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NASA NTRS2018

GeneLab: "Omics" Data Systems for Spaceflight and Simulated Spaceflight Environment

Determining the biological impact of spaceflight through novel approaches is essential to reduce the health risks to astronauts for long-term space missions. The current established health risks due to spaceflight are only reflecting known symptomatic and physiologic responses and do not reflect early onset of other potential diseases. There are many unknown variables which still need to be identified to fully understand the health impacts due to the environmental factors in space. One method to uncover potential novel biological mechanisms responsible for health risks in astronauts is by utilizing NASA's GeneLab Data Systems (genelab.nasa.gov). GeneLab is public repository that hosts multiple omics datasets generated from space biology experiments that include experiments flown in space, simulated cosmic radiation experiments, and simulated microgravity experiments. This presentation will provide an overview of GeneLab and examples of analysis that are being done with GeneLab datasets. These example will include novel data and work being generated with various scientists around the world involved with GeneLab's Analysis Working Groups (AWG) that are assisting with the development of pipelines and advancing GeneLab to the next phase, a publication from GeneLab discovering novel Carbon Dioxide impact due to rodent habitats, another publication from GeneLab discovering a potential master regulator responsible for health risk associated due to spaceflight, and potential cardiovascular risk from space radiation

spaceflight↗
NASA NTRS2018

Analysis and Review of NASA Earth Science Metadata: How Automation Plays a Role

The Analysis and Review of the Common Metadata Repository (CMR ARC) Team reviews all EOSDIS metadata. The team’s objective is to achieve consistency, correctness, and completeness for all metadata records in the CMR, as well as improve the discoverability of NASA's Earth Science data within the CMR framework. This work is currently being completed at Marshall Space Flight Center. CMR makes a single discovery point possible for NASA's Earth Science data users. The CMR team, in collaboration with three other core metadata teams, contributes to the stewardship of NASA's Earth Science data through a process of continual curation and the ongoing development of the Unified Metadata Model (UMM). A key tool now used in the curation process, referred to as the NASA CMR Dashboard, is an online curation dashboard developed in collaboration with software development company, Element 84. This tool facilitates the review of Earth Science metadata records and subsequent stakeholder collaboration on the resolution of identified issues. A key capability of the new tool is a suite of automated compliance checks written in Python 3.6 that verify the integrity of various metadata elements across multiple standards.

Staton, Patrick↗
NASA NTRS2018

End-to-End Solution for Data Customization with NASA's Earthdata Search

The goal of NASA's Earthdata Search End-to-End Services workflow is to take the pain and headache out of searching for data and getting that data back in a format that is usable with only that data that is relevant for you. For too long scientists have had to jump through endless hoops, use tools that only offer specific data or specific services, and perform any number of other non-science tasks just to get started on their actual project. Earthdata Search leverages the Common Metadata Repository's (CMR) newly implemented Unified Metadata Models for Services and Variables as well as a new service broker to expose and seamlessly integrate a collection's service capabilities and variables into an intuitive user interface. Using the new End-to-End Services workflow, scientists will be able to quickly see what data is available to be customized, what customization options are available, and actually perform those customizations on the data all within Earthdata Search, regardless of who the data provider is. This talk will demonstrate the simple workflow that will be available to end users and also give an overview covering how the workflow is enabled by the metadata stored within the CMR. (https://search.earthdata.nasa.gov/)

Reese, Mark↗
NASA NTRS2018

Earthdata User Interface (EUI) Library

As more remote sensing data moves to the cloud, the design tools we use to build user experiences and visualizations need to change and adapt to make the best use this new data reality. EUI 2.0, the next major iteration of the Earthdata User Interface Library, aims to make creating rich user experiences around NASA's Earth Observation System Data and Information System (EOSDIS) data easy and user-friendly. Building on a solid framework of design components, EUI 2.0 will be open source and have off-the-shelf integration with the Common Metadata Repository (CMR), basic mapping and visualization tools, a refreshed design toolkit for building apps and websites that fit the Earthdata design theme and guidelines. EUI 2.0 will allow for the rapid development of websites and applications based on EOSDIS tools and data holdings. It will also make use of cloud data availability to enable data visualization and analysis without the need to download and sync data.

