS1997

Seedborne fungal contamination: consequences in space-grown wheat

Plants grown in microgravity are subject to many environmental stresses that may promote microbial growth and result in disease symptoms. Wheat (cv. Super Dwarf) recovered from an 8-day mission aboard a NASA (National Aeronautics and Space Administration) space shuttle showed disease symptoms, including girdling of leaf sheaths and chlorosis and necrosis of leaf and root tissues. A Neotyphodium species was isolated from the seed and leaf sheaths of symptomatic wheat used in the spaceflight mission. Certain isozymes of a peroxidase unique to extracts from the microgravity-grown plants were observed in extracts from earth-grown Neotyphodium-infected plants but were not present in noninfected wheat. The endophytic fungus was eliminated from the wheat seed by prolonged heat treatment at 50 degrees C followed by washes with water at 50 degrees C. Plants from wheat seed infected with the Neotyphodium endophyte were symptomless when grown under greenhouse conditions, whereas symptoms appeared after only 4 days of growth in closed containers. Disease spread from an infected plant to noninfected plants in closed containers. Dispersion via spores was found on asymptomatic plants at distances of 7 to 18 cm from infected plants. The size and shape of the conidia, mycelia, and phialide-bearing structures and the ability to grow rapidly on carbohydrates, especially xylose, resembled the characteristics of N. chilense, which is pathogenic on orchard grass, Doctylis glomerati. The Neotyphodium wheat isolate caused disease symptoms on other cereals (wheat cv. Malcolm, orchard grass, barley, and maize) grown in closed containers.

NASA Discipline Plant Biology↗
NASA NTRS1997

Rat pregnancy and parturition survive spaceflight challenge: new considerations of developmental consequences

Results of the NASA-NIH.R1 and NASA-NIH.R2 pregnant rat studies are reported and compared with results of Cosmos-1514 study. Similarities and differences between the Cosmos and STS flights are reviewed. STS rats were videotaped so that in-flight and post-flight behavior could be observed. Rats were observed during readaptation to 1-g and labor and delivery. Results indicate that pregnancy can proceed after exposure to microgravity and that vaginal delivery can occur despite readaptation to 1-g. Analysis of videotape revealed that flight dams experienced almost twice as many labor contractions as controls.

short duration↗
NASA NTRS1991

Pharmacokinetic consequences of spaceflight

Spaceflight induces a wide range of physiological and biochemical changes, including disruption of gastrointestinal (GI) function, fluid and electrolyte balance, circulatory dynamics, and organ blood flow, as well as hormonal and metabolic perturbations. Any of these changes can influence the pharmacokinetics and pharmacodynamics of in-flight medication. That spaceflight may alter bioavailability was proposed when drugs prescribed to alleviate space motion sickness (SMS) had little therapeutic effect. Characterization of the pharmacokinetic and/or pharmacodynamic behavior of operationally critical medications is crucial for their effective use in flight; as a first step, we sought to determine whether drugs administered in space actually reach the site of action at concentrations sufficient to elicit the therapeutic response.

NASA Center JSC↗
NASA NTRS1979

A review of the consequences of fluid and electrolyte shifts in weightlessness

This review describes the renal-endocrine mechanisms related to the early losses of fluid-electrolytes from the body during weightlessness as well as their contribution to longer term adaptation of fluid-electrolyte balance. The hypotheses presented were generated by a systematic analysis of body fluid and renal dynamics observed under conditions of actual and simulated spaceflight. These have increased our understanding of the effects of acute headward fluid shifts on renal excretion, the factors promoting excess sodium excretion and the regulation of extracellular fluid composition.

