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At least 523 records · Page 29

All sources NASA NTRS DOE OSTI

DOE OSTI2017

Multi-Speed Transmission For Commercial Delivery Medium Duty PEDVs

Successful completion of the proposed project will set a course for improving quality of life by overcoming key challenges in the gearbox for commercial-delivery, medium-duty, plug-in electric drive vehicles: It will reduce US dependency on foreign oil through the use of electric driven propulsion instead of fuel driven. It will reduce health risks by replacing tailpipe emissions in densely populated city centers. Finally, it will improve the performance-cost basis to meet or exceed the expectations of the targeted medium duty vehicle fleet owners and the independent customers. The proposed multi-speed transmission will narrow motor operation to the peak efficiency region, thereby increasing the electric powertrain efficiency to help close the range gap. Further, it will enhance customer satisfaction by improving vehicle acceleration, top speed and gradeability over the baseline. The project was conducted in three budget periods: In BP1: Technology Development, High-level vehicle powertrain models were used to optimize candidate transmission architectures and ratios along with a variety of traction motor characteristics for concept selection. The detailed driveline designs and component dynamics were investigated to meet medium-duty EV requirements; In BP2: Technology Development and Prototype Demonstration, The modeling and simulations with multi-speed transmissions were extended to other MD and HD EV platforms. Clean sheet design of a compact, lightweight, flexible, and modular, four-speed transmission was completed. Development of novel shifting and controls strategies were started and procurement of the prototype transmission and the controller hardware was begun; In BP3: Technology Integration, Testing, and Demonstration, Prototyping the four-speed automated mechanical transmission was completed. The transmission controls system and software development and preliminary gearbox dyno tests were done at Eaton. ORNL conducted integrated powertrain HIL tests. One of the prototype units was fully integrated into a Proterra BE35 demonstration electric bus. The shift control strategy was fine-tuned on the integrated vehicle at Eaton Marshall Proving Grounds. NREL tested the vehicle and validated the performance gains. Simulations predicted up to 20% increase in system energy efficiency depending on drive cycles, a top speed of greater than70 mph on flat road, 40% faster acceleration and a doubled gradeability with four-speed transmission as compared to the baseline EVs. Chassis Dyno Tests at NREL verified the simulation results of Eaton team and the HIL test results of ORNL team. The new four-speed EV transmission is efficient, reliable, modular, scalable, light weight, small size, and will be affordable. Furthermore, four-speed transmission enables downsizing of motor, battery and final drive, thereby reducing the total system cost.

33 ADVANCED PROPULSION SYSTEMS↗

DOE OSTI2023

Status Report on Thermal Delivery Modeling in HYBRID

This report details the modeling efforts consistent with the HYBRID repository of the Integrated Energy Systems (IES) program, motivated to develop information data tables characterizing the thermodynamic losses associated with transporting thermal energy over large distances. The described model establishes a methodology to currently characterize the impacts of certain parameters such as distance, piping geometry, and heat transfer fluid among others as well as sets up ability to interconnect the delivery model into Modelica IES simulations in the future. This report describes the modeling efforts completed and describes some of the future studies that will be done using results produced by the modeling efforts.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

DOE OSTI2017

Recent Advances in Nanomaterials for Gene Delivery—A Review

With the rapid development of nanotechnology in the recent decade, novel DNA and RNA delivery systems for gene therapy have become available that can be used instead of viral vectors. These non-viral vectors can be made of a variety of materials, including inorganic nanoparticles, carbon nanotubes, liposomes, protein and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have as advantages over viral vectors a decreased immune response, and additionally offer flexibility in design, allowing them to be functionalized and targeted to specific sites in a biological system with low cytotoxicity. The focus of this review is to provide an overview of novel nanotechnology-based methods to deliver DNA and small interfering RNAs into biological systems.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2019

