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At least 505 records · Page 28

miR-448-3p controls intracranial aneurysm by regulating KLF5 expression

Highlights: • KLF5 was significantly upregulated and miR-448-3p was downregulated in the rat model of IA. • Klf5 was the direct target of miR-448-3p. • Overexpression of miR-448-3p inhibits IA development in the rat model. • Overexpression of miR-488-3p suppresses macrophage infiltration and activation in IA. microRNAs (miRNAs) control several processes known to be involved in progression of aneurysm. Here, intracranial aneurysms (IAs) were surgically induced in Sprague–Dawley rats, and we found that miR-448-3p was downregulated and KLF5 was upregulated in IA rats. We identified Klf5 as a direct target of miR-448-3p in smooth muscle cells (SMCs). In addition, aneurysms size and the lumen area of the aneurysms were smaller 4 weeks after IA induction in the miR-448-3p–treated group. miR-448-3p treatment protected the wall thickness ratio and suppressed macrophage infiltration after IA induction. IAs caused a significant increase in KLF5 expression and were alleviated by miR-448-3p. Moreover, the anti-inflammatory effect of miR-448-3p was verified in lipopolysaccharide -stimulated RAW 264.7 macrophage cells. The expression levels of KLF5, MMP2, and MMP9 levels were elevated by LPS, and were attenuated by miR-448-3p. These data suggest that miR-448-3p plays the inhibitory role in IA progression, indicating that miR-448-3p overexpression is crucial for preventing the development of IA through downregulation of macrophage-mediated inflammation.

60 APPLIED LIFE SCIENCES↗

Time evolution of intrinsic alignments of galaxies

Intrinsic alignments (IA), correlations between the intrinsic shapes and orientations of galaxies on the sky, are both a significant systematic in weak lensing and a probe of the effect of large-scale structure on galactic structure and angular momentum. In the era of precision cosmology, it is thus especially important to model IA with high accuracy. Efforts to use cosmological perturbation theory to model the dependence of IA on the large-scale structure have thus far been relatively successful; however, extant models do not consistently account for time evolution. In particular, advection of galaxies due to peculiar velocities alters the impact of IA, because galaxy positions when observed are generally different from their positions at the epoch when IA is believed to be set. In this work, we evolve the galaxy IA from the time of galaxy formation to the time at which they are observed, including the effects of this advection, and show how this process naturally leads to a dependence of IA on the velocity shear. We calculate the galaxy-galaxy-IA bispectrum to tree level (in the linear matter density) in terms of the evolved IA coefficients. We then discuss the implications for weak lensing systematics as well as for studies of galaxy formation and evolution. We find that considering advection introduces nonlocality into the bispectrum, and that the degree of nonlocality represents the memory of a galaxy's path from the time of its formation to the time of observation. We discuss how this result can be used to constrain the redshift at which IA is determined and provide Fisher estimation for the relevant measurements using the example of SDSS-BOSS.

79 ASTRONOMY AND ASTROPHYSICS↗

Fluid – Fluid Interfacial Area and Its Impact on Relative Permeability - A Pore Network Modeling Study

