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NASA NTRS2009

Declining Global Per Capita Agricultural Production and Warming Oceans Threaten Food Security

Despite accelerating globalization, most people still eat food that was grown locally. Developing countries with weak purchasing power tend to import as little food as possible from global markets, suffering consumption deficits during times of high prices or production declines. Local agricultural production, therefore, is critical to both food security and economic development among the rural poor. The level of local agricultural production, in turn, will be controlled by the amount and quality of arable land, the amount and quality of agricultural inputs (fertilizer, seeds, pesticides, etc.), as well as farm-related technology, practices, and policies. In this paper we discuss several emerging threats to global and regional food security, including declining yield gains that are failing to keep up with population increases, and warming in the tropical Indian Ocean and its impact on rainfall. If yields continue to grow more slowly than per capita harvested area, parts of Africa, Asia, and Central and Southern America will experience substantial declines in per capita cereal production. Global per capita cereal production will potentially decline by 14 percent between 2008 and 2030. Climate change is likely to further affect food production, particularly in regions that have very low yields due to lack of technology. Drought, caused by anthropogenic warming in the Indian and Pacific Oceans, may also reduce 21 st century food availability by disrupting Indian Ocean moisture transports and tilting the 21 st century climate toward a more El Nino-like state. The impacts of these circulation changes over Asia remain uncertain. For Africa, however, Indian Ocean warming appears to have already reduced main growing season rainfall along the eastern edge of tropical Africa, from southern Somalia to northern parts of the Republic of South Africa. Through a combination of quantitative modeling of food balances and an examination of climate change, we present an analysis of emerging threats to global food security.

Funk, Chris C.↗

NASA NTRS2011

Characterizing Vegetation Cover in Global Savannas with an Annual Foliage Clumping Index Derived from the MODIS BRDF Product

The global savanna biome is characterized by enormous diversity in the physiognomy and spatial structure of the vegetation. The foliage clumping index can be calculated from bidirectional reflectance distribution function (BRDF) data. It measures the response of the darkspot reflectance to increased shadow associated with clumped vegetation and is related to leaf area index. Clumping index theoretically declines with increasing woody cover until the tree canopy begins to become uniform. In this study, clumping index is calculated for Moderate Resolution Imaging Spectroradiometer BRDF data for the Australian tropical savanna, the tropical savannas of South America, and the tropical savannas of east, west and southern Africa and compared with site-based measurements of tree canopy cover, and with area-based classifications of land cover. There were differences in sensitivity of clumping index between red and near-infrared reflectance channels, and between savanna systems with markedly different woody vegetation physiognomy. Clumping index was broadly related to foliage cover from historical site data in Australia and in West Africa and Kenya, but not in Southern Africa nor with detailed site-based demographic data in the cerrado of Brazil. However, clumping index decreased with proportion of woody cover in land cover datasets for east Africa, Australia and the Colombian Llanos. There was overlap in the range of clumping index values for forest, cerrado and campo land covers in Brazil. Clumping index was generally negatively correlated with percentage tree cover from the MODIS Vegetation Continuous Fields product, but regional differences in the relationship were evident. There were large differences in the frequency distributions of clumping index from savanna, woody savanna and grassland land cover classes between global ecoregions. The clumping index shows differing sensitivity to savanna woody cover for red and NIR reflectance, and requires regional calibration for application as a universal indicator.

Hill, Michael J.↗

NASA NTRS2014

Toward Improved Land Surface Initialization in Support of Regional WRF Forecasts at the Kenya Meteorological Service (KMS)

