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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 505 records · Page 28
All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney

Molecular assessments at the single-cell level can accelerate biological research by providing detailed assessments of cellular organization and tissue heterogeneity in both disease and health. The human kidney has complex multi-cellular states with varying functionality, much of which can now be completely harnessed with recent technological advances in tissue proteomics at a near single-cell level. We discuss the foundational steps in the first application of this mass spectrometry (MS) based proteomics method for analysis of sub-sections of the normal human kidney, as part of the Kidney Precision Medicine Project (KPMP). Using approximately 30-40 laser captured micro-dissected kidney cells, we identified more than 2500 human proteins, with specificity to the proximal tubular (PT; n=25 proteins) and glomerular (Glom; n=67 proteins) regions of the kidney and their unique metabolic functions. This pilot study provides the roadmap for application of our near-single-cell proteomics workflow for the analysis of other renal micro-compartments, on a larger scale, to unravel perturbations of renal sub-cellular function in the normal kidney as well as different etiologies of acute and chronic kidney disease.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression

Central insulin receptor-mediated signaling is attracting the growing attention of researchers because of rapidly accumulating evidence implicating it in the mechanisms of plasticity, stress response, and neuropsychiatric disorders including depression. Dicholine succinate (DS), a mitochondrial complex II substrate, was shown to enhance insulin-receptor mediated signaling in neurons and is regarded as a sensitizer of the neuronal insulin receptor. Compounds enhancing neuronal insulin receptor-mediated transmission exert an antidepressant-like effect in several pre-clinical paradigms of depression; similarly, such properties for DS were found with a stress-induced anhedonia model. Here, we additionally studied the effects of DS on several variables which were ameliorated by other insulin receptor sensitizers in mice. Pre-treatment with DS of chronically stressed C 57 BL6 mice rescued normal contextual fear conditioning, hippocampal gene expression of NMDA receptor subunit NR2A, the NR2A/NR2B ratio and increased REM sleep rebound after acute predation. In 18-month-old C57BL6 mice, a model of elderly depression, DS restored normal sucrose preference and activated the expression of neural plasticity factors in the hippocampus as shown by Illumina microarray. Finally, young naïve DS-treated C 57 BL6 mice had reduced depressive- and anxiety-like behaviors and, similarly to imipramine-treated mice, preserved hippocampal levels of the phosphorylated (inactive) form of GSK 3 beta that was lowered by forced swimming in pharmacologically naïve animals. Thus, DS can ameliorate behavioral and molecular outcomes under a variety of stress- and depression-related conditions. This further highlights neuronal insulin signaling as a new factor of pathogenesis and a potential pharmacotherapy of affective pathologies.

Behavioral Sciences↗
DOE OSTI2020

Alterations in Progesterone Receptor Isoform Balance in Normal and Neoplastic Breast Cells Modulates the Stem Cell Population

To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere assays revealed that in murine breast, overexpression of PRB leads to an increase in luminal and basal progenitor/stem cells. Ovariectomy had a negative impact on the luminal compartment and induced an increase in mammosphere-forming capacity in cells derived from WT and PRA mice only. Treatment with ICI 182,780 augmented the mammosphere-forming capacity of cells isolated from WT and PRA mice, whilst those from PRB remained unaltered. T47D YB cells showed an increase in the CD44+/CD24Low/- subpopulation; however, the number of tumorspheres did not vary relative to T47D and YA, even though they were larger, more irregular, and had increased clonogenic capacity. T47D and YA tumorspheres were modulated by estrogen/antiestrogens, whereas YB spheres remained unchanged in size and number. Our results show that alterations in PR isoform balance have an impact on normal and tumorigenic breast progenitor/stem cells and suggest a key role for the B isoform, with implications in response to antiestrogens.

stem cells↗
DOE OSTI2016

Absence of Fast-Moving Iron in an Intermediate Type Ia Supernova Between Normal and Super-Chandrasekhar

