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At least 523 records · Page 29

Explainable Machine Learning for Functional Data

Black-box machine learning models are recognized as useful tools for prediction applications, but the algorithmic complexity of some models causes interpretation challenges. Explainability methods have been proposed to provide insight into these models, but there is little research focused on supervised modeling with functional data inputs. We argue that, especially in applications of high consequence, it is important to explicitly model the functional dependence in a black-box analysis to not obscure or misrepresent patterns in explanations. As such, we propose the V ariable importance E xplainable E lastic S hape A nalysis (VEESA) pipeline for training supervised machine learning models with functional inputs. The pipeline is an analysis process that includes the data preprocessing, modeling, and post-hoc explanations. The preprocessing is done using elastic functional principal components analysis, which accounts for vertical and horizontal variability in functional data and, ultimately, allows for explanations in the original data space that identify the important functional variability without bias due to correlated variables. Here, we demonstrate the pipeline on two high-consequence applications: explosives classification for national security and inkjet printer identification in forensic science. The applications exhibit the VEESA pipeline’s ability to provide an understanding of the characteristics of the functional data useful for prediction. Code for implementing the pipeline is available in the veesa R package (and supplemental python code).

Elastic Shape Analysis↗

POLYSITE - An interactive package for the selection and refinement of Landsat image training sites

A versatile multifunction package, POLYSITE, developed for Goddard's Land Analysis System, is described which simplifies the process of interactively selecting and correcting the sites used to study Landsat TM and MSS images. Image switching between the zoomed and nonzoomed image, color and shape cursor change and location display, and bit plane erase or color change, are global functions which are active at all times. Local functions possibly include manipulation of intensive study areas, new site definition, mensuration, and new image copying. The program is illustrated with the example of a full TM maser scene of metropolitan Washington, DC.

Mack, Marilyn J. P.↗

Venus Quadrangle Geological Mapping: Use of Geoscience Data Visualization Systems in Mapping and Training

We are currently investigating new technological developments in computer visualization and analysis in order to assess their importance and utility in planetary geological analysis and mapping [1,2]. Last year we reported on the range of technologies available and on our application of these to various problems in planetary mapping [3]. In this contribution we focus on the application of these techniques and tools to Venus geological mapping at the 1:5M quadrangle scale. In our current Venus mapping projects we have utilized and tested the various platforms to understand their capabilities and assess their usefulness in defining units, establishing stratigraphic relationships, mapping structures, reaching consensus on interpretations and producing map products. We are specifically assessing how computer visualization display qualities (e.g., level of immersion, stereoscopic vs. monoscopic viewing, field of view, large vs. small display size, etc.) influence performance on scientific analysis and geological mapping. We have been exploring four different environments: 1) conventional desktops (DT), 2) semi-immersive Fishtank VR (FT) (i.e., a conventional desktop with head-tracked stereo and 6DOF input), 3) tiled wall displays (TW), and 4) fully immersive virtual reality (IVR) (e.g., "Cave Automatic Virtual Environment," or Cave system). Formal studies demonstrate that fully immersive Cave environments are superior to desktop systems for many tasks [e.g., 4].

Head, James W.↗

Better Buildings Workforce Accelerator – Technical Assistance Project: Northwest Energy Efficiency Council – A Replicable Analysis for Building Operator Certification Diversity, Equity, and Inclusion Objectives

The Northwest Energy Efficiency Council (NEEC) requested technical assistance through the U.S. Department of Energy (DOE) Better Buildings Workforce Accelerator (BBWA) program, with the objective of developing a replicable analytical approach to understanding Building Operator Certification (BOC) program participants and measure progress towards diversity, equity, and inclusion objectives. The technical assistance advances NEEC’s progress towards their goal of recruiting more diverse students to the BOC training and certification program. This report develops a replicable geospatial analysis of BOC program participants based on DEI indicators that can be applied at a national level, provides a step-by-step guide on repeating and updating the analysis, and presents recommendations for future data collection and analysis.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

On the feasibility of using physics-informed machine learning for underground reservoir pressure management

