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All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

Active Betweenness Cardinality: Algorithms and Applications

Centrality rankings such as degree, closeness, betweenness, Katz, PageRank, etc. are commonly used to identify critical nodes in a graph. These methods are based on two assumptions that restrict their wider applicability. First, they assume the exact topology of the network is available. Secondly, they do not take into account the activity over the network and only rely on its topology. However, in many applications, the network is autonomous, vast, and distributed, and it is hard to collect the exact topology. At the same time, the underlying pairwise activity between node pairs is not uniform and node criticality strongly depends on the activity on the underlying network. In this paper, we propose active betweenness cardinality, as a new measure, where the node criticalities are based on not the static structure, but the activity of the network. We show how this metric can be computed efficiently by using only local information for a given node and how we can find the most critical nodes starting from only a few nodes. We also show how this metric can be used to monitor a network and identify failed nodes. We present experimental results to show effectiveness by demonstrating how the failed nodes can be identified by measuring active betweenness cardinality of a few nodes in the system.

97 MATHEMATICS AND COMPUTING↗
NASA NTRS1987

Flowfield measurements in a separated and reattached flat plate turbulent boundary layer

The separation and reattachment of a large-scale, two-dimensional turbulent boundary layer at low subsonic speed on a flat plate has been studied experimentally. The separation bubble was 55 cm long and had a maximum bubble thickness, measured to the height of the mean dividing streamline, of 17 cm, which was twice the thickness of the inlet boundary layer. A combination of laser velocimetry, hot-wire anemometry, pneumatic probing techniques, and flow visualization were used as diagnostics. Principal findings were that an outer inviscid rotational flow was defined which essentially convected over the blockage associated with the inner, viscously dominated bubble recirculation region. A strong backflow region in which the flow moved upstream 100 percent of the time was measured near the test surface over the central 35 percent of the bubble. A laminar backflow boundary layer having pseudo-turbulent characteristics including a log-linear velocity profile was generated under the highly turbulent backflow. Velocity profile shapes in the reversed flow region matched a previously developed universal backflow profile at the upstream edge of the separation region but not in the steady backflow region downstream. A smoke flow visualization movie and hot-film measurements revealed low frequency nonperiodic flapping at reattachment. However, forward flow fraction data at reattachment and mean velocity profiles in the redeveloping boundary layer downstream of reattachment correlated with backward-facing step data when the axial dimension was scaled by the distance from the maximum bubble thickness to reattachment.

Patrick, William P.↗
NASA NTRS2005

Coupled Gravity and Elevation Measurement of Ice Sheet Mass Change

During June 2003, we measured surface gravity at six locations about a glaciological measurement site located on the South-central Greenland Ice. We operated a GPS unit for 90 minutes at each site -the unit was operated simultaneously with a base station unit in Sondrestrom Fjord so as to enable differential, post-processing of the data. We installed an aluminum, accumulation-rate-pole at each site. The base section of the pole also served as the mount for the GPS antenna. Two gravimeters were used simultaneously at each site. Measurements were repeated at each site with at time lapse of at least 50 minutes. We measured snow physical properties in two shallow pits The same measurement sites were occupied in 1981 and all were part of a hexagonal network of geodetic and glaciological measurements established by The Ohio State University in 1980. Additional gravity observations were acquired at three of the sites in 1993 and 1995. Gravity data were collected in conjunction with Doppler satellite measurements of position and elevation in 1981 and global positioning system measurements subsequently. The use of satellite navigation techniques permitted reoccupation of the same sites in each year to within a few 10 s of meters or better. After detrending the gravity data, making adjustments for tides and removing the residual effects of local spatial gradients in gravity, we observe an average secular decrease in gravity of about 0.01 milligal/year, but with tenths of milligal variations about the mean trend. The trend is consistent with a nearly linear increase in surface elevation of between 7 to 10 c d y r (depending on location) as measured by repeated airborne laser altimeter, surface Doppler satellite and GPS elevation measurements. Differences between the residual gravity anomalies after free air correction may be attributable to local mass changes. This project is a collaboration between the Byrd Polar Research Center of the Ohio State University and the Arctic Technology Center of the Danish Technical University.