Late Delivery of Nitrogen to the Earth

Atmospheric nitrogen may be a necessary ingredient for the habitability of a planet as its presence helps to prevent water loss from a planet. The present-day nitrogen isotopic ratio, {sup 15}N/{sup 14}N, in the Earth’s atmosphere is a combination of the primitive Earth’s ratio and the ratio that might have been delivered in comets and asteroids. Asteroids have a nitrogen isotopic ratio that is close to the Earth’s. This indicates either a similar formation environment to the Earth or that the main source of nitrogen was delivery by asteroids. However, according to geological records, the Earth’s atmosphere could have been enriched in {sup 15}N during the Archean era. Comets have a higher {sup 15}N/{sup 14}N ratio than the current atmosphere of the Earth, and we find that about 5% ∼ 10% of nitrogen in the atmosphere of the Earth may have been delivered by comets to explain the current atmosphere of the Earth or the enriched {sup 15}N atmosphere of the Earth. We model the evolution of the radii of the snow lines of molecular nitrogen and ammonia in a protoplanetary disk and find that both have radii that put them farther from the Sun than the main asteroid belt. With an analytic secular resonance model and N-body simulations we find that the ν {sub 8} apsidal precession secular resonance with Neptune, which is located in the Kuiper Belt, is a likely origin for the nitrogen-delivering comets that impact the Earth.

79 ASTRONOMY AND ASTROPHYSICS↗

NASA NTRS2003

Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers

The present work utilizes electrospinning to fabricate synthetic polymer/DNA composite scaffolds for therapeutic application in gene delivery for tissue engineering. The scaffolds are non-woven, nano-fibered, membranous structures composed predominantly of poly(lactide-co-glycolide) (PLGA) random copolymer and a poly(D,L-lactide)-poly(ethylene glycol) (PLA-PEG) block copolymer. Release of plasmid DNA from the scaffolds was sustained over a 20-day study period, with maximum release occurring at approximately 2 h. Cumulative release profiles indicated amounts released were approximately 68-80% of the initially loaded DNA. Variations in the PLGA to PLA-PEG block copolymer ratio vastly affected the overall structural morphology, as well as both the rate and efficiency of DNA release. Results indicated that DNA released directly from these electrospun scaffolds was indeed intact, capable of cellular transfection, and successfully encoded the protein beta-galactosidase. When tested under tensile loads, the electrospun polymer/DNA composite scaffolds exhibited tensile moduli of approximately 35 MPa, with approximately 45% strain initially. These values approximate those of skin and cartilage. Taken together, this work represents the first successful demonstration of plasmid DNA incorporation into a polymer scaffold using electrospinning.

Non-NASA Center↗

NASA NTRS2002

A synthesis of engineering and business best-practices to achieve breakthroughs in flight hardware delivery

This paper discusses a synthesis of engineering and business best practices to achieve breakthroughs in flight hardware delivery.

flight hardware delivery↗

NASA NTRS2006

Transferring Files Between the Deep Impact Spacecrafts and the Ground Data System Using the CCSDS File Delivery Protocol (CFDP): A Case Study

The CCSDS File Delivery Protocol (CFDP) Standard could reshape ground support architectures by enabling applications to communicate over the space link using reliable-symmetric transport services. JPL utilized the CFDP standard to support the Deep Impact Mission. The architecture was based on layering the CFDP applications on top of the CCSDS Space Link Extension Services for data transport from the mission control centers to the ground stations. On July 4, 2005 at 1:52 A.M. EDT, the Deep Impact impactor successfully collided with comet Tempel 1. During the final 48 hours prior to impact, over 300 files were uplinked to the spacecraft, while over 6 thousand files were downlinked from the spacecraft using the CFDP. This paper uses the Deep Impact Mission as a case study in a discussion of the CFDP architecture, Deep Impact Mission requirements, and design for integrating the CFDP into the JPL deep space support services. Issues and recommendations for future missions using CFDP are also provided.

