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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 469 records · Page 26
All sourcesNASA NTRSDOE OSTI
NASA NTRS1995

Building an adaptive agent to monitor and repair the electrical power system of an orbital satellite

Over several years we have developed a multistrategy apprenticeship learning methodology for building knowledge-based systems. Recently we have developed and applied our methodology to building intelligent agents. This methodology allows a subject matter expert to build an agent in the same way in which the expert would teach a human apprentice. The expert will give the agent specific examples of problems and solutions, explanations of these solutions, or supervise the agent as it solves new problems. During such interactions, the agent learns general rules and concepts, continuously extending and improving its knowledge base. In this paper we present initial results on applying this methodology to build an intelligent adaptive agent for monitoring and repair of the electrical power system of an orbital satellite, stressing the interaction with the expert during apprenticeship learning.

Tecuci, Gheorghe↗
NASA NTRS1994

Experiment K-7-29: Connective Tissue Studies: Rat Skin, Normal and Repair - Part 1

The skin repair studies started to be problematic for the following reasons: (1) It was very difficult to locate the wound and many lesions were not of the same dimensions. A considerable amount of time was devoted to the identification of the wound using polarized light. We understand that this experiment was added on to the overall project. Marking of the wound site and standard dimensions should be recommended for the next flight experiment. (2) The tissue was frozen, therefore thawing and fixation caused problems with some of the immunocytochemical staining for obtaining better special resolution with light microscopy image processing. Despite these problems, we were unable to detect any significant qualitative differences for the following wound markers: (1) Collagen Type 3, (2) Hematotoxylin and Eosin, and (3) Macrophage Factor 13. All protein markers were isolated from rat sources and antibodies prepared and tested for cross reactivity with other molecules at the University of Wisconsin Hybridoma Facility. However, rat skin from the non lesioned site 'normal' showed interesting biochemical results. Skin was prepared for the following measurements: (1) DNA content, (2) Collagen content by hydroxyproline, and (3) uronic acid content and estimation of ground substance. The results indicated there was a non-significant increase (10%) in the DNA concentration of skin from flight animals. However, the data expressed as a ratio DNA/Collagen estimates the cell or nuclear density that supports a given quantity of collagen showed a dramatic increase in the flight group (33%). This means flight conditions may have slowed down collagen secretion and/or increased cell proliferation in adult rat skin. Further biochemical tests are being done to determine the crosslinking of elastin which will enhance the insight to assessing changes in skin turnover.

Vailas, A. C.↗
NASA NTRS1998

NEAR Gamma Ray Spectrometer Characterization and Repair

This report covers the work completed in the third year of the contract. The principle activities during this period were (1) the characterization of the NEAR 2 Gamma Ray Spectrometer using a neutron generator to generate complex gamma ray spectra and a large Ge Detecter to identify all the major peaks in the spectra; (2) the evaluation and repair of the Engineering Model Unit of the Gamma Ray Spectrometer for the NEAR mission; (3) the investigation of polycapillary x-ray optics for x-ray detection; and (4) technology transfer from NASA to forensic science.

Groves, Joel Lee↗
NASA NTRS1997

Analysis, Repair, and Management of the Total Ozone Mapping Spectrometer Database

In the ensuing period we were able to demonstrate that the origin of these filamentous patterns resulted from the action of synoptic-scale vortical velocity field on the global-scale background gradient of ozone concentration in the meridional direction. Hyperbolic flow patterns between long-lived atmospheric vortices bring together air parcels from different latitudes, thus creating large gradients along the separatrices leaving the hyperbolic (stagnation) point. This result is further confirmed by the KL analysis of the ozone field in the equatorial region, where the background concentration gradient vanishes. The spectral slope in this region has been found to lie close to -1, in agreement with Batchelor's prediction. Another outcome of this result is that it at least provides indirect evidence about the kinetic energy spectrum of the atmospheric turbulence in the range of scales approximately 200 to 2000 km. Namely, Batchelor's analysis is based on the assumption that the velocity field is large-scale, that is the kinetic energy spectrum decays as O(k(sup -3)) or steeper. Since the scalar spectrum is confirmed, this also supports this form of the kinetic energy spectrum. The study of equatorial regions of TOMS data revealed the efficiency of the KL method is in detecting and separating a wave-like measurement artifact inherently present in the dataset due to the non-perfect correction for cross-track bias. Just two to three eigenfunctions represent the error, which makes it possible to enhance the data by reconstituting it from the data by eliminating the subspace of artifactual eigenfunctions. This represents a highly efficient means for achieving an improved rendering of the data. This has been implemented on the database. A wide range of techniques and algorithms have been developed for the repair and extension of the TOMS database.

