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At least 487 records · Page 27

RADAI: A Large-Scale Realistic Dataset for Radiation Detection Algorithm Development

Open, realistic datasets are essential for developing and benchmarking radiation detection algorithms, yet they remain scarce. The Radiological Anomaly Detection and Identification (RADAI) project was develop to create datasets that meet the training and testing needs for sophisticated radiation detection algorithms. The RADAI dataset is a large-scale synthetic resource that integrates high-fidelity Monte Carlo simulations with realistic urban scenarios to capture both background variability and source signatures. RADAI models construction-material NORM, people and vehicles, urban clutter, and dynamic environmental effects such as cosmic-ray and rain-induced transients, and they provide list-mode detector data with motion and response modeling suitable for algorithm training and evaluation. The RADAI project resulted in three publicly-released complementary datasets together with an online scoring portal for standardized performance assessment and an open software toolkit that supports data access, augmentation, model development, and evaluation. These resources enable reproducible comparisons across methods and promote rigorous studies at the scale required by contemporary machine learning. By grounding algorithm development in realistic, well-documented conditions, RADAI supports progress toward more robust detection, identification, and localization in complex urban environments.

Ghawaly, James M. [Division of Computer Science an↗

Sustainable Development Tool Using Meta‐Analysis and DPSIR Framework — Application to Savannah River Basin, U.S.

Abstract The Savannah River Basin (SRB), a highly stressed southeastern river in United States is a conservation priority for State, Federal government, and nongovernment organizations. A four‐stage sustainable development tool was developed in this study using meta‐analysis and the drivers–pressures–state–impacts–responses (DPSIR) framework. Through the synthesis of ~150 references in the SRB this study addressed three research questions: (1) What were the drivers, pressures, state, impacts, and responses (components of DRSIR framework) in SRB (2) Can these components be grouped together from various studies in SRB (3) Can causal chain/loops be developed, and will they be useful for policy and decision making? First in the Stage 1, the state of the SRB was represented (S component of DPSIR), in Stage 2, the drivers–pressures–impacts–responses (DPIR components of DPSIR) were represented, in the third stage (Stage 3) the common units characterizing each DPSIR component were identified. Finally, in Stage 4, the causal chains/loops were developed and organized into scientific research at a level appropriate for building better understanding about SRB and helping stakeholders and policy makers in managing basin sustainability challenges. Although the tool was applied to SRB, the methodology is applicable to other river basins and ecosystems.

Pagan, Janeesa↗

Expression quantitative trait loci mapping identified PtrXB38 as a key hub gene in adventitious root development in Populus

Summary Plant establishment requires the formation and development of an extensive root system with architecture modulated by complex genetic networks. Here, we report the identification of the PtrXB38 gene as an expression quantitative trait loci (eQTL) hotspot, mapped using 390 leaf and 444 xylem Populus trichocarpa transcriptomes. Among predicted targets of this trans ‐eQTL were genes involved in plant hormone responses and root development. Overexpression of PtrXB38 in Populus led to significant increases in callusing and formation of both stem‐born roots and base‐born adventitious roots. Omics studies revealed that genes and proteins controlling auxin transport and signaling were involved in PtrXB38‐mediated adventitious root formation. Protein–protein interaction assays indicated that PtrXB38 interacts with components of endosomal sorting complexes required for transport machinery, implying that PtrXB38‐regulated root development may be mediated by regulating endocytosis pathway. Taken together, this work identified a crucial root development regulator and sheds light on the discovery of other plant developmental regulators through combining eQTL mapping and omics approaches.