In this work, we evaluate the feasibility of using physics-informed machine learning (PIML) for underground energy-related pressure management. To this end, we develop a PIML framework to manage underground reservoir pressures by training neural networks to determine fluid extraction rates for dedicated extraction wells during fluid injection operations given a range of reservoir conditions (e.g., transmissivity and storativity). We implement an automatically-differentiable analytical physics model of fluid flow in porous media within the PIML framework as a proxy for more complicated models. This allows us to execute a sufficient number of training scenarios to fully evaluate the feasibility of using PIML to support pressure management activities. We quantify the number of physics-model parameters required for automatic differentiation to become more efficient than finite-difference gradient calculations. We use a simple scenario with a single injector, extractor, and critical location for our feasibility analysis. We evaluate the effect of the size of the training dataset (i.e., the number of reservoir condition samples) on the accuracy and efficiency of the PIML framework. For an equivalent number of model evaluations, the larger training dataset took less time to train and produced a neural network that was able to more accurately manage reservoir pressures. We also evaluate the effect of the training dataset batch size (i.e., number of reservoir condition samples used to update the neural network coefficients during training; i.e., how the training dataset is partitioned). While training ran faster with larger batch sizes, they produced neural networks that managed pressures less accurately. We demonstrate the approach on a more complex scenario involving 10 injectors, 10 extractors, and 4 critical locations (a relatively high well density of 20 wells/km2). We provide the number of forward and adjoint model evaluations required in each case as an indication of the feasibility of using PIML for pressure management when more complicated physics models with longer execution times are used.

54 ENVIRONMENTAL SCIENCES↗

Exoplanet Yield Sensitivity for the Hybrid Lyot Coronagraph from end-to-end modeling for LUVOIR-A

NASA's future direct imaging flagship mission will require telescope mirror segmentation to survey a statistically significant population of nearby stellar systems by increasing aperture size beyond that achieved by traditional space-borne monolithic apertures thus far. Segmentation is a path for the size expansion, but it entails a challenge due to the introduction of temporal pupil discontinuities in terms of both phase and amplitude. Modeling of the integrated performance of the coronagraph with the expected dynamical profile of the telescope is an important step toward realistic estimates of the mission's science yields. We present results of a study using the hybrid Lyot coronagraph with a 15-m on-axis, segmented optical telescope assembly (OTA), akin to that of the Large UV / Optical /Infrared (LUVOIR) mission. We have developed a high-fidelity, end-to-end model as part of the Segmented Coronagraph Design and Analysis (SCDA) study that includes diffractive optical propagations at the 1e-10 contrast level across the optical train including the OTA and intermediate re-imaging optics inside the coronagraph instrument. We perform a sensitivity analysis to assess the contrast sensitivity to wavefront perturbations for a set of key telescope terms including segment-level low-order and mid-spatial frequency aberrations and evaluate expected exoplanet yields obtained in the presence of these sets of aberrations. Industry-provided segment-level wavefront aberration datasets involving the following mechanisms are input to the end-to-end model: (1) thermal gradients and accelerations, and (2) telescope dynamics including line-of-sight and segment jitter. Dynamically averaged PSFs in the presence of aberrations are fed into AYO (Altruistic Yield Optimization), a mission design reference simulator, that then assesses the scientific yield sensitivities.

high-contrast imaging↗

ANS Winter 2022: ATF-2C Physics Safety and Scoping Analysis

ATF-2C comprises four tiers with six rodlets each. The experiment test train (TT) is situated in Loop 2A in the center flux trap (CFT) of the ATR, in which typical pressurized water reactor (PWR) conditions shall be approximated. Tier 1 (bottom) of the TT tests Framatome silicon carbide (SiC) cladding, containing molybdenum heater rods. Low-enriched uranium (LEU) Framatome rodlets with chrome-coated M5 cladding have been modeled in their place for the physics safety analysis to allow the substitution of this tier with fuel if needed. Tier 2 tests LEU Framatome rodlets with M5 cladding, which had irradiated in ATR in prior ATF experiments. Tier 3 tests General Atomics SiC composite cladding, also containing molybdenum heater rods. Tier 4/5/6 (top) tests the Japan Atomic Energy Agency (JAEA)/Mitsubishi Heavy Industries (MHI) fueled rodlets. This upper tier tests LEU rodlets with chrome-coated MDA cladding—several with temperature or pressure instrumentation. To flatten the axial power profile, lower portion of Tier 4/5/6 is surrounded by a hafnium (Hf) shroud, and the bottom two UO2 pellets are of natural enrichment. The ATF-2C TT is to be irradiated in the CFT of ATR (Fig. 1) for three or four 60-day cycles.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Establishing performance metrics for quantitative non-targeted analysis: a demonstration using per- and polyfluoroalkyl substances