Flooding and drought are two key forecasting challenges for the Kenya Meteorological Service (KMS). Atmospheric processes leading to excessive precipitation and/or prolonged drought can be quite sensitive to the state of the land surface, which interacts with the planetary boundary layer (PBL) of the atmosphere providing a source of heat and moisture. The development and evolution of precipitation systems are affected by heat and moisture fluxes from the land surface, particularly within weakly-sheared environments such as in the tropics and sub-tropics. These heat and moisture fluxes during the day can be strongly influenced by land cover, vegetation, and soil moisture content. Therefore, it is important to represent the land surface state as accurately as possible in land surface and numerical weather prediction (NWP) models. Enhanced regional modeling capabilities have the potential to improve forecast guidance in support of daily operations and high-impact weather over eastern Africa. KMS currently runs a configuration of the Weather Research and Forecasting (WRF) NWP model in real time to support its daily forecasting operations, making use of the NOAA/National Weather Service (NWS) Science and Training Resource Center's Environmental Modeling System (EMS) to manage and produce the KMS-WRF runs on a regional grid over eastern Africa. Two organizations at the NASA Marshall Space Flight Center in Huntsville, AL, SERVIR and the Shortterm Prediction Research and Transition (SPoRT) Center, have established a working partnership with KMS for enhancing its regional modeling capabilities through new datasets and tools. To accomplish this goal, SPoRT and SERVIR is providing enhanced, experimental land surface initialization datasets and model verification capabilities to KMS as part of this collaboration. To produce a land-surface initialization more consistent with the resolution of the KMS-WRF runs, the NASA Land Information System (LIS) is run at a comparable resolution to provide real-time, daily soil initialization data in place of data interpolated from the National Centers for Environmental Prediction (NCEP) Global Forecast System (GFS) model soil moisture and temperature fields. Additionally, realtime green vegetation fraction (GVF) data from the Visible Infrared Imaging Radiometer Suite (VIIRS) on the Suomi National Polar-orbiting Partnership (Suomi- NPP) satellite will be incorporated into the KMS-WRF runs, once it becomes publicly available from the National Environmental Satellite Data and Information Service (NESDIS). Finally, model verification capabilities will be transitioned to KMS using the Model Evaluation Tools (MET; Brown et al. 2009) package in conjunction with a dynamic scripting package developed by SPoRT (Zavodsky et al. 2014), to help quantify possible improvements in simulated temperature, moisture and precipitation resulting from the experimental land surface initialization. Furthermore, the transition of these MET tools will enable KMS to monitor model forecast accuracy in near real time. This paper presents preliminary efforts to improve land surface model initialization over eastern Africa in support of operations at KMS. The remainder of this extended abstract is organized as follows: The collaborating organizations involved in the project are described in Section 2; background information on LIS and the configuration for eastern Africa is presented in Section 3; the WRF configuration used in this modeling experiment is described in Section 4; sample experimental WRF output with and without LIS initialization data are given in Section 5; a summary is given in Section 6 followed by acknowledgements and references.

Case, Johnathan L.↗

NASA NTRS2016

Transitioning Enhanced Land Surface Initialization and Model Verification Capabilities to the Kenya Meteorological Department (KMD)

Flooding, severe weather, and drought are key forecasting challenges for the Kenya Meteorological Department (KMD), based in Nairobi, Kenya. Atmospheric processes leading to convection, excessive precipitation and/or prolonged drought can be strongly influenced by land cover, vegetation, and soil moisture content, especially during anomalous conditions and dry/wet seasonal transitions. It is thus important to represent accurately land surface state variables (green vegetation fraction, soil moisture, and soil temperature) in Numerical Weather Prediction (NWP) models. The NASA SERVIR and the Short-term Prediction Research and Transition (SPoRT) programs in Huntsville, AL have established a working partnership with KMD to enhance its regional modeling capabilities. SPoRT and SERVIR are providing experimental land surface initialization datasets and model verification capabilities for capacity building at KMD. To support its forecasting operations, KMD is running experimental configurations of the Weather Research and Forecasting (WRF; Skamarock et al. 2008) model on a 12-km/4-km nested regional domain over eastern Africa, incorporating the land surface datasets provided by NASA SPoRT and SERVIR. SPoRT, SERVIR, and KMD participated in two training sessions in March 2014 and June 2015 to foster the collaboration and use of unique land surface datasets and model verification capabilities. Enhanced regional modeling capabilities have the potential to improve guidance in support of daily operations and high-impact weather and climate outlooks over Eastern Africa. For enhanced land-surface initialization, the NASA Land Information System (LIS) is run over Eastern Africa at ~3-km resolution, providing real-time land surface initialization data in place of interpolated global model soil moisture and temperature data available at coarser resolutions. Additionally, real-time green vegetation fraction (GVF) composites from the Suomi-NPP VIIRS instrument is being incorporated into the KMD-WRF runs, using the product generated by NOAA/NESDIS. Model verification capabilities are also being transitioned to KMD using NCAR's Model *Corresponding author address: Jonathan Case, ENSCO, Inc., 320 Sparkman Dr., Room 3008, Huntsville, AL, 35805. Email: Jonathan.Case-1@nasa.gov Evaluation Tools (MET; Brown et al. 2009) software in conjunction with a SPoRT-developed scripting package, in order to quantify and compare errors in simulated temperature, moisture and precipitation in the experimental WRF model simulations. This extended abstract and accompanying presentation summarizes the efforts and training done to date to support this unique regional modeling initiative at KMD. To honor the memory of Dr. Peter J. Lamb and his extensive efforts in bolstering weather and climate science and capacity-building in Africa, we offer this contribution to the special Peter J. Lamb symposium. The remainder of this extended abstract is organized as follows. The collaborating international organizations involved in the project are presented in Section 2. Background information on the unique land surface input datasets is presented in Section 3. The hands-on training sessions from March 2014 and June 2015 are described in Section 4. Sample experimental WRF output and verification from the June 2015 training are given in Section 5. A summary is given in Section 6, followed by Acknowledgements and References.