Siarto, Jeff↗
NASA NTRS2018

The Nature of Interstellar Organics and Their Relationship to the Solar System

Carbonaceous materials are a primary compo-nent of interstellar dust, forming in the outflow of carbon stars and the diffuse interstellar me-dium (DISM). Over time, the low density DISM is swept into dense molecular clouds, the principal formation sites and repositories of most interstellar molecules. Organic com-pounds created in these clouds are the first step towards the complex materials that help to make planets habitable. Ground- and space-based telescopic observations trace interstellar organics from the diffuse to dense interstellar clouds, revealing that organic material in the diffuse ISM is predominantly hydrocarbon in nature, possessing little N or O, with the C distributed between the aromatic and aliphatic forms. A remarkable similarity between the hydrocarbons in dust in our Galaxy to that of distant galaxies, indicates that this organic component of the DISM is widespread and may be an important universal reservoir of prebiotic organic carbon. Spectroscopy of background stars seen through quiescent dust in clouds with no star formation activity re-veals that chemistry occurs early-on. Mean-while, observations of certain asteroids, com-ets, interplanetary dust particles, planets and planetary satellites present an intricate inter-weaving of preserved interstellar components and those that have been subsequently altered. The composition ofinterstellar dust grains and the evolution of dust between dense clouds (where stars and planetary systems form) and the diffuse inter-stellar medium (where stardust components are ejected), will be presented in this workshop on Carbon in the Solar System.

Intersteller Organics↗
NASA NTRS2016

Using Cloud-Based Storage Technologies for Earth Science Data

Cloud based infrastructure may offer several key benefits of scalability, built in redundancy and reduced total cost of ownership as compared with a traditional data center approach. However, most of the tools and software systems developed for NASA data repositories were not developed with a cloud based infrastructure in mind and do not fully take advantage of commonly available cloud-based technologies. Object storage services are provided through all the leading public (Amazon Web Service, Microsoft Azure, Google Cloud, etc.) and private (Open Stack) clouds, and may provide a more cost-effective means of storing large data collections online. We describe a system that utilizes object storage rather than traditional file system based storage to vend earth science data. The system described is not only cost effective, but shows superior performance for running many different analytics tasks in the cloud. To enable compatibility with existing tools and applications, we outline client libraries that are API compatible with existing libraries for HDF5 and NetCDF4. Performance of the system is demonstrated using clouds services running on Amazon Web Services.

Data↗
NASA NTRS2018

EOSDIS CMR: Shifting Data Discovery & Use into a Higher Gear

Earth observation data comes in many forms, formats, and from a multitude of sources; to make the best of a very large and diverse data catalog (data from a dozen different national Distributed Active Archive Centers (DAACs) as well as international sources), NASA has created a one-stop-shop for earth data consumers to view, find, and get the data they need regardless of its original source or format, which is powered by a Common Metadata Repository (CMR). CMR is the underpinning that allows for the visualization, search, discovery, manipulation, and acquisition of a variety of datasets, and as such it is constantly evolving to do more and serve our communities better; CMR has embraced community ownership by making itself an open-source API, being compatible with Catalog Services for the Web (CSW) and OpenSearch APIs, and by encouraging the user community to make and share improvements.

CMR↗
NASA NTRS2015

Experimental Design for Pre-Clinical Animal Model Study in Microgravity

The Rodent Research program at NASAs Ames Research Center (ARC) has pioneered a new research capability on the International Space Station in less than four years and has progressed toward translating research to the ISS utilizing commercial rockets, collaborating with academia and science industry, and training crew for research purposes on-orbit. Animal models are the foundation of pre-clinical research to understand human diseases and evaluate new therapeutics. Advancement in alleviating ground diseases such as muscle atrophy and osteoporosis can come from the study of similar conditions that are known to occur as a result of exposure to the spaceflight environment. During the completion of the flight phase of two missions, our practices, hardware and operations evolved from tested to developed standards, which successfully translated the studies from ground to space. Results from these studies contribute to the science community via both the primary investigation and banked samples that are shared in publicly available data repository such as GeneLab. Every completed mission sets a foundation to build and design greater complexity into future research and answer questions about common human diseases on ground and in space. Here, we present methods developed for the translation of a rodent experiment to the ISS including a description of hardware and kits available for investigators and a discussion of operational constraints.

