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All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

SU-E-J-185: A Systematic Review of Breathing Guidance in Radiation Oncology and Radiology

Purpose: The advent of image-guided radiation therapy (IGRT) has led to dramatic improvements in the accuracy of treatment delivery in radiotherapy. Such advancements have highlighted the deleterious impact tumor motion can have on both image quality and radiation treatment delivery. One approach to reducing tumor motion is the use of breathing guidance systems during imaging and treatment. A review of such research had not yet been performed, it was therefore our aim to perform a systematic review of breathing guidance interventions within the fields of radiation oncology and radiology. Methods: Results of online database searches were filtered in accordance to a set of eligibility criteria. The search, filtration, and analysis of articles were conducted in accordance with the PRISMAStatement reporting standard (Preferred Reporting Items for Systematic reviews and Meta-Analyses) utilizing the PICOS approach (Participants, Intervention, Comparison, Outcome, Study design). Participants: Cancer patients, healthy volunteers. Intervention: Biofeedback breathing guidance systems. Comparison: No breathing guidance of the same breathing type. Outcome: Regularity of breathing signal and anatomic/tumor motion, medical image quality, radiation treatment margins and coverage, medical imaging and radiation treatment times. Study design: Quantitative and controlled prospective or retrospective trials. Results: The systematic search yielded a total of 479 articles, which were filtered down to 27 relevant articles in accordance to the eligibility criteria. The vast majority of investigated outcomes were significantly positively impacted by the use of breathing guidance; however, this was dependent upon the nature of the breathing guidance system and study design. In 25/27 studies significant improvements from the use of breathing guidance were observed. Conclusion: The results found here indicate that further clinical studies are warranted which quantify more comprehensively the clinical impact of The results found here indicate that further clinical studies are warranted which quantify more comprehensively the clinical impact of breathing guidance interventions.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

MO-DE-201-03: This course presents a review of radiologic anatomy and physiology as it applies to projection radiography, fluoroscopy, CT, MRI, U/S, and nuclear medicine

Fundamental knowledge of radiologic anatomy and physiology is critical for medical physicists. Many physicists are exposed to this topic only in graduate school, and knowledge is seldom formally evaluated or assessed after Part I of the ABR exam. Successful interactions with clinicians, including surgeons, radiologists, and oncologists requires that the medical physicist possess this knowledge. This course presents a review of radiologic anatomy and physiology as it applies to projection radiography, fluoroscopy, CT, MRI, U/S, and nuclear medicine. We will review structural anatomy, manipulation of tissue contrast, the marriage between anatomy and physiology, and explore how medical imaging exploits normal and pathological processes in the body to generate contrast. Learning Objectives: Review radiologic anatomy. Examine techniques to manipulate tissue contrast in radiology. Integrate anatomy and physiology in molecular imaging.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

Breathing guidance in radiation oncology and radiology: A systematic review of patient and healthy volunteer studies

Purpose: The advent of image-guided radiation therapy has led to dramatic improvements in the accuracy of treatment delivery in radiotherapy. Such advancements have highlighted the deleterious impact tumor motion can have on both image quality and radiation treatment delivery. One approach to reducing tumor motion irregularities is the use of breathing guidance systems during imaging and treatment. These systems aim to facilitate regular respiratory motion which in turn improves image quality and radiation treatment accuracy. A review of such research has yet to be performed; it was therefore their aim to perform a systematic review of breathing guidance interventions within the fields of radiation oncology and radiology. Methods: From August 1–14, 2014, the following online databases were searched: Medline, Embase, PubMed, and Web of Science. Results of these searches were filtered in accordance to a set of eligibility criteria. The search, filtration, and analysis of articles were conducted in accordance with preferred reporting items for systematic reviews and meta-analyses. Reference lists of included articles, and repeat authors of included articles, were hand-searched. Results: The systematic search yielded a total of 480 articles, which were filtered down to 27 relevant articles in accordance to the eligibility criteria. These 27 articles detailed the intervention of breathing guidance strategies in controlled studies assessing its impact on such outcomes as breathing regularity, image quality, target coverage, and treatment margins, recruiting either healthy adult volunteers or patients with thoracic or abdominal lesions. In 21/27 studies, significant (p < 0.05) improvements from the use of breathing guidance were observed. Conclusions: There is a trend toward the number of breathing guidance studies increasing with time, indicating a growing clinical interest. The results found here indicate that further clinical studies are warranted that quantify the clinical impact of breathing guidance, along with the health technology assessment to determine the advantages and disadvantages of breathing guidance.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

