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At least 505 records · Page 28

Evaluation of light collection from highly scattering media using wavelength-shifting fibers

Opaque scintillators are designed to have a short scattering length such that scintillation photons are probabilistically confined to a small region of space about their origin. The benefit of this feature is that information on the interaction event topology can be recorded with greater fidelity than in traditional highly transparent media with sensors at large distances from the light production region. Opaque scintillator detectors rely on wavelength-shifting fibers to extract the scintillation light; however, the efficiency of light collection has not yet been directly measured in experiment. We measured the efficiency of light collection as a function of the optical parameters of an opaque liquid and the distance from the origin of the light to the fiber. We use the experimental data to validate a Monte Carlo model of light transport and collection and discuss a simple diffusion model that reproduces the results of Monte Carlo simulation with high fidelity. Furthermore, this combination of validated models has the potential for use in predictions of performance in various designs of future opaque scintillator detectors such as LiquidO.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Cosmic topology. Part IIa. Eigenmodes, correlation matrices, and detectability of orientable Euclidean manifolds

Abstract If the Universe has non-trivial spatial topology, observables depend on both the parameters of the spatial manifold and the position and orientation of the observer. In infinite Euclidean space, most cosmological observables arise from the amplitudes of Fourier modes of primordial scalar curvature perturbations. Topological boundary conditions replace the full set of Fourier modes with specific linear combinations of selected Fourier modes as the eigenmodes of the scalar Laplacian. We present formulas for eigenmodes in orientable Euclidean manifolds with the topologiesE 1 –E 6 ,E 11 ,E 12 ,E 16 , andE 18 that encompass the full range of manifold parameters and observer positions, generalizing previous treatments. Under the assumption that the amplitudes of primordial scalar curvature eigenmodes are independent random variables, for each topology we obtain the correlation matrices of Fourier-mode amplitudes (of scalar fields linearly related to the scalar curvature) and the correlation matrices of spherical-harmonic coefficients of such fields sampled on a sphere, such as the temperature of the cosmic microwave background (CMB). We evaluate the detectability of these correlations given the cosmic variance of the observed CMB sky. We find that topologies where the distance to our nearest clone is less than about 1.2 times the diameter of the last scattering surface of the CMB give a correlation signal that is larger than cosmic variance noise in the CMB. This implies that if cosmic topology is the explanation of large-angle anomalies in the CMB, then the distance to our nearest clone is not much larger than the diameter of the last scattering surface. We argue that the topological information is likely to be better preserved in three-dimensional data, such as will eventually be available from large-scale structure surveys.

Astronomy & Astrophysics↗

Concerning colour: The effect of environment on type Ia supernova colour in the dark energy survey

ABSTRACT Recent analyses have found intriguing correlations between the colour (c) of type Ia supernovae (SNe Ia) and the size of their ‘mass-step’, the relationship between SN Ia host galaxy stellar mass (Mstellar) and SN Ia Hubble residual, and suggest that the cause of this relationship is dust. Using 675 photometrically classified SNe Ia from the Dark Energy Survey 5-yr sample, we study the differences in Hubble residual for a variety of global host galaxy and local environmental properties for SN Ia subsamples split by their colour. We find a 3σ difference in the mass-step when comparing blue (c < 0) and red (c > 0) SNe. We observe the lowest r.m.s. scatter (∼0.14 mag) in the Hubble residual for blue SNe in low mass/blue environments, suggesting that this is the most homogeneous sample for cosmological analyses. By fitting for c-dependent relationships between Hubble residuals and Mstellar, approximating existing dust models, we remove the mass-step from the data and find tentative ∼2σ residual steps in rest-frame galaxy U − R colour. This indicates that dust modelling based on Mstellar may not fully explain the remaining dispersion in SN Ia luminosity. Instead, accounting for a c-dependent relationship between Hubble residuals and global U − R, results in ≤1σ residual steps in Mstellar and local U − R, suggesting that U − R provides different information about the environment of SNe Ia compared to Mstellar, and motivating the inclusion of galaxy U − R colour in SN Ia distance bias correction.

79 ASTRONOMY AND ASTROPHYSICS↗

National Park Service Bus Electrification Study: 2020 Report

This report summarizes important considerations for implementing BEBs in the three national park fleets, detailing information about current buses at each fleet, electric bus demonstration vehicles, as well as performance evaluations of BEBs in Zion, Bryce, and Yosemite. Results include in-use data collection results reporting metrics such as average bus speed, energy usage per trip, and daily distance traveled, as well as effects of high heating, ventilation, and air conditioning (HVAC) system use to both heat and cool the buses, emissions estimations before and after use of electric buses, operating costs, electric vehicle infrastructure, maintenance, and bus driver user experience survey information. Analysis results from this project will help the NPS understand how BEBs and future expansion of BEBs could assist in meeting their bottom line and operational goals and assist NPS in choosing appropriate locations for future BEB deployments.

