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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Cooling load forecasting-based predictive optimisation for chiller plants
Extensive electric power is required to maintain indoor thermal comfort using heating, ventilation and air conditioning (HVAC) systems, of which, water-cooled chiller plants consume more than 50% of the total electric power. To improve energy efficiency, supervisory optimisation control can be adopted. The controlled variables are usually optimised according to instant building cooling load and ambient wet bulb air temperature at regular time intervals. In this way, the energy efficiency of chiller plants has been improved. However, with an inherent assumption that the instant building cooling load and ambient wet bulb temperature remain constant in the coming time interval, the energy efficiency potential has not been fully realised, especially when cooling loads vary suddenly and extremely. To solve this problem, a cooling load forecasting-based predictive optimisation method is proposed. Rather than minimising the instant system power according to the instant building cooling load and ambient wet bulb temperature, the controlled variables are derived to minimise the sum of the instant system power and one-time-step-ahead future system power according to both instant and forecasted future building cooling loads. With this method, the energy efficiency potential of a chiller plant can be further improved without shortening the operation time interval. 80% redundant energy consumption has been reduced for the sample chiller plant; energy can be saved for chiller plants that work for years. The evaluation on the effect of cooling load forecasting accuracy turns out that the more accurate the forecasts are, the more redundant energy consumption can be reduced.
Short-term exposures to PM2.5 and cause-specific mortality of cardiovascular health in China
Highlights: • Exploring the association between PM{sub 2.5} and cardiovascular mortality in China. • Suggesting that people 65–74 years old and males might be more vulnerable to PM{sub 2.5}. • Showing the difference of PM{sub 2.5} acute effect between developed countries and China. Many multi-center epidemiological studies have robustly examined the acute health effects of exposure to low concentrations of fine particulate matter (PM{sub 2.5}) on cardiovascular mortality in developed counties. However, data limitations have resulted in few related studies being conducted in developing counties with high levels of PM{sub 2.5} exposure. In recent years, people in China with a heavy cardiovascular disease burden have been exposed to particularly high levels of PM{sub 2.5}.
Effect of galacto-oligosaccharide purity on water sorption and plasticization behavior
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Chickpea protein hydrolysate as a novel plant-based cryoprotectant in frozen surimi: Insights into protein structure integrity and gelling behaviors
Chickpea protein (CP) and its enzymatic hydrolysates are one of the most widely consumed pulse ingredients manifesting versatile applications in food industry, such as binders, emulsifiers, and meat protein substitutes. Other than those well-known functionalities, however, the use of CP as a cryoprotectant remained unexplored. Here, in this study, we prepared the chickpea protein hydrolysate (CPH) and investigated its cryoprotective effects to frozen surimi in terms of the protein structure integrity and gelling behaviors. Results indicated that CPH could inhibit myofibrillar protein (MP) denaturation and oxidation during the freeze–thaw cycling, as evidenced by their increased solubility, Ca 2+ -ATPase activity, sulfhydryl concentration, and declined content of disulfide bonds, carbonyl concentration and surface hydrophobicity. Freezing-induced changes on MP secondary structures were also retarded. Moreover, gels prepared from CPH-protected frozen surimi demonstrated more stabilized microstructure, uniform water distribution, enhanced elasticity, gel strength and water holding capacity. The CPH alone, at a reducing addition content of 4% (w/w), exhibited comparable cryoprotective performance to that of the commercial formulation (4% sucrose and 4% sorbitol). Therefore, this study provides scientific insights for development of pulse proteins as novel and high-performance food cryoprotectants.
The catalytic effect of AQDS as an electron shuttle on Mn(II) oxidation to birnessite on ferrihydrit
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On building automation system security
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On the use of LES-based turbulent thermal-stress models for rod bundle simulations
An alternative methodology is proposed here to overcome the excessive cost of large eddy simulations (LES) of full-length heated rod bundle calculations, while improving the inaccurate results typically obtained with Reynolds-averaged Navier-Stokes equations (RANS). While the cost of the full-length LES is generally too high, LES of a small section of a single rod is usually affordable. The idea presented here consists of using the information granted by the small LES calculation to determine the appropriate turbulence viscosity or turbulent thermal diffusivity that can be used to solve only for the temperature field in a pseudo-RANS approach. The study has been performed with single-rod simulations with a P/D of 1.12 and 1.24, considering rod lengths that are representative of reactor applications, for the cases of uniform heat flux and a more realistic cosine-like axial heat distribution. Here, the spectral element code Nek5000 has been used for all LES, RANS, and pseudo-RANS simulations. The recently proposed Nek5000 steady-state solver has been used for solving the temperature field in the pseudo-RANS approach and has proved significantly faster than transient schemes. Prediction of thermal quantities is compared with classical linear and nonlinear RANS models. LES for the full-length rods has also been performed and is used as a reference. Results of the proposed method show significant improvements with respect to those obtained with RANS.
