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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 487 records · Page 27
All sourcesNASA NTRSDOE OSTI
DOE OSTI2019

Experimental Measurement and Analysis of Stress/Shock Wave Propagation Speed through Pre-strained Silicone Foam Pads under Lateral Confinement

Foam materials are increasingly utilized in aerospace, military, and transportation applications to mitigate blast or shock impact. When foam materials are subjected to an external high-speed impact, shock, or blast loading, an elastic wave or shock wave will form and propagate through the thickness of the foam materials. Here, silicone foam pads, which were confined laterally and pre-strained to different levels, were experimentally characterized and theoretically analyzed to understand their effects on wave propagation characteristics under impact loading. Depending on impact velocity, either an elastic strain wave or a shock wave would be generated in the silicone foam pad with different pre-strains. Above a certain impact velocity, a shock wave will be generated whereas, below this threshold impact velocity, an elastic strain wave will be generated. This threshold impact velocity depends on the pre-strain applied to the silicone foam pad. Equations are provided to estimate the wave propagation speed for either an elastic or a shock wave from the amount of pre-strain in the silicone foam pads and the impact velocity. These equations are expected to help improve silicone foam design and assembly processes for shock or blast mitigation applications.

36 MATERIALS SCIENCE↗
DOE OSTI2018

Antibiotic anisomycin selectively targets leukemia cell lines and patient samples through suppressing Wnt/β-catenin signaling

Highlights: • Anisomycin effectively targets CML cell lines and CD34 stem/progenitor cells. • Anisomycin has little or no effect on normal bone marrow (NBM) CD34 cells. • Anisomycin acts on CML cells through inhibiting Wnt/β-catenin signaling pathway. • Anisomycin augments the effects of BCR-ABL TKI in CML. Chronic myeloid leukemia (CML) responds well to BCR-ABL tyrosine kinase inhibitors (TKI), such as imatinib and dasatinib. However, these inhibitors have been less effective as single agents in the blast phase-CML. In this work, we show that anisomycin, a clinically available drug, targets CML cells at all stages of development and enhances BCR-ABL TKIs’ efficacy. Anisomycin at nanomolar concentration inhibits proliferation and induces apoptosis in a panel of CML cell lines in a dose-dependent manner. It induces apoptosis CD34 stem/progenitor cells isolated from patients with blast phase CML. Using colony formation and serial replating assays, we further show that anisomycin inhibits CML CD34 cell differentiation, proliferation and self-renewal. Additionally, anisomycin is less effective in normal bone marrow (NBM) CD34 cells, suggesting the selective anti-leukemia activity of anisomycin. Combination of anisomycin with imatinib or dasatinib achieves significantly better efficacy than TKI alone in leukemia cell lines and patient samples while sparing normal counterparts. Mechanistically, we demonstrate that p38 MAPK/JNK activation is not required for anti-leukemia activities of anisomycin. Instead, anisomycin displays preferential inhibitory effects to Wnt/β-catenin-mediated signaling in CML. Our work provides the preclinical evidence on the potent efficacy of anisomycin in leukemia and its mechanisms of action. Our work suggests that anisomycin is a potential drug to overcome resistance to BCR-ABL TKI treatment in blast phase CML.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

Selection of site specific vibration equation by using analytic hierarchy process in a quarry

This paper presents a new approach for the selection of the most accurate SSVA (Site Specific Vibration Attenuation) equation for blasting processes in a quarry located near settlements in Istanbul, Turkey. In this context, the SSVA equations obtained from the same study area in the literature were considered in terms of distance between the shot points and buildings and the amount of explosive charge. In this purpose, 11 different SSVA equations obtained from the study area in the past 12 years, forecasting capabilities according to designated new conditions, using 102 vibration records as test data obtained from the study area was investigated. In this study, AHP (Analytic Hierarchy Process) was selected as an analysis method in order to determine the most accurate equation among 11 SSAV equations, and the parameters such as year, distance, charge, and r{sup 2} of the equations were used as criteria for AHP. Finally, the most appropriate equation was selected among the existing ones, and the process of selecting according to different target criteria was presented. Furthermore, it was noted that the forecasting results of the selected equation is more accurate than that formed using the test results. - Highlights: • The optimum Site Specific Vibration Attenuation equation for blasting in a quarry located near settlements was determined. • It is indicated that SSVA equations changing over the years don’t give always accurate estimates at changing conditions. • Selection of the blast induced SSVA equation was made using AHP. • Equation selection method was highlighted based on parameters such as charge, distance, and quarry geometry changes (year).