Abstract Relative permeability (kr) is commonly modeled as an empirical function of phase saturation. Although current empirical models can provide a good match of one or two measured relative permeabilities using saturation alone, they are unable to predict relative permeabilities well when there is hysteresis or when physical properties such as wettability change. Further, current models often result in relative permeability discontinuities that can cause convergence and accuracy problems in simulation. To overcome these problems, recent research has modeled relative permeability as a state function of both saturation (S) and phase connectivity (X). Pore network modeling (PNM) data, however, shows small differences in relative permeability for the same S-X value when approached from a different flow direction. This paper examines the impact of one additional Minkowski parameter (Mecke and Arns, 2005), the fluid-fluid interfacial area, on relative permeability to identify if that satisfactorily explains this discrepancy. We calculate the total fluid-fluid interfacial areas (IA) during two-phase (oil/water) flow in porous media using pore network modeling. The area is calculated from PNM simulations using the areas associated with corners and throats in pore elements of different shapes. The pore network is modeled after a Bentheimer sandstone, using square, triangular, and circular pore shapes. Simulations were conducted for numerous primary drainage and imbibition cycles at a constant contact angle of 0° for the wetting phase. Simultaneous measurements of capillary pressure, relative permeability, saturation, and phase connectivity are made for each displacement. Fluid-fluid interfacial area is calculated from the PNM capillary pressure, the fluid location in the pore elements, and the pore element dimensional data. The results show that differences in the relative permeability at the same (S,X) point is explained well by differences in the fluid-fluid interfacial area (IA). That is, for a larger change in IA at these intersection points, the permeability difference is greater. That difference in relative permeability approaches zero as the difference in IA approaches zero. This confirms that relative permeability can be modeled better as a unique function of S, X, and IA. The results also show that an increase in IA restricts flow decreasing the nonwetting (oil) phase permeability. This decrease is caused by an increase in the throat area fraction compared to the corner area as the total area IA increases. The wetting phase relative permeability, however, shows the inverse trend, in that its relative permeability is greater when IA becomes larger owing to a greater fraction of the total area associated with the corners. The area IA, however, impacts the nonwetting phase relative permeability more than the wetting phase relative permeability. Corner flow improves the wetting phase relative permeability because the wetting phase is continuous there. Finally, a sensitivity analysis shows that relative permeability a is more sensitive to change in S than they are for IA for the case studied implying that if only two parameters are used to model relative permeability it is better to choose S and X.

Engineering↗

THE ORIGIN OF THE COSMIC GAMMA-RAY BACKGROUND IN THE MeV RANGE

There has been much debate about the origin of the diffuse γ-ray background in the MeV range. At lower energies, AGNs and Seyfert galaxies can explain the background, but not above ≃0.3 MeV. Beyond ∼10 MeV blazars appear to account for the flux observed. That leaves an unexplained gap for which different candidates have been proposed, including annihilations of WIMPS. One candidate is Type Ia supernovae (SNe Ia). Early studies concluded that they were able to account for the γ-ray background in the gap, while later work attributed a significantly lower contribution to them. All those estimates were based on SN Ia explosion models that did not reflect the full 3D hydrodynamics of SN Ia explosions. In addition, new measurements obtained since 2010 have provided new, direct estimates of high-z SN Ia rates beyond z ∼ 2. We take into account these new advances to see the predicted contribution to the gamma-ray background. We use here a wide variety of explosion models and a plethora of new measurements of SN Ia rates. SNe Ia still fall short of the observed background. Only for a fit, which would imply ∼150% systematic error in detecting SN Ia events, do the theoretical predictions approach the observed fluxes. This fit is, however, at odds at the highest redshifts with recent SN Ia rate estimates. Other astrophysical sources such as flat-spectrum radio quasars do match the observed flux levels in the MeV regime, while SNe Ia make up to 30%–50% of the observed flux.

79 ASTRONOMY AND ASTROPHYSICS↗

Pre-nebular Light Curves of SNe I

We compare analytic predictions of supernova light curves with recent high-quality data from SN2011fe (Ia), KSN2011b (Ia), and the Palomar Transient Factory and the La Silla-QUEST variability survey (LSQ) (Ia). Because of the steady, fast cadence of observations, KSN2011b provides unique new information on SNe Ia: the smoothness of the light curve, which is consistent with significant large-scale mixing during the explosion, possibly due to 3D effects (e.g., Rayleigh–Taylor instabilities), and provides support for a slowly varying leakage (mean opacity). For a more complex light curve (SN2008D, SN Ib), we separate the luminosity due to multiple causes and indicate the possibility of a radioactive plume. The early rise in luminosity is shown to be affected by the opacity (leakage rate) for thermal and non-thermal radiation. A general derivation of Arnett’s rule again shows that it depends upon all processes heating the plasma, not just radioactive ones, so that SNe Ia will differ from SNe Ibc if the latter have multiple heating processes.

