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All sourcesNASA NTRSDOE OSTI
NASA NTRS2004

Developing a Simulation-Based Training Program for Non-Traditional Caregivers

Simulation-based training enables learning in controlled environments which nevertheless mimic real-world scenarios. It has proven effective in the training of medical personnel and affords rapid assimilation and integration of necessary skills. Non-traditional caregivers often operate in austere environments, where resource and personnel limitations preclude more standard provision of care by highly trained and fully equipped health care teams. In these settings, training time for the caregivers may be limited, with long gaps between time of the training and use of the skills, a limited grasp of the underlying physiology, and unfamiliarity with "medical English" which can render it difficult to communicate concepts to more advanced practitioners when such interaction can take place, as for example, when telemedicine can be used to project medical skills further forward . Methods: Simulation-based training can assist in the familiarization of caregivers to the environment, ensure adequate execution of skills at the appropriate time(s), and allow practice of telemedicine communication patterns between the mentor and caregiver. Results: Scenario-based training can and has been used for initial and sustainment training modules, including self-taught modules for use in the field. Strict identification of the critical concepts is vital, as is development and practice of technically simple procedures wherever possible. Medical devices can off-load tasks from caregivers, as well as to minimize the necessary level of caregiver knowledge, while integrated simulations among all members of the mission team can improve communication and efficiency. Discuss ion: Nontraditional caregivers face unique challenges when learning to provide medical care. Scenario-based curricula allow lesson plans to be tailored to each group's individual needs, as well as being suited for the participation of numerous groups, including the caregiver, evacuation/transport staff, decision-makers, and hospital-based physician.

Bacal, Kira↗
DOE OSTI2021

A Community Roadmap for Scientific Workflows Research and Development

The landscape of workflow systems for scientific applications is notoriously convoluted with hundreds of seemingly equivalent workflow systems, many isolated research claims, and a steep learning curve. To address some of these challenges and lay the groundwork for transforming workflows research and development, the WorkflowsRI and ExaWorks projects partnered to bring the international workflows community together. This paper reports on discussions and findings from two virtual “Workflows Community Summits” (January and April, 2021). The overarching goals of these workshops were to develop a view of the state of the art, identify crucial research challenges in the workflows community, articulate a vision for potential community efforts, and discuss technical approaches for realizing this vision. To this end, participants identified six broad themes: FAIR computational workflows; AI workflows; exascale challenges; APIs, interoperability, reuse, and standards; training and education; and building a workflows community. We summarize discussions and recommendations for each of these themes.

Ferreira Da Silva, Rafael↗
DOE OSTI2016

Protecting the Columbia River through Removal and Packaging of Radioactive Sludge in Hanford's K Area - 16572

The Columbia River once provided power and cooling water to operations on the Hanford Site; today, more than a million people downstream from Hanford rely on the river for agriculture, fishing and recreation. The Department of Energy and contractor CH2M HILL Plateau Remediation Company (CH2M) is making significant progress in protecting that vital resource. Eight of nine reactors along the river have been cocooned and soil and groundwater remediation is successfully reducing the concentration of contaminants in groundwater. The 100-K area is the last area where significant work remains to protect the river. CH2M has accomplished much in the past ten years, including demolishing the K East reactor fuel storage basin in 2009. Prior to demolition of the basin, highly radioactive sludge from that basin was transferred into containers located in the nearby K West reactor fuel storage basin. Today, the K East reactor is in interim surveillance mode, and work is underway in the K West basin to remove the sludge, which is a mixture of tiny fuel corrosion particles, fuel rod and metal fragments and soil and sand less than 1/4-inch in diameter. CH2M has designed a sludge removal system that will safely and efficiently remove the sludge from the K West basin and deposit it into specially designed containers which will be relocated to a storage facility on Hanford's Central Plateau. Procurement, fabrication and delivery of the sludge removal system is underway, with extensive testing and training planned for 2016 and 2017 ahead of the goal of removing sludge from the river by September 30, 2018. This project must account for many technical and safety considerations that render the project very challenging. Several safety measures have been incorporated as a result of safety evaluations. This paper will describe the issues facing the project team in developing the safety basis requirements and incorporating them into the design of the process equipment and construction of the facility to house the repackaging operations. This paper will allow CH2M and DOE-RL to share lessons learned and progress to date with other complex and hazardous projects across the DOE complex. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2017