Rodent Research↗
NASA NTRS2018

Changes in Exercise Data Management

The suite of exercise hardware aboard the International Space Station (ISS) generates an immense amount of data. The data collected, treadmill, cycle ergometer, and resistance strength training hardware, are basic exercise parameters (time, heart rate, speed, load, etc.). The raw data are processed in the laboratory and more detailed parameters are calculated from each exercise data file. Updates recently have been made to how these valuable data are stored, adding an additional level of security, increasing accessibility, and resulting in overall increased efficiency of medical report delivery. Questions regarding exercise performance or how exercise may influence other variables of crew health frequently arise within the crew health care community. Inquiries regarding the health of the exercise hardware often need quick analysis and response to ensure the exercise system is operable on a continuous basis. Consolidating all of the exercise system data in a single repository enables a quick response to both the medical and engineering communities. A SQL server database is currently in use, and provides a secure location for all of the exercise data starting at ISS Expedition 1 to current date. The database has been structured to update derived metrics automatically, making analysis and reporting available within minutes of dropping the in-flight data into the database. Commercial tools were evaluated to help aggregate and visualize data from the SQL database. The Tableau software provides manageable interface, which has improved the laboratory’s output time of crew reports by 67%. Expansion of the SQL database, to be inclusive of additional medical requirement metrics, addition of ‘app-like’ tools for mobile visualization, and collaborative use (e.g., operational support teams, research groups, and International Partners) of the data system, is currently being explored.

Buxton, R. E.↗
NASA NTRS2018

The NASA GeneLab Project

"NASA's GeneLab Project has evolved from being a simple repository that hosts multi-omics datasets generated from spaceflight experiments, to a complete solution for analysis and visualization of spaceflight related omics. We will show how Omics can help elucidate the impact of spaceflight factors (e.g. CO2) on organisms, tissues and cells."

OMICS↗
NASA NTRS2018

Planetary Spectrum Generator: An Accurate Online Radiative Transfer Suite for Atmospheres, Comets, Small Bodies and Exoplanets

We have developed an online radiative-transfer suite (https://psg.gsfc.nasa.gov) applicable to a broad range of planetary objects (e.g., planets, moons, comets, asteroids, TNOs, KBOs, exoplanets). The Planetary Spectrum Generator (PSG) can synthesize planetary spectra (atmospheres and surfaces) for a broad range of wavelengths (UV/Vis/near-IR/IR/far-IR/THz/sub-mm/Radio) from any observatory (e.g., JWST, ALMA, Keck, SOFIA), any orbiter (e.g., ExoMars, Juno), or any lander (e.g., MSL). This is achieved by combining several state-of-the-art radiative transfer models, spectroscopic databases and planetary databases (i.e., climatological and orbital). PSG has a 3D (three-dimensional) orbital calculator for most bodies in the solar system, and all confirmed exoplanets, while the radiative-transfer models can ingest billions of spectral signatures for hundreds of species from several spectroscopic repositories. It integrates the latest radiative-transfer and scattering methods in order to compute high resolution spectra via line-by-line calculations, and utilizes the efficient correlated-k method at moderate resolutions, while for computing cometary spectra, PSG handles non-LTE and LTE excitation processes. PSG includes a realistic noise calculator that integrates several telescope/instrument configurations (e.g., interferometry, coronagraphs) and detector technologies (e.g., CCD, heterodyne detectors, bolometers). Such an integration of advanced spectroscopic methods into an online tool can greatly serve the planetary community, ultimately enabling the retrieval of planetary parameters from remote sensing data, efficient mission planning strategies, interpretation of current and future planetary data, calibration of spectroscopic data, and development of new instrument/spacecraft concepts.

Villanueva, G. L.↗
NASA NTRS2019

IDN Update

The objective of this presentation is to provide IDN (International Directory Network) updates on features and activities to the Committee on Earth Observation Satellites (CEOS) Working Group on Information Systems and Services (WGISS) and provider community. The following topics will be discussed during the presentation: IDN Activities (since WGISS-46); Registration of services with granules stored outside NASA CMR (Common Metadata Repository; Setting up CEOS 2-Step OpenSearch in the IDN (CMR); Update on efforts to provide consistent Quality Assurance (QA) Rule messaging.