In this study, we report observations of a peculiar SN Ia iPTF13asv (a.k.a., SN2013cv) from the onset of the explosion to months after its peak. The early-phase spectra of iPTF13asv show an absence of iron absorption, indicating that synthesized iron elements are confined to low-velocity regions of the ejecta, which, in turn, implies a stratified ejecta structure along the line of sight. Our analysis of iPTF13asv's light curves and spectra shows that it is an intermediate case between normal and super-Chandrasekhar events. On the one hand, its light curve shape (B-band ${\rm{\Delta }}{m}_{15}=1.03\pm 0.01$) and overall spectral features resemble those of normal SNe Ia. On the other hand, its large peak optical and UV luminosity (${M}_{B}=-19.84\;{\rm{mag}}$, ${M}_{{uvm}2}=-15.5\;{\rm{mag}}$) and its low but almost constant Si ii velocities of about 10,000 km s -1 are similar to those in super-Chandrasekhar events, and its persistent carbon signatures in the spectra are weaker than those seen commonly in super-Chandrasekhar events. We estimate a 56 Ni mass of ${0.81}_{-0.18}^{+0.10}{M}_{\odot }$ and a total ejecta mass of ${1.59}_{-0.12}^{+0.45}{M}_{\odot }$. Finally, the large ejecta mass of iPTF13asv and its stratified ejecta structure together seemingly favor a double-degenerate origin.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2016

The evolution of normal galaxy X-ray emission through cosmic history: constraints from the 6 Ms Chandra deep field-south

We present measurements of the evolution of normal-galaxy X-ray emission from z ≈ 0–7 using local galaxies and galaxy samples in the ≈6 Ms Chandra Deep Field-South (CDF-S) survey. The majority of the CDF-S galaxies are observed at rest-frame energies above 2 keV, where the emission is expected to be dominated by X-ray binary (XRB) populations; however, hot gas is expected to provide small contributions to the observed-frame ≲1 keV emission at z ≲ 1. We show that a single scaling relation between X-ray luminosity (L{sub X}) and star-formation rate (SFR) literature, is insufficient for characterizing the average X-ray emission at all redshifts. We establish that scaling relations involving not only SFR, but also stellar mass (M{sub ⋆}) and redshift, provide significantly improved characterizations of the average X-ray emission from normal galaxy populations at z ≈ 0–7. We further provide the first empirical constraints on the redshift evolution of X-ray emission from both low-mass XRB (LMXB) and high-mass XRB (HMXB) populations and their scalings with M{sub ⋆} and SFR, respectively. We find L{sub 2−10keV}(LMXB)/M{sub ⋆}∝(1+z){sup 2−3} and L{sub 2−10keV}(HMXB)/SFR ∝ (1+z), and show that these relations are consistent with XRB population-synthesis model predictions, which attribute the increase in LMXB and HMXB scaling relations with redshift as being due to declining host galaxy stellar ages and metallicities, respectively. We discuss how emission from XRBs could provide an important source of heating to the intergalactic medium in the early universe, exceeding that of active galactic nuclei.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2024

Probabilistic Forward Modeling of Galaxy Catalogs with Normalizing Flows

Abstract Evaluating the accuracy and calibration of the redshift posteriors produced by photometric redshift (photo- z ) estimators is vital for enabling precision cosmology and extragalactic astrophysics with modern wide-field photometric surveys. Evaluating photo- z posteriors on a per-galaxy basis is difficult, however, as real galaxies have a true redshift but not a true redshift posterior. We introduce PZFlow, a Python package for the probabilistic forward modeling of galaxy catalogs with normalizing flows. For catalogs simulated with PZFlow, there is a natural notion of “true” redshift posteriors that can be used for photo- z validation. We use PZFlow to simulate a photometric galaxy catalog where each galaxy has a redshift, noisy photometry, shape information, and a true redshift posterior. We also demonstrate the use of an ensemble of normalizing flows for photo- z estimation. We discuss how PZFlow will be used to validate the photo- z estimation pipeline of the Dark Energy Science Collaboration, and the wider applicability of PZFlow for statistical modeling of any tabular data.