79 ASTRONOMY AND ASTROPHYSICS↗

Expression profile analysis of differentially expressed genes in ruptured intracranial aneurysms: In search of biomarkers

Highlights: • Bioinformatics can identify potential biomarkers of ruptured intracranial aneurysm. • BASP1, CD74, CEBPB, ECHDC2, GZMK, HLA-DRB3, KLHL3, SLC2A3 & SOCS3 affect IA rupture. • DEGs are involved in antigen processing and presentation and immune response. • Vascular brain injury affects gene expression in IA tissue. Intracranial aneurysms (IAs) result from the bulging of arterial walls secondary to several factors such as flow, vessel morphology, and genetics. Subarachnoid hemorrhage occurs when such walls rupture, leading to high disability and mortality. Despite numerous investigations pertaining to the relationship between geometric characteristics and IA rupture, only a few have obtained consistent results. This study aimed to further identify the potential genes associated with the pathogenesis of IAs, which may provide novel molecular biomarkers. We downloaded and reanalyzed six datasets, which were divided into four groups. IA walls and blood samples were screened for differentially expressed genes (DEGs); then, functional and pathway enrichment analyses were conducted. In total, 158 common DEGs were identified from Groups 1–3 and 396 genes (187 upregulated and 209 downregulated genes) were differentially expressed in Group 4. The functional analysis revealed that the DEGs were mainly associated with the major histocompatibility complex class II protein complex and antigen processing and presentation. Finally, we identified nine key genes, both in aneurysm tissue samples and blood samples, of which three were mostly associated with the progression and rupture of IAs. Bioinformatics was used to analyze the datasets of the ruptured IAs and identify potential biomarkers, which may provide information for the early detection and treatment of IAs.

60 APPLIED LIFE SCIENCES↗

Life cycle thinking in impact assessment—Current practice and LCA gains

It has been advocated that life cycle thinking (LCT) should be applied in impact assessment (IA) to a greater extent, since some development proposals pose a risk of significant impacts throughout the interconnected activities of product systems. Multiple authors have proposed the usage of life cycle assessment (LCA) for such analytical advancement, but little to no research on this tool application has been founded in IA practice so far. The aim of this article is to elaborate further on the gains assigned to application of LCA. The research builds on a review of 85 Danish IA reports, which were analysed for analytical appropriateness and application of LCT. Through a focus on the non-technical summary, the conclusion and the use of specific search words, passages containing LCT were searched for in each IA report. These passages were then analysed with a generic framework. The results reveal that LCT is appropriate for most of the IAs, but that LCA is rarely applied to provide such a perspective. Without LCA, the IAs show mixed performance in regard to LCT. Most IAs do consider the product provision of development proposals, but they rarely relate impacts to this function explicitly. Many IAs do consider downstream impacts, but assessments of upstream, distant impacts are generally absent. It is concluded that multiple analytical gains can be attributed to greater application of LCA in IA practice, though some level of LCT already exists. - Highlights: • Life cycle thinking is appropriate across the types and topics of impact assessment. • Yet, life cycle assessment is rarely used for adding such perspective. • Impact assessment practice does apply some degree of life cycle thinking. • However, application of life cycle assessment could bring analytical gains.

54 ENVIRONMENTAL SCIENCES↗

Separating the intrinsic alignment signal and the lensing signal using self-calibration in photo- z surveys with KiDS450 and KV450 Data

ABSTRACT To reach the full potential for the next generation of weak lensing surveys, it is necessary to mitigate the contamination of intrinsic alignments (IAs) of galaxies in the observed cosmic shear signal. The self-calibration (SC) of IAs provides an independent method to measure the IA signal from the survey data and the photometric redshift information. It operates differently from the marginalization method based on the IA modelling. In this work, we present the first application of SC to the KiDS450 data and the KV450 data, to split directly the intrinsic shape–galaxy density (Ig) correlation signal and the gravitational shear–galaxy density (Gg) correlation signal, using the information from photometric redshift (photo-z). We achieved a clear separation of the two signals and performed several validation tests. Our measured signals are found to be in general agreement with the KiDS450 cosmic shear best-fitting cosmology, for both lensing and IA measurements. For KV450, we use partial (high-z) data, and our lensing measurements are also in good agreement with KV450 cosmic shear best fit, while our IA signal suggests a larger IA amplitude for the high-z sample. We discussed the impact of photo-z quality on IA detection and several other potential systematic biases. Finally, we discuss the potential application of the information extracted for both the lensing signal and the IA signal in future surveys.

