A transducer for the continuous external measurement of arterial blood pressure final report
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Direct force measuring transducer acts as an arterial tonometer, gives a direct readout to instrumentation, and is unaffected by ambient noise. It uses a semiconductor strain gage which is deflected by pressure pulses in the artery. The deflection changes the resistance of the gage and alters the voltage reading on the associated instrumentation.
Effect of unilateral renal vasodilatation on sodium excretion by infusing acetylcholine into renal artery of dogs
Liquid breathing effects on dogs in hyperbaric chamber
Oxygen reserves of circulatory minute volumes in animals of different age groups
Research in medical science, University of Southern California
Basic components of system are - occluding cuff with mounted cuff microscope, cuff pump deflator, pressure transducer, preamplifier unit, electrocardiograph machine, an analog to digital convertor unit, and digital display unit. System utilizes indirect auscultatory method, based on Korotkoff sounds, for measurement.
System consisting of solid state electronics package and a pair of standard flow-transducer cuffs is useful in cardiovascular studies. Device shows good zero stability and calibrations, and low noise levels.
Heart rate and systolic pressure variability control through visual feedback of physiological information, obtaining respiratory measurements and ECG
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Some existing theories, on elastic thin shells, are reviewed to ascertain their influence on the computation of phase velocities in fluid filled cylinders representing certain aspects of the behavior of arteries and veins in vivo. For physiologically meaningful parameters, including moderately large in plane prestrain that occurs in mammals, the results suggest that with one exception, the small differences in the formulations exercise little influence on the phase velocities. However, it is demonstrated that inclusion of the forces induced by the rotation of the hydrostatic pressure is essential or significantly erroneous torsional wave speeds result. Also the introduction of moderate implane prestrains that are present in living mammals is shown to lead to nonselfadjoint differential equations of motion, whose biorthogonal eigenvectors differ slightly from each other.
Rats were exposed to 100% oxygen at 600 torr for up to 8 days. Highly significant increases in RBC anaerobic glycolysis occurred during the first 4 days of exposure and then subsided. Two significant peaks were found, one on days 1 and 2 and one on day 4. The first peak is attributed to reticulocytosis, which was maximal after 90 minutes and had disappeared by day 3. A second mechanism must account for the peak on day 4. An interpretation of the second peak is provided by existing evidence that selective removal of older RBCs occurs during the first few days of exposure to hypobaric oxygen, with maximum effect on day 4. Results in splenectomized, sham-operated and intact animals were indistinguishable from each other. A significant decrease in RBC specific gravity was found in exposed animals with spleens intact, but not in splenectomized animals. Theoretical aspects of age-related parameters as an aid to continuous detection and evaluation of changes in RBC populations are discussed.
Comparison of previously described theoretical predictions with in vivo data from anesthetized dogs. It is shown that the observed attenuation of the pressure and axial waves cannot be accounted for by fluid viscosity alone. For large values of the frequency parameter alpha, the previous analysis is extended to include the effects of viscoelasticity of the vessel wall. The results indicate that the speeds of both types of waves are essentially unaffected by a realistic viscoelasticity model while the attenuation per wavelength is significantly increased and becomes frequency independent. There is fair agreement between theory and experiment.
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The developments are reported in physiological instrumentation, surgical procedures, measurement and data analysis techniques, and the definition of flight experiments to determine the effects of prolonged weightlessness on the cardiovascular system of subhuman primates. The development of an implantable telemetric data acquisition system is discussed along with cardiovascular research applications in renal hemodynamics. It is concluded that the implant technique permits a valid interpretation, free of emotional response, for the manipulated variable on physiological functions. It also allows a better definition of normal physiological baseline conditions.
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The cytogenetic study of the crew appears to indicate that Skylab-type environmental conditions have no deleterious effect upon chromosomal material. The findings are, however, less clear-cut than might be desired, due in large measure to confounding of the experimental design by the administration of isotope injections for the purposes of other experiments and to the lack of control subjects.