Jezek, K. C.↗
NASA NTRS1986

Mechanism for negative water balance during weightlessness An hypothesis

The mechanism for the apparent decrease in body fluid volume in astronauts during spaceflight remains obscure. The widespread postulate that the hypohydration is the result of the Henry-Gauer reflex, a diuresis caused by inhibition of vasopressin secretion resulting from increased left and perhaps right atrial (central) venous pressure, has not been established with direct measurements on astronauts. An hypothesis is proposed to account for fluid-electrolyte shifts during weightlessness. A moderate but transient increase in central venous pressure occurs when orbit is entered that is insufficient to activate the Henry-Gauer reflex but sufficient to stimulate the release of atrial natriuretic peptides. Increased sodium excretion would facilitate some increased urinary water loss. The resulting relatively dilute plasma and interstitial fluids would cause fluid to shift into the cellular space, resulting in edema in the head and trunk and inhibition of thirst and drinking. Thus, the negative water balance in astronauts would be caused by a gradual natriuresis and diuresis coupled with reduced fluid intake.

Greenleaf, J. E.↗
NASA NTRS2001

A Study of Supernova Remnants with Center-Filled X-Ray Morphology

The proposed study entails use of archival data, primarily from past and active X-ray observatories, to study the properties of a class of supernova remnants (SNRs) which display a centrally-bright X-ray morphology. Several models which have been proposed to explain the morphology are being investigated for comparisons with measured characteristics of several remnants: nonthermal emission from a central synchrotron nebula; thermal emission enhanced by slow evaporation of cool clouds in the hot SNR interior; and relic thermal emission from the SNR interior after the remnant has entered the radiative phase of evolution, thus causing the shell emission to cease.

Slane, Patrick O.↗
DOE OSTI2026

Measuring the neutrino-oxygen neutral current quasielastic cross section using the accelerator neutrino neutron interaction experiment

The Accelerator Neutrino Neutron Interaction Experiment (ANNIE) is a 26-ton gadolinium-doped water Cherenkov detector located on-axis to Fermilab’s Booster Neutrino Beam (BNB). ANNIE is uniquely positioned to perform high-statistics measurements of neutrino-nucleus interactions in water, benefiting from a large neutrino flux due to a short (100-meter) baseline. A central focus of ANNIE’s physics program is the measurement of both charged current (CC) and neutral current (NC) cross sections on water, including neutral current quasielastic (NCQE) and CC-inclusive channels. The NCQE measurement is particularly critical for constraining uncertainties in rare-event searches such as the Diffuse Supernova Neutrino Background (DSNB), where atmospheric $\nu$NCQE interactions constitute a significant and poorly constrained background. This dissertation presents a measurement of the flux-averaged neutrino-oxygen neutral current quasielastic ($\nu$NCQE) cross section using $2.573 \times 10^{20}$~POT of BNB exposure from the 2022 and 2023 beam years. The $\nu$NCQE interaction is identified through the primary $\gamma$-rays produced by nuclear de-excitation of the residual $^{15}$N$^*$ or $^{15}$O$^*$ nucleus following nucleon knockout from $^{16}$O. A dedicated Monte Carlo (MC) re-tuning campaign was conducted using an americium-beryllium (AmBe) calibration source, Michel electrons from stopped muons, and throughgoing dirt muons originating upstream of the detector. This multi-sample approach provided a wide-ranging $\mathcal{O}(\text{MeV})$--$\mathcal{O}(\text{GeV})$ dataset for tuning the simulated detector response, which was subsequently validated against AmBe neutron and Michel electron data for use in the $\nu$NCQE analysis. A dedicated laser calibration campaign was carried out to reduce timing uncertainties across the PMT system, enabling reconstruction of the BNB bunch substructure with sufficient resolution to serve as a background rejection tool. By selecting events in-time with individual neutrino bunches, beam-correlated $\nu$NCQE events are separated from diffuse and accelerator-induced backgrounds, notably skyshine neutrons and externally-originating events, that would otherwise dominate traditional charge-based selections within a small-scale, surface-level, short-baseline detector. A data-driven estimation of the skyshine neutron and external background rates was performed and incorporated into the systematic uncertainty budget. The flux-averaged $\nu$NCQE cross section on oxygen is measured to be $1.57 \pm 0.06\,(\text{stat.})$ $^{+0.91}_{-0.67}\,(\text{syst.})$ $\times 10^{-38}\ \text{cm}^{2}$. A full systematic budget is constructed by propagating uncertainties in the secondary hadronic interaction modeling, background cross section normalizations, detector response, neutrino flux, and the primary $\gamma$-ray emission probabilities from oxygen nuclear de-excitation. An idealized de-excitation model, constructed from existing measurements in the literature is developed to benchmark the predictions of the \textsc{GENIE} event generator. A comparison reveals that \textsc{GENIE} systematically overpredicts the primary $\gamma$-ray emission probability from oxygen de-excitation by a factor of $1.49\times$ for $E_\gamma > 6$~MeV and $3.07\times$ in the $3$--$6$~MeV band. This comparison motivates the dominant systematic uncertainty in this analysis, where a conservative uncertainty of $^{+39.9\%}_{-0\%}$ on the primary $\gamma$-ray signal prediction is assigned. The ANNIE result is consistent with and complementary to existing flux-averaged $\nu$NCQE cross section measurements from T2K and Super-Kamiokande, providing an independent measurement with a different detector, neutrino beam, and analysis methodology. Looking ahead, an upgrade to the ANNIE DAQ infrastructure enabling continuous extended readout will allow a complementary $\nu$NCQE neutron multiplicity measurement, directly relevant to constraining the NCQE background in DSNB searches, competitive with the recent T2K measurement at SK-Gd. The planned Super-SANDI upgrade, deploying a large Water-based Liquid Scintillator (WbLS) volume, will further extend ANNIE's reach to hadronic final states and exclusive NC channels, and enable joint measurements with liquid argon detectors sharing the BNB beamline ahead of DUNE and Hyper-Kamiokande.

