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All sourcesNASA NTRSDOE OSTI
NASA NTRS2002

Foam Optics and Mechanics

The Foam Optics and Mechanics (FOAM) project will exploit the microgravity environment to more accurately measure the rheological and optical characteristics of wet aqueous foams. Using both rheology and laser light scattering diagnostics, the goal is to quantify the unusual elastic character of foams in terms of their underlying microscopic structure and dynamics. Of particular interest is determining how the elastic character vanishes, i.e., how the foam 'melts' into a simple viscous liquid, as a function of both increasing liquid content and increasing shear strain rate. The unusual elastic character of foams will be quantified macroscopically by measurement of the shear stress as a function of shear strain rate and of time following a step strain. Such data will be analyzed in terms of a yield stress, shear moduli, and dynamical time scales. Microscopic information about bubble packing and rearrangement dynamics, from which the macroscopic non-Newtonian properties ultimately arise, will be obtained non-invasively by multiple-light scattering: diffuse transmission spectroscopy (DTS) and diffusing wave spectroscopy (DWS). Quantitative trends with materials parameters, most importantly average bubble size and liquid content, will be sought in order to elucidate the fundamental connection between the microscopic structure and dynamics and the macroscopic rheology.

Durian, Douglas J.↗
NASA NTRS2003

Diabatic Initialization of Mesoscale Models in the Southeastern United States: Can 0 to 12h Warm Season QPF be Improved?

It is well known that numerical warm season quantitative precipitation forecasts lack significant skill for numerous reasons. Some are related to the model--it may lack physical processes required to realistically simulate convection or the numerical algorithms and dynamics employed may not be adequate. Others are related to initialization-mesoscale features play an important role in convective initialization and atmospheric observation systems are incapable of properly depicting the three-dimensional stability structure at the mesoscale. The purpose of this study is to determine if a mesoscale model initialized with a diabatic initialization scheme can improve short-term (0 to 12h) warm season quantitative precipitation forecasts in the Southeastern United States. The Local Analysis and Prediction System (LAPS) developed at the Forecast System Laboratory is used to diabatically initialize the Pennsylvania State University/National center for Atmospheric Research (PSUNCAR) Mesoscale Model version 5 (MM5). The SPORT Center runs LAPS operationally on an hourly cycle to produce analyses on a 15 km covering the eastern 2/3 of the United States. The 20 km National Centers for Environmental Prediction (NCEP) Rapid Update Cycle analyses are used for the background fields. Standard observational data are acquired from MADIS with GOES/CRAFT Nexrad data acquired from in-house feeds. The MM5 is configured on a 140 x 140 12 km grid centered on Huntsville Alabama. Preliminary results indicate that MM5 runs initialized with LAPS produce improved 6 and 12h QPF threat scores compared with those initialized with the NCEP RUC.

Lapenta, William M.↗
NASA NTRS1997

Microgravity Foam Structure and Rheology

To exploit rheological and multiple-light scattering techniques, and ultimately microgravity conditions, in order to quantify and elucidate the unusual elastic character of foams in terms of their underlying microscopic structure and dynamics. Special interest is in determining how this elastic character vanishes, i.e. how the foam melts into a simple viscous liquid, as a function of both increasing liquid content and shear strain rate. The unusual elastic character of foams will be quantified macroscopically by measurement of the shear stress as a function of static shear strain, shear strain rate, and time following a step strain; such data will be analyzed in terms of a yield stress, a static shear modulus, and dynamical time scales. Microscopic information about bubble packing and rearrangement dynamics, from which these macroscopic non-Newtonian properties presumably arise, will be obtained non-invasively by novel multiple-light scattering diagnostics such as Diffusing-Wave Spectroscopy (DWS). Quantitative trends with materials parameters, such as average bubble size, and liquid content, will be sought in order to elucidate the fundamental connection between the microscopic structure and dynamics and the macroscopic rheology.