54 ENVIRONMENTAL SCIENCES↗

Review—Development of Highly Active and Durable Hybrid Compressive Platinum Lattice Catalysts for Polymer Electrolyte Membrane Fuel Cells: Mathematical Modeling and Experimental Work

This review provides a comprehensive overview on the development of highly active and durable platinum catalysts with ultra-low Pt loadings for polymer electrolyte membrane fuel cells (PEMFCs) through a combined mathematical modeling and experimental work. First, simulation techniques were applied to evaluate the validity of the Tafel approximation for the calculation of the mass activity (MA) and specific activity (SA). A one-dimensional agglomeration model was developed and solved to understand the effects of exchange current density, porosity, agglomerate size, Nafion ® film thickness, and Pt loading on the MA and SA. High porosity (> 60%) and agglomerations at high Pt loadings cause the loss of the Tafel approximation and consequently the decrease in MA and SA. A new structure parameter was introduced to estimate the real porous structure using the fractal theory. The volumetric catalyst density was corrected by the fractal dimension (measured by Hg porosimetry), which gave a good agreement with the experimental values. The loading-dependent Tafel equation was then derived, which contains both the utilization and the non-linear scaling factor. Second, activated carbon composite support (ACCS) with optimized surface area, porosity, pore size, and pore size distribution was developed. The hydrophilic/hydrophobic ratio, structural properties (amorphous/crystalline ratio), and the number of active sites were optimized through metal-catalyzed pyrolysis. Stability of ACCS and Pt/ACCS were evaluated using an accelerated stress test (AST). The results indicated that Pt/ACCS showed no significant loss of MA and power density after 5,000 cycles at 1.0–1.5 V, while the commercial Pt/C catalysts showed drastic losses of MA and power density. Finally, monolayers of compressed Pt (core–shell-type Pt 3 Co 1 ) catalysts were structured by diffusing Co atoms (previously embedded in ACCS) into Pt. Compressive Pt lattice (Pt * ) catalysts were synthesized through an annealing procedure developed at the University of South Carolina (USC). The Pt * /ACCS catalyst showed high initial power density (rated) of 0.174 g Pt kW −1 and high stability (24 mV loss) at 0.8 A cm −2 after 30,000 cycles (0.6–1.0 V). The outstanding performance of Pt * /ACCS is due to the synergistic effect of ACCS and compressive Pt * lattice.

25 ENERGY STORAGE↗

The Prediction Model of Risk Factors for COVID-19 Developing into Severe Illness Based on 1046 Patients with COVID-19

This study analyzed the risk factors for patients with COVID-19 developing severe illnesses and explored the value of applying the logistic model combined with ROC curve analysis to predict the risk of severe illnesses at COVID-19 patients’ admissions. The clinical data of 1046 COVID-19 patients admitted to a designated hospital in a certain city from July to September 2020 were retrospectively analyzed, the clinical characteristics of the patients were collected, and a multivariate unconditional logistic regression analysis was used to determine the risk factors for severe illnesses in COVID-19 patients during hospitalization. Based on the analysis results, a prediction model for severe conditions and the ROC curve were constructed, and the predictive value of the model was assessed. Logistic regression analysis showed that age (OR = 3.257, 95% CI 10.466–18.584), complications with chronic obstructive pulmonary disease (OR = 7.337, 95% CI 0.227–87.021), cough (OR = 5517, 95% CI 0.258–65.024), and venous thrombosis (OR = 7322, 95% CI 0.278–95.020) were risk factors for COVID-19 patients developing severe conditions during hospitalization. When complications were not taken into consideration, COVID-19 patients’ ages, number of diseases, and underlying diseases were risk factors influencing the development of severe illnesses. The ROC curve analysis results showed that the AUC that predicted the severity of COVID-19 patients at admission was 0.943, the optimal threshold was −3.24, and the specificity was 0.824, while the sensitivity was 0.827. The changes in the condition of severe COVID-19 patients are related to many factors such as age, clinical symptoms, and underlying diseases. This study has a certain value in predicting COVID-19 patients that develop from mild to severe conditions, and this prediction model is a useful tool in the quick prediction of the changes in patients’ conditions and providing early intervention for those with risk factors.