Review↗
NASA NTRS2000

Neocortical malformation as consequence of nonadaptive regulation of neuronogenetic sequence

Variations in the structure of the neocortex induced by single gene mutations may be extreme or subtle. They differ from variations in neocortical structure encountered across and within species in that these "normal" structural variations are adaptive (both structurally and behaviorally), whereas those associated with disorders of development are not. Here we propose that they also differ in principle in that they represent disruptions of molecular mechanisms that are not normally regulatory to variations in the histogenetic sequence. We propose an algorithm for the operation of the neuronogenetic sequence in relation to the overall neocortical histogenetic sequence and highlight the restriction point of the G1 phase of the cell cycle as the master regulatory control point for normal coordinate structural variation across species and importantly within species. From considerations based on the anatomic evidence from neocortical malformation in humans, we illustrate in principle how this overall sequence appears to be disrupted by molecular biological linkages operating principally outside the control mechanisms responsible for the normal structural variation of the neocortex. MRDD Research Reviews 6:22-33, 2000. Copyright 2000 Wiley-Liss, Inc.

Review↗
NASA NTRS2000

Paleoproterozoic snowball earth: extreme climatic and geochemical global change and its biological consequences

Geological, geophysical, and geochemical data support a theory that Earth experienced several intervals of intense, global glaciation ("snowball Earth" conditions) during Precambrian time. This snowball model predicts that postglacial, greenhouse-induced warming would lead to the deposition of banded iron formations and cap carbonates. Although global glaciation would have drastically curtailed biological productivity, melting of the oceanic ice would also have induced a cyanobacterial bloom, leading to an oxygen spike in the euphotic zone and to the oxidative precipitation of iron and manganese. A Paleoproterozoic snowball Earth at 2.4 Giga-annum before present (Ga) immediately precedes the Kalahari Manganese Field in southern Africa, suggesting that this rapid and massive change in global climate was responsible for its deposition. As large quantities of O(2) are needed to precipitate this Mn, photosystem II and oxygen radical protection mechanisms must have evolved before 2.4 Ga. This geochemical event may have triggered a compensatory evolutionary branching in the Fe/Mn superoxide dismutase enzyme, providing a Paleoproterozoic calibration point for studies of molecular evolution.

Earth (Planet)↗
NASA NTRS1997

Cardiovascular consequences of bed rest: effect on maximal oxygen uptake

Maximal oxygen uptake (VO2max) is reduced in healthy individuals confined to bed rest, suggesting it is independent of any disease state. The magnitude of reduction in VO2max is dependent on duration of bed rest and the initial level of aerobic fitness (VO2max), but it appears to be independent of age or gender. Bed rest induces an elevated maximal heart rate which, in turn, is associated with decreased cardiac vagal tone, increased sympathetic catecholamine secretion, and greater cardiac beta-receptor sensitivity. Despite the elevation in heart rate, VO2max is reduced primarily from decreased maximal stroke volume and cardiac output. An elevated ejection fraction during exercise following bed rest suggests that the lower stroke volume is not caused by ventricular dysfunction but is primarily the result of decreased venous return associated with lower circulating blood volume, reduced central venous pressure, and higher venous compliance in the lower extremities. VO2max, stroke volume, and cardiac output are further compromised by exercise in the upright posture. The contribution of hypovolemia to reduced cardiac output during exercise following bed rest is supported by the close relationship between the relative magnitude (% delta) and time course of change in blood volume and VO2max during bed rest, and also by the fact that retention of plasma volume is associated with maintenance of VO2max after bed rest. Arteriovenous oxygen difference during maximal exercise is not altered by bed rest, suggesting that peripheral mechanisms may not contribute significantly to the decreased VO2max. However reduction in baseline and maximal muscle blood flow, red blood cell volume, and capillarization in working muscles represent peripheral mechanisms that may contribute to limited oxygen delivery and, subsequently, lowered VO2max. Thus, alterations in cardiac and vascular functions induced by prolonged confinement to bed rest contribute to diminution of maximal oxygen uptake and reserve capacity to perform physical work.