land surface modeling↗

NASA NTRS2024

Interannual Lightning Variability within the TRMM LIS Dataset Using an ENSO Perspective

The Tropical Rainfall Measuring Mission (TRMM) Lightning Imaging Sensor (LIS) was used to investigate inter-annual variability of lightning from 1998-2014 within the 38° S – 38° N range. Previous studies have indicated that the El-Niño/Southern Oscillation (ENSO) phenomenon is one significant contributor to inter-annual lightning variability, potentially the dominant mechanism on the global scale. This period of 16 years contained four warm- (El Niño), eight cold- (La Niña), and four neutral-phase ENSO years based on the oceanic Niño index. Large magnitude lightning anomalies were found during the warm phase of ENSO, with mean warm-phase anomalies of > 10 Fl (1000 km) −2 min −1 in north-central Africa and Argentina. This includes a +35 Fl (1000 km) −2 min −1 anomaly in Argentina during the 2009 El Niño. In general, large-scale anomalies of thermodynamic properties and upper-atmospheric vertical motion coincided with the lightning anomalies observed in both Africa and South America. The anomaly over north-central Africa, however, was characterized by a 6-week shift in the annual lightning maximum with the warm phase, a result of the more complex environmental response to ENSO over the Sahel. The most consistent ENSO anomalies with appreciable lightning were found in southeastern Africa, northwestern Brazil, central Mexico, and the southern Red Sea. Of these, all but the Mexico region had enhanced lightning with the cold phase and suppressed lightning with the warm phase.

Austin G. Clark↗

DOE OSTI2023

The Misrepresentation of the Southern African Easterly Jet in Models and Its Implications for Aerosol, Clouds, and Precipitation Distributions

The southern African easterly jet (AEJ-S) is an important midtropospheric feature critical to understanding the tropical convective system over central Africa and the aerosol–cloud interactions over the southeast Atlantic Ocean. However, it remains unclear how well models represent the AEJ-S and its influence on aerosol transport, clouds, and precipitation distribution. Here, in this work, we use ground- and satellite-based observations and reanalysis datasets to assess the representation of AEJ-S in the Coupled Model Intercomparison Project phase 6 (CMIP6) models between September and October during the peak of midtropospheric winds, aerosol transport, clouds, and precipitation. We find that most CMIP6 models have difficulty accurately simulating the strength, position, and spatial distribution of the AEJ-S. Specifically, the AEJ-S is relatively weaker and at a slightly lower altitude in the ensemble of CMIP6 models than represented by observation and reanalysis datasets. To assess the influence of the misrepresented the AEJ-S on CMIP6-simulated aerosol, clouds, and precipitation distributions, we performed composite analyses using models with low and high biases based on the estimates of their midtropospheric easterly wind speed. We find that the misrepresentation of the AEJ-S in CMIP6 models is associated with the overestimation of clouds and precipitation over central Africa, the underestimation of clouds over the southeast Atlantic Ocean, and the limitation of aerosol transport over the continent or the deviation of its spatial distribution from the typical zonal transport over the Atlantic Ocean. Because aerosols, clouds, and precipitation are important components of the regional climate system, we conclude that accurate representation of the AEJ-S is essential over central Africa and the southeast Atlantic Ocean.