Los Alamos National Laboratory nuclear criticality safety pipeline for expedited qualification of personnel

The Los Alamos National Laboratory (LANL) Nuclear Criticality Safety (NCS) Pipeline is a method of accelerating the training and qualification of its next generation nuclear criticality safety professionals. An upper division university course in NCS will be offered at participating universities; students who perform well can participate in a summer internship in the LANL NCS Division the following summer focusing on NCS practices and facility specific training for qualification. Standout students may proceed with a criticality safety oriented research project worked during the senior academic year. The culmination of the pipeline is the hiring of students as full time personnel. This practice reduces the uncertainty around knowing whether the individual: -1) has the technical skills, knowledge, and abilities to succeed in criticality safety, -2) will be able to effectively integrate within the organization, and -3) is interested enough in the discipline to reduce potential retention issues. This approach will address significant challenges in the NCS industry, including rising attrition rates over the next two decades, significant time and resources typically required to train qualified criticality safety professionals once hired, and the absence of available NCS-related academic course work available at colleges and universities. The university pipeline results in several benefits: -1) reduced training time and costs, -2) interested students will naturally self-sort and pursue the discipline at the university level, and -3) a pipeline of criticality safety candidates is readily available within the DOE Complex so that unexpected organizational or mission changes can be reacted to with increased agility. (authors)

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗
DOE OSTI2015

Contributions of the SCK.CEN Academy to education and training in nuclear science and technology

Thanks to its thorough experience in the field of nuclear science and technology, its innovative research and the availability of large and unique nuclear installations, SCK.CEN is not only a renowned nuclear research institution, but also an important partner for nuclear education and training in Belgium as well as at international level. Within the SCK.CEN Academy, more than 60 years of nuclear expertise and experience gained from our different research projects is collected and transferred. In the interest of maintaining a competent workforce in industry, Healthcare, research, and policy, and of transferring nuclear knowledge and skills to the next generations, the SCK.CEN Academy takes it as its mission to: - provide guidance for students and early-stage researchers; - organize academic courses and customized training for professionals; - offer policy support with regard to education and training matters; - care for critical-intellectual capacities for society. Specifically in the domain of nuclear instrumentation the SCK.CEN Academy provides an opportunity to students at Bachelor, Master and PhD level to make use of the SCK.CEN infrastructure to support their thesis research or to perform an internship with the aim to improve and extend their knowledge and skills in a specific research or technical domain. Further, they can contribute to new findings in the field of nuclear instrumentation. The students are guided by our scientists, engineers and technicians who have years of experience in the relevant field. In addition, the SCK.CEN Academy contributes to traditional university education programs and delivers courses in several nuclear topics such as dosimetry. We also coordinate the Belgian Nuclear higher Engineering Network (BNEN), a one year (60 ECTS) master-after-master specialization in nuclear engineering in which 6 Belgian universities and SCK.CEN are involved. Beyond the contributions to academic education, we also provide several customized training programs tailored to the needs of the learners in terms of content, duration, level, language, location, etc. Complementary to the theoretical classes, ample attention is given to practical sessions and technical visits are foreseen which enable trainees to enrich and illustrate their acquired knowledge with the practice of real-life situations. In this poster presentation an overview will be given of the activities in the domains described above. Moreover it will be shown how these initiatives are embedded in the most recent European approaches to nuclear education and training via collaboration in several EU projects and networks. (authors)

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗
DOE OSTI2017

Estimating the Effective System Dead Time Parameter for Correlated Neutron Counting