33 ADVANCED PROPULSION SYSTEMS↗

An analysis of flight data from aircraft landings with and without the aid of a painted diamond on the same runway

The usefulness of a painted diamond on a runway as a visual aid to perform safe landings of aircraft was studied. Flight data on glideslope intercepts, flight path elevation angles, and touchdown distances were collected and analyzed. It is concluded that an appropriately painted diamond on a runway has the potential of providing glideslope information for the light weight class of general aviation aircraft. This conclusion holds irrespective of the differences in landing techniques used by the pilots.

Swaroop, R.↗

Catalog of open clusters and associated interstellar matter

The Catalog of Open Clusters and Associated Interstellar Matter summarizes observations of 128 open clusters and their associated ionized, atomic, and molecular iinterstellar matter. Cluster sizes, distances, radial velocities, ages, and masses, and the radial velocities and masses of associated interstellar medium components, are given. The database contains information from approximately 400 references published in the scientific literature before 1988.

Leisawitz, David↗

Functional characteristics of the calcium modulated proteins seen from an evolutionary perspective

We have constructed dendrograms relating 173 EF-hand proteins of known amino acid sequence. We aligned all of these proteins by their EF-hand domains, omitting interdomain regions. Initial dendrograms were computed by minimum mutation distance methods. Using these as starting points, we determined the best dendrogram by the method of maximum parsimony, scored by minimum mutation distance. We identified 14 distinct subfamilies as well as 6 unique proteins that are perhaps the sole representatives of other subfamilies. This information is given in tabular form. Within subfamilies one can easily align interdomain regions. The resulting dendrograms are very similar to those computed using domains only. Dendrograms constructed using pairs of domains show general congruence. However, there are enough exceptions to caution against an overly simple scheme in which one pair of gene duplications leads from one domain precurser to a four domain prototype from which all other forms evolved. The ability to bind calcium was lost and acquired several times during evolution. The distribution of introns does not conform to the dendrogram based on amino acid sequences. The rates of evolution appear to be much slower within subfamilies, especially within calmodulin, than those prior to the definition of subfamily.

Kretsinger, R. H.↗

Electronic neural network for solving traveling salesman and similar global optimization problems

This invention is a novel high-speed neural network based processor for solving the 'traveling salesman' and other global optimization problems. It comprises a novel hybrid architecture employing a binary synaptic array whose embodiment incorporates the fixed rules of the problem, such as the number of cities to be visited. The array is prompted by analog voltages representing variables such as distances. The processor incorporates two interconnected feedback networks, each of which solves part of the problem independently and simultaneously, yet which exchange information dynamically.

Thakoor, Anilkumar P.↗

Methods for Characterizing Fine Particulate Matter Using Satellite Remote-Sensing Data and Ground Observations: Potential Use for Environmental Public Health Surveillance

This study describes and demonstrates different techniques for surfacing daily environmental / hazards data of particulate matter with aerodynamic diameter less than or equal to 2.5 micrometers (PM2.5) for the purpose of integrating respiratory health and environmental data for the Centers for Disease Control and Prevention (CDC s) pilot study of Health and Environment Linked for Information Exchange (HELIX)-Atlanta. It described a methodology for estimating ground-level continuous PM2.5 concentrations using B-Spline and inverse distance weighting (IDW) surfacing techniques and leveraging National Aeronautics and Space Administration (NASA) Moderate Resolution Imaging Spectrometer (MODIS) data to complement The Environmental Protection Agency (EPA) ground observation data. The study used measurements of ambient PM2.5 from the EPA database for the year 2003 as well as PM2.5 estimates derived from NASA s satellite data. Hazard data have been processed to derive the surrogate exposure PM2.5 estimates. The paper has shown that merging MODIS remote sensing data with surface observations of PM2.5 not only provides a more complete daily representation of PM2.5 than either data set alone would allow, but it also reduces the errors in the PM2.5 estimated surfaces. The results of this paper have shown that the daily IDW PM2.5 surfaces had smaller errors, with respect to observations, than those of the B-Spline surfaces in the year studied. However the IDW mean annual composite surface had more numerical artifacts, which could be due to the interpolating nature of the IDW that assumes that the maxima and minima can occur only at the observation points. Finally, the methods discussed in this paper improve temporal and spatial resolutions and establish a foundation for environmental public health linkage and association studies for which determining the concentrations of an environmental hazard such as PM2.5 with good accuracy levels is critical.