WGISS↗
NASA NTRS2019

Prebiotic Chemistry of Pluto

We present the case for the presence of complex organic molecules, such as amino acids and nucleobases, formed by abiotic processes on the surface and in near-subsurface regions of Pluto. Pluto's surface is tinted with a range of non-ice substances with colors ranging from light yellow to red to dark brown; the colors match those of laboratory organic residues called tholins. Tholins are broadly characterized as complex, macromolecular organic solids consisting of a network of aromatic structures connected by aliphatic bridging units (e.g., Imanaka et al.,2004; Materese et al.,2014, 2015). The synthesis of tholins in planetary atmospheres and in surface ices has been explored in numerous laboratory experiments, and both gas- and solid-phase varieties are found on Pluto. A third variety of tholins, exposed at a site of tectonic surface fracturing called Virgil Fossae, appears to have come from a reservoir in the subsurface. Eruptions of tholin-laden liquid H2O from a subsurface aqueous repository appear to have covered portions of Virgil Fossae and its surroundings with a uniquely colored deposit (D.P. Cruikshank, personal communication) that is geographically correlated with an exposure of H2O ice that includes spectroscopically detected NH3 (C.M. Dalle Ore, personal communication). The subsurface organic material could have been derived from presolar or solar nebula processes, or might have formed in situ. Photolysis and radiolysis of a mixture of ices relevant to Pluto's surface composition (N2, CH4, CO) have produced strongly colored, complex organics with a significant aromatic content having a high degree of nitrogen substitution similar to the aromatic heterocycles pyrimidine and purine (Materese et al.,2014, 2015; Cruikshank et al.,2016). Experiments with pyrimidines and purines frozen in H2O-NH3 ice resulted in the formation of numerous nucleobases, including the biologically relevant guanine, cytosine, adenine, uracil, and thymine (Materese et al.,2017). The red material associated with the H2O ice may contain nucleobases resulting from energetic processing on Pluto's surface or in the interior. Some other Kuiper Belt objects also exhibit red colors similar to those found on Pluto and may therefore carry similar inventories of complex organic materials. The widespread and ubiquitous nature of similarly complex organic materials observed in a variety of astronomical settings drives the need for additional laboratory and modeling efforts to explain the origin and evolution of organic molecules. Pluto observations reveal complex organics on a small body that remains close to its place of origin in the outermost regions of the Solar System.

Cruikshank, D. P.↗
NASA NTRS2014

Automated Discovery of Flight Track Anomalies

As new technologies are developed to handle the complexities of the Next Generation Air Transportation System (NextGen), it is increasingly important to address both current and future safety concerns along with the operational, environmental, and efficiency issues within the National Airspace System (NAS). In recent years, the Federal Aviation Administration’s (FAA) safety offices have been researching ways to utilize the many safety databases maintained by the FAA, such as those involving flight recorders, radar tracks, weather, and many other high- volume sensors, in order to monitor this unique and complex system. Although a number of current technologies do monitor the frequency of known safety risks in the NAS, very few methods currently exist that are capable of analyzing large data repositories with the purpose of discovering new and previously unmonitored safety risks. While monitoring the frequency of known events in the NAS enables mitigation of already identified problems, a more proactive approach of finding unidentified issues still needs to be addressed. This is especially important in the proactive identification of new, emergent safety issues that may result from the planned introduction of advanced NextGen air traffic management technologies and procedures. Development of an automated tool that continuously evaluates the NAS to discover both events exhibiting flight characteristics indicative of safety-related concerns as well as operational anomalies will heighten the awareness of such situations in the aviation community and serve to increase the overall safety of the NAS. This paper discusses the extension of previous anomaly detection work to identify operationally significant flights within the highly complex airspace encompassing the New York area of operations, focusing on the major airports of Newark International (EWR), LaGuardia International (LGA), and John F. Kennedy International (JFK). In addition, flight traffic in the vicinity of Denver International (DEN) airport/airspace is also investigated to evaluate the impact on operations due to variances in seasonal weather and airport elevation. From our previous research, subject matter experts determined that some of the identified anomalies were significant, but could not reach conclusive findings without additional supportive data. To advance this research further, causal examination using domain experts is continued along with the integration of air traffic control (ATC) voice data to shed much needed insight into resolving which flight characteristic(s) may be impacting an aircraft's unusual profile. Once a flight characteristic is identified, it could be included in a list of potential safety precursors. This paper also describes a process that has been developed and implemented to automatically identify and produce daily reports on flights of interest from the previous day.

Matthews, Bryan↗
NASA NTRS2019

Science Driven By Space Biology Omics Data Utilizing NASA's GeneLab Platform

Determining the biological impact of spaceflight through novel approaches is essential to reduce the health risks to astronauts for long-term space missions. The current established health risks due to spaceflight are only reflecting known symptomatic and physiologic responses and do not reflect early onset of other potential diseases. There are many unknown variables which still need to be identified to fully understand the health impacts due to the environmental factors in space. One method to uncover potential novel biological mechanisms responsible for health risks in astronauts is by utilizing NASA's GeneLab Data Systems (genelab.nasa.gov). GeneLab is public repository that hosts multiple omics datasets generated from space biology experiments that include experiments flown in space, simulated cosmic radiation.

