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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 487 records · Page 27
All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds

Tuberculosis (TB) remains a worldwide problem and the need for new drugs is increasingly more urgent with the emergence of multidrug- and extensively-drug resistant TB. Inosine 5’-monophosphate dehydrogenase 2 (IMPDH2) from Mycobacterium tuberculosis(Mtb) is an attractive drug target. The enzyme catalyzes the conversion of inosine 5’-monophosphate into xanthosine 5’-monophosphate with the concomitant reduction of NAD+ to NADH. This reaction controls flux into the guanine nucleotide pool. We report seventeen selective IMPDH inhibitors with antitubercular activity. The crystal structures of a deletion mutant ofMtbIMPDH2 in the apo form and in complex with the product XMP and substrate NAD+ are determined. We also report the structures of complexes with IMP and three structurally distinct inhibitors, including two with antitubercular activity. These structures will greatly facilitate the development of MtbIMPDH2-targeted antibiotics.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2018

Experimental Demonstration of Ion Beam Cooling with Pulsed Electron Beam

Cooling ion beams at high energy is presently considered for several ion colliders, in order to achieve high luminosities by enabling a significant reduction of emittance of hadron beams. Electron beam at cooling channel in a few to tens MeV can be accelerated by a RF/SRF linac, and thus using bunched electrons to cool bunched ions. To study such cooling process, the DC electron gun of EC35 cooler at the storage ring CSRm, IMP was modified by pulsing the grid voltage. A 0.07-3.5 micro-second pulse length with a repetition frequency of less than 250 kHz and synchronized with the ion revolution frequency was obtained. The first experimental demonstration of cooling of a coasting and bunched ion beam by a pulsed electron beam was carried out. Data analysis indicates the bunch length shrinkage and the momentum spread reduction of bunched 12C+6 ion beam as evidence of cooling. A longitudinal grouping effect of the coasting ion beam by the electron pulses has also been observed*. In this paper, we will present experimental results and comparison to the simulation modelling, particularly on the bunched electron cooling data after carefully analyzing the beam diagnostic signals.

Zhang, Yuhong↗
DOE OSTI2020

Radar Motion Measurements and Synthetic Aperture Radar Image Geolocation Accuracy

Once a Synthetic Aperture Radar (SAR) image is formed, the natural question then is, "Where is this image?" and/or "Where exactly is this feature displayed in the image?" Thus, geolocation is an important exploitation of the SAR image. Since SAR measures relative location to its own position, it is crucial to understand how the radars position and motion imp acts the ability to geolocate a feature in the SAR image. Furthermore, accuracy and precision of navigation aids like GPS directly impact the goodness of the geolocation solution. These relationships are developed and discussed.

58 GEOSCIENCES↗
DOE OSTI2017

Comparative Genomic Analysis of Neutrophilic Iron(II) Oxidizer Genomes for Candidate Genes in Extracellular Electron Transfer [Plus Supplementary Data]

Extracellular electron transfer (EET) is recognized as a key biochemical process in circumneutral pH Fe(II)-oxidizing bacteria (FeOB). In this study, we searched for candidate EET genes in 73 neutrophilic FeOB genomes, among which 43 genomes are complete or close-to-complete and the rest have estimated genome completeness ranging from 5 to 91%. These neutrophilic FeOB span members of the microaerophilic, anaerobic phototrophic, and anaerobic nitrate-reducing FeOB groups. We found that many microaerophilic and several anaerobic FeOB possess homologs of Cyc2, an outer membrane cytochrome c originally identified in Acidithiobacillus ferrooxidans. The “porin-cytochrome c complex” (PCC) gene clusters homologous to MtoAB/PioAB are present in eight FeOB, accounting for 19% of complete and close-to-complete genomes examined, whereas PCC genes homologous to OmbB-OmaB-OmcB in Geobacter sulfurreducens are absent. Further, we discovered gene clusters that may potentially encode two novel PCC types. First, a cluster (tentatively named “PCC3”) encodes a porin, an extracellular and a periplasmic cytochrome c with remarkably large numbers of heme-binding motifs. Second, a cluster (tentatively named “PCC4”) encodes a porin and three periplasmic multiheme cytochromes c. A conserved inner membrane protein (IMP) encoded in PCC3 and PCC4 gene clusters might be responsible for translocating electrons across the inner membrane. Other bacteria possessing PCC3 and PCC4 are mostly Proteobacteria isolated from environments with a potential niche for Fe(II) oxidation. In addition to cytochrome c, multicopper oxidase (MCO) genes potentially involved in Fe(II) oxidation were also identified. Notably, candidate EET genes were not found in some FeOB, especially the anaerobic ones, probably suggesting EET genes or Fe(II) oxidation mechanisms are different from the searched models. Overall, based on current EET models, the search extends our understanding of bacterial EET and provides candidate genes for future research.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2022

Designing Harvesting and Hauling Cost Models for Energy Cane Production for Biorefineries

The harvesting and hauling operations of bioenergy feedstock is an important area in biofuel production. Production costs can be minimized by maintaining optimal machinery units for these operations. The objective of this study is to design an optimal harvesting unit for bioenergy refinery and estimate harvesting and hauling costs of energy cane. A biorefinery with the annual capacity of processing twenty-five million imp. gallons of ethanol were considered. Given the efficiency of harvesting, a two-row soldier system was considered. Considering the year-round supply of energy cane to the refinery, the optimal machinery unit was designed, and the combined operation costs were derived. The average estimated ownership, repair, labor and fuel and lubricant costs of biomass harvest unit were calculated to be $\$$0.50, $\$$0.54, $\$$1.78 and $\$$1.51/mt, respectively. The costs distribution generated showed harvesting and hauling costs could range between $\$$5.47–$\$$9.23/mt of energy cane. The methodology and the research output will provide guidelines for investors in designing harvesting and hauling units and estimating costs for different scales of operation.

