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At least 487 records · Page 27

Skeletal muscle satellite cells

Evidence now suggests that satellite cells constitute a class of myogenic cells that differ distinctly from other embryonic myoblasts. Satellite cells arise from somites and first appear as a distinct myoblast type well before birth. Satellite cells from different muscles cannot be functionally distinguished from one another and are able to provide nuclei to all fibers without regard to phenotype. Thus, it is difficult to ascribe any significant function to establishing or stabilizing fiber type, even during regeneration. Within a muscle, satellite cells exhibit marked heterogeneity with respect to their proliferative behavior. The satellite cell population on a fiber can be partitioned into those that function as stem cells and those which are readily available for fusion. Recent studies have shown that the cells are not simply spindle shaped, but are very diverse in their morphology and have multiple branches emanating from the poles of the cells. This finding is consistent with other studies indicating that the cells have the capacity for extensive migration within, and perhaps between, muscles. Complexity of cell shape usually reflects increased cytoplasmic volume and organelles including a well developed Golgi, and is usually associated with growing postnatal muscle or muscles undergoing some form of induced adaptive change or repair. The appearance of activated satellite cells suggests some function of the cells in the adaptive process through elaboration and secretion of a product. Significant advances have been made in determining the potential secretion products that satellite cells make. The manner in which satellite cell proliferative and fusion behavior is controlled has also been studied. There seems to be little doubt that cellcell coupling is not how satellite cells and myofibers communicate. Rather satellite cell regulation is through a number of potential growth factors that arise from a number of sources. Critical to the understanding of this form of control is to determine which of the many growth factors that can alter satellite cell behavior in vitro are at work in vivo. Little work has been done to determine what controls are at work after a regeneration response has been initiated. It seems likely that, after injury, growth factors are liberated through proteolytic activity and initiate an activation process whereby cells enter into a proliferative phase. After myofibers are formed, it also seems likely that satellite cell behavior is regulated through diffusible factors arising from the fibers rather than continuous control by circulating factors.(ABSTRACT TRUNCATED AT 400 WORDS).

NASA Program Space Biology↗

Preparation of Proton Exchange Membranes and Lithium Batteries from Melamine-containing Ormosils

Our laboratory has recently reported a series of rodcoil polymers for lithium batteries that display dimensionally stable films with good ionic conductivity. The rod segments consist of rigid linear and branched polyimides and the coil segments are polyethylene oxides (PEO). It has been proposed that good mechanical and transport properties are due to phase separation between the rod and coil segments. It was also observed that increased branching and molecular weight lead to increased conductivity. The following study was undertaken to assess the effects of phase separation in polyalkylene oxides connected by melamine linkages. Melamine was chosen as the linking unit because it provides a branching site, cation binding sites to help ionic transport between polymer chains, and the opportunity for self assembly through hydrogen bonding. Polymers were made by the reaction of cyanuric chloride with a series of amine-terminated alkylene oxides. A linear polymer was first made, followed by reaction of the third site on cyanuric chloride with varying ratios of monofunctional Jeffamine and (3-aminopropyl)triethoxysilane. The lithium trifluoromethane sulfonamide-doped polymers are then crosslinked through a sol-gel process to form free-standing films. Initial results have shown mechanically strong films with lithium conductivities on the order of 2 x 10(exp -5) S/cm at ambient temperature. In a separate study, organically modified silanes (Ormosils) that contain sulfonic acid derivatized melamines have been incorporated into proton exchange membranes. The membranes are made by reaction of the primary amine groups of various ratios of melamine derivative and difunctional Jeffamine (MW = 2000) with the epoxide group of (3-Glycidyloxypropyl)trimethoxysilane. The films were then cross-linked through a sol-gel process. Resulting sulfuric acid doped films are strong, flexible, and have proton conductivities on the order of 2 x l0(exp -2) S/cm (120 C, 25% relative humidity). Our best results have been observed when films contain 60% PEO and 40% sulfonated melamine.

Tigelaar, Dean M.↗

Polarimetric radar measurements of a forested area near Mt. Shasta

The authors present the results of an experiment using the NASA/JPL DC-8 AIRSAR (aircraft synthetic-aperture radar) over a coniferous forest near Mt. Shasta (California) in 1989. Calibration devices were deployed in clearings and under the forest canopy and passes at 20, 40, and 55 deg incidence angles were made with the AIRSAR. A total of eight images at differing incidence angles have been processed and calibrated. The multipolarization, multifrequency data were examined, and it was found that the C-band cross section averaged over like and cross polarizations is the best parameter for distinguishing between two stands with differing forest biomass. The average cross section at P- and L-bands is useful only for smaller incidence angles. Parameters describing the polarization behavior of the scattering were primarily useful in identifying the dominant scattering mechanisms for forest backscatter. It was found that both branch scattering and ground/tree interactions are important at P-band. At L-band and C-bands, the return is primarily from the canopy. Comparison with model calculations verified this conclusion.