Non-NASA Center↗
NASA NTRS1995

Nutritional value of protein hydrolysis products (oligopeptides and free amino acids) as a consequence of absorption and metabolism kinetics

When pigs were submitted to duodenal infusion of solutions containing a large percentage of small peptides (PEP) or free amino acids with the same pattern (AAL) amino acids appear in the portal blood more rapidly and more uniformly after infusion of PEP then after infusion of AAL, with the notable exception of methionine for which the opposite was true. These differences were lowered when a carbohydrate (maltose dextrin) was present in the solution, but nevertheless remained significant for the first hour after the infusion. The long-term (8-hour) uptake of free amino acids into the liver and the peripheral tissues differed in profile according to the nature of the duodenal infusion. Peripheral uptake was appreciably less well balanced after infusion of free amino acids (deficiency of threonine and phenylalanine) than after infusion of small peptides (deficiency of methionine). Accordingly, in the rat, under conditions of discontinuous enteral nutrition the mixture of small peptides was of greater nutritive value than the mixture of free amino acids. It thus appears that the absorption kinetics which results in important variations in the temporal distribution of free amino acids in the tissues may be at the origin of transitory imbalances in tissue amino acid uptake, and as a result of a lower nutritive value.

Intestinal Absorption/drug effects↗
NASA NTRS1993

[Genotoxic modification of nucleic acid bases and biological consequences of it. Review and prospects of experimental and computational investigations]

The review is presented of experimental and computational data on the influence of genotoxic modification of bases (deamination, alkylation, oxidation) on the structure and biological functioning of nucleic acids. Pathways are discussed for the influence of modification on coding properties of bases, on possible errors of nucleic acid biosynthesis, and on configurations of nucleotide mispairs. The atomic structure of nucleic acid fragments with modified bases and the role of base damages in mutagenesis and carcinogenesis are considered.

Non-NASA Center↗
NASA NTRS1992

Changes in skeletal muscle gene expression consequent to altered weight bearing

Skeletal muscle is a dynamic organ that adapts to alterations in weight bearing. This brief review examines changes in muscle gene expression resulting from the removal of weight bearing by hindlimb suspension and from increased weight bearing due to eccentric exercise. Acute (less than or equal to 2 days) non-weight bearing of adult rat soleus muscle alters only the translational control of muscle gene expression, while chronic (greater than or equal to 7 days) removal of weight bearing appears to influence pretranslational, translational, and posttranslational mechanisms of control. Acute and chronic eccentric exercise are associated with alterations of translational and posttranslational control, while chronic eccentric training also alters the pretranslational control of muscle gene expression. Thus alterations in weight bearing influence multiple sites of gene regulation.

NASA Discipline Musculoskeletal↗
NASA NTRS1988

Metabolic consequences of resistive-type exercise

This brief review concerns acute and chronic metabolic responses to resistive-type exercise (RTE) (i.e., Olympic/power weight lifting and bodybuilding). Performance of RTE presents power output substantially greater (10-15-fold) than that evident with endurance-type exercise. Accordingly, RTE relies heavily on the anaerobic enzyme machinery of skeletal muscle for energy supply, with alterations in the rate of aerobic metabolism being modest. Hydrolysis of high energy phosphate compounds (PC, ATP), glycogenolysis, and glycolysis are evident during an acute bout of RTE as indicated by metabolic markers in mixed fiber type skeletal muscle samples. The type of RTE probably influences the magnitude of these responses since the increase in blood lactate is much greater during a typical "bodybuilding" than "power lifting" session. The influence of RTE training on acute metabolic responses to RTE has received little attention. An individual's inherent metabolic characteristics are apparently sufficient to meet the energy demands of RTE as training of this type does not increase VO2max or substantially alter the content of marker enzymes in mixed fiber type skeletal muscle. Analyses of pools of fast- vs slow-twitch fibers, however, indicate that RTE-induced changes may be fiber type specific. Future studies should better delineate the metabolic responses to RTE and determine whether these are related to the enhanced performance associated with such training.

Review↗