SU-F-T-224: Importance of Timely Review of Daily Cone-Beam CTs: Dosimetric Evaluation of Rejected CBCTs for Head and Neck Patients

Purpose: To dosimetrically evaluate the importance of timely reviewing daily CBCTs for patients with head and neck cancer. Methods: After each fraction daily cone-beam CT (CBCT) for head and neck patients are reviewed by physicians prior to next treatment. Physician rejected image registrations of CBCT were identified and analyzed for 17 patients. These CBCT images were rigidly fused with planning CT images and the contours from the planning CT were transferred to CBCTs. Because of limited extension in the superior-inferior dimension contours with partial volumes in CBCTs were discarded. The treatment isocenter was placed by applying the clinically recorded shifts to the volume isocenter of the CBCT. Dose was recalculated at the shifted isocenter using a homogeneous dose calculation algorithm. Dosimetrically relevant changes defined as greater than 5% deviation from the clinically accepted plans but with homogeneous dose calculation were evaluated for the high dose (HD), intermediate dose (ID), and low dose (LD) CTVs, spinal cord, larynx, oropharynx, parotids, and submandibular glands. Results: Among seventeen rejected CBCTS, HD-CTVs, ID-CTVs, and LD-CTVs were completely included in the CBCTs for 17, 1, and 15 patients, respectively. The prescription doses to the HD-CTV, ID-CTV, and LD-CTV were received by < 95% of the CTV volumes in 5/17, 1/1, and 5/15 patients respectively. For the spinal cord, the maximum doses (D0.03cc) were increased > 5% in 13 of 17 patients. For the oropharynx, larynx, parotid, and submandibular glands, the mean dose of these organs at risk was increased > 5% in 7/17, 8/12, 11/16 and 6/16 patients, respectively. Conclusion: Timely review daily CBCTs for head and neck patients under daily CBCT guidance is important, and uncorrected setup errors can translate to dosimetrically relevant dose increases in organsat- risk and dose decreases in the clinical target volumes.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

A review of projection radiography of plasma and biological objects in X-Pinch radiation

A review of studies on the X-pinch as a radiation source for X-ray projection shadow radiography (XPSR) and X-ray absorption spectroscopy (XAS) is presented. The ultimate capabilities of the techniques and ways of their achievement are considered. XPSR has been successfully used to study high-energy-density plasma objects, in particular, exploding wires and wire arrays. Using XPSR, the internal structure and dynamics of a wire explosion and wire array implosion have been investigated for the first time, which has made it possible to develop an adequate consistent theory of the processes occurring in the wire loads of generators with currents from several units of kiloamperes to a few tens of megamperes. The use of XAS for diagnostics of wire loads has allowed one for the first time to measure the parameters of matter in the wire core and plasma corona of the load. X-ray images of various biological objects have obtained, including those with the use of the phase contrast method. This review is a logical continuation of the review ''X-Pinch'' [Plasma Phys. Rep. 41, 319, 493 (2015)], in which the X-pinch as a physical object was considered.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2024

Promoting Sustainable Transportation Modes: A Systematic Review of Behavior-Change Strategies

In previous studies, many travel-behavior-change strategies often relied on single behavior determinants or psychological theories, overlooking the incorporation of sociopsychological theories for guidance in their design. Integrating these theories could offer consistent guidance for program developers and enhance intervention effectiveness. This paper systematically reviews interventions targeting travel-behavior change, with a focus on self-determination theory and its principles of satisfying individuals’ competence, autonomy, and relatedness needs for enacting change. Additionally, experiment design methods, including randomized controlled trials and quasi-experimental designs, are reviewed and discussed. Key findings highlight the effectiveness of personalized interventions and integrating feedback with goal-setting strategies. Given the limited direct references to sociopsychological theories in existing studies, we explore relevant sociopsychological theories applicable to travel-behavior-change programs to provide examples of how strategies could be designed based on them. This review contributes valuable insights into the development of strategies for changing travel behavior, offering a theoretical framework for researchers and practitioners to guide intervention design, experimentation, and evaluation. In conclusion, leveraging these theories not only facilitates reproducibility but also provides a standardized approach for transportation demand management program developers.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
DOE OSTI2019

Local Recurrence of Benign, Borderline, and Malignant Phyllodes Tumors of the Breast: A Systematic Review and Meta-analysis