Durden, Stephen L.↗

Responses of Precipitation and Hydrologic Processes to Tropical SST

The goal of the research is to identify the mechanisms in the response of tropical precipitation and atmospheric hydrologic cycle to sea surface temperature (SST) variability at seasonal-to-interannual time scales, and to utilize the knowledge for better understanding of climate feedback processes relevant to global change. As a first step to achieve the goal, we characterize the inter-relationship among convective/stratiform rain, ice/water clouds water vapor, and SST using TRMM satellite data and a cloud-resolving model. We examined the daily hydrologic variables [column water vapor (PW), cloud liquid water (CW), rainfall rates (RR)] as a function of SST using high-resolution data (0.25 x 0.25, daily) derived from TRMM satellite measurements. Comparing the winter of 97/98 (El Nino condition) against the winter of 99/00 (La Nina condition), area-mean values of all four hydrologic variables in cloudy areas within the tropical Pacific are higher in the El Nino winter than in the La Nina winter. This is consistent with previous observational analyses and SST warming experiments (idealized or ENSO-like) that showed the interaction between hydrologic cyclic and radiation at the seasonal to interannual time scales leads to intensified tropical circulation and hydrologic cycle. However, there is evidence that the enhanced hydrologic cycle over the warm pool is accompanied by an expansion of radiatively -driven subsidence in response to a stronger SST gradient between warm pool and surrounding cold pool. The expanding subsidence effectively reduces cloud amounts over the warm pool. Our analysis of daily variability further indicates a more vigorous water cycle characterized by higher PW, CW, and RR in response to overall warming. This is expected from the Clausius Clapeyron relation as a thermodynamic response to warming. However cloudy areas decrease in response to overall warming. This may be due to factors that are fundamentally different. One possibility is that in a warmer climate, there may be alteration in the microphysical processes in clouds, e.g., increased coalescence of cloud size droplets and increased entrainment of dry air from above due to the invigorated convective motions in response to overall warming. As a result, cloud amounts are less. Another interpretation is that, in colder air masses, more ice particles will be produced and, because of their lower densities, are less likely to precipitate, hence the higher cloud amount. This suggests that, when averaged over a sufficiently large area covering both the rising and sinking branches of the tropical circulation, there maybe an increase in the precipitation efficiency in stratiform clouds, in conjunction with increased subsidence in an enhanced water cycle. This is supported by the residence time at different rainrates.

Sui, C.-H.↗

Flywheel Technology

Throughout the summer of 2004, I am working on a number of different projects. While located in the Space Power and Propulsion Test Engineering branch, my main area of study is flywheel technology. I have been exposed to flywheels, their components, and their uses in today's society. I have been able to experience numerous flywheels here in the flywheel lab at NASA Glenn. My first main project was to explore the attributes and physical characteristics of a flywheel. Our branch was constructing a flywheel demonstration to be presented at the public open house taking place in June. Our Flywheel Interactive Demo, or FIDO, represents a real life multi-flywheel system here at NASA. I was given the opportunity to learn about how these flywheels store energy and are able to position a satellite. With all of this new knowledge, I was able to create the posters that explained how our demonstration worked. I also composed a step-by-step process made up of four experiments that any visitor could follow and perform on FIDO. By stepping through these experiments, the individual learns how a flywheel works. They not only read the explanation of what is happening, but they are also able to see it happen. Creating these two posters not only taught me, but also helped teach the general public during the open house, how flywheel technology is a very important part of our future. Through my research, I have learned that flywheels are able to store massive amounts of energy. They can be described as an electro-mechanical battery that stores kinetic energy while rotating. The faster it rotates, the more energy it stores. Their lifetime is about triple that of an ordinary battery. Flywheels also have the ability to combine energy storage with attitude control all in a single system. Attitude control is the ability to position a satellite as required. FIDO helps us to understand the rotational force (torque) that is applied upon a turn-table or satellite during wheel acceleration/deceleration. My other main project that I have just begun is to create a flywheel presentation, brochure, and video all explaining the history, applications, early attempts, and working processes of modem flywheels. These items are all usefull tools for educating school children and even adults about flywheels. This task will require a large amount of research and skills in the use of multiple applications. My goal this summer is to learn the dynamics and uses of a flywheel in today s society, and then inform and encourage the public about flywheels. I am able to express my knowledge by creating some effective as well as attractive posters, presentations, brochures, videos, etc. that are able to explain how a flywheel works along with how our FIDO demonstration simulates a real flywheel. My goal is underway, and should be successfully reached with the help of my mentor, other coworkers, and fellow interns.