Al-Hamdan, Mohammad Z.↗

3D Representation of UAV-obstacle Collision Risk under off-nominal conditions

Safe operations of autonomous unmanned aerial vehicles (UAVs) in low-altitude airspace with beyond visual line-of-sight (BVLOS) flights demand robust risk monitoring of airspace as well as of people and property on ground. One of the safety critical factors for UAV flights is the risk of collision with static and dynamic obstacles in proximity to its flight path. This paper presents a detailed formulation of risk likelihood of obstacle collision incorporating the effects of off-nominal conditions introduced by component failures, degraded controllability and environmental disturbances such as wind gusts. The deviation in the planned trajectory caused due to wind is computed utilizing a point-mass 3D kinematic simulation model of the vehicle. Likelihood of risk for the flight plan is then analyzed based on generating the probability of collision for each point in the trajectory. The proposed risk factor is demonstrated on real flight data from experimental flights of an octocopter at NASA Langley Research Center in presence of simulated obstacles and wind conditions. Effect of varying wind conditions, distance from obstacles, level of controllability and obstacle measurement noise on the risk factor is demonstrated. The proposed approach enables risk-informed decision making for timely mitigation of current and future unsafe events in autonomous systems.

Portia Banerjee↗

Solar Activity Relations in Energetic Electron Events Measured By the MESSENGER Mission

Aims. We perform a statistical study of the relations between the properties of solar energetic electron (SEE) events measured by the MESSENGER mission from 2010 to 2015 and the parameters of the respective parent solar activity phenomena in order to identify the potential correlations between them. During the time of analysis, the MESSENGER heliocentric distance varied between 0.31 and 0.47 au. Methods. We used a published list of 61 SEE events measured by MESSENGER, which includes information on the near-relativistic electron peak intensities, the peak-intensity energy spectral indices, and the measured X-ray peak intensity of the flares related to the SEE events. Taking advantage of multi-viewpoint remote-sensing observations, we reconstructed, whenever possible, the associated coronal mass ejections (CMEs) and shock waves; and we determined the three-dimensional (3D) properties (location, speed, and width) of the CMEs and the maximum speed of the 3D CME-driven shocks in the corona. We used different methods (Spearman, Pearson, and a Bayesian approach, namely the Kelly method to linear regression) to estimate the correlation coefficients between the flare intensity, maximum speed at the apex of the CME-driven shock, CME speed at the apex, and CME width with the electron peak intensities and with the energy spectral indices. In this statistical study, we considered and addressed the limitations of the particle instrument on board MESSENGER (elevated background intensity level, anti-Sun pointing). Results. There is an asymmetry to the east in the range of connection angles (CAs) for which the SEE events present the highest peak intensities, where the CA is the longitudinal separation between the footpoint of the magnetic field connecting to the spacecraft and the flare location. Based on this asymmetry, we define a subsample of well-connected events as when −65° ≤ CA ≤ +33°. For the well-connected sample, we find moderate to strong correlations between the near-relativistic electron peak intensity and the 3D CME-driven shock maximum speed at the apex (Spearman: cc = 0.53 ± 0.05; Pearson: cc = 0.65 ± 0.04; Kelly: cc = 0.87 ± 0.20), the flare peak intensity (Spearman: cc = 0.63 ± 0.03; Pearson: cc = 0.59 ± 0.03; Kelly: cc = 0.74 ± 0.30), and the 3D CME speed at the apex (Spearman: cc = 0.50 ± 0.04; Pearson: cc = 0.46 ± 0.03; Kelly: cc = 0.60 ± 0.39). When including poorly connected events (full sample), the relations between the peak intensities and the solar-activity phenomena are blurred, showing lower correlation coefficients. Conclusions. Based on the comparison of the correlation coefficients presented in this study using near 0.4 au data, (1) both flare and shock-related processes may contribute to the acceleration of near relativistic electrons in large SEE events, in agreement with previous studies based on near 1 au data; and (2) the maximum speed of the CME-driven shock is a better parameter to investigate particle-acceleration-related mechanisms than the average CME speed, as suggested by the stronger correlation with the SEE peak intensities.