Lian, Zhichuang↗

Analysis of the first ten years of FDA’s rare pediatric disease priority review voucher program: designations, diseases, and drug development

Abstract Background The Rare Pediatric Disease (RPD) Priority Review Voucher (PRV) Program was enacted in 2012 to support the development of new products for children. Prior to requesting a voucher, applicants can request RPD designation, which confirms their product treats or prevents a rare disease in which the serious manifestations primarily affect children. This study describes the trends and characteristics of these designations. Details of RPD designations are not publicly disclosable; this research represents the first analysis of the RPD designation component of the program. Results We used an internal US Food and Drug Administration database to analyze all RPD designations between 2013 and 2022. Multiple characteristics were analyzed, including the diseases targeted by RPD designation, whether the product targeted a neonatal disease, product type (drug/biologic), and the level of evidence (preclinical/clinical) to support designation. There were 569 RPD designations during the study period. The top therapeutic areas were neurology (26%, n = 149), metabolism (23%, n = 131), oncology (18%, n = 105). The top diseases targeted by RPD designation were Duchenne muscular dystrophy, neuroblastoma, and sickle cell disease. Neonatology products represented 6% (n = 33), over half were for drug products and 38% were supported by clinical data. Conclusions The RPD PRV program was created to encourage development of new products for children. The results of this study establish that a wide range of diseases have seen development—from rare pediatric cancers to rare genetic disorders. Continued support of product development for children with rare diseases is needed to find treatments for all children with unmet needs.

Mease, Catherine (ORCID:000900050156198X)↗

Development of genetic tools for the thermophilic filamentous fungus Thermoascus aurantiacus

Abstract Background Fungal enzymes are vital for industrial biotechnology, including the conversion of plant biomass to biofuels and bio-based chemicals. In recent years, there is increasing interest in using enzymes from thermophilic fungi, which often have higher reaction rates and thermal tolerance compared to currently used fungal enzymes. The thermophilic filamentous fungus Thermoascus aurantiacus produces large amounts of highly thermostable plant cell wall-degrading enzymes. However, no genetic tools have yet been developed for this fungus, which prevents strain engineering efforts. The goal of this study was to develop strain engineering tools such as a transformation system, a CRISPR/Cas9 gene editing system and a sexual crossing protocol to improve the enzyme production. Results Here, we report Agrobacterium tumefaciens -mediated transformation (ATMT) of T. aurantiacus using the hph marker gene, conferring resistance to hygromycin B. The newly developed transformation protocol was optimized and used to integrate an expression cassette of the transcriptional xylanase regulator xlnR , which led to up to 500% increased xylanase activity. Furthermore, a CRISPR/Cas9 gene editing system was established in this fungus, and two different gRNAs were tested to delete the pyrG orthologue with 10% and 35% deletion efficiency, respectively. Lastly, a sexual crossing protocol was established using a hygromycin B- and a 5-fluoroorotic acid-resistant parent strain. Crossing and isolation of progeny on selective media were completed in a week. Conclusion The genetic tools developed for T. aurantiacus can now be used individually or in combination to further improve thermostable enzyme production by this fungus.

09 BIOMASS FUELS↗

An Agile/XP software development process for modernizing the accelerator control system at Fermilab

Fermilab is undergoing the most ambitious upgrade to its accelerator control system of the 21st century. As part of the ACORN project, hundreds of legacy control system applications written in C/C++ will be re-imagined and developed from the ground up. In addition, applications to support Fermilab’s new super-conducting linear accelerator are already under construction. To manage the development of modern controls applications, the Controls department has adopted an Agile software development process based on eXtreme Programming. In this paper we will describe our process and detail our experience applying it to the development of two case studies.

