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At least 487 records · Page 27

Development and Application of DropletProbe Mass Spectrometry for Examining Biodistribution of Therapeutics

dropletProbe mass spectrometry is a novel technique for molecular characterization of surfaces. It can be used for rapid ex vivo analysis of therapeutics from thin animal tissue sections and has been shown to improve understanding of a drug’s absorption, distribution, metabolism and excretion (ADME) properties. Here, we describe the tissue distribution analysis of diclofenac from a dosed whole-body mouse thin tissue section using a dropletProbe mass spectrometry system.

Chen, Bingming↗

Modeling techniques of thin walled beams with open cross sections

A composite element is presented which includes the effects of warping and offset shear centers. It is shown to be mathematically consistent with thin walled open beam theory and can be incorporated into any structural analysis program by use of NASTRAN'S standard elements. A numerical example analyzing the vibration of a channel beam is presented, and, by using the composite element, the numerical results agreed well with theoretical data.

Skattum, K. S.↗

Static and dynamic response of graphite-epoxy curved frames

Experiments were conducted to measure the three-dimensional static and vibratory response of two graphite-epoxy, thin-walled, open section frames. The frames are semicircular with a radius of three feet. One specimen had an I cross section and the other had a channel cross section. The experimental data is used to evaluate a mixed finite element model of the frames that is based on Vlasov-type, thin-walled, open section curved beam theory.

Collins, J. S.↗

Effect of damage on elastically tailored composite laminates

A variationally consistent theory is derived in order to predict the response of anisotropic thin-walled closed sections subjected to axial load, torsion and bending. The theory is valid for arbitrary cross-sections made of laminated composite materials with variable thickness and stiffness. Closed form expressions for the stiffness coefficients are provided as integrals in terms of lay-ups parameters and cross-sectional geometry. A comparison of stiffness coefficients and response with finite element predictions and a closed form solution is performed. The theory is applied to the investigation of the effect of damage on the extension-twist coupling in a thin-walled closed section beam. The damage is simulated as a progressive ply-by-ply failure. Results show that damage can have a significant effect on the extension-twist coupling.

Armanios, Erian↗

The Strength of Thin-wall Cylinders of D Cross Section in Combined Pure Bending and Torsion

The results of tests of 56 cylinders of D cross section conducted in the Aeronautical Laboratory of the University of Maryland are presented in this report. These cylinders were subjected to pure bending and torsional moments of varying proportions to give the strength under combined loading conditions. The average buckling stress of these cylinders has been related to that of circumscribing circular cylinders for conditions of pure torsion and pure bending and the equation of the interaction curve has been determined for conditions of combined loading.

CYLINDERS, CIRCULAR - BUCKLING↗

Coupled elastic response of open section laminated composite beams subject to generalized beam loading

A generalized beam theory for arbitrary open section laminated composite beams subjected to generalized beam loading is developed using a strength of materials approach. At present, the theory is limited to statistically determinate beams. Solution of the general system of equations yields strain and curvature distributions as functions of the axial coordinate x and the contour coordinate s. Average stresses on a given cross section or ply stresses in a local coordinate system are determined using these distributions. Data obtained for thin-walled open section composite beams reveal that elastic coupling occurs among curvatures, shearing strains, and axial strain, depending on the laminate stiffness parameters. Laminate ply layup does not affect the location of the shear center in the thin-wall approximation, but may have a significant impact for thicker walled open sections. The average axial stress distribution is found to be distinctly different from the isotropic distribution, but the average shear stress distribution is the same as that in the isotropic case.

Zvarick, Albert G.↗

Transverse vibrations of shear-deformable beams using a general higher order theory

A general higher order theory is developed to study the static and vibrational behavior of beam structures having an arbitrary cross section that utilizes both out-of-plane shear-dependent warping and in-plane (anticlastic) deformations. The equations of motion are derived via Hamilton's principle, where the full 3D constitutive relations are used. A simplified version of the general higher-order theory is also presented for beams having an arbitrary cross section that includes out-of-plane shear deformation but assumes that stresses within the cross section and in-plane deformations are negligible. This simplified model, which is accurate for long to moderately short wavelengths, offers substantial improvements over existing higher order theories that are limited to beams with thin rectangular cross sections. The current approach will be very useful in the study of thin-wall closed-cell beams such as airfoil-type sections where the magnitude of shear-related cross-sectional warping is significant.

Kosmatka, J. B.↗

Built-in templates speed up process for making accurate models

From accurate scale drawings of a model, photographic negatives of the cross sections are printed on thin sheets of aluminum. These cross-section images are cut out and mounted, and mahogany blocks placed between them. The wood can be worked down using the aluminum as a built-in template.

Source record↗

Application of a boundary element method to the study of dynamical torsion of beams

During dynamic torsion of beam elements, consideration of nonuniform warping effects involves a more general technical formulation then that of Saint-Venant. Nonclassical torsion constants appear in addition to the well known torsional rigidity. The adaptation of the boundary integral element method to the calculation of these constants for general section shapes is described. The suitability of the formulation is investigated with some examples of thick as well as thin walled cross sections.

Czekajski, C.↗