Durian, Douglas J.↗
NASA NTRS2021

Physics and Chemistry of Te and HgTe-based Ternary Melts

Historically, the theoretical treatment of the liquid phases has always been more difficult and complicated than that for solid and gas phases. A liquid has no lattice structure as crystalline solids and the atoms/molecules in the liquid can migrate through it relatively rapidly. On the other hand, it is also interacting with many other atoms/molecules so that the simplifications of the kinetic theory of gases cannot be employed. For more complicated liquids, such as the liquids of high ionicity and those containing hydrogen bonds and electric dipoles, the understanding is far from complete. At the same time, accurate information on the physics and chemistry of semiconductor melts is needed for the quantitative descriptions of the process of crystal growth from melt. The pre-crystallization phenomena in the liquid phase are critical because the properties of the grown crystals depend on the state and structure of the melt as well as the thermal history of the melt during solidification process. However, the data on the liquid phase, such as thermophysical properties of semiconductor melts are scarce, especially for the HgTe-based II-VI ternary compound semiconductors because of their high vapor pressure and extreme toxicity. Analysis of the thermophysical properties of the melt can provide information about structural transitions of the melt during the solidification process. From a broader point of view, the structure of liquids is much more complicated than the crystalline solids, especially the relaxation behavior through different thermal histories. The theory of hetero-phase fluctuations of liquids is applicable to any many-body systems including condensed-matter physics, field theory, physics of nuclear-matter, cosmology, biology and even sociology. This book summarizes the physics and chemistry from the experimental measurements and theoretical analyses of phase diagram, thermodynamic properties, density, thermal conductivity, viscosity, and electrical conductivity on the binary, pseudo-binary and ternary melts of the most advanced IR-detector material systems of HgCdTe and HgZnTe as well as the analyses of these results. The main objectives of this study are: (1) to provide the phase diagrams and thermodynamic properties of Hg-Cd-Te and Hg-Zn-Te systems through quantitatively fitting the experimental data by assuming an associated solution model for the liquid phase, (2) to experimentally measure the thermophysical properties of the Hg-Cd-Te and Hg-Zn-Te melts, including density, viscosity, electrical conductivity and thermal conductivity as functions of temperature and composition and (3) to enhance the fundamental knowledge of hetero-phase fluctuations and relaxation phenomena in the melts and extend our understanding of the solidification process in order to interpret the experimental results of crystal growth so as to improve the melt growth processes of the compound semiconductor. The physics and chemistry of Te and HgTe-based ternary melts were explored through the studies of the structural transformation during melting, the supercooling during solidification, the relaxation phenomena after rapid cooling of the melts and the metal-semiconductor transition in the melts through the analyses of electrical conductivity and Lorenz number. An in-depth study on the thermophysical properties and their time-dependent structural dynamic processes taking place in the vicinity of the solid-liquid phase transition of the narrow homogeneity range HgTe-based ternary semiconductors as well as the analysis of the homogenization process in the melt will also be presented.

Thermophysical properties↗
NASA NTRS1987

Computing 3-D structure of rigid objects using stereo and motion

Work performed as a step toward an intelligent automatic machine vision system for 3-D imaging is discussed. The problem considered is the quantitative 3-D reconstruction of rigid objects. Motion and stereo are the two clues considered in this system. The system basically consists of three processes: the low level process to extract image features, the middle level process to establish the correspondence in the stereo (spatial) and motion (temporal) modalities, and the high level process to compute the 3-D coordinates of the corner points by integrating the spatial and temporal correspondences.

Nguyen, Thinh V.↗
NASA NTRS2001

Quantitative Studies on the Propagation and Extinction of Near-Limit Premixed Flames under Normal- and Micro-gravity

Strained laminar flames have been systematically studied, as the understanding of their structure and dynamic behavior is of relevance to turbulent combustion.. Most of these studies have been conducted in opposed-jet, stagnation-type flow configurations. Studies at high strain rates are important in quantifying and understanding the response of vigorously burning flames and determine extinction states. Studies of weakly strained flames can be of particular interest for all stoichiometries. For example, the laminar flame speeds, S(sup o)(sub u), can be accurately determined by using the counterflow technique only if measurements are obtained at very low strain rates. Furthermore, near-limit flames are stabilized by weak strain rates. Previous studies have shown that near-limit flames are particularly sensitive to chain mechanisms, thermal radiation, and unsteadiness. The stabilization and study of weakly strained flames is complicated by the presence of buoyancy that can render the flames unstable to the point of extinction. Thus, the use of microgravity (mu-g) becomes essential in order to provide meaningful insight into this important combustion regime. In our past studies the laminar flame speeds and extinction strain rates were directly measured at ultra-low strain rates. The laminar flame speeds were measured by having a positively strained planar flame undergoing a transition to a negatively strained Bunsen flame and by measuring the propagation speed during that transition. The extinction strain rates of near-limit flames were measured in mu-g. Results obtained for CH4/air and C3H8/air mixtures are in agreement with those obtained by Maruta et al.