We present that neutron time correlation analysis is one of the main technical nuclear safeguards techniques used to verify declarations of, or to independently assay, special nuclear materials. Quantitative information is generally extracted from the neutron-event pulse train, collected from moderated assemblies of 3 He proportional counters, in the form of correlated count rates that are derived from event-triggered coincidence gates. These count rates, most commonly referred to as singles, doubles and triples rates etc., when extracted using shift-register autocorrelation logic, are related to the reduced factorial moments of the time correlated clusters of neutrons emerging from the measurement items. Correcting these various rates for dead time losses has received considerable attention recently. The dead time losses for the higher moments in particular, and especially for large mass (high rate and highly multiplying) items, can be significant. Consequently, even in thoughtfully designed systems, accurate dead time treatments are needed if biased mass determinations are to be avoided. In support of this effort, in this paper we discuss a new approach to experimentally estimate the effective system dead time of neutron coincidence counting systems. It involves counting a random neutron source (e.g. AmLi is a good approximation to a source without correlated emission) and relating the second and higher moments of the neutron number distribution recorded in random triggered interrogation coincidence gates to the effective value of dead time parameter. We develop the theoretical basis of the method and apply it to the Oak Ridge Large Volume Active Well Coincidence Counter using sealed AmLi radionuclide neutron sources and standard multiplicity shift register electronics. The method is simple to apply compared to the predominant present approach which involves using a set of 252 Cf sources of wide emission rate, it gives excellent precision in a conveniently short time, and it yields consistent results as a function of the order of the moment used to extract the dead time parameter. In addition, this latter observation is reassuring in that it suggests the assumptions underpinning the theoretical analysis are fit for practical application purposes. However, we found that the effective dead time parameter obtained is not constant, as might be expected for a parameter that in the dead time model is characteristic of the detector system, but rather, varies systematically with gate width.

98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL P↗
DOE OSTI2024

ReLIC: Full-Scale Realization of Reinforcement Learning for Infrastructure Control

Prior efforts have shown that deep reinforcement learning (DRL) may provide a new method for controlling networked power systems. Though successful, prior approaches have not yet demonstrated their behavior on systems of realistic scale. This effort examined multiple theoretical and technical approaches to allow a DRL model to operate over a system of 2,000 buses or more. We find that allowing the DRL models to run training episodes in parallel provides near limitless efficiency gains, allowing us to train successful agents to behave on our Kuramoto transmission model of up to 4,000 buses. We further show that we can expand our PowerWorld DRL implementation to systems of up to 25 buses but struggle to go beyond this limit due to PowerWorld’s inability to run multiple instances at once. Finally, we examine a multi-agent approach and find that it performs as well if not better than our existing centralized approach.

97 MATHEMATICS AND COMPUTING↗
NASA NTRS2001

Phase 1 research program overview

The Phase 1 research program was unprecedented in its scope and ambitious in its objectives. The National Aeronautics and Space Administration committed to conducting a multidisciplinary long-duration research program on a platform whose capabilities were not well known, not to mention belonging to another country. For the United States, it provided the first opportunity to conduct research in a long-duration space flight environment since the Skylab program in the 1970's. Multiple technical as well as cultural challenges were successfully overcome through the dedicated efforts of a relatively small cadre of individuals. The program developed processes to successfully plan, train for and execute research in a long-duration environment, with significant differences identified from short-duration space flight science operations. Between August 1994 and June 1998, thousands of kilograms of research hardware was prepared and launched to Mir, and thousands of kilograms of hardware and data products were returned to Earth. More than 150 Principal Investigators from eight countries were involved in the program in seven major research disciplines: Advanced Technology; Earth Sciences; Fundamental Biology; Human Life Sciences; International Space Station Risk Mitigation; Microgravity; and Space Sciences. Approximately 75 long-duration investigations were completed on Mir, with additional investigations performed on the Shuttle flights that docked with Mir. The flight phase included the participation of seven US astronauts and 20 Russian cosmonauts. The successful completion of the Phase 1 research program not only resulted in high quality science return but also in numerous lessons learned to make the ISS experience more productive. The cooperation developed during the program was instrumental in its success. c2001 AIAA. Published by Elsevier Science Ltd.

short duration↗
NASA NTRS2005

The Space Shuttle Columbia Preservation Project - The Debris Loan Process

The purpose of this project is to provide a process for loan of Columbia debris to qualified researchers and technical educators to: (1) Aid in advanced spacecraft design and flight safety development (2) Advance the study of hypersonic re-entry to enhance ground safety. (3) Train and instruct accident investigators and (4) Establish an enduring legacy for Space Shuttle Columbia and her crew.