Doran, Steven [Iowa State U.]↗
DOE OSTI2024

A red-emitting carborhodamine for monitoring and measuring membrane potential

Biological membrane potentials, or voltages, are a central facet of cellular life. Optical methods to visualize cellular membrane voltages with fluorescent indicators are an attractive complement to traditional electrode-based approaches, since imaging methods can be high throughput, less invasive, and provide more spatial resolution than electrodes. Recently developed fluorescent indicators for voltage largely report changes in membrane voltage by monitoring voltage-dependent fluctuations in fluorescence intensity. However, it would be useful to be able to not only monitor changes but also measure values of membrane potentials. This study discloses a fluorescent indicator which can address both. We describe the synthesis of a sulfonated tetramethyl carborhodamine fluorophore. When this carborhodamine is conjugated with an electron-rich, methoxy (-OMe) containing phenylenevinylene molecular wire, the resulting molecule, CRhOMe, is a voltage-sensitive fluorophore with red/far-red fluorescence. Using CRhOMe, changes in cellular membrane potential can be read out using fluorescence intensity or lifetime. In fluorescence intensity mode, CRhOMe tracks fast-spiking neuronal action potentials (APs) with greater signal-to-noise than state-of-the-art BeRST 1 (another voltage-sensitive fluorophore). CRhOMe can also measure values of membrane potential. The fluorescence lifetime of CRhOMe follows a single exponential decay, substantially improving the quantification of membrane potential values using fluorescence lifetime imaging microscopy (FLIM). The combination of red-shifted excitation and emission, mono-exponential decay, and high voltage sensitivity enable fast FLIM recording of APs in cardiomyocytes. The ability to both monitor and measure membrane potentials with red light using CRhOMe makes it an important approach for studying biological voltages.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1993

Assessing fire emissions from tropical savanna and forests of central Brazil

Wildfires in tropical forest and savanna are a strong source of trace gas and particulate emissions to the atmosphere, but estimates of the continental-scale impacts are limited by large uncertainties in the rates of fire occurrence and biomass combustion. Satellite-based remote sensing offers promise for characterizing fire physical properties and impacts on the environment, but currently available sensors saturate over high-radiance targets and provide only indications of regions and times at which fires are extensive and their areal rate of growing as recorded in ash layers. Here we describe an approach combining satellite- and aircraft-based remote sensing with in situ measurements of smoke to estimate emissions from central Brazil. These estimates will improve global accounting of radiation-absorbing gases and particulates that may be contributing to climate change and will provide strategic data for fire management.

Riggan, Philip J.↗
NASA NTRS1978

Influence of central venous pressure upon sinus node responses to arterial baroreflex stimulation in man

Measurements were made of sinus node responses to arterial baroreceptor stimulation with phenylephrine injection or neck suction, before and during changes of central venous pressure provoked by lower body negative pressure or leg and lower truck elevation. Variations of central venous pressure between 1.1 and 9.0 mm Hg did not influence arterial baroreflex mediated bradycardia. Baroreflex sinus node responses were augmented by intravenous propranolol, but the level of responses after propranolol was comparable during the control state, lower body negative pressure, and leg and trunk elevation. Sinus node responses to very brief baroreceptor stimuli applied during the transitions of central venous pressure also were comparable in the three states. The authors conclude that physiological variations of central venous pressure do not influence sinus node responses to arterial baroreceptor stimulation in man.