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2016

Optical shaping of gas targets for laser–plasma ion sources

In this paper, we report on the experimental demonstration of a technique to generate steep density gradients in gas-jet targets of interest to laser–plasma ion acceleration. By using an intentional low-energy prepulse, we generated a hydrodynamic blast wave in the gas to shape the target prior to the arrival of an intense CO $_{2}$ ( ${\it\lambda}\approx 10~{\rm\mu}\text{m}$ ) drive pulse. This technique has been recently shown to facilitate the generation of ion beams by shockwave acceleration (Tresca et al. , Phys. Rev. Lett. , vol. 115 (9), 2015, 094802). Here, we discuss and introduce a model to understand the generation of these blast waves and discuss in depth the experimental realisation of the technique, supported by hydrodynamics simulations. With appropriate prepulse energy and timing, this blast wave can generate steepened density gradients as short as $l\approx 20~{\rm\mu}\text{m}$ ( $1/e$ ), opening up new possibilities for laser–plasma studies with near-critical gaseous targets.

43 PARTICLE ACCELERATORS↗
DOE OSTI2022

Metaplastic and energy-efficient biocompatible graphene artificial synaptic transistors for enhanced accuracy neuromorphic computing

CMOS-based computing systems that employ the von Neumann architecture are relatively limited when it comes to parallel data storage and processing. In contrast, the human brain is a living computational signal processing unit that operates with extreme parallelism and energy efficiency. Although numerous neuromorphic electronic devices have emerged in the last decade, most of them are rigid or contain materials that are toxic to biological systems. In this work, we report on biocompatible bilayer graphene-based artificial synaptic transistors (BLAST) capable of mimicking synaptic behavior. The BLAST devices leverage a dry ion-selective membrane, enabling long-term potentiation, with ~50 aJ/µm 2 switching energy efficiency, at least an order of magnitude lower than previous reports on two-dimensional material-based artificial synapses. The devices show unique metaplasticity, a useful feature for generalizable deep neural networks, and we demonstrate that metaplastic BLASTs outperform ideal linear synapses in classic image classification tasks. With switching energy well below the 1 fJ energy estimated per biological synapse, the proposed devices are powerful candidates for bio-interfaced online learning, bridging the gap between artificial and biological neural networks.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2021

Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms

Military and law enforcement breachers are exposed to many low-level blasts during their training and occupational experiences in which they detonate explosives to force entry into secured structures. There is a concern that exposure to these repetitive blast events in career breachers could result in cumulative neurological effects. This study aimed to determine concentrations of neurofilament light (NF-L), tau, and amyloid-beta 42 (Aβ42) in serum and in neuronal-derived extracellular vesicles (EVs) in an experienced breacher population, and to examine biomarker associations with neurobehavioral symptoms. Thirty-four participants enrolled in the study: 20 experienced breachers and 14 matched military or civilian law enforcement controls. EV tau concentrations were significantly elevated in experienced breachers (0.3301 ± 0.5225) compared to controls (–0.4279 ± 0.7557; F = 10.43, p = 0.003). No statistically significant changes were observed in EV levels of NF-L or Aβ42 or in serum levels of NF-L, tau, or Aβ42 (p’s > 0.05). Elevated EV tau concentrations correlated with increased Neurobehavioral Symptom Inventory (NSI) score in experienced breachers (r = 0.596, p = 0.015) and predicted higher NSI score (F(1,14) = 7.702, p = 0.015, R 2 = 0.355). These findings show that neuronal-derived EV concentrations of tau are significantly elevated and associated with neurobehavioral symptoms in this sample of experienced breachers who have a history of many low-level blast exposures.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2019

Constraining preheat energy deposition in MagLIF experiments with multi-frame shadowgraphy