Background: This systematic review and meta-analysis aimed to investigate local recurrence (LR) rates among the three grades (benign, borderline, and malignant) of phyllodes tumors (PTs). The study also assessed various risk factors for LR. Methods: Electronic articles published between 1 January 1995 and 31 May 2018, were searched and critically appraised. The authors independently reviewed the abstracts and extracted data for LR rates and LR risk factors. Results: The review incorporated 54 studies with 9234 individual cases. The pooled LR rates were 8% for benign, 13% for borderline, and 18% for malignant PTs. The risk of LR was significantly increased by borderline versus benign PTs (odds ratio [OR] 2.00; 95% confidence interval [CI] 1.68–2.38) and malignant versus borderline PTs (OR 1.28; 95% CI 1.05–1.55). The significant risk factors for LR were mitoses, tumor border (infiltrating vs. pushing), stromal cellularity (moderate/severe vs. mild), stromal atypia (severe vs. mild/absent), stromal overgrowth (severe vs. mild/absent), and tumor necrosis (positive vs. negative). Age and tumor size were not associated with LR risk. The subgroup analysis showed that breast-conserving surgery versus mastectomy and positive versus negative surgical margins were significantly associated with an increased LR risk only in malignant PTs. Conclusions: The risk of LR was significantly increased from benign to borderline to malignant PTs. Mitoses, tumor border, stromal cellularity, stromal atypia, stromal overgrowth, tumor necrosis, type of surgery, and surgical margin status may be risk factors for LR. Different management strategies could be considered for different PT grades.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2013

Idaho National Laboratory Integrated Safety Management System FY 2013 Effectiveness Review and Declaration Report

Idaho National Laboratory (INL) performed an Annual Effectiveness Review of the Integrated Safety Management System (ISMS), per 48 Code of Federal Regulations (CFR) 970.5223 1, “Integration of Environment, Safety and Health into Work Planning and Execution.” The annual review assessed Integrated Safety Management (ISM) effectiveness, provided feedback to maintain system integrity, and identified target areas for focused improvements and assessments for Fiscal Year (FY) 2014. Results of the FY 2013 annual effectiveness review demonstrate that the INL’s ISMS program is “Effective” and continually improving and shows signs of being significantly strengthened. Although there have been unacceptable serious events in the past, there has also been significant attention, dedication, and resources focused on improvement, lessons learned and future prevention. BEA’s strategy of focusing on these improvements includes extensive action and improvement plans that include PLN 4030, “INL Sustained Operational Improvement Plan, PLN 4058, “MFC Strategic Excellence Plan,” PLN 4141, “ATR Sustained Excellence Plan,” and PLN 4145, “Radiological Control Road to Excellence,” and the development of LWP 20000, “Conduct of Research.” As a result of these action plans, coupled with other assurance activities and metrics, significant improvement in operational performance, organizational competence, management oversight and a reduction in the number of operational events is being realized. In short, the realization of the fifth core function of ISMS (feedback and continuous improvement) and the associated benefits are apparent.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2014

Independent Review of AFC 2A, 2B, and 2E ATR Irradiation Tests

As part of the Department of Energy Advanced Fuel Cycle program, a series of fuels development irradiation tests have been performed in the Advanced Test Reactor (ATR) at the Idaho National Laboratory. These tests are providing excellent data for advanced fuels development. The program is focused on the transmutation of higher actinides which best can be accomplished in a sodium-cooled fast reactor. Because a fast test reactor is no longer available in the US, a special test vehicle is used to achieve near-prototypic fast reactor conditions (neutron spectra and temperature) for use in ATR (a water-cooled thermal reactor). As part of the testing program, there were many successful tests of advanced fuels including metals and ceramics. Recently however, there have been three experimental campaigns using metal fuels that experienced failure during irradiation. At the request of the program, an independent review committee was convened to review the post-test analyses performed by the fuels development team, to assess the conclusions of the team for the cause of the failures, to assess the adequacy and completeness of the analyses, to identify issues that were missed, and to make recommendations for improvements in the design and operation of future tests. Although there is some difference of opinion, the review committee largely agreed with the conclusions of the fuel development team regarding the cause of the failures. For the most part, the analyses that support the conclusions are sufficient.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2016

Response to External Peer Review Team Report for Corrective Action Unit 97: Yucca Flat/Climax Mine, Nevada National Security Site, Nye County, Nevada, Revision 1