Mark, A. L.↗
NASA NTRS1994

Review of European microgravity measurements

AA In a French/Russion cooperation, CNES developed a microgravity detection system for analyzing the Mir space station micro-g-environment for the first time. European efforts to characterize the microgravity (1/9) environment within a space laboratory began in the late seventies with the design of the First Spacelab Mission SL-1. Its Material Science Double Rack was the first payload element to carry its own tri-axial acceleration package. Even though incapable for any frequency analysis, the data provided a wealth of novel information for optimal experiment and hardware design and operations for missions to come. Theoretical investigations under ESA contract demonstrated the significance of the detailed knowledge of micro-g data for a thorough experiment analysis. They especially revealed the high sensitivity of numerous phenomena to low frequency acceleration. Accordingly, the payloads of the Spacelab missions D-1 and D-2 were furnished with state-of-the-art detection systems to ensure frequency analysis between 0.1 and 100 Hz. The Microgravity Measurement Assembly (MMA) of D-2 was a centralized system comprising fixed installed as well as mobile tri-axial packages showing real-time data processing and transmission to ground. ESA's free flyer EURECA carried a system for continuous measurement over the entire mission. All EURECA subsystems and experimental facilities had to meet tough requirements defining the upper acceleration limits. In a French/Russion cooperation, CNES developed a mi crogravity detection system for analyzing the Mir space station micro-g-environment for the first time. An approach to get access to low frequency acceleration between 0 and 0.02 Hz will be realized by QSAM (Quasi-steady Acceleration Measurement) on IML-2, complementary to the NASA system Spacelab Acceleration Measurement System SAMS. A second flight of QSAM is planned for the Russian free flyer FOTON.

Hamacher, Hans↗
DOE OSTI2024

Predicting synthetic mRNA stability using massively parallel kinetic measurements, biophysical modeling, and machine learning

Abstract mRNA degradation is a central process that affects all gene expression levels, though it remains challenging to predict the stability of a mRNA from its sequence, due to the many coupled interactions that control degradation rate. Here, we carried out massively parallel kinetic decay measurements on over 50,000 bacterial mRNAs, using a learn-by-design approach to develop and validate a predictive sequence-to-function model of mRNA stability. mRNAs were designed to systematically vary translation rates, secondary structures, sequence compositions, G-quadruplexes, i-motifs, and RppH activity, resulting in mRNA half-lives from about 20 seconds to 20 minutes. We combined biophysical models and machine learning to develop steady-state and kinetic decay models of mRNA stability with high accuracy and generalizability, utilizing transcription rate models to identify mRNA isoforms and translation rate models to calculate ribosome protection. Overall, the developed model quantifies the key interactions that collectively control mRNA stability in bacterial operons and predicts how changing mRNA sequence alters mRNA stability, which is important when studying and engineering bacterial genetic systems.

Cetnar, Daniel P.↗
DOE OSTI2021

Study of detached plasma profile in the divertor simulation experimental module of tandem mirror GAMMA 10/PDX

A divertor simulation experimental module (D-module) in the tandem mirror GAMMA 10/PDX was used for the study of plasma detachment. In previous studies, it was difficult to measure far-upstream plasma parameters in the D-module, and only electrostatic probes on the target plate were used to perform electron temperature and density measurements. Furthermore, to study the detached plasma structure, a Thomson scattering (TS) system and a microwave interferometer system have been installed to measure the inside plasma parameters of the D-module, and a movable electrostatic probe has been placed at the inlet of the D-module to measure the inlet plasma density and temperature. The TS system in the central cell observed the electron temperature and density of the core plasma simultaneously. These measurements revealed the entire density and temperature structure from the core plasma to the divertor plate. The line average electron density measured by the microwave interferometer showed a rollover behavior during detachment. The results indicated that the ionization region was located around the center of the D-module, and it appears to move upstream along the axis.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
NASA NTRS1980

The position angle of Jupiter's linearly polarized synchrotron emission Observations extending over 16 years

Parkes, Owens Valley and Goldstone measurements are presented, showing the variation with central meridian longitude of the position angle of Jupiter's linearly polarized synchrotron emission at wavelengths of 21, 13, 11 and 6 cm; the observations span a total time interval greater than one Jovian orbital period. The form of the position angle versus longitude curve shows a slight dependence on wavelength and epoch. The epoch dependence appears to reflect Jupiter's changing aspect with respect to the earth. The observations yield a Jovian rotation period agreeing to within about 0.02 s with that derived from the decametric burst measurements, implying a highly stable inner magnetic field configuration.

Komesaroff, M. M.↗
NASA NTRS1987

CCD photometry of globular cluster core structure. I - NGC 6388, NGC 6624, and M15: One flat core and two cusps

The first results of a major survey of globular cluster core structure are reported. Surface brightness profiles for three clusters are presented: one with a normal flat core profile (NGC 6388), and two with central cusps (NGC 6624 and M15). The profiles are fitted with both seeing-convolved King models and seeing-convolved power laws. A King model provides a reasonable fit to the entire profile of NGC 6388, but there are no acceptable King profiles for NGC 6624 and M15. For these two clusters, a seeing-convolved power law provides a good fit to the inner part of the profile, while a King model gives a good fit to the outer part of the profile. The interpretation of the measured power-law slopes of the central surface brightness cusps of NGC 6624 and M15 are discussed in terms of models for core collapse in a multicomponent cluster.

