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Results for “Directional Effect”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 505 records · Page 28
All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

Global functional connectivity density alterations in patients with bipolar disorder with auditory verbal hallucinations and modest short‐term effects of transcranial direct current stimulation augmentation treatment—Baseline and follow‐up study

Abstract Objectives To investigate the neuroimaging characteristics of auditory verbal hallucinations (AVHs) in patients with bipolar disorder (BP) experiencing depressive episodes with and without AVHs, and alterations in those characteristics after transcranial direct current stimulation (tDCS). Methods For a baseline pilot study, we recruited 80 patients with BP and depressive status (40 with and 40 without AVHs), and 40 healthy controls (HCs). Their global functional connectivity density (gFCD) was screened by functional magnetic resonance imaging (fMRI). Voxel‐wise one‐way analysis of covariance (ANCOVA) was conducted to detect intergroup differences in gFCD. In a follow‐up study, the effects of 5 weeks of tDCS augmentation treatment on clinical symptoms and gFCD were assessed in the 40 BP patients with AVHs. Results Compared to HCs, BP patients with and without AVHs exhibited increased gFCD in the central parietal lobe, insular lobe, and middle cingulate cortex, with decreased gFCD in the posterior parietal cortex, lateral prefrontal cortex, and occipital lobe (all bilateral). Only patients with AVHs showed increased gFCD in the Broca and Wernicke regions, and decreased gFCD in the hippocampus (all bilateral). After 5 weeks of tDCS, AVHs were slightly alleviated and gFCD abnormalities in the hippocampus were mildly attenuated. Conclusions Patients with BP and AVHs showed disturbances in the brain's communication capacity mainly in the left frontoparietal network, control network, and memory circuitry. Five weeks of tDCS alleviated AVHs slightly, without improving depressive symptoms, and attenuated hippocampal gFCD alterations in these patients.

Zhuo, Chuanjun↗
NASA NTRS1994

Directional and polarimetric effects in the optical domain

Papers focused on land surface, atmospheric, and ocean properties are reported. Specific comments pertaining to polarization, models and inversion, and measurements, are given. Recommendations are: continued research into the application potential of the BRDF (Bidirectional Reflectance Distribution Function) and polarization properties of ground surface and atmospheric targets; three dimensional models, which account for the statistical behavior of remotely sensed data, should be extended and inverted in order to support analysis of data potentially covering rolling terrain such that pixels represent heterogeneous mixtures of surface cover types and project ground footprints with sizes between 10 to 6 km, the ground pixel sizes of planned future sensors; available reflectance models should be further validated by means of multi dimensional (directional, spectral, temporal) field data and existing models should be intercompared in more depth to evaluate their performance and limitations; existing methods for model inversion should be validated in more depth in order to quantify the practical limitations and the expected accuracy of the parameters retrieved and new approaches should be developed based upon apriori knowledge of plant canopy development and spectral BRDF properties; there is a need to establish a protocol of validation and intercomparison of the indices and compositing techniques which have been proposed during these last years.

Vanderbilt, V. C.↗
DOE OSTI2021

Adaptive mesh based combustion simulations of direct fuel injection effects in a supersonic cavity flame-holder

Here, we present high-fidelity reacting simulations of a supersonic cavity flame-holder configuration. The focus of this work is on flame stabilization brought about by varying the location of fuel injection in a cavity stabilized supersonic flow of air. Central to our approach is a compressible multi-species reacting flow solver that uses adaptive-mesh-refinement (AMR), enabling the resolution of flame, shock-waves, boundary-layers, and small-scale structures in the computational domain. Our analysis indicates that fuel injection closer to the ramp at the aft end of the cavity allows for greater mixing and lower peak temperatures compared to fuel injection upstream that is closer to the backward facing step of the cavity. This difference is mainly due to greater turbulent fluctuations generated from the shear-layer towards the cavity ramp, thereby enhancing the mixing of fuel and air. A low frequency oscillatory behaviour in heat-release and pressure was also observed for the upstream injection case while a much higher-frequency phenomena was observed in the near-ramp injection case. By identifying the important physical determinants of the combustion processes, this study illustrates a promising pathway to design and optimize direct fuel injection strategies in supersonic cavity flame-holders that can improve flame stability, combustion efficiency, and reduce emissions.