Ritchie, Lisa M.↗

Software Engineering Improvement Plan

In performance of this task order, bd Systems personnel provided support to the Flight Software Branch and the Software Working Group through multiple tasks related to software engineering improvement and to activities of the independent Technical Authority (iTA) Discipline Technical Warrant Holder (DTWH) for software engineering. To ensure that the products, comments, and recommendations complied with customer requirements and the statement of work, bd Systems personnel maintained close coordination with the customer. These personnel performed work in areas such as update of agency requirements and directives database, software effort estimation, software problem reports, a web-based process asset library, miscellaneous documentation review, software system requirements, issue tracking software survey, systems engineering NPR, and project-related reviews. This report contains a summary of the work performed and the accomplishments in each of these areas.

Source record↗

Laser Pulse Production for NASA's Global Ecosystem Dynamics Investigation (GEDI) Lidar

The Lasers and Electro-Optics Branch at Goddard Space Flight Center has been tasked with building the Lasers for the Global Ecosystems Dynamics Investigation (GEDI) Lidar Mission, to be installed on the Japanese Experiment Module (JEM) on the International Space Station (ISS). GEDI will use three NASA-developed lasers, each coupled with a Beam Dithering Unit (BDU) to produce three sets of staggered footprints on the Earth's surface to accurately measure global biomass. We will report on the design, assembly progress, test results, and delivery process of this laser system.

Laser Oscillator↗

Confessions of a robot lobotomist

Since its inception, numerically controlled (NC) machining methods have been used throughout the aerospace industry to mill, drill, and turn complex shapes by sequentially stepping through motion programs. However, the recent demand for more precision, faster feeds, exotic sensors, and branching execution have existing computer numerical control (CNC) and distributed numerical control (DNC) systems running at maximum controller capacity. Typical disadvantages of current CNC's include fixed memory capacities, limited communication ports, and the use of multiple control languages. The need to tailor CNC's to meet specific applications, whether it be expanded memory, additional communications, or integrated vision, often requires replacing the original controller supplied with the commercial machine tool with a more powerful and capable system. This paper briefly describes the process and equipment requirements for new controllers and their evolutionary implementation in an aerospace environment. The process of controller retrofit with currently available machines is examined, along with several case studies and their computational and architectural implications.

Gottshall, R. Marc↗

Corrosive Space Gas Restores Artwork, Promises Myriad Applications

Atomic oxygen's unique characteristic of oxidizing primarily hydrogen, carbon, and hydrocarbon polymers at surface levels has been applied in the restoration of artwork, detection of document forgeries, and removal of bacterial contaminants from surgical implants. The Electro-Physics Branch at Glenn Research Center built on corrosion studies of long-duration coatings for use in space, and applied atomic oxygen's selectivity to instances where elements need to be removed from a surface. Atomic oxygen is able to remove organic compounds high in carbon (mostly soot) from fire-damaged artworks without causing a shift in the paint color. First successfully tested on oil paintings, the team then applied the restoration technique to acrylics, watercolors, and ink. The successful art restoration process was well-publicized, and soon a multinational, nonprofit professional organization dedicated to the art of forensic analysis of documents had successfully applied this process in the field of forgery detection. The gas has biomedical applications as well-Atomic Oxygen technology can be used to decontaminate orthopedic surgical hip and knee implants prior to surgery, and additional collaborative research between the Cleveland Clinic Foundation and the Glenn team shows that this gas's roughening of surfaces improves cell adhesion, which is important for the development of new drugs.