The Underground Test Area (UGTA) Corrective Action Unit (CAU) 97, Yucca Flat/Climax Mine (YF/CM), in the northeast part of the Nevada National Security Site (NNSS) requires environmental corrective action activities to assess contamination resulting from underground nuclear testing. These activities are necessary to comply with the UGTA corrective action strategy defined in Appendix VI, Revision No. 4, of the Federal Facility Agreement and Consent Order (FFACO) (1996, as amended). The Phase I Flow and Transport Model Document for Corrective Action Unit 97: Yucca Flat/Climax Mine, Nevada National Security Site, Nye County, Nevada (N-I, 2013a) was developed and subjected to an external peer review as required by the corrective action investigation (CAI) stage of the UGTA strategy. The YF/CM Peer Review Committee (PRC) raised a number of questions and provided recommendations for supplemental analyses (in the External Peer Review Team Report for Corrective Action Unit 97: Yucca Flat/Climax Mine, Nevada National Security Site, Nye County, Nevada [N-I, 2015]). The purpose of this document is to provide responses to the PRC recommendations addressing the uncertainties identified by the PRC so that sufficient confidence in the contaminant boundary forecasts is established to advance to the Corrective Action Decision Document (CADD)/Corrective Action Plan (CAP) stage and initiate model evaluations. The PRC summarized their concerns and recommendations, and presented discussions of each of these uncertainties in their report (N-I, 2015). The U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) responses are summarized in Table ES-1.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2019

Underground Test Area Activity Preemptive Review Guidance Nevada National Security Site, Nevada

This report is a revision to the preemptive review (PER) guidance originally released as U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) document DOE/NV--1552 in 2016 (NNSA/NFO, 2016). PER committees review various products, including data, documents, software/codes, analyses, and models. PER committees provide technical recommendations to support regulatory decisions that are the responsibility of the DOE Environmental Management (EM) Nevada Program and NDEP. PERs are designed to be adaptable to the varying requirements of individual CAU studies. Their goals include the following: Maintaining high technical standards; ensuring work is technically adequate, competently performed, and documented consistent with other programmatic documents; and verifying that established quality requirements are satisfied. Helping focus CAU studies on UGTA Activity objectives identified in the FFACO by implementing Section 3 of Appendix VI, which includes the UGTA Strategy Flowchart (Figure 3-2) and Process Flow Diagram Dictionary for the UGTA CAUs (Table 3-1). Providing a mechanism for early identification of technical and/or strategy issues that could affect successfully implementing the UGTA strategy. Providing assurance to NDEP that work in progress and final reports are technically sound. Providing independent reviews that allow for a better understanding of the technical work, and result in products that are transparent and sufficient to allow the DOE EM Nevada Program to meet regulatory objectives.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2020

Water Power Technologies Office 2019 Peer Review Final Report

The U.S. Department of Energy’s (DOE’s) Office of Energy Efficiency and Renewable Energy’s (EERE’s) Water Power Technologies Office (WPTO, or “the office”) 2019 Peer Review was held on October 8–10, 2019, in Alexandria, Virginia. The purpose of the peer review was to evaluate DOE-funded projects for their contribution to the mission and goals of the office, to assess progress made against stated objectives, and to assess the office’s overall management and performance. All programs within EERE are required to undertake rigorous, objective peer reviews covering their key projects, as well as 80%–90% of their funded active project portfolio every two years.

13 HYDRO ENERGY↗
DOE OSTI2024

2023 IEDO Peer Review Report

On behalf of the U.S. Department of Energy (DOE) Industrial Efficiency and Decarbonization Office (IEDO), we are pleased to share the report from our 2023 peer review. Peer review provides us with invaluable insight into our office strategy and program direction from a diverse group of external thought leaders. The findings and actionable recommendations from peer review inform our decision making and help us maintain a constant state of evolution and growth.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2019

Snails In Silico: A Review of Computational Studies on the Conopeptides

Marine cone snails are carnivorous gastropods that use peptide toxins called conopeptides both as a defense mechanism and as a means to immobilize and kill their prey. These peptide toxins exhibit a large chemical diversity that enables exquisite specificity and potency for target receptor proteins. This diversity arises in terms of variations both in amino acid sequence and length, and in posttranslational modifications, particularly the formation of multiple disulfide linkages. Most of the functionally characterized conopeptides target ion channels of animal nervous systems, which has led to research on their therapeutic applications. Many facets of the underlying molecular mechanisms responsible for the specificity and virulence of conopeptides, however, remain poorly understood. In this review, we will explore the chemical diversity of conopeptides from a computational perspective. First, we discuss current approaches used for classifying conopeptides. Next, we review different computational strategies that have been applied to understanding and predicting their structure and function, from machine learning techniques for predictive classification to docking studies and molecular dynamics simulations for molecular-level understanding. We then review recent novel computational approaches for rapid high-throughput screening and chemical design of conopeptides for particular applications. We close with an assessment of the state of the field, emphasizing important questions for future lines of inquiry.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS2023

