Engineering Papers⌕ Search

SEARCH · Engineering Papers

Results for “Aging analysis”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 505 records · Page 28
All sourcesNASA NTRSDOE OSTI
NASA NTRS2017

Getting to the Heart of Cardiovascular Risk Assessment in Astronauts for Exploration Class Missions

Since the beginning of manned spaceflight, NASA has recognized the potential risk of cardiovascular decrements due to stressors in the space environment. Of particular concern is the effect of space radiation on cardiovascular disease since astronauts will be exposed to higher levels of galactic cosmic rays outside the Earth's protective magnetosphere. To date, only a few studies have examined the effects of heavy ion radiation on cardiovascular disease, and at lower, space-relevant doses, the association between radiation exposure and cardiovascular pathology is more varied and unclear. Furthermore, other spaceflight conditions such as microgravity, circadian shifts, and confinement stress pose unique challenges in estimating the health risks that can be attributed to exposure to ionizing radiations. In this work, we review age, cause of mortality, and radiation exposure amongst early NASA astronauts in selection groups and discuss the limitations of assessing such a cohort when attempting to characterize the risk of space flight, including stressors such as space radiation and microgravity exposure, on cardiovascular health. METHODS: NASA astronauts in selection groups 1-7 were chosen and the comparison population was white men of the same birth cohort as drawn from data from the CDC Wonder Database and CDC National Center for Health Statistics Life Tables. Cause of death information was obtained from the Lifetime Surveillance of Astronaut Health program and deceased astronauts were classified based on ICD-10 codes: ischemic heart disease (IHD), stroke, cancer, acute occupational events, non-NASA accidents, and other/unknown. Expected years of life left and expected age at death were calculated for the cohort. RESULTS AND CONCLUSIONS: There were 32 deaths in this early astronaut population, 12 of which were due to accidents or acute occupational events that impacted lifespan considerably. The average age at death from these causes is 30 years lower than the average expected ~70 years of age in the general population. Remarkably, all 41 living early astronauts outlived our calculated expected age at death for members of their birth cohort; furthermore, 13 of the 20 deceased astronauts who did not die in NASA/non-NASA accidents exceeded this age. There was no difference in IHD between the astronaut cohort and the comparison population; therefore, it is not possible to associate IHD mortality with radiation in that astronaut cohort. As NASA looks toward future exploration-class missions, early astronaut cohorts provide a convenient option for assessing these risks and for developing mitigation strategies. However, many challenges still exist when assessing such limited evidence, including small cohort size, health and lifestyle confounders (such as smoking and drinking), the high accident mortality rate, and the fact that many of these astronauts are still alive, outliving many of their birth-cohort peers. Future analysis should include a longitudinal study, monitoring cases as they occur in the cohort. As this cohort is currently followed-up over time, and as more IHD cases are anticipated in a population of this age, this type of study is not as resource-intensive as would normally be the case.

Elgart, S. R.↗
NASA NTRS1993

Reverse polarity magnetized melt rocks from the Chicxulub impact structure, Yucatan Peninsula, Mexico

Further paleomagnetic data for core samples of melt rock recovered in the Petroleos Mexicanos (PEMEX) exploratory wells within the Chicxulub structure, northern Yucatan peninsula, Mexico are reported. A previous report by Sharpton showed that the rocks studied contain high iridium levels and shocked breccia clasts, and an Ar-40/Ar-39 age of 65.2 plus or minus 0.4 Ma. The geomagnetic polarity determined for two samples is reverse (R) and was correlated with chron 29R that includes the K/T boundary. Our present analysis is based on two samples from each of three clasts of the melt rock from PEMEX well Y6-N17 (1295 to 1299 m b.s.l.). This study concentrates on the vectorial nature and stability of the remanence (NRM), the magnetic mineralogy and remanence carriers (i.e., the reliability and origin of the record), and on the implications (correlation with expected paleolatitude and polarity). The relative orientation of the drill core samples with respect to the horizontal is known. Samples were stable under alternating field (AF) and thermal treatments, and after removal of a small component they exhibited single-vectorial behavior. The characteristic remanence inclinations show small dispersion and a mean value (-43 deg) in close agreement with the expected inclination and paleolatitude (derived from the North American apparent polar wander path). Isothermal remenence (IRM) acquisition experiments, Lowrie-Fuller tests, coercivity and unblocking temperature spectra of NRM and saturation IRM, susceptibility and Q-coefficient analyses, and the single-component nature indicate a dominant mineralogy of iron-rich titanomagnetites with single or pseduo-single domain states. The stable characteristic magnetization may be interpreted as a result of shock heating of the rock at the time of formation of the inpact structure and its polarity, age, and paleolatitude are consistent with a time about the K/T boundary.

