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At least 505 records · Page 28
All sourcesNASA NTRSDOE OSTI
DOE OSTI2018

Novel Agents for Gram-Negative Biodefense Pathogens Final Report CRADA No. TC02128.0

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Trius Therapeutics, Inc. ("Trius") to develop novel agents for gram-negative biodefense pathogens. LLNL and Trius jointly responded to a U.S. Health and Human Services (National Institutes of Health) request for proposals (solicitation # BAA NIH-NIAID-DMID 08-20) to develop new therapeutic countermeasures with a proposal entitled "Development of Therapeutic Agents for Select Biodefense Pathogens" which resulted in this CRADA, with a goal of developing gram-negative, dual-target antibacterial agents that show no cross-resistance to existing drugs. Trius was awarded Contract HHSN272200800042C to accomplish the goals in the proposal, with LLNL as a major subcontractor.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2018

Low Cost Field Emission Flat Panel Displays Final Report CRADA No. TC-0774-94

The ion accelerator at LLNL enabled the fabrication of field emitter cathodes with unique physical attributes not previously avaiIabIe. These properties enabled Candescent to fabricate field emission displays in a low cost, manufacturable manner with cathode performance (efficienq and emission quality) unprecedented in the industry. Candescent and LLNL delivered to ARPA, at the end of the 15 month program, a 3" diagonal black and white display with 80 lines per inch resolution, greater than 20 footlamberts brightness, and at least 16 levels of gray. Additionally, there was a like 3" diagonal color display DOE deliverable. In comparison to liquid crystal displays, the field emission display was brighter, sharper, and consumed 1/3 to 1/2 the power per unit area. The objective of the project was to confirm the efficacy of a new technology (ion tracking) for making efficient, cost effective cathodes for flat panel displays. LLNL was to provide the ion tracking system and experfise and Candescent was to provide the requirements, complete the fabrication of the cathodes, and incorporate them in flat panel displays. The program was quite successful. Candescent is now on the verge of commercializing 5.3 inch diagonal full color flat panel displays using this technology.

42 ENGINEERING↗
DOE OSTI2018

Fibre Channel Development Final Report CRADA No. TC-0340-92-D

The Fibre Channel (FC) Development project was designed to enhance U.S. industrial competitiveness by accelerating the standardization and subsequent industrial acceptance of the American National Standards Institute’s (AIW) Fibre Channel Standard (now X3T1 1). It was also intended to give the principal U.S. participants a one- to two-year lead in developing heterogeneous high-speed computer networks, dktibuted computing through clustering, scientific visualization techniques, and high speed channels. The project was proposed to benefit U.S. industry as these high performance computing methods became generally available. In 1992-93, during the initial project phases, Fibre Channel PC) was emerging as a new ANSI standard. It was envisioned as becoming the mechanism for data transfer between the next generation of computers, and between these computers and their peripherals. Using this channel standard, U.S. computer vendors were expecting to be able to provide high-speed interoperability between heterogeneous computers and their storage devices, with data transfer rates greater than a GBit/sec. Our project was composed of key principal players in the FC standardization effort from both U.S. industry and the Department of Energy’s (DOES) Lawrence Liverrnore National Laboratory (LLNL). The industial participants were developing individual FC interfaces to operate with their platform products. LLNL’s role was to be a neutral testing site and a facilitator for helping to resolve conflicting interpretations of the embryonic Fibre Channel specification. LLNL anticipated that conflicts in the interpretation of such a standard would arise and require neutral resolution and that such resolutions would best be achieved in cooperation with the ANSI FC Working Group. Project plans included transferring to U.S. industry any resilient FC testing capabilities at the project conclusion.