Diamond, John [Fermilab]↗

Developments in commercial scale farming of microalgae and seaweeds

Expanding markets for microalgae and macroalgae products have led to increased development of commercial farming operations. While microalgae and macroalgae, or seaweed, have historically been harvested in many parts of globe, more recent developments seek to improve productivity, decrease production costs, increase scale, and mitigate environmental impacts of cultivation. Furthermore, this chapter highlights some of those recent developments and identifies future focus areas for research and development.

09 BIOMASS FUELS↗

Northstar Technology Transfer and Facility Development Work Package FY19 Summary Report

Northstar is rapidly advancing toward a Mo99 production facility. This will be a demonstration and technology development or proof-of-concept facility comprised of 1 target station. The target will be 2 sided, irradiated by 2 rhodotrons. Diagrams of the facility are included in this report. LANL has provided support in FY19 on many components and systems toward the realization of this facility. Besides providing the documentation and lessons learned from years of concept development and tests of targets and other subsystems, specific development work was provided in a number of areas, including bulk and local shielding, target insertion and removal, facility layout, and target holder development. These will be discussed in some detail.

43 PARTICLE ACCELERATORS↗

Development of MGMC: A proxy Multi-Group Monte Carlo Particle Transport Application

This document details the development and current state of MGMC: a proxy Multi-Group Monte Carlo transport application. The goal of this work was to develop a light-weight Monte Carlo transport solver that could be easily reconfigured to test parallelization strategies targeting advanced architectures and heterogeneous computing environments. Additionally, MGMC is able to act as a proxy-app for testing the development of algorithms and the integration of other libraries and into Monte Carlo transport codes. MGMC is currently able to run in parallel using OpenMP for CPU threads or CUDA for NVIDIA GPUs. MGMC was also used to investigate the using SYCL for portable parallelization targeting either CPU threads, vender-agnostic GPUs, and ARM chips, detailed in Section II. In the process of developing MGMC, several other C++ libraries have been created with the intent for re-use in future research projects and potential inclusion in production-level codes, detailed in Section III. The physics capabilities in MGMC are detailed in Section IV, code verification is detailed in Section V, and performance results are detailed in Section VI.

97 MATHEMATICS AND COMPUTING↗

Advancing Scientific Productivity through Better Scientific Software: Developer Productivity and Software Sustainability Report

The Exascale Computing Project (ECP) provides a unique opportunity to advance computational science and engineering (CSE) through an accelerated growth phase in extreme-scale computing. Central to the project is the development of next-generation applications and software technologies that can exploit emerging architectures for optimal performance and provide high-fidelity, multiphysics, multiscale capabilities. However, disruptive changes in computer architectures and the complexities of tackling new frontiers in extreme-scale modeling, simulation, and analysis present daunting challenges to the productivity of software developers and the sustainability of software artifacts. Members of the CSE community - especially at extreme scales but more broadly at all scales of computing - face an urgent need to improve developer productivity, positively impacting product quality, development time, and staffing resources, and software sustainability, reducing the cost of maintaining, sustaining, and evolving software capabilities.

97 MATHEMATICS AND COMPUTING↗

Glycolate Analysis in Tank 22: Developing and Testing Analytical Methods for the Savannah River Site Liquid Waste System