Sun↗

Demystification of Processes that Effect Prioritization of Space Radiation Element Research

In an effort to demystify how research funding priorities are established , the Space Radiation Element will present an introduction to the Human Space Risk Board (HSRB) framework that is that used to inform Human System Risk and can be found at https://humanresearchroadmap.nasa.gov/Risks/. These risks are based on the consequences of hazards (space radiation, altered gravity, isolation & confinement, distance from earth and hostile/closed environment) a human body is exposed to during spaceflight. The HSRB regularly evaluates risks to humans in space which includes updating the knowledge base to reflect emerging research, the development of effective countermeasures, and evolving operational approaches toward addressing those risks. To increase understanding and clarity, this talk will step through how risks (with the focus on Risk of Radiation Carcinogenesis) are assigned a rating (and color code) based on design reference missions, likelihood, and consequence. Further, The Space Radiation Element will discuss how risks, including the magnitude/rating, required technical deliverables, and expected products from current research efforts affect our element strategy and prioritization of research. In addition, navigation of the publicly available www.nasa.gov/hrp, will be demonstrated to inform principal investigators where this information can be readily accessed. Our primary objectives for this presentation/demonstration are to demystify The Space Radiation Element’s internal processes and to educate researchers concerning publicly available documents that can be used to better align their proposed objectives with Element priorities.

J A Zawaski↗

Modeling inter‐reader variability in clinical target volume delineation for soft tissue sarcomas using diffusion model

Abstract Background Accurate delineation of the clinical target volume (CTV) is essential in the radiotherapy treatment of soft tissue sarcomas. However, this process is subject to inter‐reader variability due to the need for clinical assessment of risk and extent of potential microscopic spread. This can lead to inconsistencies in treatment planning, potentially impacting treatment outcomes. Most existing automatic CTV delineation methods do not account for this variability and can only generate a single CTV for each case. Purpose This study aims to develop a deep learning‐based technique to generate multiple CTV contours for each case, simulating the inter‐reader variability in the clinical practice. Methods We employed a publicly available dataset consisting of fluorodeoxyglucose positron emission tomography (FDG‐PET), x‐ray computed tomography (CT), and pre‐contrast T1‐weighted magnetic resonance imaging (MRI) scans from 51 patients with soft tissue sarcoma, along with an independent validation set containing five additional patients. An experienced reader drew a contour of the gross tumor volume (GTV) for each patient based on multi‐modality images. Subsequently, two additional readers, together with the first one, were responsible for contouring three CTVs in total based on the GTV. We developed a diffusion model‐based deep learning method that is capable of generating arbitrary number of different and plausible CTVs to mimic the inter‐reader variability in CTV delineation. The proposed model incorporates a separate encoder to extract features from the GTV masks, leveraging the critical role of GTV information in accurate CTV delineation. Results The proposed diffusion model demonstrated superior performance with the highest Dice Index (0.902 compared to values below 0.881 for state‐of‐the‐art models) and the best generalized energy distance (GED) (0.209 compared to values exceeding 0.221 for state‐of‐the‐art models). It also achieved the second‐highest recall and precision metrics among the compared ambiguous image segmentation models. Results from both datasets exhibited consistent trends, reinforcing the reliability of our findings. Additionally, ablation studies exploring different model structures and input configurations highlighted the significance of incorporating prior GTV information for accurate CTV delineation. Conclusions The proposed diffusion model successfully generates multiple plausible CTV contours for soft tissue sarcomas, effectively capturing inter‐reader variability in CTV delineation.

Dong, Yafei [Yale Biomedical Imaging Institute Yal↗

Standoff inspection using geometry-informed full-wavefield response measurements

A vibrometer may measure acoustic responses in portions of a structure along a scan path to acoustic excitation of the structure. A ranging device may measure distances to the portions of the structure along the scan path. A three-dimensional point cloud may be generated based on the acoustic responses in the portions of the structure and the distances to the portions of the structure. The three-dimensional point cloud may include points representing geometry of the portions of the structure. The points may be associated with the acoustic responses in corresponding portions of the structure. One or more properties of the structure may be determined based on an analysis of the three-dimensional point cloud.

Flynn, Eric Brian↗

FAR and NEAR Target Dynamic Visual Acuity: A Functional Assessment of Canal and Otolith Performance

Upon their return to earth, astronauts experience the effects of vestibular adaptation to microgravity. The postflight changes in vestibular information processing can affect postural and locomotor stability and may lead to oscillopsia during activities of daily living. However, it is likely that time spent in microgravity affects canal and otolith function differently. As a result, the isolated rotational stimuli used in traditional tests of canal function may fail to identify vestibular deficits after spaceflight. Also, the functional consequences of deficits that are identified often remain unknown. In a gaze control task, the relative contributions of the canal and otolith organs are modulated with viewing distance. The ability to stabilize gaze during a perturbation, on visual targets placed at different distances from the head may therefore provide independent insight into the function of this systems. Our goal was to develop a functional measure of gaze control that can also offer independent information about the function of the canal and otolith organs.

