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At least 523 records · Page 29

Three-Year Outcomes of a Canadian Multicenter Study of Accelerated Partial Breast Irradiation Using Conformal Radiation Therapy

Purpose: To report 3-year toxicity, cosmesis, and efficacy of a multicenter study of external beam, accelerated partial breast irradiation (APBI) for early-stage breast cancer. Methods and Materials: Between March 2005 and August 2006, 127 women aged {>=}40 years with ductal carcinoma in situ or node-negative invasive breast cancer {<=}3 cm in diameter, treated with breast-conserving surgery achieving negative margins, were accrued to a prospective study involving five Canadian cancer centers. Women meeting predefined dose constraints were treated with APBI using 3 to 5 photon beams, delivering 35 to 38.5 Gy in 10 fractions, twice a day, over 1 week. Patients were assessed for treatment-related toxicities, cosmesis, and efficacy before APBI and at specified time points for as long as 3 years after APBI. Results: 104 women had planning computed tomography scans showing visible seromas, met dosimetric constraints, and were treated with APBI to doses of 35 Gy (n = 9), 36 Gy (n = 33), or 38.5 Gy (n = 62). Eighty-seven patients were evaluated with minimum 3-year follow-up after APBI. Radiation dermatitis, breast edema, breast induration, and fatigue decreased from baseline levels or stabilized by the 3-year follow-up. Hypopigmentation, hyperpigmentation, breast pain, and telangiectasia slightly increased from baseline levels. Most toxicities at 3 years were Grade 1. Only 1 patient had a Grade 3 toxicity with telangiectasia in a skin fold inside the 95% isodose. Cosmesis was good to excellent in 86% (89/104) of women at baseline and 82% (70/85) at 3 years. The 3-year disease-free survival was 97%, with only one local recurrence that occurred in a different quadrant away from the treated site and two distant recurrences. Conclusions: At 3 years, toxicity and cosmesis were acceptable, and local control and disease-free survival were excellent, supporting continued accrual to randomized APBI trials.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

On the Pointing Angle of Electron Beams from Laser Wakefield Accelerators

Laser wakefield accelerators offer electron beams which could be useful for many applications. However, the problem of stabilizing the electron beam parameters has not been resolved yet. Here, we propose a method to minimize the electron beam pointing and report the generation of a relativistic electron beam with a stabilized pointing angle of 2 mrad (rms). This was achieved by using asymmetric non-relativistic laser pulses interacting with low-density helium gas jet. In such a weakly-nonlinear regime, symmetric laser pulses were neither able to generate reproducible nor stable electron beams. Thus, we propose asymmetric laser pulses for generating electron beams having stable and small pointing angles from laser-plasma accelerators.

43 PARTICLE ACCELERATORS↗

Electron beam induced evolution in Au, Ag, and interfaced heterogeneous Au/Ag nanoparticles

Sintering and sublimation process of nanoparticles made of Ag, Au, and interfaced Ag/Au heterodimers has been investigated by in-situ transmission electron microscopy at room temperature. Such process is driven by the illumination of high-energy electron beam accelerated at 200kV that promotes atom diffusion in the physically contacted nanoparticles. Upon electron illumination, adjacent Au nanoparticles gradually merge together to form a larger particle along with the reduction of surface area despite that orientated attachment is not observed. The nanoparticle fusion process is significantly different from the well-established thermal diffusion mechanism. In addition to the similar fusion process, Ag nanoparticles undergo apparent sublimation because the transferred energy from electron beam to nanoparticles is higher than the surface binding energy of Ag atoms when the electron scattering angle is larger than 112°. The electron beam illumination can transform the interfaced Au/Ag dimers to Au@Ag core-shell particles followed by a slow sublimation of the Ag shells. Both diffusion and sublimation of Ag atoms are dependent on the intensity of electron beam, i.e., higher beam intensity is favorable to accelerate both process.