Lugger, Phyllis M.↗
NASA NTRS2017

Statistical Approaches for the Definition of Landslide Rainfall Thresholds and their Uncertainty Using Rain Gauge and Satellite Data

Models for forecasting rainfall-induced landslides are mostly based on the identification of empirical rainfall thresholds obtained exploiting rain gauge data. Despite their increased availability, satellite rainfall estimates are scarcely used for this purpose. Satellite data should be useful in ungauged and remote areas, or should provide a significant spatial and temporal reference in gauged areas. In this paper, the analysis of the reliability of rainfall thresholds based on rainfall remote sensed and rain gauge data for the prediction of landslide occurrence is carried out. To date, the estimation of the uncertainty associated with the empirical rainfall thresholds is mostly based on a bootstrap resampling of the rainfall duration and the cumulated event rainfall pairs (D,E) characterizing rainfall events responsible for past failures. This estimation does not consider the measurement uncertainty associated with D and E. In the paper, we propose (i) a new automated procedure to reconstruct ED conditions responsible for the landslide triggering and their uncertainties, and (ii) three new methods to identify rainfall threshold for the possible landslide occurrence, exploiting rain gauge and satellite data. In particular, the proposed methods are based on Least Square (LS), Quantile Regression (QR) and Nonlinear Least Square (NLS) statistical approaches. We applied the new procedure and methods to define empirical rainfall thresholds and their associated uncertainties in the Umbria region (central Italy) using both rain-gauge measurements and satellite estimates. We finally validated the thresholds and tested the effectiveness of the different threshold definition methods with independent landslide information. The NLS method among the others performed better in calculating thresholds in the full range of rainfall durations. We found that the thresholds obtained from satellite data are lower than those obtained from rain gauge measurements. This is in agreement with the literature, where satellite rainfall data underestimate the 'ground' rainfall registered by rain gauges.

landslide prediction↗
NASA NTRS1982

The ionization structure of the Ring Nebula. II - Ultraviolet observations

Good agreement is found for O and N abundances, and the importance of charge-transfer reactions to the ionization of Ne is confirmed, in UV observations of emission line intensities for four positions in the Ring Nebula that have been previously studied optically. It is noted that the C(2+) abundance inferred from the optical 4267 A recombination line is as much as 10 times brighter than that measured from the UV lines, and that this discrepancy is greatest near the central star. The most attractive explanation for this phenomenon is the resonance fluorescence due to light from the central star. Both Ne/O and C/H abundances are in good agreement with previously measured average values for planetary nebulae.

Barker, T.↗
NASA NTRS2002

Multipoint sensing by intelligent collectives

Many remote sensing applications require that multiple sensors collect data simultaneously at spatially distributed locations and their information combined in order to characterize the phenomena of interest. Several basic classes of such multipoint measurement systems may be identified. For each, centralized methods exist for combining the raw data from the various sensors. However, recent advancements have given rise to small, integrated nodes comprised of one or more miniaturized sensors, processor, wireless communications capability and power supplies. Collections of these may be deployed and self-organized into intelligent sensor networks capable of performing cooperative signal processing locally, thereby providing substantial benefits.

multipoint measurement sensor networks↗
NASA NTRS1988

Shock tube investigation of dynamic response of pressure transducers for validation of rotor performance measurements

For some time now, NASA has had a program under way to aid in the validation of rotor performance and acoustics codes associated with the UH-60 rotary-wing aircraft; and to correlate results of such studies with those obtained from investigations of other selected aircraft rotor performance. A central feature of these studies concerns the dynamic measurement of surface pressure at various locations up to frequencies of 25 KHz. For this purpose, fast-response gauges of the Kulite type are employed. The latter need to be buried in the rotor; they record surface pressures which are transmitted by a pipette connected to the gauge. The other end of the pipette is cut flush with the surface. In certain locations, the pipette configuration includes a rather sharp right-angle bend. The natural question has arisen in this connection: In what way are the pipettes modifying the signals received at the rotor surface and subsequently transmitted to the sensitive Kulite transducer element. The basic details and results of the program performed and recently completed in the High Pressure Shock Tube Laboratory of the Department of Aeronautics and Astronautics at Stanford University are given.

Bershader, Daniel↗