A multi-frame shadowgraphy diagnostic has been developed and applied to laser preheat experiments relevant to the Magnetized Liner Inertial Fusion (MagLIF) concept. The diagnostic views the plasma created by laser preheat in MagLIF-relevant gas cells immediately after the laser deposits energy as well as the resulting blast wave evolution later in time. The expansion of the blast wave is modeled with 1D radiation-hydrodynamic simulations that relate the boundary of the blast wave at a given time to the energy deposited into the fuel. This technique is applied to four different preheat protocols that have been used in integrated MagLIF experiments to infer the amount of energy deposited by the laser into the fuel. The results of the integrated MagLIF experiments are compared with those of two-dimensional LASNEX simulations. Here, the best performing shots returned neutron yields ~40–55% of the simulated predictions for three different preheat protocols

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2013

LATE-TIME RADIO EMISSION FROM X-RAY-SELECTED TIDAL DISRUPTION EVENTS

We present new observations with the Karl G. Jansky Very Large Array of seven X-ray-selected tidal disruption events (TDEs). The radio observations were carried out between 9 and 22 years after the initial X-ray discovery, and thus probe the late-time formation of relativistic jets and jet interactions with the interstellar medium in these systems. We detect a compact radio source in the nucleus of the galaxy IC 3599 and a compact radio source that is a possible counterpart to RX J1420.4+5334. We find no radio counterparts for five other sources with flux density upper limits between 51 and 200 {mu}Jy (3{sigma}). If the detections truly represent late radio emission associated with a TDE, then our results suggest that a fraction, {approx}> 10%, of X-ray-detected TDEs are accompanied by relativistic jets. We explore several models for producing late radio emission, including interaction of the jet with gas in the circumnuclear environment (blast wave model), and emission from the core of the jet itself. Upper limits on the radio flux density from archival observations suggest that the jet formation may have been delayed for years after the TDE, possibly triggered by the accretion rate dropping below a critical threshold of {approx}10{sup -2}-10{sup -3} M-dot {sub Edd}. The non-detections are also consistent with this scenario; deeper radio observations can determine whether relativistic jets are present in these systems. The emission from RX J1420.4+5334 is also consistent with the predictions of the blast wave model; however, the radio emission from IC 3599 is substantially underluminous, and its spectral slope is too flat, relative to the blast wave model expectations. Future radio monitoring of IC 3599 and RX J1420.4+5334 will help to better constrain the nature of the jets in these systems.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2015

Measuring ambient densities and Lorentz factors of gamma-ray bursts from GeV and optical observations

The Fermi satellite detected GeV flashes from cosmological gamma-ray bursts (GRBs). In two GRBs, an optical counterpart of the GeV flash was detected. Such flashes are predicted by the model of a blast wave running into a medium loaded with copious e{sup ±} pairs. Here we examine a sample of seven bursts with the best GeV+optical data and further test the model. We find that the observed light curves are in agreement with the theoretical predictions, which allows us to measure three parameters for each burst: the Lorentz factor of the explosion, its isotropic kinetic energy, and the external density. With the possible exception of GRB 090510 (the only short burst in the sample), the ambient medium is consistent with a wind from a Wolf–Rayet progenitor. The wind density parameter A=ρr{sup 2} varies in the sample around 10{sup 11} g cm{sup −1}. The initial Lorentz factor of the blast wave varies from 200 to 540, and correlates with the burst luminosity. Radiative efficiency of the prompt emission varies between 0.1 and 0.8. For the two bursts with a detected optical flash, GRB 120711A and GRB 130427A, we also estimate the magnetization of the external blast wave. Remarkably, despite its small number of free parameters, the model reproduces the entire optical light curve of GRB 120711A (with its sharp peak, fast decay, plateau, and break) as well as the GeV data. The spectra of GeV flashes are predicted to extend above 0.1 TeV, where they can be detected by ground-based Cherenkov telescopes.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2014