Thurston, Scott↗
NASA NTRS2016

The Business Change Initiative: A Novel Approach to Improved Cost and Schedule Management

Goddard Space Flight Center's Flight Projects Directorate employed a Business Change Initiative (BCI) to infuse a series of activities coordinated to drive improved cost and schedule performance across Goddard's missions. This sustaining change framework provides a platform to manage and implement cost and schedule control techniques throughout the project portfolio. The BCI concluded in December 2014, deploying over 100 cost and schedule management changes including best practices, tools, methods, training, and knowledge sharing. The new business approach has driven the portfolio to improved programmatic performance. The last eight launched GSFC missions have optimized cost, schedule, and technical performance on a sustained basis to deliver on time and within budget, returning funds in many cases. While not every future mission will boast such strong performance, improved cost and schedule tools, management practices, and ongoing comprehensive evaluations of program planning and control methods to refine and implement best practices will continue to provide a framework for sustained performance. This paper will describe the tools, techniques, and processes developed during the BCI and the utilization of collaborative content management tools to disseminate project planning and control techniques to ensure continuous collaboration and optimization of cost and schedule management in the future.

Schedule↗
DOE OSTI2013

Weld Repair of a Stamped Pressure Vessel in a Radiologically Controlled Zone

In September 2012 an ASME B&PVC Section VIII stamped pressure vessel located at the DOE Hanford Site Effluent Treatment Facility (ETF) developed a through-wall leak. The vessel, a steam/brine heat exchanger, operated in a radiologically controlled zone (by the CH2MHill PRC or CHPRC), had been in service for approximately 17 years. The heat exchanger is part of a single train evaporator process and its failure caused the entire system to be shut down, significantly impacting facility operations. This paper describes the activities associated with failure characterization, technical decision making/planning for repair by welding, logistical challenges associated with performing work in a radiologically controlled zone, performing the repair, and administrative considerations related to ASME code requirements.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2026

An Educational Program on Concentrated Solar Power and Heliostats for Power Generation and Industrial Processes

The objective of this project was to design and implement a comprehensive educational and applied research program in Concentrated Solar Thermal Power (CSTP) and heliostat technologies at Northeastern University. In alignment with the U.S. Department of Energy's Heliostat Consortium (HelioCon) goals, the project aimed to expand student and public understanding of CSTP systems while simultaneously contributing to workforce development and the broader decarbonization strategy. A particular emphasis was placed on integrating hands-on student design projects and publicly disseminating educational content relevant to CSTP systems. The project addressed a critical gap in renewable energy education: CSTP and heliostats, despite their importance in utility-scale solar energy, are rarely included in standard mechanical engineering programs. This project established new pathways for students to engage with the topic through the creation of a 4-credit graduate/senior elective course, development of five industry-facing short courses, and the inclusion of CSTP-based capstone design projects. Over two academic years, 36 students across six senior design teams developed and tested technologies such as deformable heliostats, beacon-based tracking systems, and solar-powered pyrolizers for biomass-to-biochar conversion. Concurrently, 30 undergraduate and graduate students were enrolled in the new academic course centered around CSTP principles. To ensure the relevance and accessibility of the short course content, the project team engaged with industry professionals, technical policy stakeholders, and potential course participants through structured surveys and informal consultations. Feedback from 28 respondents guided the structure, length, and delivery format of the courses - resulting in a modular design broken into five workshops. The feedback emphasized the need for flexible, asynchronous delivery and practical case studies, particularly in areas such as heliostat control, thermal storage, and solar fuel production. This engagement helped align the courses with the evolving knowledge demands of the renewable energy workforce and ensured that participants from both technical and policy backgrounds could meaningfully benefit from the material. The research and educational activities advanced the understanding of heliostat control systems, optical performance under misalignment, and thermal system integration in solar-driven pyrolysis applications. Methods and designs explored in this project proved to be both technically effective and economically feasible at the lab scale. Prototypes were constructed using commercially available components and custom-fabricated elements, demonstrating that meaningful performance improvements can be achieved with modest material and fabrication costs, supporting the feasibility of student-led research in this field. The public benefit of this project is twofold. First, it cultivates a pipeline of engineers trained to be familiar with CSTP principles, an essential workforce need identified by the Department of Energy for achieving its 2030 cost and deployment targets. Second, it contributes openly accessible educational materials, course content, and experimental frameworks to the broader community, enabling other institutions to adopt or adapt similar programming. Through outreach activities, curriculum integration, and technical exposure, this project contributes to a more informed and capable renewable energy workforce while supporting innovation in heliostat and CSTP system design. A new technical report is being prepared to document the development of the course and its outcomes, with plans to publish it in the ASME Open Access Journal of Engineering to ensure global accessibility, free of cost.