Abstract Non-targeted analysis (NTA) is an increasingly popular technique for characterizing undefined chemical analytes. Generating quantitative NTA (qNTA) concentration estimates requires the use of training data from calibration “surrogates,” which can yield diminished predictive performance relative to targeted analysis. To evaluate performance differences between targeted and qNTA approaches, we defined new metrics that convey predictive accuracy, uncertainty (using 95% inverse confidence intervals), and reliability (the extent to which confidence intervals contain true values). We calculated and examined these newly defined metrics across five quantitative approaches applied to a mixture of 29 per- and polyfluoroalkyl substances (PFAS). The quantitative approaches spanned a traditional targeted design using chemical-specific calibration curves to a generalizable qNTA design using bootstrap-sampled calibration values from “global” chemical surrogates. As expected, the targeted approaches performed best, with major benefits realized from matched calibration curves and internal standard correction. In comparison to the benchmark targeted approach, the most generalizable qNTA approach (using “global” surrogates) showed a decrease in accuracy by a factor of ~4, an increase in uncertainty by a factor of ~1000, and a decrease in reliability by ~5%, on average. Using “expert-selected” surrogates ( n = 3) instead of “global” surrogates ( n = 25) for qNTA yielded improvements in predictive accuracy (by ~1.5×) and uncertainty (by ~70×) but at the cost of further-reduced reliability (by ~5%). Overall, our results illustrate the utility of qNTA approaches for a subclass of emerging contaminants and present a framework on which to develop new approaches for more complex use cases. Graphical Abstract

Pu, Shirley (ORCID:0000000201223797)↗

SimSup's Loop: A Control Theory Approach to Spacecraft Operator Training

Immersive simulation is a staple of training for many complex system operators, including astronauts and ground operators of spacecraft. However, while much has been written about simulators, simulation facilities, and operator certification programs, the topic of how one develops simulation scenarios to train a spacecraft operator is relatively understated in the literature. In this paper, an approach is presented for using control theory as the basis for developing the immersive simulation scenarios for a spacecraft operator training program. The operator is effectively modeled as a high level controller of lower level hardware and software control loops that affect a select set of system state variables. Simulation scenarios are derived from a STAMP-based hazard analysis of the operator's high and low level control loops. The immersive simulation aspect of the overall training program is characterized by selecting a set of scenarios that expose the operator to the various inadequate control actions that stem from control flaws and inadequate control executions in the different sections of the typical control loop. Results from the application of this approach to the Lunar Atmosphere and Dust Environment Explorer (LADEE) mission are provided through an analysis of the simulation scenarios used for operator training and the actual anomalies that occurred during the mission. The simulation scenarios and inflight anomalies are mapped to specific control flaws and inadequate control executions in the different sections of the typical control loop to illustrate the characteristics of anomalies arising from the different sections of the typical control loop (and why it is important for operators to have exposure to these characteristics). Additionally, similarities between the simulation scenarios and inflight anomalies are highlighted to make the case that the simulation scenarios prepared the operators for the mission.

LADEE↗

Extreme Precipitation in the Southern US Great Plains in the Spring of 2015: Mechanisms and Prediction

During May of 2015, the southern US Great Plains and adjacent Gulf Coast region experienced more than twice the long-term mean precipitation, making it the wettest May since 1895. We investigate the physical mechanisms associated with this event using a suite of large-ensemble regional replay AGCM simulations from the NASA-GEOS model. In these simulations, certain regions of the globe are constrained to closely follow observations while the remainder of the domain is free running, allowing for the isolation of the remote regions that were important for the event. Preliminary analysis provides evidence that the extreme southern US precipitation was linked in part to positive precipitation anomalies in the central and eastern tropical Pacific via a wave train, which ultimately caused anomalous moisture flux from the Gulf of Mexico. An analysis of Subseasonal Experiment (SubX) model output was conducted to explore the subseasonal prediction skill of the event. Several models are able the predict the presence of positive precipitation anomalies in or near the southern US at lead times exceeding 10 days, albeit with errors in the locations and magnitude of the heaviest precipitation anomalies. A more thorough investigation with version 2 of NASA’s GEOS-S2S model shows that the prediction skill stems from the model’s ability to reasonably predict the positive tropical Pacific precipitation anomalies and the initiation of the Rossby wave train that is believed to be linked to the event. The potential causes for limitations in the prediction skill of this event will be explored.