09 BIOMASS FUELS↗
DOE OSTI2022

Tracking and Rejection of Biased Sinusoidal Signals Using Generalized Predictive Controller

Some novel applications require the tracking/rejection of biased sinusoidal reference/distur-bances. According to the internal model principle (IMP), a controller must embed the model of a biased sinusoidal signal to track references and also reject perturbations modeled through the aforementioned signal. However, the design of that kind of controller is not straightforward, especially when they are implemented in digital processors. This paper presents a controller, based on generalized predictive control (GPC), designed for tracking/rejection of biased sinusoidal signals. In general, GPC is based on the prediction of the plant responses through an augmented prediction model. The proposed approach develops an augmented model that predicts the future errors. The prediction model and the control law used in the proposed approach embed the discrete-time model of a biased sinusoidal signal. Thus, the proposed controller can track/reject biased sinusoidal references/disturbances. The predicted errors and the future inputs of the proposed augmented model are used to define the cost function that measures the control performance. An optimization technique was applied to obtain the solution of the cost function, which is the optimal sequence of future model inputs that allows defining the control law. Experimental tests prove that the proposed controller can asymptotically track and reject biased sinusoidal signals.

42 ENGINEERING↗
DOE OSTI2016

CHARGE SPECTRUM OF HEAVY AND SUPERHEAVY COMPONENTS OF GALACTIC COSMIC RAYS: RESULTS OF THE OLIMPIYA EXPERIMENT

The aim of the OLIMPIYA experiment is to search for and identify traces of heavy and superheavy nuclei of galactic cosmic rays (GCR) in olivine crystals from stony–iron meteorites serving as nuclear track detectors. The method is based on layer-by-layer grinding and etching of particle tracks in these crystals. Unlike the techniques of other authors, this annealing-free method uses two parameters: the etching rate along the track ( V {sub etch}) and the total track length ( L ), to identify charge Z of a projectile. A series of irradiations with different swift heavy ions at the accelerator facilities of GSI (Darmstadt) and IMP (Lanzhou) were performed in order to determine and calibrate the dependence of projectile charge on V {sub etch} and L . To date, one of the most essential results of the experiment is the obtained charge spectrum of GCR nuclei within the range of Z > 40, based on about 11.6 thousand processed tracks. As the result of data processing, 384 nuclei with charges Z ≥ 75 have been identified, including 10 nuclei identified as actinides (90 < Z < 103). Three tracks were identified to be produced by nuclei with charges 113 < Z < 129. Such nuclei may be part of the Island of Stability of transfermium elements.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2016

The thermal state of KS 1731−260 after 14.5 years in quiescence

Crustal cooling of accretion-heated neutron stars provides insight into the stellar interior of neutron stars. The neutron star X-ray transient, KS 1731−260, was in outburst for 12.5 years before returning to quiescence in 2001. We have monitored the cooling of this source since then through Chandra and XMM-Newton observations. Here we present a 150 ks Chandra observation of KS 1731−260 taken in 2015 August, about 14.5 years into quiescence and 6 years after the previous observation. We find that the neutron star surface temperature is consistent with the previous observation, suggesting that crustal cooling has likely stopped and the crust has reached thermal equilibrium with the core. Using a theoretical crust thermal evolution code, we fit the observed cooling curves and constrain the core temperature (T {sub c} = 9.35 ± 0.25 × 10{sup 7} K), composition (Q {sub imp}=4.4{sub −0.5}{sup +2.2}), and level of extra shallow heating required (Q {sub sh} = 1.36 ± 0.18 MeV/nucleon). We find that the presence of a low thermal conductivity layer, as expected from nuclear pasta, is not required to fit the cooling curve well, but cannot be excluded either.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2018

Nuclear Reactions in the Crusts of Accreting Neutron Stars

X-ray observations of transiently accreting neutron stars during quiescence provide information about the structure of neutron star crusts and the properties of dense matter. Interpretation of the observational data requires an understanding of the nuclear reactions that heat and cool the crust during accretion and define its nonequilibrium composition. We identify here in detail the typical nuclear reaction sequences down to a depth in the inner crust where the mass density is $\rho =2\times {10}^{12}\,{\rm{g}}\,{\mathrm{cm}}^{-3}$ using a full nuclear reaction network for a range of initial compositions. The reaction sequences differ substantially from previous work. We find a robust reduction of crust impurity at the transition to the inner crust regardless of initial composition, though shell effects can delay the formation of a pure crust somewhat to densities beyond $\rho =2\times {10}^{12}\,{\rm{g}}\,{\mathrm{cm}}^{-3}$. This naturally explains the small inner crust impurity inferred from observations of a broad range of systems. The exception are initial compositions with A ≥ 102 nuclei, where the inner crust remains impure with an impurity parameter of Q imp ≈ 20 owing to the N = 82 shell closure. In agreement with previous work, we find that nuclear heating is relatively robust and independent of initial composition, while cooling via nuclear Urca cycles in the outer crust depends strongly on initial composition. As a result, this work forms a basis for future studies of the sensitivity of crust models to nuclear physics and provides profiles of composition for realistic crust models.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
NASA NTRS1965

The earth's magnetic tail.

Earth magnetic field at more than 7 Earth-radii measured by Imp satellite, noting topology, magnetic tail and position of collisionless bow shock wave

GEOMAGNETIC FIELD↗
NASA NTRS1965

The earth's magnetic tail.

Earth magnetic field at more than 7 Earth-radii measured by Imp satellite noting topology, magnetic tail and position of collisionless bow shock wave

GEOMAGNETIC FIELD↗