CCSDS File Delivery Protocol (CFDP)↗

NASA NTRS1994

Economical Ground Data Delivery

Data delivery in the Deep Space Network (DSN) involves transmission of a small amount of constant, high-priority traffic and a large amount of bursty, low-priority data. The bursty traffic may be initially buffered and then metered back slowly as bandwidth becomes available. Today both types of data are transmitted over dedicated leased circuits. The authors investigated the potential of saving money by designing a hybrid communucations architecture that uses leased circuits for high-priority network communications and dial-up circuits for low-priority traffic. The architecture presented here may also be applied to any ground station-to-customer network within the range of a common carrier. The authors compare estimated costs for various scenerios and suggest security safeguards that should be considered.

communications↗

NASA NTRSDate not supplied

A Cognitive Walkthrough of Multiple Drone Delivery Operations

Advances of early twenty-first century aviation and transportation technologies provide opportunities for enhanced aerial projects, and the overall integration of unmanned aircraft systems (UAS) into the National Airspace System (NAS) has applications across a wide range of operations. Through these, remote operators have learned to manage several UAS at the same time in a variety of operational environments. The present work details a component piece of an ongoing body of research into multi-UAS operations. Beginning in early 2020, NASA has collaborated with Uber Technologies to design and develop concepts of operations, roles and responsibilities, and ground control station (GCS) concepts to enable food delivery operations via multiple, small UAS (sUAS). A cognitive walkthrough was chosen as the method for data collection. This allowed information to be gathered from UAS subject matter experts (SMEs) that could further mature designs for future human-in-the-loop (HITL) simulations; in addition, it allowed information to be collected remotely during the stringent restrictions of the COVID-19 pandemic. Consequently, the described cognitive walkthrough activity utilized remote data collection protocols mediated through the usage of programs designed for presentation and telecommunications. Scenarios were designed, complete with airspace, contingencies, and remedial actions, to be presented to the SMEs. Information was collected using a combination of rating scales and open-ended questions. Results received from the SMEs revealed expected hazards, workloads, and information concerns inherent in the contingency scenarios. SMEs also provided insight into the design of GCS tools and displays as well as the duties and relationships of human operators (i.e., monitors) and automation (i.e., informers and flight managers). Implications of these findings are discussed.

unmanned aircraft systems↗

NASA NTRS2021

A Cognitive Walkthrough of Multiple Drone Delivery Operations

unmanned aircraft systems↗

DOE OSTI2016

The Evaluation of the Impact of New Technologies for Medium-Duty Parcel Delivery Trucks on Fuel Consumption

In this paper, researchers at the National Renewable Energy Laboratory present the results of simulation studies to evaluate potential fuel savings as a result of improvements to vehicle rolling resistance, coefficient of drag, and vehicle weight as well as hybridization for four power trains for medium-duty parcel delivery vehicles. The vehicles will be modeled and simulated over 1,290 real-world driving trips to determine the fuel savings potential based on improvements to each technology and to identify best use cases for each platform. The results of impacts of new technologies on fuel saving will be presented, and the most favorable driving routes on which to adopt them will be explored.

33 ADVANCED PROPULSION SYSTEMS↗

DOE OSTI2025

Development of a Discrepancy Checker for the Digital Twin in a Supervisory Control System for a Thermal Energy Delivery System

Defined as a virtual representation of a physical object, process, or service, and used to support real-world decision-making, a digital twin (DT) can be utilized to combine classical and novel frameworks in sensors, state predictions, and multi-input/multi-output systems, and to enable optimal autonomous operations. However, a DT’s usefulness largely depends on its ability to adequately mirror the state of its physical counterpart, and this adequacy should be reflected by the level of uncertainty in the underlying simulation models when estimating and predicting quantities of interest (QOIs). Moreover, simulation models in a DT may involve multiple fidelities of representations—ranging from physics-based models to data-driven ones—but classical uncertainty quantification (UQ) methods struggle to handle numerous uncertainty sources, nor are they designed for real-time applications. This work presents a UQ-based discrepancy checking and diagnosis tool for a DT-based supervisory control system applied to a thermal energy delivery system (TEDS) at Idaho National Laboratory. The discrepancy checker was developed using metadata from an automated DT development process, and these metadata included different combinations of physical model forms and model parameters, training data and hyperparameters for surrogate models, and design parameters for supervisory control systems. Next, correlations between the uncertainty results and the metadata were established and then applied to the DT operations. The discrepancy checker evaluates the discrepancies between model predictions from virtual and sensor measurements and backtraces them to the corresponding major sources of uncertainty. The discrepancy checker showed reasonable performance in detecting discrepancies and diagnosing sources of uncertainty in testing scenarios.