Urrutia-Fucugauchi, Jaime↗
NASA NTRS1986

Analysis of forest structure using thematic mapper simulator data

The potential of Thematic Mapper Simulator (TMS) data for sensing forest structure information has been explored by principal components and feature selection techniques. In a survey of forest structural properties conducted for 123 field sites of the Sequoia National Park, the canopy closure could be well estimated (r = 0.62 to 0.69) by a variety of channel bands and band ratios, without reference to the forest type. Estimation of the basal area was less successful (r = 0.51 or less) on the average, but could be improved for certain forest types when data were stratified by floristic composition. To achieve such a stratification, individual sites were ordinated by a detrended correspondence analysis based on the canopy of dominant species. The analysis of forest structure in the Sequoia data suggests that total basal area can be best predicted in stands of lower density, and in younger even-aged managed stands.

Peterson, D. L.↗
NASA NTRS1992

Geologic evolution of the east rim of the Hellas basin, Mars

The east rim of the Hellas basin, one of the largest obvious impact features on Mars, is studied. The distribution of geologic materials in the region is documented, and their modes of origin are constrained based on their geomorphologic characteristics. Superposition relationship and crater size-frequency distributions allow the relative ages of the geologic units to be determined and provide information regarding the timing and extent of the geologic processes emplacing and modifying the surface materials. Systematic analysis of the degradation of the Hellas basin is used to illustrate the sequence of events and interplay of geologic processes which control the evolution of many regions on Mars.

Crown, David A.↗
NASA NTRS1994

Recommended techniques for effective maintainability. A continuous improvement initiative of the NASA Reliability and Maintainability Steering Committee

This manual presents a series of recommended techniques that can increase overall operational effectiveness of both flight and ground based NASA systems. It provides a set of tools that minimizes risk associated with: (1) restoring failed functions (both ground and flight based); (2) conducting complex and highly visible maintenance operations; and (3) sustaining a technical capability to support the NASA mission using aging equipment or facilities. It considers (1) program management - key elements of an effective maintainability effort; (2) design and development - techniques that have benefited previous programs; (3) analysis and test - quantitative and qualitative analysis processes and testing techniques; and (4) operations and operational design techniques that address NASA field experience. This document is a valuable resource for continuous improvement ideas in executing the systems development process in accordance with the NASA 'better, faster, smaller, and cheaper' goal without compromising safety.

Source record↗
NASA NTRS2003

Quantification of rat retinal growth and vascular population changes after single and split doses of proton irradiation: translational study using stereology methods

This study quantified architectural and population changes in the rat retinal vasculature after proton irradiation using stereology. A 100 MeV conformal proton beam delivered 8, 14, 20 and 28 Gy as single and split doses to the whole eye. The vascular networks were prepared from retinal digests. Stereological methods were used to obtain the area of the retina and unbiased estimates of microvessel/artery/vein endothelial, pericyte and smooth muscle population, and vessel length. The retinal area increased progressively in the unirradiated, age-matched controls and in the retinas irradiated with 8 and 14 Gy, indicating uniform progressive retinal growth. No growth occurred after 20 and 28 Gy. Regression analysis of total endothelial cell number in all vessels (arteries, veins and capillaries) after irradiation documented a progressive time- and dose-dependent cell loss occurring over 15 to 24 months. The difference from controls was significant (P<0.01) after 28 Gy given in single and split doses and after 20 Gy given as a split dose (P<0.05). Total vessel length in microvessel was significantly shortened at 20 and 28 Gy compared to that of controls (P<0.05). No evident dose recovery was observed in the endothelial populations after split doses. At 10 Gy, the rate of endothelial cell loss, a dose parameter used to characterize the time- and dose-dependent loss of the endothelial population, was doubled.

NASA Discipline Radiation Health↗
NASA NTRS2001

HST Observations of Star Formation in Interacting Galaxies: NGC 4194, the "Medusa"

Ultraviolet and visible imaging of the blue compact galaxy NGC4194 was obtained to survey the star-forming knots in the center of this galaxy. Photometry and image analysis were performed on these regions. Comparison with evolutionary tracks indicates many of the knots are reddened with a typical E(B-V)approx.0.3. The knot ages range from 10(exp 6-10(exp 8)years. Some of the knots may have masses 3-5x10(exp 5) solar mass. The FUV fluxes correspond to the flux from 60-3.8x10(exp 3) O5V stars.