42 ENGINEERING↗
DOE OSTI2018

Fibre Channel Development Final Report CRADA No. TC-0340-92-C

The Fibre Channel (FC) Development project was designed to enhance U.S. industrial competitiveness by accelerating the standardization and subsequent industrial acceptance of the American National Standards Institute’s (ANSI) Fibre Channel Standard (now X3T1 1). It was also intended to give the principal U.S. participants a one-to two-year lead in developing heterogeneous high-speed computer networks, distributed computing through clustering, scientific visualization techniques, and high speed channels. The project was proposed to benefit U.S. industry as these high performance computing methods became generally available. In 1992-93, during the initial project phases, Fibre Channel (FC) was emerging as a new ANSI standard. It was envisioned as becoming the mechanism for data transfer between the next generation of computers, and between these computers and their peripherals. Using this channel standard, U.S. computer vendors were expecting to be able to provide high-speed interoperatillity between heterogeneous computers and their storage devices, with data transfer rates greater than a GBit/sec. Our project was composed of key principal players in the FC standardization effort from both U.S. industry and the Department of Energy’s@OEs) Lawrence Liverrnore National Laboratory (LLNL). The industrial participants were developing individual FC interfaces to operate with their platform products. LLNL’s.role was to be a neutral testing site and a facilitator for helping to resolve conflicting interpretations of the embryonic Fibre Channel specification. LLNL anticipated that conflicts in the interpretation of such a standard would arise and require neutral resolution and that such resolutions would best be achieved in cooperation with the ANSI FC Working Group. Project plans included transferring to U.S. industry any resilient FC testing capabilities at the project conclusion.

42 ENGINEERING↗
DOE OSTI2018

Technical Equivalency Evaluation of Electrically Cooled Detectors for the In Vivo Measurement of Low Energy Photon Emitters in Human Lungs

LLNL maintains equipment, capability, and operations to measure low energy photon emitting radionuclides potentially deposited inside of workers. Ongoing quality improvement includes the maintenance of detection systems capable of measuring radionuclides o f interest to the LLNL Health and Safety program. This document describes the technical equivalency evaluation of upgraded detectors for LLNL’s routine lung measurement program.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2018

Development of a Novel Vaccine to Prevent Urinary Tract Infections, CRADA TC02219.0

This project was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Syntiron LLC to develop novel vaccine formulations against bacterial urinary tract infections (UTIs). The project leveraged expertise at Syntiron to develop vaccine antigens for bacterial pathogens and nanoparticle technology at LLNL to enchance the efficacy of vaccine formulations. In particular, Syntiron has developed vaccine antigens by identifying and isolating specific proteins from the membranes of extraintestinal pathogenic E. coli , the bacteria responsible for the majority of UTIs. These membrane protein antigens consist of iron regulating proteins (IRPs), a class of highly conserved putative antigens. Membrane protein antigens are difficult to formulate for vaccine applications. The formulations typically required to solubilize membrane protein antigens often result in non-native protein folding, thereby masking the antigenic epitopes required for efficacy. LLNL's nanolipoprotein particle (NLP) platform provides a mimic of a membrane protein's native environment, greatly increasing the proteins' native attributes. In addition, the NLP can accommodate myriad other biomolecules in addition to the protein antigen, facilitating the co-localized delivery of both antigen and immune stimulating compounds necessary for eliciting a protective immune response in vivo. The goal of this project was to incorporate membrane protein antigens into NLPs and evaluate the efficacy of these formulations to protect against urinary tract infections in an animal model.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

Potential Ideas for an El Capitan Center of Excellence (COE) Around Intelligent Simulation

Proposing a Center of Excellence under the CORAL-2 NRE is a mandatory requirement. The current Sierra COE (CORAL-1) is largely focused on helping LLNL applications make the disruptive transition to a heterogeneous GPU-based system by 2018. We expect a continuation of COE activities around optimizing our broad and diverse application base (of so-called “traditional” simulation codes) optimized for the El Capitan architecture, as well as supporting the underlying software stack (compilers, tools, programming models, etc.) – but do not expect this to require as much effort in the El Capitan COE (assuming a heterogeneous node architecture). What follows are some thoughts on 3 potential topics of interest for an El Capitan COE at LLNL – largely focused around AI and machine learning and the concept of advancing our goal of intelligent simulation or cognitive computing in the timeframe of deployment and production use of El Capitan (2023-2038). We believe vendor engagement through a COE in this area will provide a natural point-of-interest between LLNL and our vendor partner for common advancement of machine learning capabilities focused on scientific data – potentially greatly broadening the ecosystem around HPC architectures and the supporting software stack for scientific simulation-based AI.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2017

Special Analysis for the Disposal of U.S. Department of Energy High Activity Cesium Sources Waste Stream at the Area 5 Radioactive Waste Management Site, Nevada National Security Site, Nye County, Nevada

This special analysis evaluates whether the Lawrence Livermore National Laboratory (LLNL) U.S. Department of Energy (DOE) High Activity Cesium (Cs) Sources waste stream is suitable for shallow land burial at the Area 5 Radioactive Waste Management Site on the Nevada National Security Site. Disposal of the LLNL DOE High Activity Cs Sources waste meets all DOE M 435.1-1, “Radioactive Waste Management Manual,” Chapter IV, Section P performance objectives (DOE 1999). The LLNL DOE High Activity Cs Sources waste stream is recommended for acceptance with the conditions that 1) the total waste stream cesium-137 activity be limited to 1.7E16 Bq and 2) the waste be disposed 4.4 m (10 ft) below existing grade.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2019