Astronomy & Astrophysics↗
DOE OSTI2017

Spectral Sequences of Type Ia Supernovae. I. Connecting Normal and Subluminous SNe Ia and the Presence of Unburned Carbon

Type Ia supernovae (SNe Ia) are generally agreed to arise from thermonuclear explosions of carbon–oxygen white dwarfs. The actual path to explosion, however, remains elusive, with numerous plausible parent systems and explosion mechanisms suggested. Observationally, SNe Ia have multiple subclasses, distinguished by their light curves and spectra. This raises the question of whether these indicate that multiple mechanisms occur in nature or that explosions have a large but continuous range of physical properties. We revisit the idea that normal and 91bg-like SNe can be understood as part of a spectral sequence in which changes in temperature dominate. Specifically, we find that a single ejecta structure is sufficient to provide reasonable fits of both the normal SN Ia SN 2011fe and the 91bg-like SN 2005bl, provided that the luminosity and thus temperature of the ejecta are adjusted appropriately. This suggests that the outer layers of the ejecta are similar, thus providing some support for a common explosion mechanism. Our spectral sequence also helps to shed light on the conditions under which carbon can be detected in premaximum SN Ia spectra—we find that emission from iron can “fill in” the carbon trough in cool SNe Ia. This may indicate that the outer layers of the ejecta of events in which carbon is detected are relatively metal-poor compared to events in which carbon is not detected.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2016

India Direct Normal & Global Horizontal Irradiance Solar Resources

GIS data for India's direct normal irradiance (DNI) and global horizontal irradiance. Provides 10-kilometer (km) solar resource maps and data for India. The 10-km hourly solar resource data were developed using weather satellite (METEOSAT) measurements incorporated into a site-time specific solar modeling approach developed at the U.S. State University of New York at Albany. The data is made publicly available in geographic information system (GIS) format (shape files etc). The new maps and data were released in June 2013. The new data expands the time period of analysis from 2002-2007 to 2002-2011 and incorporates enhanced aerosols information to improve direct normal irradiance (DNI). These products were developed by the U.S. National Renewable Energy Laboratory (NREL) in cooperation with India's Ministry of New and Renewable Energy, through funding from the U.S. Department of Energy and U.S. Department of State.

10-kilometer↗
NASA NTRS1966

Log-normal model for microbial survival in heat sterilization

An analytical model is developed for the survival times of organisms in heat sterilization in which the probability of inactivation as a function of exposure time is log-normally distributed. Experimental data is examined relative to this model and it is concluded that the model is valid except during the initial period of heating when an additional interaction between the organisms and their surrounding medium appears to be present. At long heating times, the log-normal model appears more accurate for extrapolating to low survival probabilities than the usual logarithmic survivor curves and is generally more conservative.

SURVIVAL↗
NASA NTRS1972

Interplanetary shock normals

A scheme has been developed to improve the estimate of an interplanetary shock normal by using both magnetic field and plasma data from a single spacecraft. Calculation of the basic shock model employs a subset of the eight magnetohydrodynamic conservation relations for a shock in an isotropic medium. This subset consists of six equations that are devoid of pressure and temperature terms. A sigma-weighted least squares loss function technique is used to best fit the overdetermination equations with respect to the eleven parameters of the system. This procedure usually yields a normal much more accurate than the one obtained using magnetic field values alone. An example is given of the use of the technique on the data for the Pioneer 7 shock of 29 August 1966.

Lepping, R. P.↗
NASA NTRS1972

Proximity effect between superconductivity and normal metals

The SNS junctions were limited to having gold (n) layers of less than 3000 A in order to avoid having the tin (S) films become normal under the influence of the signal current in the gold. The gold layer was alloyed with 10 wt% copper to shorten its electronic mean free path, increasing the tin layer critical current while decreasing the Josephson critical current. It was also found that a previously reported anomalous voltage shift in the presence of I2 is caused by the tin being driven normal. After deposition, the samples were transferred to a conventional cryostat to provide better thermal contact to the films. This reduction of heating in the films produced more linear I-V characteristics and a change in the constant voltage current gain. In order to achieve power gain the SNS device must be operated at lower temperatures were the effects of fluctuations are less and be constructed such that the input resistance is much reduced and the dynamic output resistance increased. A geometry is proposed using a more sophisticated evaporator.