54 ENVIRONMENTAL SCIENCES↗

NASA NTRS2014

Meningitis and Climate: From Science to Practice

Meningococcal meningitis is a climate sensitive infectious disease. The regional extent of the Meningitis Belt in Africa, where the majority of epidemics occur, was originally defined by Lapeysonnie in the 1960s. A combination of climatic and environmental conditions and biological and social factors have been associated to the spatial and temporal patterns of epidemics observed since the disease first emerged in West Africa over a century ago. However, there is still a lack of knowledge and data that would allow disentangling the relative effects of the diverse risk factors upon epidemics. The Meningitis Environmental Risk Information Technologies Initiative (MERIT), a collaborative research-to-practice consortium, seeks to inform national and regional prevention and control strategies across the African Meningitis Belt through the provision of new data and tools that better determine risk factors. In particular MERIT seeks to consolidate a body of knowledge that provides evidence of the contribution of climatic and environmental factors to seasonal and year-to-year variations in meningococcal meningitis incidence at both district and national scales. Here we review recent research and practice seeking to provide useful information for the epidemic response strategy of National Ministries of Health in the Meningitis Belt of Africa. In particular the research and derived tools described in this paper have focused at "getting science into policy and practice" by engaging with practitioner communities under the umbrella of MERIT to ensure the relevance of their work to operational decision-making. We limit our focus to that of reactive vaccination for meningococcal meningitis. Important but external to our discussion is the development and implementation of the new conjugate vaccine, which specifically targets meningococcus A

Mineral dust↗

DOE OSTI2025

Soybean rust‐resistant and tolerant varieties identified through the Pan‐African Trial Network

Abstract BACKGROUND The global demand for soybeans is increasing rapidly, with projections indicating an escalation of 70–80 million metric tons over the next decade. Sub‐Saharan Africa (SSA) contributes significantly to this growth, with soybean production increasing by 6.8% per year, outpacing the global average increase of 4.7%. Despite the expansion, soybean productivity in Africa remains less than half of the global average. This yield gap is largely due to diseases and pests, such as soybean rust, which can be particularly severe. Effective management of soybean rust depends on several factors, including resistant cultivars. However, there has been limited information on the rust‐resistance levels of African cultivars. To address this gap, the Pan‐African Trial network conducted soybean varietal trials across diverse locations. RESULT Analyzing data from 370 individual trials conducted between 2015–2022, the network identified 81 cultivars with sufficient rust‐resistance data. Six cultivars including, Black Hawk, Dundee, Egret, Heron, Ibis, and Peka 06 were found to be resistant, and 12 were classified as tolerant. CONCLUSION This research is a significant step forward in improving soybean productivity in Africa, and further assessments are being undertaken to address other crop production challenges in the region. © 2025 Society of Chemical Industry.

Favoretto, Vitor Rampazzo [Cenex Harvest States (C↗

DOE OSTI2021

Climate hazard indices projections based on CORDEX-CORE, CMIP5 and CMIP6 ensemble