14 SOLAR ENERGY↗
DOE OSTI2024

Wide Bandgap Generation (WBGen): Developing the Future Wide Bandgap Power Electronics Engineering Workforce

This Final Technical Report (FTR) summarizes the work conducted at the Center for Power Electronics Systems (CPES) under the Wide-Bandgap Generation (WBGen) fellowship and traineeship program established by the Advanced Manufacturing and Technologies Office (AMMTO) of the U.S. Department of Energy Office of Energy Efficiency and Renewable Energy (EERE) at Virginia Tech, which had as main objective to train the next generation of U.S. citizen power engineers with wide-bandgap (WBG) power semiconductor expertise, with the intent to aid in fulfilling the future workforce needs in this field. The latter was deemed of strategic importance given the fast-paced growth observed—and predicted—in the demand of this technical expertise, whose practitioners have become the enablers and executioners of the electrification transformation process that not just the U.S., but the whole world, is currently undergoing as it seeks for more effective and efficient ways to use energy. As such, the WBGen program set forth to achieve its educational goals, which in addition sought to broaden the range of WBG-based power electronics by conducting research and development on high-efficiency grid apparatus and high-efficiency electrical power systems, and to also enhance the power engineering curriculum by formalizing WBG-oriented design procedures replacing existent yet now obsolete design procedures developed for Silicon (Si) based power electronics. This effort led CPES to spearhead the development of a new major within The Bradley Electrical and Computer Engineering (ECE) Department at Virginia Tech, namely Electronic Power and Energy Systems (EPES), which coalesced power electronics and power systems courses to provide undergraduate students with a strong formation in the power engineering field, while creating a pipeline of graduate students that could pursue the WBG-based curriculum and conduct research at CPES. In all, in what is considered a true success, eight of the twenty WBGen fellows that graduated program were recruited from the ECE department undergraduate cohort. The traineeship emphasized as well, from its beginning, the partnership with industry and national laboratories, which took advantage of the successful industry consortium at CPES that has historically been formed by 80–90 power and energy companies working in close collaboration with the center. This gave WBGen fellows the accessibility and possibility to conduct internships at partner facilities during the summer months, focused solely on the evaluation, testing, and adoption of WBG devices, which were many times tightly related to their respective research work and plans. In addition, WBGen fellows conducted their main research work within the confines of research programs at CPES conducted with these industry partners, providing them with a unique opportunity to develop not just their technical expertise—while advancing their knowledge, but to also learn and practice a slew of skills needed for their professional growth. As such, the fellows tackled a variety of WBG-related research topics, from device reliability and capability aspects as well as packaging and integration, encompassing the use of advanced materials and new structures, current sharing challenges, and insulation systems, to advanced gate-drivers with integrated sensors and protection mechanisms and active current- and voltage-based control, to optimized layouts seeking to maximize the switching and power processing performance of these devices, to power processing solutions adopting Gallium-Nitride (GaN) and Silicon-Carbide (SiC) power semiconductors for a variety of applications; including radiation-hardened converters for space dc distribution systems, direct three-phase ac-to-ac power converters for aerospace systems, dc-ac inverters for automotive traction drives, high-frequency isolated dc-dc battery chargers also for heavy transportation systems, and medium-voltage dc-dc and dc-ac converters for distribution systems and future power grids. The WBGen program ultimately graduated a total of 20 power engineers, all experts on WBG-based power electronics, awarding 18 M.S. and 2 PhD degrees in the process. These fellows, all U.S. citizens, allowed CPES to increase the number of citizens students to 33 % at the peak of the program, as the traineeship made possible the recruitment of talent with more attractive graduate research assistantship (GRA) contracts. Unfortunately, the present U.S. citizen enrollment at CPES has declined back to historic levels—approximately 10 %, as the regular GRA rates are not competitive enough when compared with entry-level industry jobs. In all, WBGen fellows published a total of 7 peer-reviewed journal articles, 44 papers at international technical conferences, made 42 presentations at international technical conferences, and filed 4 invention disclosures and patent applications, which have since then been granted by the U.S. Patent and Trademark Office (USPTO). Their contribution to CPES, Virginia Tech, the United States, and the world, has been significant, and continues to yield results thanks to the exemplary career that the fellows have initiated at many of the partners of the program, which include Wolfspeed, Raytheon Technologies, Infineon, Lockheed Martin, Dominion Energy, Northrop Grumman, Rivian, Aerospace Corporation, Sandia National Laboratory, National Renewable Energy Laboratory, John Hopkins University, and Virginia Tech.