79 ASTRONOMY AND ASTROPHYSICS↗

Linking transients to their host galaxies – II. A comparison of host galaxy properties and rate dependencies across supernova types

ABSTRACT We use the latest data set of supernova (SN) host galaxies to investigate how the host properties – stellar mass, star formation rate (SFR), metallicity, absolute magnitude, and colour–differ across SN types, with redshift-driven selection effects controlled. SN Ib and Ic host galaxies, on average, are more massive, metal-rich, and redder than SN II hosts. For subtypes, SN Ibn and Ic-BL have bluer hosts than their normal SN Ib and Ic siblings; SN IIb has consistent host properties with SN Ib, while hosts of SN IIn are more metal-rich than those of SN II. Hydrogen-deficient superluminous SNe feature bluer and lower luminosity hosts than most subtypes of core-collapse supernova (CC SN). Assuming simple proportionality of CC SN rates and host SFRs does not recover the observed mean host properties; either a population of long-lived progenitors or a metallicity-dependent SN production efficiency better reproduces the observed host properties. Assuming the latter case, the rates of SN II are insensitive to host metallicity, but the rates of SN Ib and Ic are substantially enhanced in metal-rich hosts by a factor of $\sim 10$ per dex increase in metallicity. Hosts of SN Ia are diverse in their observed properties; subtypes including SN Ia-91T, Ia-02cx, and Ia-CSM prefer star-forming hosts, while subtypes like SN Ia-91bg and Ca-rich prefer quiescent hosts. The rates of SN Ia-91T, Ia-02cx, and Ia-CSM are closely dependent on, or even proportional to, their host SFRs, indicating relatively short-lived progenitors. Conversely, the rates of SN Ia-91bg and Ca-rich transients are proportional to the total stellar mass, favouring long-lived progenitors.

Qin, Yu-Jing (ORCID:0000000336586026)↗

Color Me Intrigued: the Discovery of iPTF 16fnm, a Supernova 2002cx-like Object

Modern wide-field, optical time-domain surveys must solve a basic optimization problem: maximize the number of transient discoveries or minimize the follow-up needed for the new discoveries. Here, we describe the Color Me Intrigued experiment, the first from the intermediate Palomar Transient Factory (iPTF) to search for transients simultaneously in the $g_\mathrm{PTF}$- and $R_\mathrm{PTF}$-bands. During the course of this experiment we discovered iPTF$\,$16fnm, a new member of the 02cx-like subclass of type Ia supernovae (SNe). iPTF$\,$16fnm peaked at $M_{g_\mathrm{PTF}} = -15.09 \pm 0.17 \; \mathrm{mag}$, making it the second least-luminous known type Ia SN. iPTF 16fnm exhibits all the hallmarks of the 02cx-like class: (i) low luminosity at peak, (ii) low ejecta velocities, and (iii) a non-nebular spectra several months after peak. Spectroscopically, iPTF$\,$16fnm exhibits a striking resemblence to 2 other low-luminosity 02cx-like SNe: SNe 2007qd and 2010ae. iPTF$\,$16fnm and SN 2005hk decline at nearly the same rate, despite a 3 mag difference in brightness at peak. When considering the full subclass of 02cx-like SNe, we do not find evidence for a tight correlation between peak luminosity and decline rate in either the $g'$ or $r'$ band. We further examine the $g' - r'$ evolution of 02cx-like SNe and find that their unique color evolution can be used to separate them from 91bg-like and normal type Ia SNe. This selection function will be especially important in the spectroscopically incomplete Zwicky Transient Facility/Large Synoptic Survey Telescope era. We measure the relative rate of 02cx-like SNe to normal SNe Ia and find $r_{N_{02cx}/N_{Ia}} = 25^{+75}_{-18.5}\%$. Finally, we close by recommending that LSST periodically evaluate, and possibly update, its observing cadence to maximize transient science.