42 ENGINEERING↗
DOE OSTI2020

The direct and indirect effects of copper on vector-borne disease dynamics

Metal pollution is a growing concern that affects the health of humans and animals globally. Copper is an essential insect micronutrient required for respiration, pigmentation and oxidative stress protection but can also act as a potentially toxic trace element. While several studies have focused on the negative fitness effects of copper on the aquatic larvae of mosquitoes, the effects of larval copper exposure on adult mosquito fitness (i.e., survival and fecundity) and their ability to transmit parasites (i.e., vector competence) remains unclear. Here, using a well-studied model vector-parasite system, the mosquito Aedes aegypti and parasite Dirofilaria immitis, we show that sublethal copper exposure in larval mosquitoes alters adult female fecundity and vector competence. Specifically, mosquitoes exposed to copper had a hormetic fecundity response and mosquitoes exposed to 600 μg/L of copper had significantly fewer infective parasite larvae than control mosquitoes not exposed to copper. Therefore, exposure of mosquito larvae to copper levels far below EPA-mandated safe drinking water limits (1300 μg/L) can impact vector-borne disease dynamics not only by reducing mosquito abundance (through increased larval mortality), but also by reducing parasite transmission risk. Our results also demonstrated that larval copper is retained through metamorphosis to adulthood in mosquitoes, indicating that these insects could transfer copper from aquatic to terrestrial foodwebs, especially in urban areas where they are abundant. To our knowledge this is the first study to directly link metal exposure with vector competence (i.e., ability to transmit parasites) in any vector-parasite system. Additionally, it also demonstrates unequivocally that mosquitoes can transfer contaminants from aquatic to terrestrial ecosystems. These results have broad implications for public health because they directly linking contaminants and vector-borne disease dynamics, as well as linking mosquitoes and contaminant dynamics.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2025

Three‐trophic level food webs support the safety of a biocontrol agent 3 years after release

Biological control (biocontrol) is a powerful tool for managing invasive alien species and assisting the restoration of native ecosystems. Rigorous post‐release monitoring of biocontrol agents is critical to evaluate the success of biocontrol programs; however, this is still rarely implemented. Here, we combined the use of species interaction networks with a Before‐After Control‐Impact design to evaluate the target and non‐target, direct and indirect effects of the Australian gall wasp Trichilogaster acaciaelongifoliae , released to control the invasive plant Acacia longifolia in Portugal. We compared the structure of plant‐galling insect‐parasitoid food webs before and 3 years after the release of the biocontrol agent. Exhaustive sampling did not detect any non‐target effects, either direct (on non‐target plants) or indirect (on other galling insects via shared plants). Additionally, no significant changes were detected in network structure that could be related to the establishment of the biocontrol agent. This study shows that monitoring biocontrol at the community level is possible and that, when carefully planned, biocontrol poses minimal risk of non‐target effects.

López‐Núñez, Francisco A. [Centre for Functional E↗
DOE OSTI2020

The effect of loading direction on the fracture behaviors of cortical bone at a dynamic loading rate