36 MATERIALS SCIENCE↗

SANE's Measurement of the Proton's Virtual Photon Spin Asymmetry, A p 1 , at Large Bjorken x

The experiment SANE (Spin Asymmetries of the Nucleon Experiment) measured inclusive double polarization electron asymmetries on a proton target at the Continuous Electron Beam Accelerator Facility at the Thomas Jefferson National Laboratory in Newport News Virgina. Polarized electrons were scattered from a solid 14 NH 3 polarized target provided by the University of Virginia target group. Measurements were taken with the target polarization oriented at 80 degrees and 180 degrees relative to the beam direction, and beam energies of 4.7 and 5.9 GeV were used. Scattered electrons were detected by a multi-component novel non-magnetic detector package constructed for this experiment. Asymmetries measured at the two target orientations allow for the extraction of the virtual Compton asymmetries A 1 p and A 2 p as well as the spin structure functions g 1 p and g 2 p . This work addresses the extraction of the virtual Compton asymmetry A 1 p in the deep inelastic regime. The analysis uses data in the kinematic range from Bjorken x of 0.30 to 0.55, separated into four Q 2 bins from 1.9 to 4.7 GeV 2 .

43 PARTICLE ACCELERATORS↗

Strong field physics and QED experiments with ELI-NP 2×10PW laser beams

The ELI-NP facility will focus a 10 PW pulsed laser beam at intensities of ∼10{sup 23} W/cm{sup 2} for the first time, enabling investigation of the new physical phenomena at the interfaces of plasma, nuclear and particle physics. The electric field in the laser focus has a maximum value of ∼10{sup 15} V/m at such laser intensities. In the ELI-NP Experimental Area E6, we propose the study of Radiation Reaction, Strong Field Quantum Electrodynamics (QED) effects and resulting production of Ultra-bright Sources of Gamma-rays which could be used for nuclear activation. Two powerful, synchronized 10 PW laser beams will be focused in the E6 Interaction Chamber on either gas or solid targets. One 10 PW beam is the Pump-beam and the other is the Probe-beam. The focused Pump beam accelerates the electrons to relativistic energies. The accelerated electron bunches interact with the very high electro-magnetic field of the focused Probe beam. The layout of the experimental area E6 will be presented with several options for the experimental configurations.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Characterization and performance of the Silicon Vertex Tracker modules for the CLAS12 experiment

The Continuous Electron Beam Accelerator Facility's (CEBAF) Large Acceptance Spectrometer (CLAS) is being upgraded for the 12 GeV electron beam. The Silicon Vertex Tracker (SVT) will be part of the Central Tracker for the CLAS12 experiment and will be centered inside of the solenoid, which has 5 T magnetic field. We present the design, fabrication, characterization and performance of the SVT modules.

Gotra, Yuri↗

Powering CEBAF's Extraction Cavities At 12 GeV

CEBAF (Continuous Electron Beam Accelerator Facility) at Jefferson Lab was initially designed to deliver up to a 4 GeV electron beam simultaneously to three experimental halls. The maximum deliverable energy was raised to 6 GeV and CEBAF ran there until May of 2012 after which CEBAF entered an upgrade shutdown. After the upgrade, scientists plan to use CEBAF to deliver 11 GeV beam to the three original experimental halls and 12 GeV to new hall ? Hall D. Delivering beams to multiple halls at the new energy requires increased RF power to drive the separation cavities and adding a 750 MHz beam repetition rate to deliver beam to all halls simultaneously. Doubling the beam energy means doubling field strength in the cavities by quadrupling delivered power. 750 MHz beam repetition rate requires new 750 MHz capable cavities and a frequency change to one of the existing IOT amplifiers powering these cavities, and new 499 MHz Solid State Amplifiers to power four downstream cavities. Topics covered will include: verifying the Cavity?s power capabilities, modifications to the 750 MHz system and new cavities, and the decision process in selecting an amplifier type to power four downstream cavities.