79 ASTRONOMY AND ASTROPHYSICS↗

Projected Cosmological Constraints from Strongly Lensed Supernovae with the Roman Space Telescope

One of the primary mission objectives of the Roman Space Telescope is to investigate the nature of dark energy with a variety of methods. Observations of Type I supernovae (SNe Ia) will be one of the principal anchors of the Roman cosmology program through traditional luminosity distance measurements. This SNe Ia cosmology program can provide another valuable cosmological probe, without altering the strategy of the mission: time delay cosmography with gravitationally lensed supernova (SN). In this work, we forecast lensed SN cosmology constraints with the Roman Space Telescope, while providing useful tools for future work. Using the anticipated characteristics of the Roman SNe Ia survey, we have constructed mock catalogs of expected resolved lensing systems, as well as strongly lensed Type Ia and core-collapse (CC) SN light curves, including microlensing effects. We predict Roman will find ~11 lensed SNe Ia and ~20 CCSNe, depending on the survey strategy. Next, we estimate the time delay precision obtainable with Roman (Ia: ~2 days, CC: ~3 days), and use a Fisher matrix analysis to derive projected constraints on H 0 ,Ω m , and the dark energy equation of state, w, for each SNe Ia survey strategy. Here, a strategy optimized for the discovery of high-redshift SNe Ia is preferred when considering the constraints possible from both SNe Ia and lensed SN cosmology, also delivering ~1.5 times more lensed SNe than other proposed survey strategies.

79 ASTRONOMY AND ASTROPHYSICS↗

Deletion analysis of the itaconic acid biosynthesis gene cluster components in Aspergillus pseudoterreus ATCC32359

The filamentous fungus Aspergillus terreus has been successfully used for industrial production of itaconic acid (IA) for many years. The IA biosynthesis pathway has recently been characterized at a molecular genetic level as an IA gene cluster (IA cluster) by a clone-based transcriptomic approach. The cluster consists of four genes, including genes for cis-aconitic acid decarboxylase (cadA), a predicted transcription factor (tf), mitochondrial organic acid transporter (mttA), and MFS (Major Facilitator Superfamily) type transporter (mfsA). In this research, we performed EST (Expressed Sequence Tag) analysis and systematic gene deletions to investigate the role of those genes in IA biosynthesis in A. pseudoterreus ATCC32359. EST analysis showed a similar expression pattern among those four genes that was distinct from neighbouring genes and further confirmed that they belong to the same biosynthesis cluster. Systematic gene deletion analysis demonstrated that tf, cadA, mttA, and mfsA genes in the cluster are essential for IA production. Deletion of any of them will either completely abolish the IA production or dramatically decrease amount of IA produced. More importantly, a significant amount of aconitic acid was detected in the cadA deletion strain but not in the other deletion strains. Therefore, the cadA deletion strain is a novel microorganism host for production of aconitic acid and other value-added chemicals from lignocellulosic biomass.

Deng, Shuang↗

Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms

Highlights: • Heterogeneity of IA walls was examined with imaging mass spectroscopy. • Phosphatidylinositol (PI 18:0/20:4) was more abundant in the thickened wall of IAs. • SMCs in thick and thin wall were dedifferentiated and differentiated, respectively. • Dedifferentiated SMCs had higher levels of PI (18:0/20:4) than differentiated SMCs. • PI (18:0/20:4) could be associated with phenotypic switching of SMCs in rat IAs. The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has been used to reveal the distribution of phospholipids in vascular diseases. To investigate the feature of phospholipid composition of IA walls, we conducted IMS in a rat model of experimentally induced IA.

60 APPLIED LIFE SCIENCES↗

A contribution to the conceptualisation of quality in impact assessment

Quality is much sought after in, and a basic foundation for, good impact assessment (IA). However, the term is rarely defined, has an uncertain relationship with IA effectiveness, and it means different things to different stakeholders, which can lead to debates over the legitimacy associated with an IA process. Thus, IA quality needs conceptualising to position research and practice within broader understandings. This paper contributes to this conceptualisation by identifying nine dimensions of quality through a process of literature review drawing on three fields of study in which quality and quality management have already been debated and conceptualised: education; health care; and business. This approach sidesteps the plural views on quality existing within the field of IA itself which might otherwise bias the identification of quality dimensions. We therefore propose that the dimensions of IA quality are: Efficiency; Optimacy; Conformance; Legitimacy; Equity; Capacity Maintenance; Transformative Capacity; and Quality Management. A literature review of IA research and practice confirms the relevance of the identified quality dimensions to IA. We identify, to an extent, the relationship between quality and effectiveness. Quality aligns with procedural and transactive effectiveness, partly aligns with normative effectiveness and is distinct from, but helps to deliver, substantive effectiveness.