22 - GENERAL STUDIES OF NUCLEAR REACTORS↗

DOE OSTI2022

A Metal‐Organic Framework (MOF)‐Based Multifunctional Cargo Vehicle for Reactive‐Gas Delivery and Catalysis

Abstract The efficient delivery of reactive and toxic gaseous reagents to organic reactions was studied using metal‐organic frameworks (MOFs). The simultaneous cargo vehicle and catalytic capabilities of several MOFs were probed for the first time using the examples of aromatization, aminocarbonylation, and carbonylative Suzuki–Miyaura coupling reactions. These reactions highlight that MOFs can serve a dual role as a gas cargo vehicle and a catalyst, leading to product formation with yields similar to reactions employing pure gases. Furthermore, the MOFs can be recycled without sacrificing product yield, while simultaneously maintaining crystallinity. The reported findings were supported crystallographically and spectroscopically (e.g., diffuse reflectance infrared Fourier transform spectroscopy), foreshadowing a pathway for the development of multifunctional MOF‐based reagent‐catalyst cargo vessels for reactive gas reagents as an attractive alternative to the use of toxic pure gases or gas generators.

Kittikhunnatham, Preecha↗

DOE OSTI2021

A Metal-Organic Framework (MOF)-Based Multifunctional Cargo Vehicle for Reactive-Gas Delivery and Catalysis

The efficient delivery of reactive and toxic gaseous reagents to organic reactions was studied using metal-organic frameworks (MOFs). The simultaneous cargo vehicle and catalytic capabilities of several MOFs were probed for the first time using the examples of aromatization, aminocarbonylation, and carbonylative Suzuki–Miyaura coupling reactions. These reactions highlight that MOFs can serve a dual role as a gas cargo vehicle and a catalyst, leading to product formation with yields similar to reactions employing pure gases. Furthermore, the MOFs can be recycled without sacrificing product yield, while simultaneously maintaining crystallinity. Our reported findings were supported crystallographically and spectroscopically (e.g., diffuse reflectance infrared Fourier transform spectroscopy), foreshadowing a pathway for the development of multifunctional MOF-based reagent-catalyst cargo vessels for reactive gas reagents as an attractive alternative to the use of toxic pure gases or gas generators.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2018

Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery

The precise delivery of biofunctionalized matters is of great interest from the fundamental and applied viewpoints. In spite of significant progress achieved during the last decade, a parallel and automated isolation and manipulation of rare analyte, and their simultaneous on-chip separation and trapping, still remain challenging. In this work, a universal micromagnet junction for self-navigating gates of microrobotic particles to deliver the biomolecules to specific sites using a remote magnetic field is described. In the proposed concept, the nonmagnetic gap between the lithographically defined donor and acceptor micromagnets creates a crucial energy barrier to restrict particle gating. It is shown that by carefully designing the geometry of the junctions, it becomes possible to deliver multiple protein-functionalized carriers in high resolution, as well as MCF-7 and THP-1 cells from the mixture, with high fidelity and trap them in individual apartments. Integration of such junctions with magnetophoretic circuitry elements could lead to novel platforms without retrieving for the synchronous digital manipulation of particles/biomolecules in microfluidic multiplex arrays for next-generation biochips.

36 MATERIALS SCIENCE↗

DOE OSTI2026

Uptake and Binding of At‐211 Into K‐ and Cs‐Derivatives of Alpha‐Zirconium Phosphate Nanoplatelets for Use as a Targeted Alpha Therapy Delivery Platform