Wissmann, Mark↗

Acceleration of uranium beam to record power of 10.4 kW and observation of new isotopes at Facility for Rare Isotope Beams

The Facility for Rare Isotope Beams (FRIB) is a major nuclear physics facility for research with fast, stopped, and reaccelerated beams that was successfully commissioned in May 2022. A key capability of FRIB is the production of an acceleration of the uranium beam, but this capability requires the facility to work at the design limits of the lowest charge-to-mass ratio and the highest power density on the beam intercepting devices. This paper presents techniques for overcoming the significant challenges in accelerating the uranium beam, culminating in the demonstration of 10.4 kW on target, and the discovery of three new isotopes. The high-power uranium beam enabled us to produce and identify G 88 a , A 93 s , and S 96 e , within the first 24 h of operation. The successful uranium operation at FRIB sets a new record for accelerated uranium beam power above 10 kW and opens a new avenue of research with rare isotopes. Published by the American Physical Society 2024

43 PARTICLE ACCELERATORS↗

Advanced treatment planning methods for efficient radiation therapy with laser accelerated proton and ion beams

Purpose: Laser plasma acceleration can potentially replace large and expensive cyclotrons or synchrotrons for radiotherapy with protons and ions. On the way toward a clinical implementation, various challenges such as the maximum obtainable energy still remain to be solved. In any case, laser accelerated particles exhibit differences compared to particles from conventional accelerators. They typically have a wide energy spread and the beam is extremely pulsed (i.e., quantized) due to the pulsed nature of the employed lasers. The energy spread leads to depth dose curves that do not show a pristine Bragg peak but a wide high dose area, making precise radiotherapy impossible without an additional energy selection system. Problems with the beam quantization include the limited repetition rate and the number of accelerated particles per laser shot. This number might be too low, which requires a high repetition rate, or it might be too high, which requires an additional fluence selection system to reduce the number of particles. Trying to use laser accelerated particles in a conventional way such as spot scanning leads to long treatment times and a high amount of secondary radiation produced when blocking unwanted particles. Methods: The authors present methods of beam delivery and treatment planning that are specifically adapted to laser accelerated particles. In general, it is not necessary to fully utilize the energy selection system to create monoenergetic beams for the whole treatment plan. Instead, within wide parts of the target volume, beams with broader energy spectra can be used to simultaneously cover multiple axially adjacent spots of a conventional dose delivery grid as applied in intensity modulated particle therapy. If one laser shot produces too many particles, they can be distributed over a wider area with the help of a scattering foil and a multileaf collimator to cover multiple lateral spot positions at the same time. These methods are called axial and lateral clustering and reduce the number of particles that have to be blocked in the beam delivery system. Furthermore, the optimization routine can be adjusted to reduce the number of dose spots and laser shots. The authors implemented these methods into a research treatment planning system for laser accelerated particles. Results: The authors' proposed methods can decrease the amount of secondary radiation produced when blocking particles with wrong energies or when reducing the total number of particles from one laser shot. Additionally, caused by the efficient use of the beam, the treatment time is reduced considerably. Both improvements can be achieved without extensively changing the quality of the treatment plan since conventional intensity modulated particle therapy usually includes a certain amount of unused degrees of freedom which can be used to adapt to laser specific properties. Conclusions: The advanced beam delivery and treatment planning methods reduce the need to have a perfect laser-based accelerator reproducing the properties of conventional accelerators that might not be possible without increasing treatment time and secondary radiation to the patient. The authors show how some of the differences to conventional beams can be overcome and efficiently used for radiation treatment.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Neural networks for modeling and control of particle accelerators