Weistrop, D.↗
NASA NTRS2011

Measuring Sulfur Isotope Ratios from Solid Samples with the Sample Analysis at Mars Instrument and the Effects of Dead Time Corrections

The Sample Analysis at Mars (SAM) instrument suite comprises the largest science payload on the Mars Science Laboratory (MSL) "Curiosity" rover. SAM will perform chemical and isotopic analysis of volatile compounds from atmospheric and solid samples to address questions pertaining to habitability and geochemical processes on Mars. Sulfur is a key element of interest in this regard, as sulfur compounds have been detected on the Martian surface by both in situ and remote sensing techniques. Their chemical and isotopic composition can belp constrain environmental conditions and mechanisms at the time of formation. A previous study examined the capability of the SAM quadrupole mass spectrometer (QMS) to determine sulfur isotope ratios of SO2 gas from a statistical perspective. Here we discuss the development of a method for determining sulfur isotope ratios with the QMS by sampling SO2 generated from heating of solid sulfate samples in SAM's pyrolysis oven. This analysis, which was performed with the SAM breadboard system, also required development of a novel treatment of the QMS dead time to accommodate the characteristics of an aging detector.

Franz, H. B.↗
NASA NTRS2013

Space View Issues for Hyperspectral Sounders

The expectation for climate quality measurements from hyperspectral sounders is absolute calibration accuracy at the 100 mK level and stability at the < 40 mK/decade level. The Atmospheric InfraRed Sounder (AIRS)1, Cross-track Infrared Sounder (CrIS), and Infrared Atmospheric Sounding Interferometer (IASI) hyperspectral sounders currently in orbit have been shown to agree well over most of their brightness temperature range. Some larger discrepancies are seen, however, at the coldest scene temperatures, such as those seen in Antarctic winter and deep convective clouds. A key limiting factor for the calibrated scene radiance accuracy for cold scenes is how well the effective radiance of the cold space view pertains to the scene views. The space view signal is composed of external sources and instrument thermal emission at about 270 K from the scan mirror, external baffles, etc. Any difference in any of these contributions between space views and scene views will impact the absolute calibration accuracy, and the impact can be critical for cold scenes. Any change over time in these will show up as an apparent trend in calibrated radiances. We use AIRS data to investigate the validity of the space view assumption in view of the 100 mK accuracy and 40 mK/decade trend expectations. We show that the space views used for the cold calibration point for AIRS v5 Level-1B products meet these standards except under special circumstances and that AIRS v6 Level-1B products will meet them under all circumstances. This analysis also shows the value of having multiple distinct space views to give operational redundancy and analytic data, and that reaching climate quality requires continuing monitoring of aging instruments and adjustment of calibration.

trends↗
NASA NTRS1991

Structural verification of an aged composite reflector

A structural verification program applied to qualifying two heritage composite antenna reflectors for flight on the TOPEX satellite is outlined. The verification requirements and an integrated analyses/test approach employed to meet these requirements are described. Structural analysis results and qualification vibration test data are presented and discussed. It was determined that degradation of the composite and bonding materials caused by long-term exposure to an uncontrolled environment had not severely impaired the integrity of the reflector structures. The reflectors were assessed to be structurally adequate for the intended TOPEX application.

Lou, Michael C.↗
NASA NTRS2011

Analysis of Association Between Remotely Sensed (RS) Data and Soil Transmitted Helminthes Infection Using Geographical Information Systems (GIS): Boaco, Nicaragua

Soil-transmitted helminths are intestinal nematodes that can infect all members of a population but specially school-age children living in poverty. Infection can be significantly reversed with anthelmintic drug treatments and sanitation improvement. Implementation of effective public health programs requires reliable and updated information to identify areas at higher risk and to calculate amount of drug required. Geo-referenced in situ prevalence data will be overlaid over an ecological map derived from RS data using ARC Map 9.3 (ESRI). Prevalence data and RS data matching at the same geographical location will be analyzed for correlation and those variables from RS data that better correlate with prevalence will be included in a multivariate regression model. Temperature, vegetation, and distance to bodies of water will be inferred using data from Moderate-Resolution Imaging Spectroradiometer (MODIS) and Landsat TM and ETM+. Elevation will be estimated with data from The Shuttle Radar Topography Mission (SRTM). Prevalence and intensity of infections are determined by parasitological survey (Kato Katz) of children enrolled in rural schools in Boaco, Nicaragua, in the communities of El Roblar, Cumaica Norte, Malacatoya 1, and Malacatoya 2). This study will demonstrate the importance of an integrated GIS/RS approach to define sampling clusters without the need for any ground-based survey. Such information is invaluable to identify areas of high risk and to geographically target control programs that maximize cost-effectiveness and sanitation efforts.