Peters, Brian T.↗

Detecting anomalous sequences in electronic health records using higher-order tensor networks

Detecting anomalous sequences is an integral part of building and protecting modern large-scale health information technology (HIT) systems. These HIT systems generate a large volume of records of patients’ state and significant events, which provide a valuable resource to help improve clinical decisions, patient care processes, and other issues. However, detecting anomalous sequences in electronic health records (EHR) remains a challenge in healthcare applications for several reasons, including imbalances in the data, complexity of relationships between events in the sequence, and the curse of dimensionality. Conventional anomaly detection methods use the finite sequence of events to discriminate sequences. They fail to incorporate salient event details under variable higher-order dependencies (e.g., duration between events) that can provide better discrimination of sequences in their models. To address this problem, we propose event sequence and subsequence anomaly detection algorithms that (1) use network-based representations of interactions in the data, (2) account for variable higher-order dependencies in the data, and (3) incorporate events duration for adequate discrimination of the data. The proposed approach identifies anomalies by monitoring the change in the graph after the test sequence is removed from the network. The change is quantified using graph distance metrics so that dramatic changes in the network can be attributed to the removed sequence. Furthermore, the proposed subsequence algorithm recommends plausible paths and salient information for the detected anomalous subsequences. Our results show that the proposed event sequence anomaly detection algorithm outperforms the baseline methods for both synthetic data and real-world EHR data.

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗

Improved Accuracy in Semi-Experimental Structure Determination by Resolving Problems Associated with Rotation of Principal Inertial Axes of Isotopologues: Structures of 1,3-Oxazole ( c -C 3 H 3 NO)

The rotational spectrum of the normal isotopologue of 1,3-oxazole (c-C 3 H 3 NO) was observed from 43 to 750 GHz. Over 3900 transitions for the ground vibrational state are measured, assigned, and least-squares fit to sextic centrifugally distorted-rotor Hamiltonians. The measured frequencies and resulting spectroscopic constants from this extended spectral range, combined with previous measurements of the nuclear quadrupole coupling constants, will facilitate astronomical searches for oxazole across the majority of the range of modern radiotelescopes. Spectra for a set of 30 oxazole isotopologues, which include multiple isotopic substitutions of each atom, are used to determine the first semi-experimental equilibrium ($r$$^{SE}_{e}$) structure and semi-experimental substitution structure ($r$$^{SE}_{e}$), each using CCSD(T) computed values for the vibration–rotation interaction and electron-mass corrections. The large number of isotopologues, including 21 isotopologues observed for the first time, and the redundant substitutions of each atom provide sufficient spectroscopic information to determine the $r$$^{SE}_{e}$ structure with the expected high level of accuracy and precision (0.0001 or 0.0002 Å in bond distances and 0.013 to 0.025° in bond angles). In the course of this study, we analyzed a known issue for some $r$$^{SE}_{e}$ structure determinations of near-oblate asymmetric tops in which inclusion of individual isotopologues degrades the structure determination. We demonstrate that this problem primarily arises from the difference in the values of the computed vibration–rotation interaction corrections as evaluated at the computed re geometry vs the $r$$^{SE}_{e}$ geometry of the “real” molecule. Our solution to this problem substantially improves the $r$$^{SE}_{e}$ structure of oxazole and likely can be generalized to many other molecules.

Chemical structure↗

Spectral Addressability in a Modular Two Qubit System

The combination of structural precision and reproducibility of synthetic chemistry is perfectly suited for the creation of chemical qubits, the core units of a quantum information science (QIS) system. By exploiting the atomistic control inherent to synthetic chemistry, we address a fundamental question of how the spin–spin distance between two qubits impacts electronic spin coherence. To achieve this goal, in this study we designed a series of molecules featuring two spectrally distinct qubits, an early transition metal, Ti 3+ , and a late transition metal, Cu 2+ with increasing separation between the two metals. The spectral separation between the two metals enables us to probe each metal individually in the bimetallic species and compare it with monometallic control samples. Coherence times found to be governed by the distance to nuclear spins on the other qubit’s ligand framework. This finding offers guidance for the design of spectrally addressable molecular qubits.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