Source record↗

Feature Acquisition with Imbalanced Training Data

This work considers cost-sensitive feature acquisition that attempts to classify a candidate datapoint from incomplete information. In this task, an agent acquires features of the datapoint using one or more costly diagnostic tests, and eventually ascribes a classification label. A cost function describes both the penalties for feature acquisition, as well as misclassification errors. A common solution is a Cost Sensitive Decision Tree (CSDT), a branching sequence of tests with features acquired at interior decision points and class assignment at the leaves. CSDT's can incorporate a wide range of diagnostic tests and can reflect arbitrary cost structures. They are particularly useful for online applications due to their low computational overhead. In this innovation, CSDT's are applied to cost-sensitive feature acquisition where the goal is to recognize very rare or unique phenomena in real time. Example applications from this domain include four areas. In stream processing, one seeks unique events in a real time data stream that is too large to store. In fault protection, a system must adapt quickly to react to anticipated errors by triggering repair activities or follow- up diagnostics. With real-time sensor networks, one seeks to classify unique, new events as they occur. With observational sciences, a new generation of instrumentation seeks unique events through online analysis of large observational datasets. This work presents a solution based on transfer learning principles that permits principled CSDT learning while exploiting any prior knowledge of the designer to correct both between-class and withinclass imbalance. Training examples are adaptively reweighted based on a decomposition of the data attributes. The result is a new, nonparametric representation that matches the anticipated attribute distribution for the target events.

Thompson, David R.↗

Laser Pulse Production for NASA's Global Ecosystem Dynamics Investigation (GEDI) Lidar

The Lasers and Electro-Optics Branch at Goddard Space Flight Center has been tasked with building the Lasers for the Global Ecosystems Dynamics Investigation (GEDI) Lidar Mission, to be installed on the Japanese Experiment Module (JEM) on the International Space Station (ISS)1. GEDI will use three NASA-developed lasers, each coupled with a Beam Dithering Unit (BDU) to produce three sets of staggered footprints on the Earth's surface to accurately measure global biomass. We will report on the design, assembly progress, test results, and delivery process of this laser system.

Laser Oscillator↗

Formation and Recondensation of Complex Organic Molecules During Protostellar Luminosity Outbursts

During the formation of stars, the accretion of surrounding material toward the central object is thought to undergo strong luminosity outbursts followed by long periods of relative quiescence, even at the early stages of star formation when the protostar is still embedded in a large envelope. We investigated the gas-phase formation and recondensation of the complex organic molecules (COMs) di-methyl ether and methyl formate, induced by sudden ice evaporation processes occurring during luminosity outbursts of different amplitudes in protostellar envelopes. For this purpose, we updated a gas-phase chemical network forming COMs in which ammonia plays a key role. The model calculations presented here demonstrate that ion-molecule reactions alone could account for the observed presence of di-methyl ether and methyl formate in a large fraction of protostellar cores without recourse to grain-surface chemistry, although they depend on uncertain ice abundances and gas-phase reaction branching ratios. In spite of the short outburst timescales of about 100 years, abundance ratios of the considered species higher than 10% with respect to methanol are predicted during outbursts due to their low binding energies relative to water and methanol which delay their recondensation during cooling. Although the current luminosity of most embedded protostars would be too low to produce complex organics in the hot-core regions that are observable with current sub-millimetric interferometers, previous luminosity outburst events would induce the formation of COMs in extended regions of protostellar envelopes with sizes increasing by up to one order of magnitude.

astrochemistry↗

Modeling Spacecraft Power Systems Using the SPACE Code

The NASA Glenn Research Center’s Power Architecture and Analysis Branch performs spacecraft electrical power system (EPS) performance analysis using the System Power Analysis for Capability Evaluation (SPACE) model. Accurately predicting EPS performance requires a wide range of inputs, including the spacecraft’s position, attitude, solar array temperature, load demand, and data on the EPS itself. By operating as a combined analysis tool with integrated orbit mechanics, attitude, shadowing, thermal, solar array, battery, and electrical component models, SPACE provides flexibility for the analyst to examine various scenarios without a time-consuming iterative process involving separate analysis tools and groups. SPACE also achieves short run times by tailoring the complexity of the included models, providing enough fidelity to ensure accurate EPS performance predictions without being bogged down by unnecessary detail. These advantages that SPACE has over similar power system models has contributed to its successful use on a variety of human spaceflight programs for over three decades, and makes it applicable across the development cycle from early conceptual design up through on-orbit operations.

Electrical Power System↗

Ion-molecule reactions in unsaturated hydrocarbons - Allene, propyne, diacetylene, and vinylacetylene

Ion-molecule reactions in allene, propyne, diacetylene, and vinylacetylene (1-buten-3-yne) have been studied at near-thermal energies by the technique of ion cyclotron resonance mass spectrometry. Rate coefficients and branching ratios are reported for the reactions of C3Hn(+) (n = 1-4) with allene and propyne and for the reactions of C4Hn(+) (n = 0-5) with diacetylene and vinylacetylene. Branching ratios are also given for the reactions of C4Hn(+), C5Hn and C6Hn(+) with propyne and for reactions of C6Hn(+) with diacetylene and vinylacetylene. More than 90 percent of the reactive channels lead to product ions having a larger carbon skeleton than the reactant ion. Evidence for ions with the same m/e ratio having differing reactivities was obtained for C3Hn(+), C6H7(+), and C7H7(+). Ion reaction sequences in allene and propyne were followed at higher pressures (0.0001 torr) to investigate secondary, tertiary, and higher order processes.