Beheshti, Afshin↗
NASA NTRS2019

Evolving UMM-S to Better Accommodate NASA EOSDIS Web User Interfaces and Downloadable Tools for Data Use

EOSDIS has a services metadata model that is growing too complex and trying to serve multiple use cases. A potential solution being explored is to break out the model for front-end and back-end use cases. This talk will discuss how best to accommodate web user interfaces and downloadable tools in NASA's Common Metadata Repository (CMR) and how to model this information for improved discovery centered around the user experience (UI/UX) approach. The challenges and strategy for addressing the evolution of the model will be discussed along with a proposed path forward for implementation.

User Experience↗
NASA NTRS2019

Nasa GeneLab Computomics Reveal Horizontal Gene Transfer on International Space Station Environmental Metagenomes

Prokaryotic lifeforms can be observed to demonstrate many keen adaptive advantages, perhaps facilitated by a nature simplistic relative to divergent domains of life. In particular, decompartmentalized gene expression facilitates adaptation by allowing free exchange of genetic material, albeit at the cost of increased susceptibility to genetic damage. Thus, these lifeforms must compensate by embracing diverse investment strategies in an attempt to “brute force” the evolvability equation through precipitous genesis, lean metabolic efficiency, and sheer population. This prokaryotic archetype also enables symbiotic relationships with secondary mobile genetic elements known as plasmids, which have been shown to drive evolution on rapid temporal scales through processes such as conjugation and transformation. This study attempts to decipher whether these mechanisms of horizontal gene transfer (HGT) are major factors in determining prokaryote fitness within a unique isolated environment, the International Space Station (ISS). The ISS Microbial Tracking (MT) project has generated a wealth of data concerning the successive reigns of microbial genera that appear to thrive amidst harsh conditions for life. Despite relatively higher doses of ionizing radiation as compared to Earth, complications associated with microgravity, and the anti-microbial mélange deployed, microbial life still persists in this environment. The NASA GeneLab serves as a data repository and analysis platform to enable researchers to access space flight factor related data. With the use of GeneLab’s modern computational suites (computomics), phylogenetic and functional genomic investigations of HGT events were conducted on the data generated from the MT-1 project. The putative data concerning the plasmid population (plasmidome) of the ISS was algorithmically derived and compared to those of habitats with similar environmental dynamics- such as living quarters and hospitals- to investigate whether these HGT elements may play crucial role(s) in shaping the microbiome of this closed habitat that serves as the only inhabited structure in space.

Bense, Nicholas↗
NASA NTRS2016

Mapping in the Northern Martian Plains: A Renewed Survey of the Acidalia Mensae and Colles Regions

Acidalia Mensae is an oblong field of tilted mesas roughly trending east-west, with Acidalia Colles encompassing a regime of knobby terrain trending northeast from the center of the mesa region. Each province extends for approximately 300km in their respective directions in the heart of the vast plains of Acidalia Planitia. As part of efforts in the 1980s targeting evidences for a putative northern Martian paleo-ocean – manifesting itself most notably in geologic maps of quadrangles in East Acidalia – the Acidalia Mensae region was selected and divided into three quadrangles ranging across 26.8 deg W to 36 deg W and 47.5 deg N to 52.5 deg N. The region was then mapped at a 1:1,000,000 scale using Canvas on a Viking base map. We present an updated draft of this document converted into ArcMap, including a completed fourth quadrangle that covers the bulk of the Acidalia Colles region. Previously mapped units have been updated according to the availability of new higher-resolution data – particularly, Thermal Emission Imaging System (THEMIS) Day Infrared (IR) data as a base map, paired with supporting Context Camera (CTX) and High Resolution Stereo Camera (HRSC) HRSC stamps extracted from the Mars Orbital Data Explorer repository. Geologic units and contacts for the mesa and knob regimes, interstitial alluvial units and the surrounding plains are comprehensively presented alongside lower-level features such as levels (hypothesized to be shorelines) and pitted cones (putative pingos). The project was mapped in a transverse Mercator projection. Upon minor revision, the map is to be submitted to the USGS for publication.

Siwabessy, Andrew G.↗