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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 505 records · Page 28
All sourcesNASA NTRSDOE OSTI
DOE OSTI2018

Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry [Tracking Tumor Colonization in vivo Using Accelerator Mass Spectrometry]

Here we propose an Accelerator Mass Spectrometry (AMS)-based high precision method for quantifying the number of cancer cells that initiate metastatic tumors, in xenograft mice. Quantification of 14 C per cell prior to injection into animals, and quantification of 14 C in whole organs allows us to extrapolate the number of cancer cells available to initiate metastatic tumors. The 14 C labeling was optimized such that 1 cancer cell was detected among 1 million normal cells. We show that ~1–5% of human cancer cells injected into immunodeficient mice form subcutaneous tumors, and even fewer cells initiate metastatic tumors. Comparisons of metastatic site colonization between a highly metastatic (PC3) and a non-metastatic (LnCap) cell line showed that PC3 cells colonize target tissues in greater quantities at 2 weeks post-delivery, and by 12 weeks post-delivery no 14 C was detected in LnCap xenografts, suggesting that all metastatic cells were cleared. The 14 C-signal correlated with the presence and the severity of metastatic tumors. AMS measurements of 14 C-labeled cells provides a highly-sensitive, quantitative assay to experimentally evaluate metastasis and colonization of target tissues in xenograft mouse models. This method can potentially be used to evaluate tumor aggressiveness and assist in making informed decisions regarding treatment.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

Multi-matrix, dual polarity, tandem mass spectrometry imaging strategy applied to a germinated maize seed: toward mass spectrometry imaging of an untargeted metabolome

Mass spectrometry imaging (MSI) provides high spatial resolution information that is unprecedented in traditional metabolomics analyses; however, the molecular coverage is often limited to a handful of compounds and is insufficient to understand overall metabolomic changes of a biological system. Here, we propose an MSI methodology to increase the diversity of chemical compounds that can be imaged and identified, in order to eventually perform untargeted metabolomic analysis using MSI. We use the desorption/ionization bias of various matrixes for different metabolite classes along with dual polarities and a tandem MSI strategy. The use of multiple matrixes and dual polarities allows us to visualize various classes of compounds, while data-dependent MS/MS spectra acquired in the same MSI scans allow us to identify the compounds directly on the tissue. In a proof of concept application to a germinated corn seed, a total of 166 unique ions were determined to have high-quality MS/MS spectra, without counting structural isomers, of which 52 were identified as unique compounds. According to an estimation based on precursor MSI datasets, we expect over five hundred metabolites could be potentially identified and visualized once all experimental conditions are optimized and an MS/MS library is available. Finally, metabolites involved in the glycolysis pathway and tricarboxylic acid cycle were imaged to demonstrate the potential of this technology to better understand metabolic biology.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2015

Baseline Optimization for the Measurement of CP Violation, Mass Hierarchy, and $\theta_{23}$ Octant in a Long-Baseline Neutrino Oscillation Experiment

Next-generation long-baseline electron neutrino appearance experiments will seek to discover C P violation, determine the mass hierarchy and resolve the θ 23 octant. In light of the recent precision measurements of θ 13 , we consider the sensitivity of these measurements in a study to determine the optimal baseline, including practical considerations regarding beam and detector performance. We conclude that a detector at a baseline of at least 1000 km in a wide-band muon neutrino beam is the optimal configuration.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2017

Combination of D0 measurements of the top quark mass

We present a combination of measurements of the top quark mass by the D0 experiment in the lepton+jets and dilepton channels. We use all the data collected in Run I (1992–1996) at s=1.8 TeV and Run II (2001–2011) at s=1.96 TeV of the Tevatron pp¯ collider, corresponding to integrated luminosities of 0.1 fb-1 and 9.7 fb-1, respectively. The combined result is: mt=174.95±0.40(stat)±0.64(syst) GeV=174.95±0.75 GeV.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2017

Unveiling ν secrets with cosmological data: Neutrino masses and mass hierarchy

Using some of the latest cosmological datasets publicly available, we derive the strongest bounds in the literature on the sum of the three active neutrino masses, M ν , within the assumption of a background flat ΛCDM cosmology. In the most conservative scheme, combining Planck cosmic microwave background (CMB) temperature anisotropies and baryon acoustic oscillations (BAO) data, as well as the up-to-date constraint on the optical depth to reionization (τ), the tightest 95% confidence level (C.L.) upper bound we find is M ν <0.151~eV. The addition of Planck high-ℓ polarization data, which however might still be contaminated by systematics, further tightens the bound to M ν <0.118~eV. A proper model comparison treatment shows that the two aforementioned combinations disfavor the IH at ~64%~C.L. and ~71%~C.L. respectively. Furthermore, we compare the constraining power of measurements of the full-shape galaxy power spectrum versus the BAO signature, from the BOSS survey. Even though the latest BOSS full shape measurements cover a larger volume and benefit from smaller error bars compared to previous similar measurements, the analysis method commonly adopted results in their constraining power still being less powerful than that of the extracted BAO signal. Our research uses only cosmological data; imposing the constraint M ν >0.06eV from oscillations data would raise the quoted upper bounds by O(0.1σ) and would not affect our conclusions.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2018

Secondary Ion Mass Spectrometry Methodology for Isotopic Ratio Measurement of Micro‐Grains in Thin Sections: True Grain Size Estimation and Deconvolution of Inter‐Grain Size Gradients and Intra‐Grain Radial Gradients

In a thin section, grains that were approximately spherical in situ appear circular in cross section, and the distribution of apparent diameters frequently assumed to be their size distribution. Scanning ion imaging by secondary ion mass spectrometry (SIMS) is capable of providing precise (< 1‰) stable isotope ratio measurements of such grains, but, importantly, also registers their rate of evolution in apparent size as they are ablated by the primary beam. By assessing rates of radius change with depth, the described methodology enables the ‘true’ size of grains to be estimated, as well as the distance of the sectioned surface from the original grain centre. Transects in three dimensions are made possible, and this capability enables better identification (and thus separation) of both inter‐grain chemical signatures as a function of grain size, and intra‐grain radial trends. In this example, we highlight the specific application to pyrite (FeS 2 ) minerals, which are frequently analysed by SIMS to determine their inter‐grain and intra‐grain geochemical variations, particularly in their sulfur stable isotopic ratios (δ 34 S). Benefits of the new methodology over the Faraday cup ‘spot mode’ are described. Data correction algorithms and precision considerations are discussed.