Egolfopoulos, F. N.↗
NASA NTRSDate not supplied

Citizen Science Approach for Searching and Curating Literature of the Effects of Spaceflight on Cardiovascular Outcomes in Rodents and Humans

The spaceflight environment causes significant changes to the structure and function of the cardiovascular system, including fluid redistribution, alterations in blood pressure, and changes in cardiac output. The goal of this project is to quantitatively summarize the data on the effects of actual or simulated microgravity and radiation exposure resulting from spaceflight on the cardiovascular system. As the first step, a group of investigators approached through a collaboration of the Ames Life Science Data Archive (ALSDA) Analysis Working Group developed a list of relevant cardiovascular search terms. Based on these, medical librarians generated and executed the search strategy in Medline, CINAHL, Embase and NASA repositories. In parallel, we recruited students and young professionals from various space industry-affiliated organizations, resulting in ~100 individuals joining. With this program we aimed to reach students and young people underrepresented in STEM, including first-generation, female, minorities, disadvantaged backgrounds, fostered individuals, etc. These individuals completed a virtual training course on the nature and methodologies of the project. Following this, the participants were structured into teams with more senior/experienced individuals designated as team leaders. Currently, the teams are screening approximately 15,000 studies using the systematic review tool, Covidence. Teams will be extracting and curating data for meta-analysis of the cardiovascular spaceflight literature, but also extracting, submitting, and curating appropriate datasets into the new ALSDA submission portal and repository. This effort will result in collaborative publications based upon the literature meta-analyses, and a number of publicly accessible datasets for reuse, modeling, machine learning, and knowledge graph-type approaches. This approach reduces the length of time to complete title/abstract screening time from 1-2 years needed for this volume of studies, to 3-4 months, while also providing a unique, open-access educational experience to space research and training in knowledge synthesis tools to interested individuals.

space biology↗
NASA NTRS1986

Control design for robust stability in linear regulators: Application to aerospace flight control

Time domain stability robustness analysis and design for linear multivariable uncertain systems with bounded uncertainties is the central theme of the research. After reviewing the recently developed upper bounds on the linear elemental (structured), time varying perturbation of an asymptotically stable linear time invariant regulator, it is shown that it is possible to further improve these bounds by employing state transformations. Then introducing a quantitative measure called the stability robustness index, a state feedback conrol design algorithm is presented for a general linear regulator problem and then specialized to the case of modal systems as well as matched systems. The extension of the algorithm to stochastic systems with Kalman filter as the state estimator is presented. Finally an algorithm for robust dynamic compensator design is presented using Parameter Optimization (PO) procedure. Applications in a aircraft control and flexible structure control are presented along with a comparison with other existing methods.

Yedavalli, R. K.↗
NASA NTRS2003

Factors Affecting the Evolution of Hurricane Erin and the Distributions of Hydrometeors: Role of Microphysical Processes

Fine-resolution simulations of Hurricane Erin 2001 are conducted using the Penn State University/National Center for Atmospheric Research mesoscale model version 3.5 to investigate the role of thermodynamic, boundary layer and microphysical processes in Erin's growth and maintenance, and their effects on the horizontal and vertical distributions of hydrometeors. Through comparison against radar, radiometer, and dropsonde data collected during the Convection and Moisture Experiment 4, it is seen that realistic simulations of Erin are obtained provided that fine resolution simulations with detailed representations of physical processes are conducted. The principle findings of the study are as follows: 1) a new iterative condensation scheme, which limits the unphysical increase of equivalent potential temperature associated with most condensation schemes, increases the horizontal size of the hurricane, decreases its maximum rainfall rate, reduces its intensity, and makes its eye more moist; 2) in general, microphysical parameterization schemes with more categories of hydrometeors produce more intense hurricanes, larger hydrometeor mixing ratios, and more intense updrafts and downdrafts; 3) the choice of coefficients describing hydrometeor fall velocities has as big of an impact on the hurricane simulations as does choice of microphysical parameterization scheme with no clear relationship between fall velocity and hurricane intensity; and 4) in order for a tropical cyclone to adequately intensify, an advanced boundary layer scheme (e.g., Burk-Thompson scheme) must be used to represent boundary layer processes. The impacts of varying simulations on the horizontal and vertical distributions of different categories of hydrometeor species, on equivalent potential temperature, and on storm updrafts and downdrafts are examined to determine how the release of latent heat feedbacks upon the structure of Erin. In general, all simulations tend to overpredict precipitation rate and hydrometeor mixing ratios. The ramifications of these findings for quantitative precipitation forecasts (QPFs) of tropical cyclones are discussed.