MorenoMadrinan, Max J.↗
NASA NTRS1976

Voltage stress effects on microcircuit accelerated life test failure rates

The applicability of Arrhenius and Eyring reaction rate models for describing microcircuit aging characteristics as a function of junction temperature and applied voltage was evaluated. The results of a matrix of accelerated life tests with a single metal oxide semiconductor microcircuit operated at six different combinations of temperature and voltage were used to evaluate the models. A total of 450 devices from two different lots were tested at ambient temperatures between 200 C and 250 C and applied voltages between 5 Vdc and 15 Vdc. A statistical analysis of the surface related failure data resulted in bimodal failure distributions comprising two lognormal distributions; a 'freak' distribution observed early in time, and a 'main' distribution observed later in time. The Arrhenius model was shown to provide a good description of device aging as a function of temperature at a fixed voltage. The Eyring model also appeared to provide a reasonable description of main distribution device aging as a function of temperature and voltage. Circuit diagrams are shown.

Johnson, G. M.↗
NASA NTRS2000

Statistical Analysis of Risk Factors in the Prebreathe Reduction Protocol

The 165 exposures from four 2-hour protocols were analyzed for correlations or trends between decompression sickness (DCS) or venous gas emboli (VGE), and variables that affect risk in the subject and astronaut populations. The assumption in this global survey is that the distributions of gender, age, body mass index, etc., are equally represented in all four tested procedures. We used Student t-test for comparisons between means and chi-square test between comparisons of proportions with p<0.05 defining a significant level. The type and distribution of the 19 cases of DCS were similar to historical cases. There was no correlation of age, gender, body mass index or fitness level with greater incidence of DCS or VGE. However increased age was associated with more Grade IV VGE in males. The duration and quantity of exercise during prebreathe is inversely related to risk of DCS and VGE. The latency time for VGE was longer (103 min +/- 56 SD, n = 15) when the ergometry was done approximately 15 min into the prebreathe than when done at the start of the prebreathe (53 min +/- 31, n = 13). The order of the ergometry did not influence the overall DCS and VGE incidence. We identified variables other than those of the prebreathe procedures that influence the DCS and VGE outcome. The analysis suggests that males over 40 years have a high incidence of Grade IV VGE.

Gerth, Wayne A.↗
NASA NTRS2017

Renin-Angiotensin System (RAS) in Hematopoietic Stem/Progenitor Cells (HS/PC) Predicts Vaso-Reparative Dysfunction and Progression of Diabetic Retinopathy (DR)

Purpose: We tested the hypothesis that loss of angiotensin converting enzyme 2 (ACE2) within diabetic HS/PCs (Hematopoietic Stem/Progenitor Cells) would be detrimental to HS/PC reparative function, and alter their ability to contribute to vascular remodeling in human subjects and rodent models of DR (Diabetic Retinopathy). Methods: Subjects (n52) were recruited as controls (n13) or diabetics (n39) with either no DR, mild non-proliferative DR (NPDR), moderate NPDR, severe NPDR or proliferative DR (PDR). Fluorescein angiograms were analyzed using Vessel Generation Analysis (VESGEN) software in a cohort of subjects. CD34+ HS/PCs were isolated from peripheral blood. RAS (Renin-Angiotensin System) gene expression and migration was measured. Diabetic ACE2 knockout (KO)C57BL6-Ins2 (Akita) mice at 3, 6 and 9 months of diabetes were compared to age-matched controls. Bone marrow HS/PC populations were analyzed by flow cytometry and migration and proliferation studies performed. Results: ACE2 gene expression in human CD34+ cells from diabetics without DR was increased compared to controls (p0.0437). Mas receptor mRNA was also increased in diabetics without DR, but reduced with the onset of NPDR (p0.0002), suggesting a loss of compensation. DR was associated with CD34+ cell migratory dysfunction. By VESGEN analysis, vessel density measured by several confirming parameters in early NPDR (n3) was greater than in normal retina (n6) in both arteries and veins, which suggests active retinal remodeling. ACE2KO-Akita and Akita cohorts showed reduced retinal thickness by OCT (Optical Coherence Tomography) at 9 months of diabetes. Absence of ACE2 in 9-month Akita mice led to an accelerated increase in acellular capillaries compared to diabetic alone. Electroretinogram (ERG) in ACE2KO-Akita mice resulted in persistent deterioration of the neural retina. Reparative function studies showed that ACE2KO exacerbated diabetes-induced impairment of LK (Low Potassium) cell migration and proliferative functions as early as 3-month of diabetes (p0.0019). Conclusions: Retinopathy and adverse vascular remodeling in subjects with diabetes was associated with a loss of the protective arm of RAS in HS/PCs. Loss of ACE2 exacerbated vascular dysfunction in diabetic mice.