M4SF-19LL010301042: Code Development in Support of the SFWST Thermodynamic Database

This progress report (Level 4 Milestone Number M4SF-19LL010301042) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within the Argillite Activity Number SF-19LL010301041. LLNL is leading efforts in the development of thermodynamic databases in support of the Spent Fuel and Waste and Science Technology (SFWST) program. Thermodynamic models provide the basis for understanding the stability of solid phases and speciation of aqueous species and modeling the evolution of repository conditions. The LLNL effort is being performed in coordination with other US database development efforts. The effort includes a review of available thermochemical databases and a path forward for database integration. International coordination with the NEA-TDB is supported through crystalline international work package

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗
DOE OSTI2018

2018 Technology Transfer Report: Innovation in Action

Inside LLNL’s gates, our scientists and engineers create the spark, which moves onward, beyond LLNL, to startup companies in nearby Silicon Valley, and across the nation, where entrepreneurs and investors adapt our technology to solve a broad range of challenges. With this year’s report regarding LLNL’s technology transfer activities, we highlight many of these exciting initiatives. For example, we are pioneering new advanced manufacturing techniques that can produce precisely calibrated optics for lasers, microscopes, and cameras. We are collaborating with industry to test new solutions to our nation’s energy challenges, such as a large-scale, subsurface energy storage system that can dispatch stored energy to the power grid whenever it’s needed. Our innovators are leveraging their expertise in optics to transform the safety of self-driving cars, using thousands of tiny mirrors to spot potential hazards.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2019

The Quantum Nature and Mass of the Neutrino: FY19 Annual Laboratory Continuation Progress Report

Over the last 100 years we have learned a much about the neutrino, but there remain interesting questions about this weakly interacting particle. In particular, at LLNL we are developing experiments to measure short baseline oscillation, the mass and the quantum nature of the neutrino, the latter two are within the scope of DOE-SC NP and are the subject of this report. The 2015 long range plan recommended tonne-scale neutrinoless double beta decay experiments as the top new project priority and this experiment will target the quantum nature of the neutrino. The LLNL team is motivated and focused on developing the best technology for this experiment which is a liquid xenon time project chamber called nEXO. On a longer time scale, LLNL is also developing technology to measure the neutrino mass with tritium decay experiments.

42 ENGINEERING↗
DOE OSTI2019

Pantex Forklift Field Measurement Report

The Lawrence Livermore National Laboratory (LLNL) container program requested measurements of forklift handling shock and vibration environments for the Pantex ramp areas to inform container design. LLNL test group personnel directed the instrumentation and measurement of representative metal-framed pallets loaded by a variety of pallet weights according to the released test plan detailed in LLNL document CODT-2018-1253. This report details the testing, data processing, and presents proposed breakpoint values for random vibration and shock environments.

42 ENGINEERING↗
DOE OSTI2019

Statistically Significant Evidence of a Release of Zinc from Pit 1 at the Lawrence Livermore National Laboratory Experimental Test Site 300 (90-Day Report)

Lawrence Livermore National Laboratory (LLNL) is submitting this 90-Day Report in accordance with Waste Discharge Requirements Order No. 93-100, Provision 4. This letter report is provided in reference to several seven-day letters in which LLNL reported that ground water sample analytical results from monitoring wells Kl-05, Kl-08, Kl-09, and W-PITl-2326 indicated "statistically significant evidence of a release" of zinc from LLNL's Site 300 Experimental Test Facility landfillPit 1 (Figure 1).

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2019

B654 Cooling Scheme Case Study [Slides]

Building 654 is physically located at the Lawrence Livermore National Laboratory (LLNL). LLNL is located roughly 45 minutes to the east of San Francisco at the edge of the SF Bay Area. The footprint for Lawrence Livermore National Laboratory is roughly a square mile. Building 654 was built in 2016 as part of the Livermore Computing Group. Building 654 supports unclassified computing at LLNL.