McFarquhar, Greg M.↗
NASA NTRS2008

Mergers of Non-spinning Black-hole Binaries: Gravitational Radiation Characteristics

We present a detailed descriptive analysis of the gravitational radiation from black-hole binary mergers of non-spinning black holes, based on numerical simulations of systems varying from equal-mass to a 6:1 mass ratio. Our primary goal is to present relatively complete information about the waveforms, including all the leading multipolar components, to interested researchers. In our analysis, we pursue the simplest physical description of the dominant features in the radiation, providing an interpretation of the waveforms in terms of an implicit rotating source. This interpretation applies uniformly to the full wavetrain, from inspiral through ringdown. We emphasize strong relationships among the l = m modes that persist through the full wavetrain. Exploring the structure of the waveforms in more detail, we conduct detailed analytic fitting of the late-time frequency evolution, identifying a key quantitative feature shared by the l = m modes among all mass-ratios. We identify relationships, with a simple interpretation in terms of the implicit rotating source, among the evolution of frequency and amplitude, which hold for the late-time radiation. These detailed relationships provide sufficient information about the late-time radiation to yield a predictive model for the late-time waveforms, an alternative to the common practice of modeling by a sum of quasinormal mode overtones. We demonstrate an application of this in a new effective-one-body-based analytic waveform model.

Baker, John G.↗
NASA NTRS2010

Tight Fits for Americas Next Moon Rocket, Ares V

America has begun the development of a new heavy lift rocket which will enable humans to return to the moon and reach even farther destinations. Five decades ago, the National Aeronautics and Space Administration designed a system (called Saturn/Apollo) to carry men to the moon and back; the rocket which boosted them to the moon was the Saturn V. Saturn V was huge relative to contemporary rockets and is still the largest rocket ever launched. The new moon rocket is called Ares V. It will insert 40% more payload into low earth orbit than Saturn V; and after docking with the crew spacecraft, it will insert 50% more payload onto the translunar trajectory than Saturn V. The current design of Ares V calls for two liquid-fueled stages and 2 "strap-on" solid rockets. The solid rockets are extended-length versions of the solid rockets used on the Shuttle. The diameter of the liquid stages is at least as large as the first stage of the Saturn V; the height of the lower liquid stage (called the core stage) is longer than the external tank of the Shuttle. Huge rockets require huge infrastructure and, during the Saturn/Apollo era, America invested significantly in manufacturing, assembly and launch facilities which are still in use today. Since the Saturn/Apollo era, America has invested in additional infrastructure for the Shuttle program. Ares V must utilize this existing infrastructure, with reasonable modifications. Building a rocket with 50% more capability in the same buildings, testing it in the same test stands, shipping on the same canals under the same bridges, assembling it in the same building, rolling it to the pad on the same crawler, and launching it from the same launch pad is an engineering and logistics challenge which goes hand-in-hand with designing the structure, tanks, turbines, engines, software, etc. necessary to carry such a large payload to earth orbit and to the moon. This paper quantitatively discusses the significant "tight fits" that are constraining Ares V. The engineers designing and building the infrastructure for the Saturn/Apollo program usually added margins and growth capability; sometimes the size of existing facilities (such as the width of a draw bridge) was not a constraint. Ares V may utilize the "extra" space in the existing facilities and expand other tight fits. Some of the tight fits cannot be overcome without great expense; raising the roof on the Vertical Assembly Building for example. Other tight fits are easily overcome; the transporter at the manufacturing facility for the core stage can pass under low ceilings and later over a dike (without dragging the middle) by retracting or extending the struts which support the stage. Tight fits discussed in this paper include manufacturing (jigs, widths, heights, and local transportation), testing (test stand sizes and crane capability), transportation to the test stands and the launch site (barge, waterway, and rail), assembly (VAB internal dimensions and door size), roll-out limits, and launch pad size.