Researchers developed and tested a range of techniques to support a low mg/L Limit of Quantitation (LOQ) of glycolate in radioactive Tank 22 waste solution by Ion Chromatography (IC) and by proton NMR. For the IC method, Dionex OnGuard II cartridges were tested as a means of removing alkali earth and transition metals that can interfere during ion chromatography applications especially when analyzing for low-concentration, chelating analytes. Additionally, concentrations of nitrate in the raw Tank 22 sample (5,000 to 10,000 mg/L) were managed by using reasonable levels of sample dilution. The resulting IC performance quality was enhanced by improving the baseline, increasing sensitivity [Limit of Quantitation (LOQ) of 12 mg/L and Limit of Detection (LOD) of 4.0 mg/L], and resolving analytes into well-defined Gaussian peaks when using the Dionex OnGuard II H⁺ cartridges to remove matrix interferences. High concentrations of nitrate limited the performance of the IC method. To achieve an acceptable baseline, samples with high nitrate content require more dilution, resulting in higher detection limits. Tests on samples with higher concentrations of nitrate (Tank 30 and 32 supernate with approximately 150000 mg/L nitrate) suggested that IC detection limits for glycolate in these samples would be > 500 mg/L. Thus, an LOQ of 12 mg/L is not feasible by this IC method on evaporator feed samples. An alternative method of glycolate analysis, using proton nuclear magnetic resonance (H NMR), was developed by the research team. In initial tests, the H NMR technique provided reasonable quantitation of glycolate in Tank 22 conditions by direct observation of the liquid. The H NMR method may provide improved detection limits for solutions with higher nitrate concentrations. We recommend further development of this analysis for high nitrate LWS samples such as evaporator feed and evaporator drop tank content. A method for pretreatment of samples using crystalline silicotitanate (CST) was developed and tested. The objective of the pretreatment was to facilitate analysis of samples with higher levels of radioactivity. The pretreatment did not influence the glycolate concentration in solution, and the pretreatment is projected to reduce Cs 137 activity in a sample by a factor of 16,200. The double strike CST pretreatment was demonstrated and would allow milliliters of higher activity samples to be transferred from the Shielded Cells and handled in a containment unit for glycolate analysis. The various studies validated IC and H NMR methods for glycolate analysis, defined the range of applicability, and demonstrated key supporting analytical protocols. Based on the results, high quality glycolate analysis of Tank 22 is feasible down to approximately 12 mg/L, with the potential for broader applicability of the methods to other conditions in the Savannah River Site Liquid Waste System (LWS).

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Development of Spouting Bed Reactor for Reduction of Hematite to Magnetite (Final Report)

This project was designed to leverage both past and current technology development efforts and utilize the expertise of the National Energy Technology Laboratory (NETL) in a collaborative effort with SIOX for the development of a spouting bed reactor to produce magnetite from very fine hematite waste. More specifically, the effort involved the conversion of a steel manufacturing byproduct, iron oxide hematite (Fe 2 O 3 ), and reduces it chemically into a salable magnetite product applicable to a number of markets. SIOX previously operated a magnetite batch production facility based on a rotary kiln reactor process. Unfortunately, that process was both costly and inefficient, making it difficult to achieve desired economies, purity, and throughput levels. NETL’s technology, developed in this work, replaced the batch inefficient rotary kiln with a continuous spouting bed reactor capable of producing synthetic magnetite products. In the project, NETL was to develop the spouting bed for the SIOX application and SIOX was to construct and operate a fully integrated pilot scale demonstration plant. NETL successfully completed its tasks, but SIOX due to financial issues was not able to complete their tasks. They have chosen not to participate in this final report so for their tasks a short summary of NETL’s knowledge of their efforts is included.

36 MATERIALS SCIENCE↗

FIU Project 3: Waste and D&D Engineering and Technology Development [Slides]

This project focuses on delivering solutions under deactivation and decommissioning (D&D) in support of DOE EM-4.11 as well as IT development for environmental applications (KM-IT for EM-4.11) and waste & material management (WIMS for EM-4.22). All technology development related activities will also engage the Office of Technology Development (EM-3.2). This work is also relevant to infrastructure management activities being carried out at DOE sites such as Oak Ridge, Savannah River, Hanford, Idaho and Portsmouth. As appropriate and within the parameters of the DOE-FIU Cooperative Agreement (CA), coordination at the proper level will occur with the sites and national laboratories involved in the project research efforts as well as with the points-of-contact at DOE HQ (e.g., HQ Project Leads, HQ Field Liaisons, Office of Technology Development, CA Technical Monitor, COR, etc.).