14 SOLAR ENERGY↗
DOE OSTI2018

Productive Use of Energy in African Micro-Grids: Technical and Business Considerations

Demand for electricity from small industry and businesses, which is defined as the productive use of energy (PUE), is a key success factor for micro-grids. Because of the typically low energy usage of residential customers, without linkage to and support for these energy users, micro-grids are likely to struggle to reach the critical revenue needed for financial viability. This report is a resource entrepreneurs and developers can use to understand the technical and business model challenges related to PUE in smaller micro-grids. It focuses on small agricultural processing, and small industrial and commercial loads. This report examines best practices for promoting PUE and the business models used by developers. It starts with background information and a literature review followed by a discussion of key enterprise considerations for productive use (PU) including: value chain and business case analysis, enterprise development and training, appliance financing, and developers running PU businesses. Unlike many other reports on PUE, this report is based on application specific data. The report is also unique in that it provides actual customer demographics and load profiles. This report considers PUE from both business and technical perspectives, and it considers the interests of both the micro-grid operators and the microenterprises and entrepreneurs they serve. It looks at the service levels required by different PUs and the technical characteristics and challenges of different types of PU equipment. The report also includes examples of business cases for some of the most important PU opportunities, including milling, ice making, carpentry, egg incubation, and water treatment. This report is a resource that entrepreneurs, governments, and non-governmental organizations can use to help design programs to meet their individual goals of PUE in micro-grids and economic development in rural Africa. It can also be used by developers, engineers, and other organizations designing micro-grids to inform their technical and business decisions and to improve system design, reduce risk, and increase success with adding PU loads to both new and existing micro-grids.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2016