PAIR-DOMINATED GeV-OPTICAL FLASH IN GRB 130427A

We show that the light curve of the double GeV+optical flash in GRB 130427A is consistent with radiation from the blast wave in a wind-type medium with density parameter A = ρr {sup 2} ∼ 5 × 10{sup 10} g cm{sup –1}. The peak of the flash is emitted by copious e {sup ±} pairs created and heated in the blast wave; our first-principle calculation determines the pair-loading factor and temperature of the shocked plasma. Using detailed radiative transfer simulations, we reconstruct the observed double flash. The optical flash is dominated by synchrotron emission from the thermal plasma behind the forward shock, and the GeV flash is produced via inverse Compton (IC) scattering by the same plasma. The seed photons for IC scattering are dominated by the prompt MeV radiation during the first tens of seconds, and by the optical to X-ray afterglow thereafter. IC cooling of the thermal plasma behind the forward shock reproduces all GeV data from a few seconds to ∼1 day. We find that the blast wave Lorentz factor at the peak of the flash is Γ ≈ 200, and the forward shock magnetization is ε{sub B} ∼ 2 × 10{sup –4}. An additional source is required by the data in the optical and X-ray bands at times >10{sup 2} s; we speculate that this additional source may be a long-lived reverse shock in the explosion ejecta.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2018

Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model

The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic encephalopathy, and the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes in the acute-subacute period after mild closed-head impact injury and found astrocytosis, myelinated axonopathy, microvascular injury, perivascular neuroinflammation, and phosphorylated tau protein pathology. To investigate causal mechanisms, we developed a mouse model of lateral closed-head impact injury that uses momentum transfer to induce traumatic head acceleration. Unanaesthetized mice subjected to unilateral impact exhibited abrupt onset, transient course, and rapid resolution of a concussion-like syndrome characterized by altered arousal, contralateral hemiparesis, truncal ataxia, locomotor and balance impairments, and neurobehavioural deficits. Experimental impact injury was associated with axonopathy, blood–brain barrier disruption, astrocytosis, microgliosis (with activation of triggering receptor expressed on myeloid cells, TREM2), monocyte infiltration, and phosphorylated tauopathy in cerebral cortex ipsilateral and subjacent to impact. Phosphorylated tauopathy was detected in ipsilateral axons by 24 h, bilateral axons and soma by 2 weeks, and distant cortex bilaterally at 5.5 months post-injury. Impact pathologies co-localized with serum albumin extravasation in the brain that was diagnostically detectable in living mice by dynamic contrast-enhanced MRI. These pathologies were also accompanied by early, persistent, and bilateral impairment in axonal conduction velocity in the hippocampus and defective long-term potentiation of synaptic neurotransmission in the medial prefrontal cortex, brain regions distant from acute brain injury. Surprisingly, acute neurobehavioural deficits at the time of injury did not correlate with blood–brain barrier disruption, microgliosis, neuroinflammation, phosphorylated tauopathy, or electrophysiological dysfunction. Furthermore, concussion-like deficits were observed after impact injury, but not after blast exposure under experimental conditions matched for head kinematics. Computational modelling showed that impact injury generated focal point loading on the head and seven-fold greater peak shear stress in the brain compared to blast exposure. Moreover, intracerebral shear stress peaked before onset of gross head motion. By comparison, blast induced distributed force loading on the head and diffuse, lower magnitude shear stress in the brain. We conclude that force loading mechanics at the time of injury shape acute neurobehavioural responses, structural brain damage, and neuropathological sequelae triggered by neurotrauma. These results indicate that closed-head impact injuries, independent of concussive signs, can induce traumatic brain injury as well as early pathologies and functional sequelae associated with chronic traumatic encephalopathy. These results also shed light on the origins of concussion and relationship to traumatic brain injury and its aftermath.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2022

FUSARIUM-ID v.3.0: An Updated, Downloadable Resource for Fusarium Species Identification

Species within Fusarium are of global agricultural, medical, and food/feed safety concern and have been extensively characterized. However, accurate identification of species is challenging and usually requires DNA sequence data. FUSARIUM-ID ( http://isolate.fusariumdb.org/blast.php ) is a publicly available database designed to support the identification of Fusarium species using sequences of multiple phylogenetically informative loci, especially the highly informative ~680-bp 5' portion of the translation elongation factor 1-alpha (TEF1) gene that has been adopted as the primary barcoding locus in the genus. However, FUSARIUM-ID v.1.0 and 2.0 had several limitations, including inconsistent metadata annotation for the archived sequences and poor representation of some species complexes and marker loci. Here, we present FUSARIUM-ID v.3.0, which provides the following improvements: (i) additional and updated annotation of metadata for isolates associated with each sequence, (ii) expanded taxon representation in the TEF1 sequence database, (iii) availability of the sequence database as a downloadable file to enable local BLAST queries, and (iv) a tutorial file for users to perform local BLAST searches using either freely available software, such as SequenceServer, BLAST+ executable in the command line, and Galaxy, or the proprietary Geneious software. FUSARIUM-ID will be updated on a regular basis by archiving sequences of TEF1 and other loci from newly identified species and greater in-depth sampling of currently recognized species.