Jaap, John↗
NASA NTRS2011

Demonstrating the Operational Value of Atmospheric Infrared Sounder (AIRS) Retrieved Profiles in the Pre-Convective Environment

The Short-term Prediction Research and Transition Center (SPoRT) is a collaborative partnership between NASA and operational forecasting partners, including a number of National Weather Service offices. SPoRT provides real-time NASA products and capabilities to its partners to address specific operational forecast challenges. One operational forecast challenge is forecasting convective weather in data-void regions such as large bodies of water (e.g. Gulf of Mexico). To address this forecast challenge, SPoRT produces a twice-daily three-dimensional analysis that blends a model first-guess from the Advanced Research Weather Research and Forecasting (WRF-ARW) model with retrieved profiles from the Atmospheric Infrared Sounder (AIRS) -- a hyperspectral sounding instrument aboard NASA's Aqua satellite that provides temperature and moisture profiles of the atmosphere. AIRS profiles are unique in that they give a three dimensional view of the atmosphere that is not available through the current rawinsonde network. AIRS has two overpass swaths across North America each day, one valid in the 0700-0900 UTC timeframe and the other in the 1900-2100 UTC timeframe. This is helpful because the rawinsonde network only has data from 0000 UTC and 1200 UTC at specific land-based locations. Comparing the AIRS analysis product with control analyses that include no AIRS data demonstrates the value of the retrieved profiles to situational awareness for the pre-convective (and convective) environment. In an attempt to verify that the AIRS analysis was a good representation of the vertical structure of the atmosphere, both the AIRS and control analyses are compared to a Rapid Update Cycle (RUC) analysis used by operational forecasters. Using guidance from operational forecasters, convective available potential energy (CAPE) was determined to be a vital variable in making convective forecasts and is used herein to demonstrate the utility of the AIRS profiles in changing the vertical thermodynamic structure of the atmosphere in the pre-convective and convective environment. CAPE is an important metric because of it is a quantitative measure of atmospheric stability, which is necessary information when forecasting for convective weather. Case studies from the summer of 2010 were examined, and most impact from the AIRS retrieved profiles occurred over the data-void Gulf of Mexico with fields of convective potential closer to the RUC than the CNTL. Mixed results were found when AIRS retrieved profiles were used over land, so more cases need to be examined to determine whether AIRS would be an effective tool over land. Additional analyses of problematic convective forecasts over the Gulf Coast will be needed to determine the operational impact of AIRS. SPoRT eventually plans to transition the AIRS product to select Weather Forecast Office (WFO) partners, pending the outcome of these additional analyses.

Kozlowski, Danielle M.↗
NASA NTRS1989

Global functions in global-local finite-element analysis of localized stresses in prismatic structures

An important consideration in the global local finite-element method (GLFEM) is the availability of global functions for the given problem. The role and mathematical requirements of these global functions in a GLFEM analysis of localized stress states in prismatic structures are discussed. A method is described for determining these global functions. Underlying this method are theorems due to Toupin and Knowles on strain energy decay rates, which are related to a quantitative expression of Saint-Venant's principle. It is mentioned that a mathematically complete set of global functions can be generated, so that any arbitrary interface condition between the finite element and global subregions can be represented. Convergence to the true behavior can be achieved with increasing global functions and finite-element degrees of freedom. Specific attention is devoted to mathematically two-dimensional and three-dimensional prismatic structures. Comments are offered on the GLFEM analysis of NASA flat panel with a discontinuous stiffener. Methods for determining global functions for other effects are also indicated, such as steady-state dynamics and bodies under initial stress.