24 POWER TRANSMISSION AND DISTRIBUTION↗
DOE OSTI2019

Site 300: Swainson's Hawk Survey Report, 2019

Garcia and Associates (GANDA) was contracted by the Lawrence Livermore National Laboratory (LLNL) to conduct Swainson’s Hawk surveys as described by the Swainson’s Hawk Technical Advisory Committee (TAC) within Recommended Timing and Methodology for Swainson’s Hawk Nesting Surveys for the California Central Valley (2000) at Site 300. Surveys were conducted prior to planned well decommissioning activities on LLNL property along Corral Hollow Road in San Joaquin County, located west of Tracy. Well decommissioning work started in the fall of 2018, and two sites require work in the fall of 2019. Eight surveys were conducted at Site 300 from April 2019 to July 2019. Although no nesting Swainson’s Hawks were observed during any of the surveys, LLNL wildlife biologists reported several incidental Swainson’s Hawk observations within the survey area in the spring of 2019 (Lisa Paterson, personal communication, 2019).

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2020

Further Support of the Development of Advanced Multilayer Optics Coatings for X-Ray Imaging

SAO is working with LLNL to develop Wolter-I optics for x-ray imaging applications at energies of 15-50 keV and above at NNSA facilities. Our work includes R&D on advanced multilayer coatings as well as fabrication and testing of Wolter-I multilayer coated optics. It also includes delivery of custom 3.05-meter focal length Wolter optics with response at energies of interest to Sandia National Laboratories and LLNL. The mandrels for the custom optics are fabricated at MSFC. In previous contracts, SAO delivered several optics to LLNL with response at various energies. During this present contract period two tasks were carried out. Task1: the coating, replication and characterization of a custom optic with peak response at 22.8 keV, using the custom-designed SANZ mandrels. Task2: carrying out modifications to the coating chamber at SAO to accommodate new, longer, custom-designed mandrels (SANZlong) that will be fabricated at NASA MSFC in FY2020. The longer mandrels are necessary to mitigate end effects observed in the replication process for the small optics currently being fabricated.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Further Support of the Development of Advanced Multilayer Optics Coatings for X-Ray Imaging

The Smithsonian Astrophysical Observatory (SAO) is working with Lawrence Livermore National Laboratory (LLNL) to develop Wolter-I optics for x-ray imaging applications at energies of 15-50 keV and above for National Nuclear Security Administration (NNSA) facilities. SAO work includes R&D on advanced multilayer coatings as well as fabrication and testing of Wolter multilayer coated optics. It also includes delivery of custom 3.05-meter focal length Wolter optics with response at energies of interest to Sandia National Laboratories and LLNL. The optics are fabricated using an electroform nickel replication technique which has been used to fabricate optics for X-ray astronomy satellites over the past two decades. This technique starts with a figured, polished mandrel from which the optics are replicated. To carry this technique over to fabricate optics for NNSA facilities, several additional barriers had to be overcome to deposit multilayer coatings on integral optics with radii as small as 25 mm. These breakthroughs allow fabrication of optics which meet the spatial and spectral specifications required by NNSA facilities. During this present contract period SAO delivered four custom optics to LLNL with spectral response at or near the Kα line of silver, 22.16 keV.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2019

Neptunium(IV) Diffusion through Bentonite Clay

DOE Fellow, Silvina A. Di Pietro, completed a 10-week internship at Lawrence Livermore National Laboratory (LLNL) in Livermore, California. The objective of the study was to determine the diffusion profile of neptunium (Np) in bentonite clay (potential geo-engineered barrier for nuclear waste repositories). Under the mentorship of Drs. Claudia Joseph (Karlsruhe Institute of Technology, Germany) and Mavrik Zavarin, she prepared a series of core abrasion peeling samples. This procedure was a continuation of a Np diffusion experiment conducted by Dr. Joseph during her post-doc residency at LLNL in the year 2016. The second part of the experiment (from now on will be referred as abrasive peeling) focuses on understanding (1) the Np movement through the clay core and (2) the influence of temperature (25°C, 65°C, and 85°C) for the Np transport across the clay core under anaerobic conditions. End of 2016, the diffusion core samples were embedded in epoxy resin to stabilize them for long-term. The abraded core powder samples vary in material (epoxy vs. clay), Np activity and concentration, temperature exposed during the diffusion experiment, and mass, or amount of clay peeled off. Throughout the course of the 10-week internship program at LLNL, the experiments implemented and discussed in this report aimed to answer the questions: (1) How is the Np(IV) diffusion profile through bentonite influenced by the temperature? and (2) Will Np(IV) migrate through the geoengineered barrier of a nuclear waste repository? In addition, Ph.D. candidate Di Pietro received invaluable guidance in experimental design and development that will benefit her ongoing research endeavors.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