retina↗
NASA NTRS1992

New results from FRECOPA analysis

Given Long Duration Exposure Facility (LDEF) new situation (5.8 years mission), CNES decided to set up a team to analyze FRECOPA systems (AO 138). We studied the kinematic system first. We observed damage on the DELRIN gears and lubricant ageing. The results are based on comparative appraisals between components after flight and those stored on ground in laboratory conditions. We observed also the aluminum surface treatment in the exposed areas and we measured the thermo-optical properties changes. Now, with all the results stored, we try to give a ruling on the use of FRECOPA materials in space environment.

Durin, Christian↗
NASA NTRS1998

Evidence for a Light-Rare-Earth-Element-Depleted Source for Some Ferroan Anorthosites

In the lunar magma ocean model, ferroan anorthosites (FANs) are expected to be derived from a relatively undifferentiated source with chondritic REE abundances and yield the oldest radiometric ages of any lunar rocks. Samarium-neodymium-isotopic analyses of 60025 and 67016 yielded ages of 4.44 +/- 0.02 Ga and 4.53 +/- 0.12 Ga and initial Epsilon(sub Nd)(sup 143) values in excess of -0.5. These ages are within error of ages determined on some Mg-suite rocks by researchers. Thus, the existing data are not completely consistent with the standard magma ocean model. We have completed isotopic analysis on the pristine FAN 62236 in order to place further constraints on lunar crust-forming processes.

Borg, L. E.↗
NASA NTRS2000

Thermal Stability of Otto Fuel Prepolymer

Otto Fuel II contains a nitrate ester, plasticizer, and 2-NPDA as a stabilizer. Otto Fuel with stabilizers from three vendors was investigated by dynamic and isothermal differential scanning calorimetry (DSC) using samples sealed in a glass ampoule and by Isothermal Microcalorimetry (IMC) using 10 gram samples aged at 75 C for 35 days. DSC kinetics did not show differences between the stabilizer; the samples had an activation energy of 36.7 +/- 0.6 kcal/mol. However, IMC analysis was sensitive enough to detect small differences between the stabilizer, namely energy of interaction values of 7 to 14 Joules. DSC controlled cooling and heating at 5 C/min from 30 to -60 to 40 C experiments were similar and showed a crystallization peak at -48 +/- 1 C during cooling, and upon heating there was a glass transition temperature step at approx. -54 +/- 0.5 C and a melting peak at -28 +/- 0.4 C.

Tompa, Albert S.↗
NASA NTRS2000

Thermal Stability of Otto Fuel Prepolymer

Otto Fuel II contains a nitrate ester, plasticizer, and 2-NDPA as a stabilizer. Otto Fuel with stabilizers from three vendors was investigated by dynamic and isothermal DSC using samples sealed in a glass ampoule and by Isothermal Microcalorimetry (IMC) using 10 gram samples aged at 75 C for 35 days. DSC kinetics did not show differences between the stabilizer; the samples had an activation energy of 36.7 +/- 0.6 kcal/mol. However, IMC analysis was sensitive enough to detect small differences between the stabilizer, namely energy of interaction values of 7 to 14 Joules. DSC controlled cooling and heating at 5 C/min from 30 to -60 to 40 C experiments were similar and showed a crystallization peak at -48 +/- 1 C during cooling, and upon heating there was a glass transition temperature step at approx. -54 +/- 0.5 C and a melting peak at -28 +/- 0.4 C.

Tompa, Albert S.↗