The CORDEX-CORE initiative was developed with the aim of producing homogeneous regional climate model (RCM) projections over domains world wide. In its first phase, two RCMs were run at 0.22° resolution downscaling 3 global climate models (GCMs) from the CMIP5 program for 9 CORDEX domains and two climate scenarios, the RCP2.6 and RCP8.5. The CORDEX-CORE simulations along with the CMIP5 GCM ensemble and the most recently produced CMIP6 GCM ensemble are analyzed, with focus on several temperature, heat, wet and dry hazard indicators for present day and mid-century and far future time slices. The CORDEX-CORE ensemble shows a better performance than the driving GCMs for several hazard indices due to its higher spatial resolution. For the far future time slice the 3 ensembles project an increase in all temperature and heat indices analyzed under the RCP8.5 scenario. The largest increases are always shown by the CMIP6 ensemble, except for Tx > 35 °C, for which the CORDEX-CORE projects higher warming. Extreme wet and flood prone maxima are projected to increase by the RCM ensemble over the la Plata basin in South America, the Congo basin in Africa, east North America, north east Europe, India and Indochina, regions where a better performance is obtained, whereas the GCM ensembles show small or negligible signals. Furthermore, compound hazard hotspots based on heat, drought and wet indicators are detected in each continent worldwide in region like Central America, the Amazon, the Mediterranean, South Africa and Australia, where a linear relation is shown between the heatwave and drought change signal, and region like Arabian peninsula, the central and south east Africa region (SEAF), the north west America (NWN), south east Asia, India, China and central and northern European regions (WCE, NEU) where the same linear relation is found for extreme precipitation and HW increases. Although still limited, the CORDEX-CORE initiative was able to produce high resolution climate projections with almost global coverage and can provide an important resource for impact assessment and climate service activities.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2025

Global techno-economic and life cycle greenhouse gas emissions assessment of solar and wind based renewable hydrogen production

This study conducts a global assessment of renewable hydrogen production pathways, focusing on techno-economic performance and life cycle greenhouse gas (GHG) emissions. It evaluates standalone solar photovoltaic (PV), wind, and hybrid PV/wind systems, integrated with proton exchange membrane (PEM) electrolyzers, through multi-objective optimization and considering embodied emissions in manufacturing PV, wind and electrolyzers. Results identify optimal configurations to minimize levelized cost of hydrogen (LCOH) and carbon intensity (CI) of hydrogen, showing potential reductions of cost and CI by 2030. Standalone PV systems can achieve LCOH values smaller than 6.5 USD/kg H 2 and CI less than 2.5 kg CO 2 eq/kg H 2 in regions with high solar irradiance, such as North Africa, the Middle East and Chile. Wind systems in regions such as Middle East, North Africa, Australia and Central United States achieve LCOH below 5 USD/kg H 2 and CI under 1.5 kg CO 2 eq/kg H 2 . Hybrid systems emerge as the optimal solution for minimizing both the LCOH and CI by maximizing the use of renewable energy. Moreover, the results also indicate that, with the technological advancements, future reduction in the capital cost of renewable energy systems and the PEM electrolyzer as well as the trade of coproduct O 2 could drive the LCOH of all the RES-based hydrogen systems below 1 USD/kg H 2 and the CI below zero in different regions as Middle East, North Africa and Central United State

08 HYDROGEN↗

DOE OSTI2023

East African Monsoon as a Drawbridge for the Circumnavigation of Madden–Julian Oscillation Events

The seasonality of circumnavigation of Madden-Julian Oscillation (MJO) events is examined using 42 years of observations and global model simulations. MJO events are most likely to propagate across the Atlantic Ocean, Africa and back to equatorial Indian Ocean relatively unweakened during March-April-May and to a lesser extent in October-November-December. These seasons correspond to the "long-rain" and "short-rain" periods of East African monsoon when precipitation over Africa is near the equator and extend farthest east toward Indian Ocean. Moisture budget analysis of a circumnavigating MJO event under real and hypothetical seasonally varying background conditions indicates that the seasonal zonal movement of zonal component of background circulation regulates the moistening of MJO crossing from Eastern Africa to Indian Ocean. Ensembles of Energy Exa-scale Earth System Model (E3SM) simulations of the MJO event under idealized seasonally varying background state confirm the observed drawbridge-like role of East African monsoon in the propagation of MJO.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2025

Soil moisture gradients strengthen mesoscale convective systems by increasing wind shear