Charged particle accelerators support a wide variety of scientific, industrial, and medical applications. They range in scale and complexity from systems with just a few components for beam acceleration and manipulation, to large scientific user facilities that span many kilometers and have hundreds-to-thousands of individually-controllable components. Specific operational requirements must be met by adjusting the many controllable variables of the accelerator. Meeting these requirements can be challenging, both in terms of the ability to achieve specific beam quality metrics in a reliable fashion and in terms of the time needed to set up and maintain the optimal operating conditions. One avenue toward addressing this challenge is to incorporate techniques from the fields of machine learning (ML) and artificial intelligence (AI) into the way particle accelerators are modeled and controlled. While many promising approaches within AI/ML could be used for particle accelerators, this dissertation focuses on approaches based on neural networks. Neural networks are particularly well-suited to modeling, control, and diagnostic analysis of nonlinear systems, as well as systems with large parameter spaces. They are also very appealing for their ability to process high-dimensional data types, such as images and time series (both of which are ubiquitous in particle accelerators). In this work, key studies that demonstrated the potential utility of modern neural network-based approaches to modeling and control of particle accelerators are presented. The context for this work is important: at the start of this work in 2012, there was little interest in AI/ML in the particle accelerator community, and many of the advances in neural networks and deep learning that enabled its present success had not yet been made at that time. As such, this work was both an exploration of possible application areas and a generator of proof-of-concept demonstrations in these areas.

43 PARTICLE ACCELERATORS↗

Creating high-stability high-precision bipolar trim power supply

Thomas Jefferson National Accelerator Facility (TJNAF) is founded by the US Department of Energy (DOE) office of science for the technology advancement and physics research in electron beam accelerator. This facility has the state of the art technology to carry out world-class cutting-edge experiments for the nucleus composition and atomic characteristics identification and exploration for the nature of the matter in the universe. A continuous wave electron beam is featured for such experiments, thus precise and stable trim power supply is required to meet such purpose. This paper demonstrates the challenges and solutions to design, assemble, fabrication and test such high-precision high-stability power supplies. This paper presents the novel design and first article test of the ±20A ±75V bipolar, 100ppm stability level current-regulated high-power trim power supplies for the beam manipulation. This special design can provide valuable documentation and reference values for future designs and special applications in particle accelerator power supply creation.

42 ENGINEERING↗

Electrostatic design and conditioning of a triple point junction shield for a –200 kV DC high voltage photogun [Electrostatic design of a triple point junction shield for a -200 kV DC high voltage photogun using COMSOL]

Nuclear physics experiments performed at the Continuous Electron Beam Accelerator Facility (CEBAF) at the Jefferson Lab require a DC high voltage photogun to generate polarized electron beams from GaAs photocathodes. The photogun uses a tapered ceramic insulator that extends into the vacuum chamber and mechanically holds the cathode electrode. Increasing the operating voltage from nominal –130 kV to –200 kV will provide lower beam emittance, better transmission through injector apertures, and improved photocathode lifetime. This desire to increase the photogun operating voltage led to the design of a triple-point-junction shield electrode which minimizes the electric field at the delicate insulator-metal-vacuum interface and linearizes the potential across the insulator, thus reducing the risk of arcing along the ceramic insulator. Furthermore, this work describes the results obtained using COMSOL® electrostatic-field simulation software and presents the high voltage conditioning results of the upgraded –200 kV CEBAF photogun.