Quantitative Gas Property Measurements By Filtered Rayleigh Scattering: A Review

Filtered Rayleigh scattering (FRS) is a laser-based diagnostic technique used to nonintrusively quantify various thermodynamic properties of a light-scattering gas. The backbone of FRS is the molecular filtering of Rayleigh scattered light. This concept was initially introduced by the atmospheric LIDAR community before being adopted within the aerospace research field in the early 1990s. Since then, FRS has matured into a versatile quantitative diagnostic tool and has found use in a variety of flow regimes ranging from sub- to supersonic speeds in both reacting and nonreacting environments. This adoption can be attributed to the wealth of information that can be obtained via FRS, including the gas density, pressure, temperature, velocity, species composition, or, in some cases, several of these properties at once. This article reviews the current state of FRS methodology in recovering such gas properties. As knowledge of the fundamentals of Rayleigh scattering and spectral light filtering is crucial to the design of an FRS experiment, we begin by briefly reviewing these areas. Subsequently, we conduct a survey of experimental design strategies, assumptions, and data reduction methods used to measure different gas properties using FRS. We conclude the review with a short discussion on quantification of experimental uncertainty and future trends in FRS.

filtered Rayleigh scattering↗
DOE OSTI2023

U.S. Department of Energy Hydrogen Program: 2022 Annual Merit Review and Peer Evaluation Report; June 6-8 2022

This document summarizes peer review comments and scores for the U.S. Department of Energy (DOE) Hydrogen Program 2022 Annual Merit Review and Peer Evaluation Meeting (AMR), held virtually June 6-8, 2022. The report also provides a brief overview of the Program, highlights key accomplishments since the previous AMR (held in June 2021), and summarizes activities and accomplishments within each Program office. Five Hydrogen and Fuel Cell Technologies Office subprogram chapters provide summaries of key activities and accomplishments since the preceding AMR, summaries of projects presented orally during this year's AMR, and a summary of peer reviewer comments on the subprogram.

AMR↗
DOE OSTI2013

Transition from Consultation to Monitoring-NRC's Increasingly Focused Review of Factors Important to F-Area Tank Farm Facility Performance - 13153

In consultation with the NRC, DOE issued a waste determination for the F-Area Tank Farm (FTF) facility in March 2012. The FTF consists of 22 underground tanks, each 2.8 to 4.9 million liters in capacity, used to store liquid high-level waste generated as a result of spent fuel reprocessing. The waste determination concluded stabilized waste residuals and associated tanks and auxiliary components at the time of closure are not high-level and can be disposed of as LLW. Prior to issuance of the final waste determination, during the consultation phase, NRC staff reviewed and provided comments on DOE's revision 0 and revision 1 FTF PAs that supported the waste determination and produced a technical evaluation report documenting the results of its multi-year review in October 2011. Following issuance of the waste determination, NRC began to monitor DOE disposal actions to assess compliance with the performance objectives in 10 CFR Part 61, Subpart C. To facilitate its monitoring responsibilities, NRC developed a plan to monitor DOE disposal actions. NRC staff was challenged in developing a focused monitoring plan to ensure limited resources are spent in the most cost-effective manner practical. To address this challenge, NRC prioritized monitoring areas and factors in terms of risk significance and timing. This prioritization was informed by NRC staff's review of DOE's PA documentation, independent probabilistic modeling conducted by NRC staff, and NRC-sponsored research conducted by the Center for Nuclear Waste Regulatory Analyses in San Antonio, TX. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2015

Hanford double-shell tank extent-of-condition construction review - 15498

During routine visual inspections of Hanford double-shell waste tank 241-AY-102 (AY-102), anomalies were identified on the annulus floor which resulted in further evaluations. Following a formal leak assessment in October 2012, Washington River Protection Solutions, LLC (WRPS) determined that the primary tank of AY-102 was leaking. A formal leak assessment, documented in RPP-ASMT-53793, Tank 241-AY-102 Leak Assessment Report, identified first-of-a-kind construction difficulties and trial-and-error repairs as major contributing factors to tank failure. To determine if improvements in double-shell tank (DST) construction occurred after construction of tank AY-102, a detailed review and evaluation of historical construction records was performed for Hanford's remaining twenty-seven DSTs. Review involved research of 241 boxes of historical project documentation to better understand the condition of the Hanford DST farms, noting similarities in construction difficulties/issues to tank AY-102. Information gathered provides valuable insight regarding construction difficulties, future tank operations decisions, and guidance of the current tank inspection program. Should new waste storage tanks be constructed in the future, these reviews also provide valuable lessons-learned.(authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