Mesoscale convective systems are a class of storm linked to extensive flooding and other destructive hazards in many regions globally. In West Africa, soil moisture impacts provide a valuable source of predictability for mature storm hazards, but little is known about mature storm sensitivity to soil moisture in other climatic regions. Here we use a storm track dataset, satellite observations and reanalysis fields to investigate the response of mature storms to soil moisture in seven global storm hotspots—West Africa, India, South America, South Africa, Australia and the United States Great Plains. We demonstrate that mesoscale soil moisture gradients (~500 km) can enhance storms by driving increased vertical wind shear conditions, a crucial ingredient for storm organization, through the strengthening of atmospheric temperature gradients. This is evidenced by a 10–30% increase in precipitation feature size and rainfall for the largest storms on days with favourable soil moisture gradients compared with unfavourable gradients. Global simulations confirm that soil moisture gradients influence wind shear. The results demonstrate the importance of soil moisture feedbacks for accurate forecasting of mesoscale convective systems and future projections of extreme events under climate change.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2022

Infrastructure inequality is a characteristic of urbanization

Urbanization can challenge sustainable development if it produces unequal outcomes. Infrastructure is an important urbanization dimension, providing services to support diverse urban activities. However, it can lock in unequal outcomes due to its durable nature. This paper studies inequalities in infrastructure distributions to derive insights into the structure and characteristics of unequal outcomes associated with urbanization. We analyzed infrastructure inequalities in two emerging economies in the Global South: India and South Africa. We developed and applied an inequality measure to understand the structure of inequality in infrastructure provisioning (based on census data) and infrastructure availability (based on satellite nighttime lights [NTLs] data). Consistent with differences in economic inequality, results show greater inequalities in South Africa than in India and greater urban inequalities than rural inequalities. Nevertheless, inequalities in urban infrastructure provisioning and infrastructure availability increase from finer to coarser spatial scales. NTL-based inequality measurements additionally show that inequalities are more concentrated at coarse spatial scales in India than in South Africa. Finally, results show that urban inequalities in infrastructure provisioning covary with urbanization levels conceptualized as a multidimensional phenomenon, including demographic, economic, and infrastructural dimensions. Similarly, inequalities in urban infrastructure availability increase monotonically with infrastructure development levels and urban population size. Together, these findings underscore infrastructure inequalities as a feature of urbanization and suggest that understanding urban inequalities requires applying an inequality lens to urbanization.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2023

Threefold reduction of modeled uncertainty in direct radiative effects over biomass burning regions by constraining absorbing aerosols

Absorbing aerosols emitted from biomass burning (BB) greatly affect the radiation balance, cloudiness, and circulation over tropical regions. Assessments of these impacts rely heavily on the modeled aerosol absorption from poorly constrained global models and thus exhibit large uncertainties. By combining the AeroCom model ensemble with satellite and in situ observations, we provide constraints on the aerosol absorption optical depth (AAOD) over the Amazon and Africa. Our approach enables identification of error contributions from emission, lifetime, and MAC (mass absorption coefficient) per model, with MAC and emission dominating the AAOD errors over Amazon and Africa, respectively. In addition to primary emissions, our analysis suggests substantial formation of secondary organic aerosols over the Amazon but not over Africa. Furthermore, we find that differences in direct aerosol radiative effects between models decrease by threefold over the BB source and outflow regions after correcting the identified errors. This highlights the potential to greatly reduce the uncertainty in the most uncertain radiative forcing agent.

09 BIOMASS FUELS↗

DOE OSTI2023

The 2022 Outbreaks of African Swine Fever Virus Demonstrate the First Report of Genotype II in Ghana

African swine fever (ASF) is a lethal disease of domestic pigs that has been causing outbreaks for over a century in Africa ever since its first discovery in 1921. Since 1957, there have been sporadic outbreaks outside of Africa; however, no outbreak has been as devastating and as far-reaching as the current pandemic that originated from a 2007 outbreak in the Republic of Georgia. Derivatives with a high degree of similarity to the progenitor strain, ASFV-Georgia/2007, have been sequenced from various countries in Europe and Asia. However, the current strains circulating in Africa are largely unknown, and 24 different genotypes have been implicated in different outbreaks. In this study, ASF isolates were collected from samples from swine suspected of dying from ASF on farms in Ghana in early 2022. While previous studies determined that the circulating strains in Ghana were p72 Genotype I, we demonstrate here that the strains circulating in 2022 were derivatives of the p72 Genotype II pandemic strain. Therefore, this study demonstrates for the first time the emergence of Genotype II ASFV in Ghana.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2025