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗

Development of National New Construction Weighting Factors for the Commercial Building Prototype Analyses (2003-2018)

The U.S. Department of Energy (DOE), Office of Building Technologies tasked Pacific Northwest National Laboratory to develop construction weights for various commercial building categories for the purpose of estimating weighted national energy savings from the development of ANSI/ASHRAE/IESNA Standard 90.1-2019 compared to ANSI/ASHRAE/IESNA Standard 90.1-2016. Disaggregate construction volume data was acquired from the McGraw Hill Construction Database for the years 2003-2018 and analyzed to develop detailed construction weights by climate zones, subzones and by states. These weights are provided in this report and will be subsequently used in developing a weighted national energy savings estimate for the impact of the 2019 standard. For the current update, PNNL reviewed the same data source with the latest construction data for the years 2003-2018.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

FY2020 Fourth Quarter Performance Metric: Evaluate Improvement in Simulations of Mesoscale Convective Systems from New Parameterization Developments in E3SM

Mesoscale convective systems (MCSs) consist of an assembly of cumulonimbus clouds on scales of 100 km or more and produce mesoscale circulations (Houze, 2004, 2018). As the largest form of deep convective storms, MCSs contribute to 30% – 70% of annual and warm season rainfall in the U.S. and in the global tropics (Houze 2018; Stevenson & Schumacher, 2014; Feng et al., 2019; Haberlie & Ashley, 2019). Since MCSs contribute importantly to mean and extreme precipitation in the U.S. and many other regions around the world, understanding how well they are simulated by E3SM may guide future development towards more skillful modeling of convective storms and associated hydrologic impacts. The FY2020 Second Quarter Performance Metric Report documented comparisons of MCSs in the central and eastern U.S. in a high-resolution simulation produced by E3SM v1 at 25 km resolution (Caldwell et al. 2019) with observations. MCSs in the simulation occur less frequently and produce less intense precipitation, resulting in large underestimation of MCS volumetric rain-rate compared to observations. The first and third quarter performance metric report indicated that these model biases in simulating MCSs can be attributed to model limitations in parameterizing convection, clouds, and other related processes, as well as model biases in simulating the MCS large-scale environment. In the current FY2020 Fourth Quarter Performance Metric Report, we evaluate MCSs simulated in E3SM with several new developments in convection parameterizations that are being developed for its next generation. The goal is to summarize what have been improved with the new developments and highlight what need more work in the future.

54 ENVIRONMENTAL SCIENCES↗

Cooperative Research and Development Agreement (CRADA) NFE-18-07194 with TerraPower LLC (Final Report)

Because of the potential economic and safety benefits of the molten salt reactor (MSR) concept, development of several designs has been initiated around the world over the past decade. New international nuclear safeguards needs and verification challenges are likely to arise because of the commercial interests in MSRs and the number of MSR design variants. As a result, work was undertaken to explore the cross-cutting issues specific to the application of international nuclear safeguards (i.e., safeguards) to liquid-fueled molten salt reactors (LFMSRs). Through a public-private partnership, a report was developed that focuses on the TerraPower Molten Chloride Fast Reactor (MCFR) design that has received a funding award from the US Department of Energy (DOE), Office of Nuclear Energy. The report is intended to provide a preliminary analysis for a safeguards-by-design (SBD) effort to inform designers about how safeguards could be applied to LFMSRs by the International Atomic Energy Agency (IAEA).Although the report specifically focuses on the TerraPower design, the conclusions are applicable to the main design features of LFMSRs and can be used to extrapolate how existing IAEA safeguards measures for other fuel cycle facilities can be appropriately applied or modified. The report evaluates the appropriate safeguards approaches for LFMSRs, presents existing safeguards inspection technologies are still valid for LFMSRs, and identifies new challenges that will require novel measurement instruments to meet verification standards of the IAEA and the international safeguards regime. This document summarizes the results of the work performed under the full report developed as part of the Cooperative Research and Development Agreement (CRADA). This summary does not contain any protected CRADA information and is intended for public release.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