47 OTHER INSTRUMENTATION↗

Three-Flavor Neutrino Oscillations with MINOS+

This dissertation presents the analysis of the last two years of data from the MINOS+ long-baseline neutrino oscillation experiment. The analysis explores the data above the first oscillation maximum for neutrinos in the standard three-flavor neutrino oscillation model, adding significantly more neutrino events and constraining the model with increased precision. The analysis of the high-energy region of the MINOS+ data set, where previously there has been limited study, can help constrain alternative models or possibly show evidence of new phenomena. The predecessor to MINOS+, the MINOS experiment, measured $\nu_\mu$ disappearance and $\nu_{e}$ appearance using Fermilab's NuMI $\nu_\mu$ beam from 2005 to 2012. During this period the neutrino beam's energy spectrum was focused to peak near the first oscillation maximum. In addition to measuring accelerator beam neutrinos, the MINOS Far Detector collected a sample of atmospheric neutrinos from 2003 to 2011. With the se two samples, MINOS measured the atmospheric mass splitting, $\Delta{m}^2_{32}$, at the 5\% level and the value of $\sin^2\theta_{23}$ at the 15\% level. The data also constrained the CP violating parameter $\delta_{\rm CP}$. The MINOS+ experiment exposed the MINOS detectors to a neutrino beam peaked at energies above the oscillation maximum from 2013 to 2016. With this higher energy neutrino beam, MINOS+ measures the shape of the $\nu_\mu$ survival probability away from the oscillation maximum with unprecedented precision. Measuring the shape of the oscillation probability as a function of neutrino energy is an essential test of the three-flavor oscillation model. At these higher energies where the standard oscillation probability decreases, the neutrino energy spectrum is sensitive to potential perturbations from mixing with additional sterile neutrinos or non-standard neutrino interactions. This analysis of the complete data set from MINOS+ finds no significant deviatio ns from the three-flavor oscillation probability in the ener! gy region of 4 to 10\,GeV covered by the neutrino beam. This provides increased confidence in the three-flavor model in this region and provides new constraints of the atmospheric oscillation parameters, $\Delta{m}^2_{32}$ and $\sin^2\theta_{23}$, by combining the MINOS and MINOS+ data sets. The hierarchy of the neutrino masses is related to the sign of $\Delta{m}^2_{32}$. When $\Delta{m}^2_{32} > 0$, the mass hierarchy is classified as normal. When $\Delta{m}^2_{32} < 0$, the mass hierarchy is classified as inverted. This analysis cannot rule out either of the mass hierarchies. For the normal mass hierarchy, the combined analysis measures $\lvert{\Delta{m}^2_{32}}\rvert = 2.41\pm 0.09 \times 10^{-3}\,{\mathrm{eV}^2}$ at 68\% C.L. and $\sin^2\theta_{23} = 0.42_{-0.06}^{+0.23}$ at 90\% C.L. For the inverted mass hierarchy, this analysis measures $\lvert{\Delta{m}^2_{32}}\rvert = 2.47_{-0.10}^{+0.08} \times 10^{-3}\,{\mathrm{eV}^2}$ at 68\% C.L. and $\sin^2\theta_{23} = 0.42_{ -0.06}^{+0.23}$ at 90\% C.L. In addition to the analysis and measurement of the atmospheric oscillation parameters using MINOS+, this work updates the constraint on $\delta_{\rm CP}$ from MINOS and performs an exploratory combination using $\nu_\mu$ disappearance data from the NOvA experiment. The NOvA experiment uses the NuMI beam in an off-axis strategy that results in a narrow flux of muon neutrinos at the first oscillation maximum and allows precision measurements of the three-flavor parameters. Since NOvA and MINOS+ shared the same neutrino beam, their data can be combined taking advantage of common beam related uncertainties. Combined, the data from the MINOS, MINOS+, and NOvA experiments precisely map $\nu_\mu$ oscillation probabilities using the same neutrino beam in a way that could not be attempted before.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Energy broadening due to space-charge oscillations in high current electron beams

During electron beam accelerator operation on Spacelab I, substantial fluxes of electrons were observed with energies greater than the initial beam energy. Numerical calculations are performed for the emission of an unneutralized, one-dimensional electron beam. These calculations show clearly that space charge oscillations, which are associated with the charge buildup on the emitter, strongly modify the beam and cause the returning beam particles to have a distribution of kinetic energies ranging from half to over twice the initial energy.