University of Nevada, Reno Graduate Certificate in Nuclear Packaging

This paper describes a new Graduate Certificate in Nuclear Packaging (GCNP). Nuclear materials are currently used for large-scale production of electricity without greenhouse gas generation, advanced medical treatments, food sterilization, and sophisticated measurement technologies. In order to benefit from these uses, nuclear materials packaging must be developed, manufactured, inspected, and maintained for storage, transfer, transport, and disposal that protect the public and the environment. The U.S. Department of Energy (DOE) Packaging Certification Program (PCP) originally offered the following ten, one-day to ten-day training courses. 1. Methods for Reviewing Safety Analysis Reports for Packages and Performing Confirmatory Analysis; 2. Welding Criteria for Shipping Containers; 3. Structural Analysis and Acceptance Criteria; 4. Quality Assurance (QA) for Radioactive Material Packaging Training; 5. Application of the American Society of Mechanical Engineers (ASME) Code to Radioactive Material Transportation Packaging; 6. ARG-US Radio Frequency Identification (RFID) System for Management of Nuclear and Radioactive Materials; 7. Packaging Operations and Maintenance; 8. Packaging Leakage Test Training; 9. Management of SARP Preparation; 10. Transport Security of Radioactive Material. These courses were designed in accordance with DOE standards. They were taught at a rigorous graduate-university level by experienced technical staff who are coordinated by Argonne, Lawrence Livermore, and Savannah River National Laboratories. The courses were taught at these Laboratories or nearby locations. The PCP courses are attended by personnel from government agencies, national laboratories, and the nuclear industry, from both inside and outside the United States. Students in these classes have generally earned undergraduate or higher degrees. These courses are designed to assist student with specialized job duties, and may provide them a competitive advantage when seeking employment or promotion in the nuclear packaging and other related fields. (authors)

36 MATERIALS SCIENCE↗
DOE OSTI2024

Production of High Specific Activity 155 Tb, 161 Tb and 203 Pb for Research and Clinical Applications: Effective Target Design, Target Material Recycling and Radioisotope Separation (Final Technical Report)

The overall objectives of this project were (1) to develop methods for the production and separation of a diagnostic and therapeutic or “theranostic” pair of radioisotopes, terbium-155 ( 155 Tb) and terbium-161 ( 161 Tb) and (2) to train graduate students and postdoctoral fellows in technologies and methods used in radionuclide production. Radionuclides can be incorporated into drugs called radiopharmaceuticals that target a specific disease (e.g., cancer). The need for theranostic radionuclides is escalating with the clinical translation of radiopharmaceuticals due to their implementation in personalized medicine, which has demonstrated enhanced patient treatments. High purity and high specific activity radionuclides are critical for theranostic agent development, for example to maintain diagnostic image quality, to minimize radiation dose to the patient, and to increase uptake in the targeted tissue (e.g., tumor), especially in the case of receptor- and antigen-targeted agents. The 155 Tb (diagnostic) and 161 Tb (therapeutic) radioisotopes that were generated through this project are a theranostic pair with demonstrated potential for the development and translation into individualized, targeted, and dosimetry-driven radiotherapies. However, the development of such radiotherapies has been hindered by the lack of a routine and reliable supply of these isotopes in the United States. Methods for the production, separation, and supply of 155 Tb and 161 Tb were investigated and developed in this project. Further, the strong emphasis throughout the project on the training of graduate students and postdoctoral fellows has helped to ensure and enhance the nuclear science workforce through the training of the next generation of highly qualified scientists in nuclear and radiochemistry. This grant also continued a collaboration between scientists at the University of Washington (UW), the University of Missouri (MU) and Brookhaven National Laboratory (BNL). All three institutions were involved in the project, but to different degrees on the various tasks through which the overall objectives were met.

07 ISOTOPE AND RADIATION SOURCES↗
DOE OSTI2022

Clean Energy Education and Training Resources and Opportunities in New York's Southern Tier Region

New York's Southern Tier Region is experiencing high growth and investment in the clean energy sector and is anticipating more jobs to come in energy efficiency, renewable energy, and manufacturing in the coming years. The Network for a Sustainable Tomorrow (NEST) is a nonprofit network of programs working to develop a regional backbone system for education and training programs as well as curricula to support the workforce needed for the region's growing industries to succeed. Through its participation in the US Department of Energy's Better Buildings Workforce Accelerator, NEST requested technical assistance in conducting a landscape and needs assessment of the region's existing clean energy education and workforce development assets. This report supports NEST's efforts by providing a baseline of clean energy employment data, an inventory and gap analysis of the education and workforce development assets currently available and serving the Southern Tier Region, and case studies of innovative and successful regional clean energy education and workforce coalitions from around the county.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