Plant Sciences↗
DOE OSTI2014

A Step towards Energy Efficient Computing: Redesigning a Hydrodynamic Application on CPU-GPU, In: 2014 IEEE 28th International Parallel and Distributed Processing Symposium

Power and energy consumption are becoming an increasing concern in high performance computing. Compared to multi-core CPUs, GPUs have a much better performance per watt. In this paper we discuss efforts to redesign the most computation intensive parts of BLAST, an application that solves the equations for compressible hydrodynamics with high order finite elements, using GPUs BLAST, Dobrev. In order to exploit the hardware parallelism of GPUs and achieve high performance, we implemented custom linear algebra kernels. We intensively optimized our CUDA kernels by exploiting the memory hierarchy, which exceed the vendor's library routines substantially in performance. We proposed an auto tuning technique to adapt our CUDA kernels to the orders of the finite element method. Compared to a previous base implementation, our redesign and optimization lowered the energy consumption of the GPU in two aspects: 60% less time to solution and 10% less power required. Compared to the CPU-only solution, our GPU accelerated BLAST obtained a 2.5× overall speedup and 1.42× energy efficiency (green up) using 4th order (Q_4) finite elements, and a 1.9× speedup and 1.27× green up using 2nd order (Q2) finite elements.

Computer Science↗
DOE OSTI2022

Image transformers for classifying acute lymphoblastic leukemia

Cancer is the leading cause of death by disease in American children. Each year, nearly 16,000 children in the United States and over 300,000 children globally are diagnosed with cancer. Leukemia is a form of blood cancer that originates in the bone marrow and accounts for one-third of pediatric cancers. This disease occurs when the bone marrow contains 20% or more immature white blood cell blasts. Acute lymphoblastic leukemia is the most prevalent leukemia type found in children, with half of all annual cases in the U.S. diagnosed for subjects under 20 years of age. To diagnose acute lymphoblastic leukemia, pathologists often conduct a morphological bone marrow assessment. This assessment determines whether the immature white blood cell blasts in bone marrow display the correct morphological characteristics, such as size and appearance of nuclei. Pathologists also use immunophenotyping via multi-channel flow cytometry to test whether certain antigens are present on the surface of blast cells; the antigens are used to identify the cell lineage of acute lymphoblastic leukemia. These manual processes require well-trained personnel and medical professionals, thus being costly in time and expenses. Computerized decision support via machine learning can accelerate the diagnosis process and reduce the cost. Training a reliable classification model to distinguish between mature and immature white blood cells is essential to the decision support system. Here, we adopted the Vision Transformer model to classify white blood cells. The Vision Transformer achieved superb classification performance compared to state-of-the-art convolutional neural networks while requiring less computational resources for training. Additionally, the latent self-attention architecture provided attention maps for a given image, providing clues as to which portion(s) of the image were significant in decision-making. We applied the Vision Transformer model and a convolutional neural network model to an acute lymphoblastic leukemia classification dataset of 12,528 samples and achieved accuracies of 88.4% and 86.2%.

Cho, Priscilla↗
DOE OSTI2012

Validation of Numerical Simulations of Explosion Fields

This report describes test problems that can be used to validate numerical simulations of nuclear explosion fields. A particular emphasis is placed on turbulent mixing and other “non-ideal” effects (thermal layer precursors, turbulent wall jets and dusty boundary layer flows) created by the interaction of the explosion wave with ground surfaces. The importance of such effects is illustrated by a comparison of the peak stagnation pressure versus ground range. In the precursor regime ( HOB < 700 ft / KT 1/3 and GR <1100 ft / KT 1/3 ) stagnation pressures from non-ideal effects are an order of magnitude larger that the corresponding ideal-surface case. Seven problems are considered: (i) blast waves from nuclear explosions, (ii) blast wave reflections from ideal surfaces, (iii) blast wave reflections from ground surfaces, (iv) spherical mixing layers, (v) Kelvin-Helmholtz mixing layers, (vi) wall-bounded mixing layers, and (vii) height of burst curves. The need for additional work is described in the Recommendations section, which includes tasks in support of the V&V, Complex Hydro and Output and Effects Programs.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2014