Here, the dynamic cracking processes in porcine cortical bone were visualized in real-time using the high-speed synchrotron X-ray phase-contrast imaging (PCI) technique in three osteon orientations: in-plane transverse, out-of-plane transverse and in-plane longitudinal. The dynamic flexural loading applied on the pre-notched bone specimens was introduced by a modified Kolsky compression bar. High-speed X-ray images of the entire loading events were documented with a high-speed camera. Three-dimensional X-ray micro-computed tomography was conducted to examine the intact microstructures and obtain the basic material properties of the bone material used for mechanical characterizations. The onset location, where crack initiated, and the subsequent direction, along which the incipient crack propagated, were measured quantitatively using the high-speed X-ray images and the latter was found dependent on the osteon direction significantly. The crack propagation velocities were dependent on crack extension over the entire crack path significantly for all the three directions while the initial velocity for in-plane longitudinal direction was lower than the other two directions. Straight-through crack paths were observed for in-plane longitudinal specimens while the cracks were deflected and twisted in the in-plane transverse direction. For out-of-plane transverse direction, the cracks follow paths with tortuosity fall in between the other two directions, showing a mixed mode of fractures of the former two extreme cases. The toughening mechanisms, visualized by the high-speed X-ray images, and the corresponding fracture toughness, evaluated in terms of fracture initiation toughness and crack growth resistance curve (R-curve), were also found significantly different among the three osteon directions, suggesting an overall transition from brittle to ductile-like fracture behaviors at the dynamic displacement rate (5.4 m/s) as the osteon orientation varies from in-plane longitudinal to out-of-plane transverse, and to in-plane transverse eventually.

42 ENGINEERING↗
DOE OSTI2026

Worldwide benchmarking of cost-effective radiometers for direct and diffuse irradiance

Solar energy projects can benefit from direct normal irradiance (DNI) and diffuse horizontal irradiance (DHI) measurements during all project phases. Several commercial measurement systems for DNI and DHI are available. Sun trackers with pyranometers and pyrheliometers can provide highly accurate measurements but are often impractical in solar energy applications. For less expensive and more robust sensors, it is often unclear which accuracy can be expected under a project site's specific atmospheric conditions. We address this challenge through our dedicated experimental comparison of relevant sensor systems (rotating shadowband irradiometer [short RSI], Delta-T SPN1, EKO MS-90, PyranoCam, Sunto CaptPro, Kipp & Zonen CSD3) at up to six sites worldwide. The RSI systems (rRMSD 3 to 8.6%, DNI; 4.8 to 7.6%, DHI) and PyranoCam (rRMSD 2.6 to 5.2%, DNI; 4.4 to 5.8%, DHI) exhibit similar error metrics and are the most accurate systems in the test. Delta-T SPN1 and EKO MS-90 (rRMSD 6.8 to 15%, DNI; 10.6 to 20.1%, DHI) but especially Kipp & Zonen CSD3 and Sunto CaptPro show significant deviations (rRMSD 17.7 to 20%, DNI; 33 to 58%, DHI). We evaluate the influence of relevant atmospheric parameters on the sensors' accuracies by a rather unique measurement setup. MS-90's DNI errors depend on DNI itself, with overestimations for low reference DNI. The deviations of SPN1's DHI and DNI measurements increase sharply in situations with high circumsolar irradiance. Also CaptPro and CSD3's increased measurement errors are related to circumsolar irradiance. For RSI and PyranoCam, only moderate influences on the measurements are identified, indicating a general applicability of these instruments.

14 SOLAR ENERGY↗
DOE OSTI2020

Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico

The creation of artificial enzymes is a key objective of computational protein design. Although de novo enzymes have been successfully designed, these exhibit low catalytic efficiencies, requiring directed evolution to improve activity. Here, we use room-temperature X-ray crystallography to study changes in the conformational ensemble during evolution of the designed Kemp eliminase HG3 (k cat /K M 146 M -1 s -1 ). We observe that catalytic residues are increasingly rigidified, the active site becomes better pre-organized, and its entrance is widened. Based on these observations, we engineer HG4, an efficient biocatalyst (k cat /K M 103,000 M -1 s -1 ) containing key first and second-shell mutations found during evolution. HG4 structures reveal that its active site is pre-organized and rigidified for efficient catalysis. Our results show how directed evolution circumvents challenges inherent to enzyme design by shifting conformational ensembles to favor catalytically-productive sub-states, and suggest improvements to the design methodology that incorporate ensemble modeling of crystallographic data.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Factors controlling marine aerosol size distributions and their climate effects over the northwest Atlantic Ocean region