The ion exchange behavior of K- and Cs-derivatives of α-zirconium phosphate, A-ZrP, with the targeted alpha therapy (TAT) radionuclide 211 At, as At + and AtO + , has been investigated. The K-ZrP shows strong affinity for both At+ and AtO + , ≥99% uptake. The affinity to Cs-ZrP was less pronounced, 87%–94% uptake, favoring At + . The binding strength was tested against several leaching solutions, including carbonate, phosphate buffered saline (PBS), 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) buffers, and ethylenediaminetetraacetic acid (EDTA) solutions at various concentrations (0.1–10 mM). K-ZrP retained 211 At in all buffer and EDTA solutions up to 1 mM (<0.5% leaching). The Cs-ZrP showed no leaching of At + , while AtO + leached (1%–3%) in the carbonate and HEPES buffers, along with all of the EDTA solutions, with complete retention only in the PBS buffer. In all cases, when the EDTA concentration reached 10 mM, 211 At leaching was observed. Once incorporated into the ZrP nanoplatelets, significant shielding of the α-particles was observed, not only attenuating the intensity of the emission but also reducing the energy of the α-particles themselves exiting the nanoplatelets. These properties provide the basis for K-ZrP, and to a lesser extent, Cs-ZrP to be further considered as potentially promising candidates for a delivery mechanism of 211 At for application in TAT.

astatine-211↗

DOE OSTI2019

Scalable Representation Learning for Long-Term Augmented Reality-Based Information Delivery in Collaborative Human-Robot Perception

Augmented reality (AR)-based information delivery has been attracting an increasing attention in the past few years to improve com- munication in human-robot teaming. In the long-term use of AR systems for collaborative human-robot perception, one of the biggest challenges is to perform place and scene matching under long-term environmental changes, such as dramatic variations in lighting, weather and vegetation across di erent times of the day, months, and seasons. To address this challenge, we introduce a novel representation learning approach that learns a scalable long-term representation model that can be used for place and scene matching in various long-term conditions. Our approach is formulated as a regularized optimization problem, which selects the most representative scene templates in di erent scenarios to construct a scalable representation of the same place that can exhibit signi cant long-term environment changes. Our approach adaptively learns to select a small subset of the templates to construct the representation model, based on a user-de ned representativeness threshold, which makes the learned model highly scalable to the long-term variations in real-world applications. To solve the formulated optimization problem, a new algo- rithmic solver is designed, which is theoretically guaranteed to converge to the global optima. Experiments are conducted using two large-scale benchmark datasets, which have demonstrated the superior performance of our approach for long-term place and scene matching.

42 ENGINEERING↗

DOE OSTI2019

Focal Stenting of Complex Femoropopliteal Lesions with the Multi-LOC Multiple Stent Delivery System: 12-Month Results of the Multicenter LOCOMOTIVE Study

Introduction: The purpose of this observational study is to report the 12-month clinical outcomes with the novel Multiple Stent Delivery System (MSDS) to treat complex femoropopliteal lesions. Previously, we reported the 6-month clinical outcomes of the all-comers LOCOMOTIVE study, which demonstrated the safety and efficacy of the MSDS with a favorable target lesion revascularization (TLR) rate of 5.3% and a 90.7% patency rate at 6 months in claudicants and critical limb ischemia patients. The 12-month outcomes of LOCOMOTIVE registry are presented in this report. ClinicalTrials.gov Identifier: NCT02531230. Methods: The LOCOMOTIVE study (Multi-LOC for flOw liMiting Outcomes after POBA and/or DCB Treatment in the infrainguinal position with the objecIVE to implant multiple stent segments) investigates the efficacy and safety of the MSDS approach in an all-comers population. Clinical follow-ups at 6 and 12 months are scheduled to assess TLR, ABI, and vessel patency based on sonographic imaging. Results: At 12 months, the primary unassisted patency was 85.7% and all-cause TLR rate was 9.3% in the overall cohort. Between baseline and 12 months, the target leg ABI increased from 0.62 ± 0.24 to 0.91 ± 0.38 (p < 0.001) and the mean Rutherford class improved from 3.5 to 1.9 (p < 0.001). Conclusions: Over a 12-month post-procedural period, MSDS for focal provisional stenting of complex femoropopliteal lesions demonstrated a promising primary patency and freedom from TLR after 12 months. In addition, significant improvements were observed in symptom classification and hemodynamics.

62 RADIOLOGY AND NUCLEAR MEDICINE↗