42 ENGINEERING↗

Assessing interactions of binary mixtures of Penicillium mycotoxins (PMs) by using a bovine macrophage cell line (BoMacs)

Penicillium mycotoxins (PMs) are toxic contaminants commonly found as mixtures in animal feed. Therefore, it is important to investigate potential joint toxicity of PM mixtures. In the present study, we assessed the joint effect of binary combinations of the following PMs: citrinin (CIT), ochratoxin A (OTA), patulin (PAT), mycophenolic acid (MPA) and penicillic acid (PA) using independent action (IA) and concentration addition (CA) concepts. Previously published toxicity data (i.e. IC25; PM concentration that inhibited bovine macrophage (BoMacs) proliferation by 25%) were initially analyzed, and both concepts agreed that OTA + PA demonstrated synergism (p < 0.05), while PAT + PA showed antagonism (p < 0.05). When a follow-up dilution study was carried out using binary combinations of PMs at three different dilution levels (i.e. IC25, 0.5 ∗ IC25, 0.25 ∗ IC25), only the mixture of CIT + OTA at 0.5 ∗ IC25 was determined to have synergism by both IA and CA concepts with Model Deviation Ratios (MDRs; the ratio of predicted versus observed effect concentrations) of 1.4 and 1.7, respectively. The joint effect of OTA + MPA, OTA + PA and CIT + PAT complied with the IA concept, while CIT + PA, PAT + MPA and PAT + PA were better predicted with the CA over the IA concept. The present study suggests to test both IA and CA concepts using multiple doses when assessing risk of mycotoxin mixtures if the mode of action is unknown. In addition, the study showed that the tested PMs could be predicted by IA or CA within an approximate two-fold certainty, raising the possibility for a joint risk assessment of mycotoxins in food and feed. - Highlights: • We investigated the potential joint toxicity of Penicillium mycotoxin (PM) mixtures. • Independent action (IA) and concentration addition (CA) concepts were used. • 7 out of 10 mixtures followed joint toxicity described by IA or CA concepts. • Both concepts agreed that CIT + OTA mixture had synergistic interaction.

60 APPLIED LIFE SCIENCES↗

Three gravitationally lensed supernovae behind clash galaxy clusters

We report observations of three gravitationally lensed supernovae (SNe) in the Cluster Lensing And Supernova survey with Hubble (CLASH) Multi-Cycle Treasury program. These objects, SN CLO12Car (z = 1.28), SN CLN12Did (z = 0.85), and SN CLA11Tib (z = 1.14), are located behind three different clusters, MACSJ1720.2+3536 (z = 0.391), RXJ1532.9+3021 (z = 0.345), and A383 (z = 0.187), respectively. Each SN was detected in Hubble Space Telescope optical and infrared images. Based on photometric classification, we find that SNe CLO12Car and CLN12Did are likely to be Type Ia supernovae (SNe Ia), while the classification of SN CLA11Tib is inconclusive. Using multi-color light-curve fits to determine a standardized SN Ia luminosity distance, we infer that SN CLO12Car was ∼1.0 ± 0.2 mag brighter than field SNe Ia at a similar redshift and ascribe this to gravitational lens magnification. Similarly, SN CLN12Did is ∼0.2 ± 0.2 mag brighter than field SNe Ia. We derive independent estimates of the predicted magnification from CLASH strong+weak-lensing maps of the clusters (in magnitude units, 2.5 log{sub 10}μ): 0.83 ± 0.16 mag for SN CLO12Car, 0.28 ± 0.08 mag for SN CLN12Did, and 0.43 ± 0.11 mag for SN CLA11Tib. The two SNe Ia provide a new test of the cluster lens model predictions: we find that the magnifications based on the SN Ia brightness and those predicted by the lens maps are consistent. Our results herald the promise of future observations of samples of cluster-lensed SNe Ia (from the ground or space) to help illuminate the dark-matter distribution in clusters of galaxies, through the direct determination of absolute magnifications.