Great Plains↗

As-run thermal hydraulics analysis of the EPRI-1 Experiment

The EPRI-1 experiment was designed to irradiate various types of reactor pressure vessel steels at a temperature of 288°C (PLN-3934). The specimens were irradiated in an instrumented test train inside a pressurized water loop in the center lobe of the ATR during cycle 157C. Temperature was monitored using thermocouples placed at the top of the test train. Additional temperature indications were obtained by post-irradiation examination of melt wires placed within the test train and spanning the temperature range 239°C to 327°C. The purpose of this analysis is to calculate specimen temperature using measured data on reactor power and as-run calculations of heating rates of the test train. The accuracy of the model is assessed by comparing the measured and calculated in-pile tube inlet to outlet temperature difference, comparing the measured and calculated thermocouple temperatures, and comparing the calculated specimen temperature to the temperature range indicated by the melt wires.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Physics and Modeling of Quasi-Steady and Forced Shock Trains

The dual-mode scramjet is a propulsive concept for contemporary hypersonic vehicles promising flight cruise speeds upwards of Mach 5. Despite decades of development and a recent resurgence in interest, such engines are not routinely deployed for commercial or military purposes. Instead, they have been confined to the realm of ground-test research and limited one-off flight test missions. One of the key stumbling blocks on the critical path to deployment of a dual-mode scramjet is the optimal design and stable operation of the isolator, a typically constant area duct that separates the scramjet inlet from the combustor. During ramjet mode at Mach numbers from 3 to 5 and during the transition to scramjet mode at higher Mach numbers, the isolator contains the pseudo-shock. Necessary to meet the back-pressure in the combustor, the pseudo-shock is typically divided into a shock dominated shock train region followed by a turbulence driven mixing region. Fluctuations in combustor pressure due to vehicle maneuvering, throttling, or combustion instabilities drive the shock train to shift streamwise within the isolator. In response to sharp pressure fluctuations, the shock train is unable to stabilize within the isolator, and the scramjet unstarts by ejecting the shock train out the inlet. This work addresses three key gaps in understanding of the isolator pseudo-shock. The phenomenon is studied in three experimental facilities to investigate the quasi-steady and unsteady fluid dynamics of the shock train in fueled and un-fueled test conditions. The strong link between boundary layer morphology and shock train structure is studied in detail and used as a tool to evaluate the state-of-the-art definitions and models of the pseudo-shock. Identifying the limitations of these models, a new process driven flux-conserved pseudo-shock model is proposed. This provides a computationally efficient model grounded in the fluid dynamic mechanisms of the pseudo-shock with better predictive capability than the current state-of-the-art across all facilities tested. The unsteady behavior of the shock train is further investigated to identify and understand two distinct forced dynamic modes: mechanically induced, low-rate forcing and high-rate combustion driven unsteadiness that sheds upstream propagating shocks. The proposed process driven model is found to be effective in the the limiting case of high-rate combustion driven unsteadiness by evaluating the model in a shock stationary reference frame. Further analysis identifies the approximately rigid chain motion of the shock train structure to mechanically induced forcing. The time delay between the onset of forced dynamics is found to saturate to a constant value and maximum shock train speed along the isolator with respect to the perturbation rate of change. The result of this work provides dual-mode scramjet designers with improved tools and physical understanding to develop more efficient, robust, and capable propulsion systems for hypersonic vehicles.

JAXA↗

A Parallel Machine Learning Workflow for Neutron Scattering Data Analysis

As part of a larger effort, this work-in-progress reports the possible advantages of modifying conventional workflows used to generate labelled training samples and train machine learning (ML) models on them. We compare results from three different workflows using neutron scattering data analysis as the motivating application and report about 20% improvement in speedup, with no appreciable loss of model accuracy, over a baseline workflow.