Dong, Stanley B.↗
NASA NTRSDate not supplied

TEMPERATURE CONSTRAINT OF THE MISTASTIN LAKE IMPACT STRUCTURE IMPACT MELT ROCKS

Impact melt is a product of hypervelocity cratering events formed by the instantaneous melting of near-surface target rocks. The temperatures of impact melt upon formation are believed to be superheated, vastly exceeding the liquidus temperature of igneous rocks formed via endogenic processes. However, quantitative understanding of the formation and duration of superheated temperatures remains incomplete. To date, only one datum on the hottest post-shock temperature (>2370 °C) has been derived by Timms et al. (2017) [1]. These authors studied the microstructures and crystallographic orientations preserved within a rim of vermicular ZrO2 of a zircon grain entrained within impact glass at the Mistastin Lake impact structure, Canada. Diagnostic crystallographic orientation indicated the presence of cubic zirconia, requiring a minimum temperature for the impact melt of >2370°C from the dissociation of zircon to cubic zirconia and liquid SiO2. With only one temperature datum, it cannot be stated whether the temperature of the impact melt sheet was homogenous across the entire structure or if the thermal history of the melt varied with spatial distribution. In this study, we present a preliminary investigation of 70 zircon grains, 22 of which exhibit rims of vermicular ZrO2 dissociation textures, similar to those studied by Timms et al. (2017). To acquire a more accurate temperature profile representative of impact melt, zircon crystals were collected from different types of impact melt bearing units, including additional samples of the impact glass studied by Timms et al. (2017). Of the 22 zircon grains with dissociation textures, at least 4 grains in the impact glass show diagnostic evidence of pre-existing cubic zirconia, and 1 grain from a glass-bearing breccia exhibits granular zircon textures, possible evidence of a transition from high-P to high-T conditions. These results show the heterogeneous post-shock temperature distribution of superheated impact melt within the Mistastin impact structure. [1] Timms, N.E., Erickson, T.M., Zanetti, M.R., Pearce, M.A., Cayron, C., Cavosie, A.J., Reddy, S.M., Wittmann, A. and Carpenter, P.K., 2017. Cubic zirconia in> 2370° C impact melt records Earth's hottest crust. Earth and Planetary Science Letters, 477, pp.52-58.

rock↗
NASA NTRS2016

Martian Polar Vortices: Comparison of Reanalyses

The structure and evolution of the Martian polar vortices is examined using two recently available reanalysis systems: version 1.0 of the Mars Analysis Correction Data Assimilation (MACDA) and a preliminary version of the Ensemble Mars Atmosphere Reanalysis System (EMARS). There is quantitative agreement between the reanalyses in the lower atmosphere, where Mars Global Surveyor (MGS) Thermal Emission Spectrometer (TES) data are assimilated, but there are differences at higher altitudes reflecting differences in the free-running general circulation model simulations used in the two reanalyses. The reanalyses show similar potential vorticity (PV) structure of the vortices: There is near-uniform small PV equatorward of the core of the westerly jet, steep meridional PV gradients on the polar side of the jet core, and a maximum of PV located off of the pole. In maps of 30 sol mean PV, there is a near-continuous elliptical ring of high PV with roughly constant shape and longitudinal orientation from fall to spring. However, the shape and orientation of the vortex varies on daily time scales, and there is not a continuous ring of PV but rather a series of smaller scale coherent regions of high PV. The PV structure of the Martian polar vortices is, as has been reported before, very different from that of Earth's stratospheric polar vortices, but there are similarities with Earth's tropospheric vortices which also occur at the edge of the Hadley Cell, and have near-uniform small PV equatorward of the jet, and a large increase of PV poleward of the jet due to increased stratification.

Waugh, D. W.↗
NASA NTRS1999

Low-Temperature Oxidation Reactions and Cool Flames at Earth and Reduced Gravity

Non-isothermal studies of cool flames and low temperature oxidation reactions in unstirred closed vessels are complicated by the perturbing effects of natural convection at earth gravity. Buoyant convection due to self-heating during the course of slow reaction produces spatio-temporal variations in the thermal and thus specie concentration fields due to the Arrhenius temperature dependence of the reaction rates. Such complexities have never been quantitatively modeled and were the primary impetus for the development of CSTR's (continuously stirred tank reactors) 30 years ago. While CSTR's have been widely adopted since they offer the advantage of spatial uniformity in temperature and concentration, all gradients are necessarily destroyed along with any structure that may otherwise develop. Microgravity offers a unique environment where buoyant convection can be effectively minimized and the need for stirring eliminated. Moreover, eliminating buoyancy and the need for stirring eliminates complications associated with the induced hydrodynamic field whose influence on heat transport and hot spot formation, hence explosion limits, is not fully realized. The objective of this research is to quantitatively determine and understand the fundamental mechanisms that control the onset and evolution of low temperature reactions and cool flames in both static and flow reactors. Microgravity experiments will be conducted to obtain benchmark data on the structure (spatio-temporal temperature, concentration, flow fields), the dynamics of the chemical fronts, and the ignition diagrams (pressure vs. temperature). Ground-based experiments will be conducted to ascertain the role of buoyancy. Numerical simulations including detailed kinetics will be conducted and compared to experiment.