Simulation Study of Near-Surface Coupling of Nuclear Devices vs. Equivalent High-Explosive Charges

A computational study was performed to examine the differences in near-surface ground-waves and air-blast waves generated by high-explosive energy sources and those generated by much higher energy - density low - yield nuclear sources. The study examined the effect of explosive-source emplacement (i.e., height-of-burst, HOB, or depth-of-burial, DOB) over a range from depths of -35m to heights of 20m, for explosions with an explosive yield of 1-kt . The chemical explosive was modeled by a JWL equation-of-state model for a ~14m diameter sphere of ANFO (~1,200,000kg – 1 k t equivalent yield ), and the high-energy-density source was modeled as a one tonne (1000 kg) plasma of ‘Iron-gas’ (utilizing LLNL’s tabular equation-of-state database, LEOS) in a 2m diameter sphere, with a total internal-energy content equivalent to 1 k t . A consistent equivalent-yield coupling-factor approach was developed to compare the behavior of the two sources. The results indicate that the equivalent-yield coupling-factor for air-blasts from 1 k t ANFO explosions varies monotonically and continuously from a nearly perfec t reflected wave off of the ground surface for a HOB ≈ 20m, to a coupling factor of nearly zero at DOB ≈ -25m. The nuclear air - blast coupling curve, on the other hand, remained nearly equal to a perfectly reflected wave all the way down to HOB’s very near zero, and then quickly dropped to a value near zero for explosions with a DOB ≈ -10m. The near - surface ground - wave traveling horizontally out from the explosive source region to distances of 100’s of meters exhibited equivalent - yield coupling - factors t hat varied nearly linearly with HOB/DOB for the simulated ANFO explosive source, going from a value near zero at HOB ≈ 5m to nearly one at DOB ≈ -25m. The nuclear-source generated near-surface ground wave coupling-factor remained near zero for almost all HOB’s greater than zero, and then appeared to vary nearly - linearly with depth-of-burial until it reached a value of one at a DOB between 15m and 20m. These simulations confirm the expected result that the variation of coupling to the ground, or the air, change s much more rapidly with emplacement location for a high-energy-density (i.e., nuclear-like) explosive source than it does for relatively low - energy - density chemical explosive sources. The Energy Partitioning, Energy Coupling (EPEC) platform at LLNL utilizes laser energy from one quad (i.e. 4-laser beams) of the 192 - beam NIF Laser bank to deliver ~10kJ of energy to 1mg of silver in a hohlraum creating an effective small-explosive ‘source’ with an energy density comparable to those in low-yield nuclear devices. Such experiments have the potential to provide direct experimental confirmation of the simulation results obtained in this study, at a physical scale (and time-scale) which is a factor of 1000 smaller than the spatial- or temporal-scales typically encountered when dealing with nuclear explosions.

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEF↗
DOE OSTI2026

1016516285-AA - Handling Frame Assembly Table Structural and Seismic Analysis

Within the NIF (National Ignition Facility) sustainment project, LLNL is replacing all 1,728 blast shields with new ones. Before the new blast shield glass can be installed on NIF, it must pass through the AMOL (Amplifier Main Optics Loop). The AMOL process involves cleaning and coating the glass, assembling it into a Line Replaceable Unit (LRU), and performing testing and inspection. This work will be conducted in the OPFX cleanroom facility (Building 391, Room 1250) and requires several pieces of custom equipment. One key piece of equipment within the loop is the Handling Frame Assembly Table (see Figure 1.1). Its purpose is to assist operators in installing the blast shield glass into handling frames (1014442709) (see Figure 1.2). The table is also used to store handling frame assembly components. The primary components stored are the L-frames (1015208271), which are kept in a drawer underneath the table (see Figure 1.3). The purpose of this safety note is to ensure that the system does not pose a risk of injury to personnel during a seismic event. The system owner is OMST Engineering & Maintenance.

42 ENGINEERING↗