Collision-Induced Dissociation at TRIUMF's Ion Trap for Atomic and Nuclear science
The performance of high-precision mass spectrometry of radioactive isotopes can often be hindered by large amounts of contamination, including molecular species, stemming from the production of the radioactive beam. In this paper, we report on the development of Collision-Induced Dissociation (CID) as a means of background reduction for experiments at TRIUMF's Ion Trap for Atomic and Nuclear science (TITAN). This study was conducted to characterize the quality and purity of radioactive ion beams and the reduction of molecular contaminants to allow for mass measurements of radioactive isotopes to be done further from nuclear stability. Furthermore, this is the first demonstration of CID at an ISOL-type radioactive ion beam facility, and it is shown that molecular contamination can be reduced up to an order of magnitude.
DOC-2/DAB2 Interacting Protein Status in High-Risk Prostate Cancer Correlates With Outcome for Patients Treated With Radiation Therapy
Purpose: This pilot study investigates the role of DOC-2/DAB2 Interacting Protein (DAB2IP) and enhancer of zeste homolog 2 (EZH2) as prognostic biomarkers in high-risk prostate cancer patients receiving definitive radiation therapy. Methods and Materials: Immunohistochemistry was performed and scored by an expert genitourinary pathologist. Clinical endpoints evaluated were freedom from biochemical failure (FFBF), castration resistance–free survival (CRFS), and distant metastasis–free survival (DMFS). Log-rank test and Cox regression were used to determine significance of biomarker levels with clinical outcome. Results: Fifty-four patients with high-risk prostate cancer (stage ≥T3a, or Gleason score ≥8, or prostate-specific antigen level ≥20 ng/mL) treated with radiation therapy from 2005 to 2012 at our institution were evaluated. Nearly all patients expressed EZH2 (98%), whereas 28% of patients revealed DAB2IP reduction and 72% retained DAB2IP. Median follow-up was 34.0 months for DAB2IP-reduced patients, 29.9 months for DAB2IP-retained patients, and 32.6 months in the EZH2 study. Reduction in DAB2IP portended worse outcome compared with DAB2IP-retained patients, including FFBF (4-year: 37% vs 89%, P=.04), CRFS (4-year: 50% vs 90%, P=.02), and DMFS (4-year: 36% vs 97%, P=.05). Stratified EZH2 expression trended toward significance for worse FFBF and CRFS (P=.07). Patients with reduced DAB2IP or highest-intensity EZH2 expression exhibited worse FFBF (4-year: 32% vs 95%, P=.02), CRFS (4-year: 28% vs 100%, P<.01), and DMFS (4-year: 39% vs 100%, P=.04) compared with the control group. Conclusion: Loss of DAB2IP is a potent biomarker that portends worse outcome despite definitive radiation therapy for patients with high-risk prostate cancer. Enhancer of zeste homolog 2 is expressed in most high-risk tumors and is a less potent discriminator of outcome in this study. The DAB2IP status in combination with degree of EZH2 expression may be useful for determining patients with worse outcome within the high-risk prostate cancer population.
miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway
Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation. Recent reports have demonstrated that miRNAs and Toll-like receptors could exert reciprocal effects to control cancer development in various ways. However, a novel role of miR-15a/16 in enhancing radiation sensitivity by directly targeting TLR1 has not been reported, to our knowledge. Methods and Materials: Bioinformatic analyses, luciferase reporter assay, biochemical assays, and subcutaneous tumor establishment were used to characterize the signaling pathways of miRNA-15a/16 in response to radiation treatment. Results: First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealed in non-small cell lung cancer (NSCLC) and normal lung tissues. Next, we corroborated that miR-15a/16 specifically bound to TLR1 3′UTR and inhibited the expression of TLR1 in H358 and A549 cells. Furthermore, miR-15a/16 downregulated the activity of the NF-κB signaling pathway through TLR1. In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in H358 and A549 cells. Finally, subcutaneous tumor bearing NSCLC cells in a nude mice model was established, and the results showed that combined groups (miR-15a/16 + radiation) inhibited tumor growth more significantly than did radiation alone. Conclusions: We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB signaling pathway and act as a potential therapeutic approach to overcome radioresistance for lung cancer treatment.