Abstract. Aerosols over Earth's remote and spatially extensive ocean surfaces have important influences on planetary climate. However, these aerosols and their effects remain poorly understood, in part due to the remoteness and limited observations over these regions. In this study, we seek to understand factors that shape marine aerosol size distributions and composition in the northwest Atlantic Ocean region. We use the GEOS-Chem model with the TwO-Moment Aerosol Sectional (TOMAS) microphysics algorithm model to interpret measurements collected from ship and aircraft during the four seasonal campaigns of the North Atlantic Aerosols and Marine Ecosystems Study (NAAMES) conducted between 2015 and 2018. Observations from the NAAMES campaigns show enhancements in the campaign-median number of aerosols with diameters larger than 3 nm in the lower troposphere (below 6 km), most pronounced during the phytoplankton bloom maxima (May/June) below 2 km in the free troposphere. Our simulations, combined with NAAMES ship and aircraft measurements, suggest several key factors that contribute to aerosol number and size in the northwest Atlantic lower troposphere, with significant regional-mean (40–60∘ N and 20–50∘ W) cloud-albedo aerosol indirect effect (AIE) and direct radiative effect (DRE) processes during the phytoplankton bloom. These key factors and their associated simulated radiative effects in the region include the following: (1) particle formation near and above the marine boundary layer (MBL) top (AIE: −3.37 W m−2, DRE: −0.62 W m−2); (2) particle growth due to marine secondary organic aerosol (MSOA) as the nascent particles subside into the MBL, enabling them to become cloud-condensation-nuclei-sized particles (AIE: −2.27 W m−2, DRE: −0.10 W m−2); (3) particle formation and growth due to the products of dimethyl sulfide, above and within the MBL (−1.29 W m−2, DRE: −0.06 W m−2); (4) ship emissions (AIE: −0.62 W m−2, DRE: −0.05 W m−2); and (5) primary sea spray emissions (AIE: +0.04 W m−2, DRE: −0.79 W m−2). Our results suggest that a synergy of particle formation in the lower troposphere (particularly near and above the MBL top) and growth by MSOA contributes strongly to cloud-condensation-nuclei-sized particles with significant regional radiative effects in the northwest Atlantic. To gain confidence in radiative effect magnitudes, future work is needed to understand (1) the sources and temperature dependence of condensable marine vapors forming MSOA, (2) primary sea spray emissions, and (3) the species that can form new particles in the lower troposphere and grow these particles as they descend into the marine boundary layer.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1980

Blood circulation under conditions of weightlessness

Experimental materials and published data on the problem of blood circulation in man and animals under conditions of short and long term weightlessness are summarized. The data obtained allow the conclusion, that when humans spent 5 days in a weightless state their blood circulation was not essentially distributed. Some features of the functioning of the cardiovascular system are pointed out: delay of adaptation rate, increase in lability, etc. There is a discussion of the physiological mechanisms for the direct and indirect effect of weightlessness. The direct effect comprise the complex of reactions caused by the significant fall in hydrostatic pressure and the indirect embraces all the reactions arising in the organism resulting from disturbance of the systematic character of the analyzers that take part in the analysis of space realtions and the body's orientation in space.

Kastyan, I. I.↗
NASA NTRS1984

The effect of row direction on the microwave emission from vegetation canopies

Experiments were conducted to determine the microwave brighthness temperature of corn and soybean canopies as a function of polarization and azimuth look direction. A strong dependence on row direction and polarization is observed for soybeans. The corn canopy shows a similar dependence, although to a lesser extent. The variation in brightness temperature is shown to be related to the canopy alone, since the underlying soil surface was blocked by reflecting metal screens.

Brunfeldt, D. R.↗