Pearlman, Howard↗
NASA NTRSDate not supplied

Intracranial Effects of Intermittent Lower Body Negative Pressure with Head Down Tilt Bed Rest: Comparison to Upright Posture

INTRODUCTION Spaceflight-associated neuro-ocular syndrome (SANS) affects a majority of astronauts during long-duration spaceflight. SANS is hypothesized to result from an unrelenting headward fluid shift that occurs in the microgravity environment. Altered intracranial structure and physiology documented in spaceflight and head-down tilt (HDT) experiments(1, 2) are also theorized to be related to chronic headward fluid shift and thereby can provide an independent quantitative assessment related to this mechanism. As a potential countermeasure, lower body negative pressure (LBNP) applied in the supine posture has shown efficacy in reducing headward fluid shift(3). However, it remains unknown if intermittent LBNP simulating daily upright posture fluid redistribution can mitigate SANS and intracranial changes associated with long-duration spaceflight. The goal of this study was to quantify the effects of daily application of LBNP or daily exposure to the upright posture on intracranial structure and physiology during long-term HDT in order to evaluate the potential efficacy of LBNP as a countermeasure to SANS. METHODS 22 healthy volunteers (11 men; 11 women; mean age = 35 years (SD=9.2)(age range = 24 to 52 years); mean BMI = 24.0 kg/m2 (SD=2.8)) completed an MRI study performed at the German Aerospace Facility in Cologne, Germany. Strict six-degree head-down tilt (HDT) bedrest was used as a spaceflight analog to induce a continuous headward fluid shift for 30 days. The subjects were divided equally into two groups of interventions: 1) LBNP for 3-hour sessions twice daily and 2) seated position for 3-hour sessions twice daily. Interventions were divided into morning and afternoon sessions for both groups. The LBNP intervention was maintained at 25 mmHg  2 mmHg. Pulse-gated MRI phase-contrast flow imaging was used to quantify cerebral artery stroke volume (CASV) and peak-to-peak cerebral spinal fluid (CSF) velocity (CSFVp-p) within the cerebral aqueduct. A 3D T1-MPRAGE sequence was used to quantify volumetric changes of the brain and intracranial CSF spaces using MRI Cloud software. MRI acquisitions were obtained at baseline (BDC, supine posture), 15 days into HDT (HDT15), 29 days into HDT (HDT29), and 12 days after recovery (R12, supine posture). The data were analyzed by a mixed model, which included intervention, time (four nominal levels BDC, HDT15, HDT29, R12), and intervention-time interaction as the fixed effects and included subject as a random effect. RESULTS Compared to BDC there was no statistically significant difference in CASV and CSFVp-p during HDT except for CASV at HDT29 (seated group) where there was a 1.7 mL (12%) decrease (P<0.01). Compared to BDC there was a statistically significant increase in intracranial volume (ICV; ICV = white matter + gray matter + CSF) for both interventions at HDT15 (Δ13 mL, 0.9 % (LBNP group); Δ15 mL, 1.0%, (seated group)) and HDT29 (Δ19 mL, 1.2%, (LBNP group); Δ23 mL, 1.5%) (seated group)) (All Ps<.001). Compared to baseline, lateral ventricular volume increased at HDT15 (Δ0.9 mL, 5.5%) and HDT29 (Δ1.8 mL, 10%)) for LBNP only (P=.001 for each). During HDT, white matter volume remained stable compared to baseline for both interventions. There were no significant intervention effects in the overall response to HDT (All Ps >.2). CONCLUSION LBNP had a similar response to the seated posture during 29 days of HDT. Although there was an increase in ICV and lateral ventricular volume with HDT there was no change in intracranial physiological parameters with LBNP suggesting an overall diminished response to the long-term effects of HDT. The lack of any significant increase in white matter volume during HDT with LBNP suggests maintenance of cerebral interstitial fluid transport. Final conclusions are pending the data collection for the control group (no intervention) which will be completed in 2023.

Larry A Kramer↗