Jones, Clive↗
DOE OSTI2016

Deconvolution of mass gain and mass loss mechanisms during carbothermic reduction to nitridization reactions in the zirconium system through thermogravimetric analysis

A novel approach was used to understand the effects of processing conditions on the conversion of zirconium dioxide to zirconium carbonitride using a carbothermic reduction to nitridation process. The conversion process was studied through the use of thermogravimetric analysis, X-ray diffraction (XRD), and scanning electron microscopy, resulting in an understanding of the nature and progression of conversion. The rate of mass change as measured through thermogravimetric analysis was plotted as a function of reaction progression, guiding the use of XRD in further understanding the conversion process. This approach was then used to characterize the important effect of initial compact morphology on conversion. Coupled analysis techniques allow for advancement of a number of hypotheses regarding the rate-limiting factors along the various steps in the carbothermic reduction to nitridation process. These results demonstrate the value of the proposed approach to aid in deconstruction of competing reaction mechanisms as necessary to understand the system studied here or other systems of scientific and industrial relevance.

36 MATERIALS SCIENCE↗
DOE OSTI2019

Searches for scalar leptoquarks and differential cross-section measurements in dilepton–dijet events in proton–proton collisions at a centre-of-mass energy of $\sqrt{s}$ = 13 TeV with the ATLAS experiment

Searches for scalar leptoquarks pair-produced in proton–proton collisions at $\sqrt{s}$ =13 TeV at the Large Hadron Collider are performed by the ATLAS experiment. A data set corresponding to an integrated luminosity of 36.1 fb -1 is used. Final states containing two electrons or two muons and two or more jets are studied, as are states with one electron or muon, missing transverse momentum and two or more jets. No statistically significant excess above the Standard Model expectation is observed. The observed and expected lower limits on the leptoquark mass at 95% confidence level extend up to 1.29 TeV and 1.23 TeV for first- and second-generation leptoquarks, respectively, as postulated in the minimal Buchmüller–Rückl–Wyler model, assuming a branching ratio into a charged lepton and a quark of 50%. In addition, measurements of particle-level fiducial and differential cross sections are presented for the Z→ ee, Z→ μμ and $ t\bar{t} $ processes in several regions related to the search control regions. Predictions from a range of generators are compared with the measurements, and good agreement is seen for many of the observables. However, the predictions for the Z→ ℓℓ measurements in observables sensitive to jet energies disagree with the data.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
NASA NTRS1978

The mean mass of the abundant cosmic-ray nuclei from boron to silicon at 1.2 GeV per atomic mass unit

Results are presented for an investigation of cosmic-ray isotopic composition in which a balloon-borne instrument was used to perform an isotopic analysis of the abundant elements from B through Si in the energy range from 1.0 to 1.6 GeV/amu. The technique employed, which depends on the effect of earth's magnetic field on incoming cosmic rays, and reduction of the observational data are described in detail. Mean masses of the elements B, C, N, O, Ne, Mg, and Si are extracted from normalized Cerenkov spectra and evaluated in terms of the 'leaky box' model of galactic propagation and confinement. The implications of the results for cosmic-ray sources are shown to be consistent with the nucleosynthesis of certain isotopes in the cosmic rays in explosive carbon burning under the conditions of peak temperature, density, and neutronization expected in an explosion of a massive highly evolved star. The possibility of alternate interpretations is noted.

Dwyer, R.↗
NASA NTRS1983

The mass dependence of wave particle interactions as observed with the ISEE-1 energetic ion mass spectrometer

Simultaneous measurements of the O(+) and H(+) distributions from two transverse acceleration events in the high altitude auroral ionosphere are presented. The data were acquired from the energetic ion mass spectrometer on the ISEE-1 satellite, in the dusk sector, on auroral field lines (L = 8-9), at geocentric radial distances of about 3 earth radii. Temporal and/or spatial fluctuations during the measurement cycle resulted in some scatter of the data points, but the transverse velocity distributions are reasonably well represented by maxwellians at energies in the few hundred eV range. The transverse temperatures were about 60 eV in both cases and no significant differences were observed between the temperatures of the O(+) and H(+). The flux intensities of the two ion species were also generally comparable.

Sharp, R. D.↗
NASA NTRS1988

Near-infrared mass-to-light ratios in galaxies - Stellar mass and star formation in the heart of the Whirlpool

The observed stellar population in the solar neighborhood is used to derive a relationship between the local stellar mass density and the visual and near-IR brightness, which is then extended to a wide range of galaxies. This technique is applied to near-IR (J, H, and K) images of the central 2.3 kpc (50 arcsec) of the Whirlpool Galaxy (M51, NGC 5194). It is estimated that the current high rate of star formation can last no more than about another 10-million years, and that, if a large fraction of the stars in the nucleus of M51 was created in periods of enhanced formation, the duty cycle for such events is about 5 percent.

Thronson, Harley A., Jr.↗