Wang, Tianle↗

End-to-end Modeling of Lyot Coronagraph for LUVOIR: Sensitivity to Segment-Level Aberrations

Direct imaging and spectroscopic characterization of atmospheres of Earth-like exoplanets require starlight suppression to detect a faint planetary signal at small angular separations. Future space telescopes will require segmentation to survey a statistically significant population of nearby stars systems by increasing aperture size beyond the limits set by traditional monolithic apertures; however, segmentation also represents an additional challenge due to the introduction of temporal pupil discontinuities in terms of both phase and amplitude. For this study, a baseline Lyot coronagraph is used with the Large UV / Optical /Infrared (LUVOIR) mission’s 15-m on-axis, segmented optical telescope assembly (OTA). We present a high-fidelity, end-to-end modeling approach developed as part of the Segmented Coronagraph Design and Analysis (SCDA) group that includes diffractive optical propagations at the 1e-10 contrast level across the entire optical train including the OTA and intermediate re-imaging optics inside the coronagraph instrument. We perform a tolerancing analysis to assess the contrast sensitivity to wavefront perturbations for a set of key telescope terms including segment-level low-order and mid-spatial frequency aberrations. As an input to the end-to-end telescope model, we use two industry-provided segment-level wavefront aberration datasets pertaining: (1) thermal gradients and accelerations (courtesy of Ball-Aerospace and L3-Harris), and (2) telescope dynamics including line-of-sight and segment jitter (courtesy of Lockheed-Martin). Contrast performance outputs of the coronagraph are fed into a mission design reference simulator to assess the scientific yield sensitivity. End-to-end modeling will incorporate performance improvements due to active wavefront sensing and control and/or segment-level metrology to improve system performance.

Optics↗

Rounding Error Analysis of Mixed Precision Block Householder QR Algorithms

Although mixed precision arithmetic has recently garnered interest for training dense neural networks, many other applications could benefit from the speedups and lower storage cost if applied appropriately. The growing interest in employing mixed precision computations motivates the need for rounding error analysis that properly handles behavior from mixed precision arithmetic. We develop mixed precision variants of existing Householder QR algorithms and show error analyses supported by numerical experiments.

97 MATHEMATICS AND COMPUTING↗

Autonomous System Inference, Trojan, and Adversarial Reprogramming Attack and Defense (Final)