79 ASTRONOMY AND ASTROPHYSICS↗

UNCERTAINTIES IN GALACTIC CHEMICAL EVOLUTION MODELS

We use a simple one-zone galactic chemical evolution model to quantify the uncertainties generated by the input parameters in numerical predictions for a galaxy with properties similar to those of the Milky Way. We compiled several studies from the literature to gather the current constraints for our simulations regarding the typical value and uncertainty of the following seven basic parameters: the lower and upper mass limits of the stellar initial mass function (IMF), the slope of the high-mass end of the stellar IMF, the slope of the delay-time distribution function of Type Ia supernovae (SNe Ia), the number of SNe Ia per M {sub ⊙} formed, the total stellar mass formed, and the final mass of gas. We derived a probability distribution function to express the range of likely values for every parameter, which were then included in a Monte Carlo code to run several hundred simulations with randomly selected input parameters. This approach enables us to analyze the predicted chemical evolution of 16 elements in a statistical manner by identifying the most probable solutions, along with their 68% and 95% confidence levels. Our results show that the overall uncertainties are shaped by several input parameters that individually contribute at different metallicities, and thus at different galactic ages. The level of uncertainty then depends on the metallicity and is different from one element to another. Among the seven input parameters considered in this work, the slope of the IMF and the number of SNe Ia are currently the two main sources of uncertainty. The thicknesses of the uncertainty bands bounded by the 68% and 95% confidence levels are generally within 0.3 and 0.6 dex, respectively. When looking at the evolution of individual elements as a function of galactic age instead of metallicity, those same thicknesses range from 0.1 to 0.6 dex for the 68% confidence levels and from 0.3 to 1.0 dex for the 95% confidence levels. The uncertainty in our chemical evolution model does not include uncertainties relating to stellar yields, star formation and merger histories, and modeling assumptions.

79 ASTRONOMY AND ASTROPHYSICS↗

Three Gravitationally Lensed Supernovae Behind Clash Galaxy Clusters

We report observations of three gravitationally lensed supernovae (SNe) in the Cluster Lensing And Supernova survey with Hubble (CLASH) Multi-Cycle Treasury program. These objects, SN CLO12Car (z = 1.28), SN CLN12Did (z = 0.85), and SN CLA11Tib (z = 1.14), are located behind three different clusters, MACSJ1720.2+3536 (z = 0.391), RXJ1532.9+3021 (z = 0.345), and A383 (z = 0.187), respectively. Each SN was detected in Hubble Space Telescope optical and infrared images. Based on photometric classification, we find that SNe CLO12Car and CLN12Did are likely to be Type Ia supernovae (SNe Ia), while the classification of SN CLA11Tib is inconclusive. Using multi-color light-curve fits to determine a standardized SN Ia luminosity distance, we infer that SN CLO12Car was approx. 1.0 +/- 0.2 mag brighter than field SNe Ia at a similar redshift and ascribe this to gravitational lens magnification. Similarly, SN CLN12Did is approx. 0.2 +/- 0.2 mag brighter than field SNe Ia. We derive independent estimates of the predicted magnification from CLASH strong+weak-lensing maps of the clusters (in magnitude units, 2.5 log10 μ): 0.83 +/- 0.16 mag for SN CLO12Car, 0.28 +/- 0.08 mag for SN CLN12Did, and 0.43 +/- 0.11 mag for SN CLA11Tib. The two SNe Ia provide a new test of the cluster lens model predictions: we find that the magnifications based on the SN Ia brightness and those predicted by the lens maps are consistent. Our results herald the promise of future observations of samples of cluster-lensed SNe Ia (from the ground or space) to help illuminate the dark-matter distribution in clusters of galaxies, through the direct determination of absolute magnifications.

Three↗