Katz, I.↗

Beam-spin Asymmetries from Semi-inclusive Pion Electroproduction

The moment of the semi-inclusive deep inelastic scattering (SIDIS) cross section corresponding to a polarized lepton scattering from an unpolarized target is Asin?LU. It has been extracted from measurements of beam-spin asymmetries (BSAs) from pion electro-production in SIDIS. Data were taken with the continuous electron beam accelerator facility (CEBAF) Large Acceptance Spectrometer (CLAS) at Jefferson Lab using a 5.498 GeV longitudinally polarized electron beam and an unpolarized liquid hydrogen target. All three pion channels (?+, ?0 and ??) were measured simultaneously over a large range of kinematics at the intermediate Q2 range (Q2? 1 - 4.5 GeV2). The moment is measured as functions of z, PT, x, and Q2. Asin?LU is a twist-3 structure providing information about quark-gluon-quark correlations. This new high statistical data will provide an important means of studying the transverse degrees of freedom in the nucleon.

Gohn, Wesley↗

Selection of Target Thickness and Size of Drive Electron Beam for Ce+BAF Injector

A baseline concept for a continuous wave (CW) polarized positron injector was developed for the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab. This concept is based on the generation of CW longitudinally polarized positrons by a high-current, polarized electron beam (1 mA, 130-370 MeV, and 90% longitudinal polarization) that passes through a rotating, water-cooled, tungsten target. The positron yield and longitudinal polarization are calculated for the 123 MeV Ce+BAF injector at the Low Energy Recirculator Facility (LERF). The longitudinal and transverse CEBAF acceptances, defined as an energy spread of less than 1% and a normalized emittance of less than 100 mm·mrad, have been used in these calculations. The impact of target thickness, transverse electron beam size, and electron beam energy on the yield and polarization of a positron injector is evaluated. The total energy deposited by the beams in the tungsten target and the peak energy density are calculated for different target thicknesses, electron beam sizes, and energies.

Ushakov, Andriy [Thomas Jefferson National Acceler↗

SU-E-T-237: Monte Carlo Dosimetric Characterization of the Mobetron Mobile Linac

Purpose: The aim of this work is to characterize dosimetrically a clinical intraoperative electron beam accelerator, Mobetron (IntraOp Medical, Inc.) in clinical use in our Hospital. Once this first step is completed our purpose is to evaluate shielding requirements for such a device by preparing adequate phase space files. Methods: It is known that electron beam simulation parameters required for state-of-the-art Monte Carlo codes to obtain a good match with measured data, like the mean energy or the FWHM, may not be code-independent due to the different set of process simulated and formalisms involved. Then, to cross-check our results against any issue in the simulation we have compared experimental data (PDD and profiles for electrons in the range 4 to 12 MeV) with simulations performed independently using both Penelope2011 and Geant4 codes. To do so, the geometry and materials of the head of the accelerator have been fully characterized following information provided by the manufacturer. Results: Both simulations agree with experimental data within experimental uncertainties (±1 mm displacement), although small variations (less than 10%) in the mean energy and FWHM are required to match measured values depending on the code used. Conclusion: Independent Monte Carlo simulations were used to obtain an excellent match to measured electron dose distributions. This opens the road to use such data for evaluating shielding requirements which is the main objective of this project.

07 ISOTOPE AND RADIATION SOURCES↗

Absorber Materials at Room and Cryogenic Temperatures

We recently reported on investigations of RF absorber materials at cryogenic temperatures conducted at Jefferson Laboratory (JLab). The work was initiated to find a replacement material for the 2 Kelvin low power waveguide Higher Order Mode (HOM) absorbers employed within the original cavity cryomodules of the Continuous Electron Beam Accelerator Facility (CEBAF). This effort eventually led to suitable candidates as reported in this paper. Furthermore, though constrained by small funds for labor and resources, we have analyzed a variety of lossy ceramic materials, several of which could be usable as HOM absorbers for both normal conducting and superconducting RF structures, e.g. as loads in cavity waveguides and beam tubes either at room or cryogenic temperatures and, depending on cooling measures, low to high operational power levels.

43 PARTICLE ACCELERATORS↗