A Pentavalent HIV-1 Subtype C Vaccine Containing Computationally Selected gp120 Strains Improves the Breadth of V1V2 Region Responses

Background: HIV-1 envelope (Env) variable loops 1 and 2 (V1V2) directed non-neutralizing antibodies were a correlate of decreased transmission risk in the RV144 vaccine trial. Thus, the elicitation and breadth of antibody responses against the V1V2 of HIV-1 Env are important considerations for HIV-1 vaccine candidates. The V1V2 region’s highly variable nature and the extensive diversity of subtype C HIV-1 Envelopes (Envs) make the V1V2 response breadth a high priority for HIV-1 vaccine regimens aiming for V1V2-mediated protection in Southern Africa. Here, we determined whether the breadth of the anti-V1V2 vaccine response can be broadened by including HIV-1 Env strains computationally designed to enhance the coverage of subtype C V1V2 sequence diversity. Methods: Three subtype C Env strains were selected to maximize antibody binding coverage while complementing subtype C vaccine gp120s that were given in human clinical trials in South Africa, as well as to improve epitope accessibility. Humoral immunogenicity of a novel trivalent gp120 vaccine immunogen, a bivalent gp120 boost already in clinical trials (1086C and TV1), and a pentavalent (all five gp120s combined) were evaluated in a preclinical immunization study in guinea pigs. The pentavalent combination was further evaluated with alum versus glucopyranosyl lipid adjuvants formulated in squalene-in-water emulsion (GLA-SE) adjuvants in non-human primates. The breadth of the anti-V1V2 response was assessed using an array of cross-subtype variable loops 1&2 (V1V2) scaffold proteins and linear V2 peptides. Results: The breadth of the IgG response against V1V2 antigens of the trivalent and pentavalent groups was comparable, and both were greater than the breadth of the bivalent group. Linear epitope mapping showed that two linear epitopes in V2 were targeted by the vaccinated animals: the V2 hotspot focused at 169K that potentially correlated with decreased HIV-1 risk in RV144 and the V2.2 site (179LDV/I181) that is part of the integrin α4β7 binding site. The bivalent vaccine elicited a significantly higher magnitude of binding to the V2 hotspot compared to the trivalent vaccine whereas the trivalent vaccine elicited significantly higher binding to the V2.2 epitope compared to the bivalent vaccine, while the pentavalent recognized both regions. Conclusions: These results demonstrate that the three new computationally selected subtype C Envs successfully complemented 1086C and TV1 for broader V1V2 antibody responses, and, in concert with adjuvants that stimulate V1V2 responses, can be considered as part of a rationale immunogen design to improve V1V2 IgG coverage in future vaccine trials in South Africa.

Immunology↗

NASA NTRS1972

The equatorial electrojet satellite and surface comparison

The OGO 4 and 6 (POGO) magnetic field results for the equatorial electrojet indicate that while the present models are approximately correct, the possibility of a westward component must be incorporated. The scatter diagrams of POGO amplitudes and surface data show a correlation. The ratios between the amplitudes estimated from surface data and those at 400 km altitude are as follows: India 5 to 8, East Africa (Addis Ababa) 4, Central Africa 3, West Africa (Nigeria) 3, South America (Huancayo) 5, and Philippines 5. The variation in the ratio is due to the conductivity structure of the earth in various zones.

Cain, J. C.↗

NASA NTRS1977

Convection pattern and stress system under the African plate

Studies on tectonic forces from satellite-derived gravity data have revealed a subcrustal stress system which provides a unifying mechanism for uplift, depression, rifting, plate motion and ore formation in Africa. The subcrustal stresses are due to mantle convection. Seismicity, volcanicity and kimberlite magmatism in Africa and the development of the African tectonic and magnetic features are explained in terms of this single stress system. The tensional stress fields in the crust exerted by the upwelling mantle flows are shown to be regions of structural kinship characterized by major concentration of mineral deposits. It is probable that the space techniques are capable of detecting and determining the tectonic forces in the crust of Africa.

Liu, H.-S.↗