In the world of ever-advancing technology, Autonomous Systems (AS) find extensive application, bolstering functionalities of critical infrastructures such as nuclear power plants. These systems, however, are increasingly becoming a target for nefarious activities, namely through inference attacks, trojan attacks, and adversarial reprogramming. This paper delves into a comprehensive exploration of machine learning (ML)-driven autonomous control systems within advanced nuclear reactor designs, revealing the vulnerabilities and proposing strategies for defense against potential cyber-attacks. Advanced cyber-attacks against critical infrastructure and the energy sector are becoming more common. With the invention of autonomous control systems (ACS) within advanced nuclear reactor designs, system designers, reactor operators, and regulators must consider cybersecurity during the design and operational phases. This article provides a cyber threat assessment of machine learning (ML)- based digital twinning (DT) technologies in the context of advanced reactor ACS. A cyber-physical testbed was created to emulate nuclear reactor digital instrumentation and controls (I&C) and act as a basis for the ACS. The ACS was designed as two plant-level DTs predicting reactor malfunctions and determining control actions and two component-level DTs responsible for classifying component states and forecasting component inputs and outputs (I/O). Two duplicate ACS designs– one using a traditional ML framework and one using an automated ML (AutoML) framework– were created and tested against cyber-attacks on training data, real-time process data, and ML model architectures to determine their respective qualitative cyber-risk in terms of likelihood and impact. Both frameworks showed similar cyber-resilience against training, real-time, and ML architecture attacks, proving that neither is inherently more secure. Recommended safeguard and security measures are posed to system designers, reactor operators, and regulators to maintain the cybersecurity of ML-based DT technologies such as ACS, prompting a holistic view of shared responsibility for maintaining cyber-secure ML-based systems. As global reliance on generation III reactors begins to be critically assessed, the evolution towards advanced reactor systems utilizing digital instrumentation and controls (I&C) becomes not merely preferable, but essential. The integration of semi and fully autonomous control systems (ACS), powered by digital I&C and machine learning (ML)-based digital twinning (DT) technologies, emerges as a potent strategy to mitigate operations and maintenance costs, thereby enhancing the economic feasibility of novel reactor designs. However, with a staggering 500% and 380% increase in cyber-attacks reported against the energy sector by the United States Department of Energy (DoE) and the European Union respectively, a surge in cyber vulnerabilities specifically targeting the nuclear industry has been 2 markedly observed. Notable incidents, such as the W32.Ramnit spyware infiltration at the Gundremmingen nuclear power plant in Germany and the Dtrack spyware intrusion at the Kudankulam nuclear power plant in India, while not directly compromising core industrial control systems (ICS), underscore a compelling necessity to fortify cybersecurity protocols in safeguarding reactor systems against increasingly adept digital adversaries. In light of this, our investigation extends beyond conventional cybersecurity parameters, diving into the intricate web of potential vulnerabilities woven into ML-based DTs and ACS in advanced reactor systems. A crafted cyber-physical testbed and preliminary ACS were devised to act as a mirror, reflecting potential configurations of advanced reactor control designs. Moreover, this study is intertwined with a scrutinization of ML models, developed either through conventional, manually tuned methodologies or via automated means through AutoML, probing into their cyber-risk profiles within operational technology (OT) environments. Expanding on this, two distinct ACS blueprints were forged – one navigating through the corridors of traditional ML and the other traversing the path of AutoML – in an effort to holistically encapsulate the considerations pivotal to ML-based DT control system design. Employing the SANS Institute Industrial Control System (ICS) Kill Chain and the MITRE ATT&CK Tactics, Techniques, and Procedures (TTP) framework, a structured analysis was conducted, launching three targeted attacks against the training dataset, real-time dataset, and ML models, therein dissecting the potential cyber-attack implications against both ML frameworks within an ACS milieu. It is essential to note that three distinct categories of attacks were conducted against both ACS configurations, each encompassing three distinct ML-based DTs, cumulating in a total of 18 varied attacks. This exploration extends into the realms of Autonomous System Inference, Trojan, and Adversarial Reprogramming Attack and Defense, unraveling vulnerabilities, and opportunities for fortified defenses against such intrusions, particularly where ML-driven technologies, and by extension, ACS, are deployed. Final recommendations, articulated through a lens of security, safeguard, and implementation considerations, are presented for both traditional and AutoML models, anchoring upon the existing knowledge landscape and ML-based DT modeling for ACS, and are offered as a beacon to guide the nuclear industry through the intricate cybersecurity challenges that lie ahead.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Prediction of non-intuitive metabolic targets with bayesian metabolic control analysis to improve 3-hydroxypropionic acid production in Aspergillus niger

Development of efficient bioconversion processes is limited by the ability to predictably improve metabolic flux. Here we deployed Bayesian Metabolic Control Analysis as a platform to integrate multi-omics data with metabolic modeling and evaluated its ability to predict genetic interventions that improve metabolic flux. Global Metabolomics and proteomics data was collected from 17 Aspergillus niger strains engineered to produce the platform biochemical 3-hydroxypropionic acid from which seven actional genetic interventions were predicted from significant flux control coefficients. Of the suggested genetic interventions, two were present within the intuitively designed strains used for training (malonic semialdehyde dehydrogenase and pyruvate carboxylase) while five predicted targets were present within non-intuitive areas of the metabolic network including 5-formyltetrahydrofolate deformylase and four mitochondrial enzymes, alcohol dehydrogenase, succinyl-CoA ligase, aspartate aminotransferase, and malate dehydrogenase. Six of the targets were validated in the highest performing 3-HP strain used for multi-omics data generation which contained a prior disruption of the highest scoring target malonic semialdehyde dehydrogenase. Predicted directional perturbation of five of the six tested targets significantly improved titer and rate of 3-HP production and two significantly improved yield. The greatest improvements were observed following disruption of the non-intuitive target succinyl-CoA ligase which increased titer by 39% and yield by 29% (to 20.4 g/L 3-HP and 0.31 g 3-HP/g glucose) over the strains used for training. This study demonstrates the utility of Bayesian Metabolic Control Analysis and highlights the ability to predict meaningful genetic targets in unexpected areas of metabolism to improve engineered strains for bioconversion.

3-hydroxypropionic acid↗