Anicich, V. G.↗

Metal Matrix Laminate Tailoring (MMLT) code: User's manual

The User's Manual for the Metal Matrix Laminate Tailoring (MMLT) program is presented. The code is capable of tailoring the fabrication process, constituent characteristics, and laminate parameters (individually or concurrently) for a wide variety of metal matrix composite (MMC) materials, to improve the performance and identify trends or behavior of MMC's under different thermo-mechanical loading conditions. This document is meant to serve as a guide in the use of the MMLT code. Detailed explanations of the composite mechanics and tailoring analysis are beyond the scope of this document, and may be found in the references. MMLT was developed by the Structural Mechanics Branch at NASA Lewis Research Center (LeRC).

Murthy, P. L. N.↗

Engineering Technical Review Planning Briefing

The general topics covered in the engineering technical planning briefing are 1) overviews of NASA, Marshall Space Flight Center (MSFC), and Engineering, 2) the NASA Systems Engineering(SE) Engine and its implementation , 3) the NASA Project Life Cycle, 4) MSFC Technical Management Branch Services in relation to the SE Engine and the Project Life Cycle , 5) Technical Reviews, 6) NASA Human Factor Design Guidance , and 7) the MSFC Human Factors Team. The engineering technical review portion of the presentation is the primary focus of the overall presentation and will address the definition of a design review, execution guidance, the essential stages of a technical review, and the overall review planning life cycle. Examples of a technical review plan content, review approaches, review schedules, and the review process will be provided and discussed. The human factors portion of the presentation will focus on the NASA guidance for human factors. Human factors definition, categories, design guidance, and human factor specialist roles will be addressed. In addition, the NASA Systems Engineering Engine description, definition, and application will be reviewed as background leading into the NASA Project Life Cycle Overview and technical review planning discussion.

Gardner, Terrie↗

Aeropropulsion facilities configuration control: Procedures manual

Lewis Research Center senior management directed that the aeropropulsion facilities be put under configuration control. A Configuration Management (CM) program was established by the Facilities Management Branch of the Aeropropulsion Facilities and Experiments Division. Under the CM program, a support service contractor was engaged to staff and implement the program. The Aeronautics Directorate has over 30 facilities at Lewis of various sizes and complexities. Under the program, a Facility Baseline List (FBL) was established for each facility, listing which systems and their documents were to be placed under configuration control. A Change Control System (CCS) was established requiring that any proposed changes to FBL systems or their documents were to be processed as per the CCS. Limited access control of the FBL master drawings was implemented and an audit system established to ensure all facility changes are properly processed. This procedures manual sets forth the policy and responsibilities to ensure all key documents constituting a facilities configuration are kept current, modified as needed, and verified to reflect any proposed change. This is the essence of the CM program.

Lavelle, James J.↗

Deformation Behaviors of HIPped Foil Compared with Those of Sheet Titanium Alloys

Micromechanics-based modeling of composite material behaviors requires an accurate assessment of the constituent properties and behaviors. For the specific case of continuous-fiber-reinforced metal matrix composites (MMC's) manufactured from a foil/fiber/foil process, much emphasis has been placed on characterizing foil-based matrix materials that have been fabricated in the same way as the composite. Such materials are believed to yield mechanical properties and behaviors that are representative of the matrix constituent within the composite (in situ matrix). Therefore, these materials are desired for micromechanics modeling input. Unfortunately, such foils are extremely expensive to fabricate and procure because of the labor-intensive rolling process needed to produce them. As a potential solution to this problem that would maintain appropriately representative in situ properties, the matrix constituent could be characterized with sheet-based materials, which are considerably less expensive to manufacture than foils, are more readily procured, and result in fewer plies to obtain a desired panel thickness. The critical question is, however, does the consolidated sheet material exhibit the same properties and behaviors as do the consolidated foils? Researchers at NASA Lewis Research Center's Life Prediction Branch completed a detailed experimental investigation to answer this question for three titanium alloys commonly used in metal matrix composite form.

Castelli, Michael G.↗