Meissner, H.↗
NASA NTRS1972

Digital-computer normal shock position and restart control of a Mach 2.5 axisymmetric mixed-compression inlet

Digital computer control of a mixed-compression inlet is discussed. The inlet was terminated with a choked orifice at the compressor face station to dynamically simulate a turbojet engine. Inlet diffuser exit airflow disturbances were used. A digital version of a previously tested analog control system was used for both normal shock and restart control. Digital computer algorithms were derived using z-transform and finite difference methods. Using a sample rate of 1000 samples per second, the digital normal shock and restart controls essentially duplicated the inlet analog computer control results. At a sample rate of 100 samples per second, the control system performed adequately but was less stable.

Neiner, G. H.↗
NASA NTRS1972

Propagation of the transverse normal stress in a thick plate due to distributed lateral impulsive loadings

A theoretical study of the elastic stresses produced in an infinite plate when struck by a high-speed object is presented. The solution is obtained by means of linear elasticity. Laplace transformation techniques are employed to solve the axisymmetric problem. The plate is loaded normal to its surface with a uniform load over a circular area. The normal stress at the wave front of the unreflected dilatation wave along the axis and its variation with the radius of loading are determined. Various facets of the problem are discussed.

Oline, L. W.↗
NASA NTRS1972

Influence of thermal anisotropy on best-fit estimates of shock normals.

This paper deals with the influence of thermal anisotropy on least-squares estimates of interplanetary shock parameters and the associated normals by using the Rankine-Hugoniot equations. A practical theorem is given for quantitatively correcting for anisotropic effects by weighting the before and after magnetic fields by the same 'anisotropy parameter' h. The quantity h depends only on the thermal anisotropies before and after the shock and on the angles between the magnetic fields and the shock normal. It is shown that, for fast shocks and for a liberal range of realistic conditions, the quantity h lies in the range from 0.90 to 1.22. The theorem can also be applied to most slow shocks, but in those instances h usually should be lower and sometimes markedly lower than unity.

Lepping, R. P.↗
NASA NTRS1972

Compressible boundary layer with normal pressure gradients: Quasi-similarity equations - Their properties at the wall and at sharp and blunt leading edges.

The failure of most viscous-inviscid interaction methods at strong interactions is attributed to the presence of a normal pressure gradient. A new theory is proposed for supersonic laminar boundary layers that can generate normal pressure gradients. The Navier-Stokes equations are reexamined by an order of magnitude analysis and all first and second order terms are retained. The approximation is found to be dependent not only on the boundary layer thickness but also on the ratio of the dimensionless viscosity and density. The equations are transformed into two quasi-similar, nonlinear, third order, ordinary integro-differential equations for the velocity and pressure as functions of a single transverse variable. The properties of the equations at the boundaries are discussed.

Seginer, A.↗
NASA NTRS1972

Spectral characteristics of normal and nutrient-deficient maize leaves

Reflectance, transmittance and absorbance spectra of normal and six types of mineral-deficient (N,P,K,S,Mg and Ca) maize (Zea mays L.) leaves were analyzed at 30 selected wavelengths along the electromagnetic spectrum from 500 to 2600 nm. Chlorophyll content and percent leaf moisture were also determined. Leaf thermograms were obtained for normal, N- and S- deficient leaves. The results of the analysis of variance showed significant differences in reflectance, transmittance and absorbance in the visible wavelengths among leaf numbers 3, 4, and 5, among the seven nutrient treatments, and among the interactions of leaves and treatments. In the reflective infrared wavelengths only treatments produced significant differences. The chlorophyll content of leaves was reduced in all deficiencies in comparison to controls. Percent moisture was increased in S-, Mg- and N- deficiencies. Positive correlation (r = 0.707) between moisture content and percent absorption at both 1450 and 1930 nm were obtained. Polynomial regression analysis of leaf thickness and leaf moisture content showed that these two variables were significantly and directly related (r = 0.894).

Al-Abbas, A. H.↗