Sirovich, Lawrence↗
NASA NTRS1998

Using Iterative Repair to Increase the Responsiveness of Planning and Scheduling for Autonomous Spacecraft

An autonomous spacecraft must balance long-term and short-term considerations. It must perform purposeful activities that ensure long-term science and engineering goals are achieved and ensure that it maintains positive resource margins. This requires planning in advance to avoid a series of shortsighted decisions that can lead to failure, However, it must also respond in a timely fashion to a somewhat dynamic and unpredictable environment. Thus, spacecraft plans must often be modified due to fortuitous events such as early completion of observations and setbacks such as failure to acquire a guidestar for a science observation. This paper describes the use of iterative repair to support continuous modification and updating of a current working plan in light of changing operating context.

Chien, Steve↗
NASA NTRS1994

Delta-WIND Solar Panel Repair and Move at Cape Canaveral Air Station, Hangar AO

This NASA Kennedy Space Center video release presents footage of workcrews moving the WIND solar panel in order to make repairs in Hangar AO prior to launch at Cape Canaveral Air Station, Sep. 13, 1994. WIND was launched on November 1, 1994 and is the first of two NASA spacecraft in the Global Geospace Science initiative and part of the International Solar Terrestrial Physics (ISTP) Project.

Source record↗
NASA NTRS2001

Friction Stir Weld System for Welding and Weld Repair

A friction stir weld system for welding and weld repair has a base foundation unit connected to a hydraulically controlled elevation platform and a hydraulically adjustable pin tool. The base foundation unit may be fixably connected to a horizontal surface or may be connected to a mobile support in order to provide mobility to the friction stir welding system. The elevation platform may be utilized to raise and lower the adjustable pin tool about a particular axis. Additional components which may be necessary for the friction stir welding process include back plate tooling, fixturing and/or a roller mechanism.

R. Jeffery Ding↗
NASA NTRS2003

Microsatellites in the Eukaryotic DNA Mismatch Repair Genes as Modulators of Evolutionary Mutation Rate

All "minor" components of the human DNA mismatch repair (MMR) system-MSH3, MSH6, PMS2, and the recently discovered MLH3-contain mononucleotide microsatellites in their coding sequences. This intriguing finding contrasts with the situation found in the major components of the DNA MMR system-MSH2 and MLH1-and, in fact, most human genes. Although eukaryotic genomes are rich in microsatellites, non-triplet microsatellites are rare in coding regions. The recurring presence of exonal mononucleotide repeat sequences within a single family of human genes would therefore be considered exceptional.

Chang, Dong Kyung↗
NASA NTRS2003

In-space Fabrication and Repair Utilizing In Space Resources

Abstract: The microgravity research program, simply put, has the goal of doing science (which is essentially finding out something previously unknown about nature) utilizing the unique long-term microgravity environment in Earth orbit. Our new "strategic research" program is scientific research that enables safe and economical capabilities to enable humans to live, work and do science beyond Earth orbit. One new strategic research area focuses on In Space Fabrication and Repair. This research is to enable materials processing in space for use in space. The goal of this program is to provide scientific and technical research resulting in proof-of-concept experiments providing humans in space with an energy rich, resource rich, self sustaining infrastructure at the earliest possible time and with minimum risk, launch mass and program cost. The customers could include large space science experiments, human exploration, and space commercialization.

Curreri, Peter A.↗
NASA NTRS2003

Plasma membrane disruption: repair, prevention, adaptation

Many metazoan cells inhabit mechanically stressful environments and, consequently, their plasma membranes are frequently disrupted. Survival requires that the cell rapidly repair or reseal the disruption. Rapid resealing is an active and complex structural modification that employs endomembrane as its primary building block, and cytoskeletal and membrane fusion proteins as its catalysts. Endomembrane is delivered to the damaged plasma membrane through exocytosis, a ubiquitous Ca2+-triggered response to disruption. Tissue and cell level architecture prevent disruptions from occurring, either by shielding cells from damaging levels of force, or, when this is not possible, by promoting safe force transmission through the plasma membrane via protein-based cables and linkages. Prevention of disruption also can be a dynamic cell or tissue level adaptation triggered when a damaging level of mechanical stress is imposed. Disease results from failure of either the preventive or resealing mechanisms.

NASA Discipline Cell Biology↗
NASA NTRS1995

Review of spaceflight and hindlimb suspension unloading induced sarcomere damage and repair

Hindlimb suspension unloading (HSU) and spaceflight microgravity induce atrophy of the slow adductor longus muscle fibers which, following reloading, exhibit eccentric contraction (EC)-like lesions (abnormal widening of sarcomeres with A band disruption and excessively wavy, extracted Z lines). These lesions are similar morphologically to those produced in normal muscles after strenuous eccentric exercise. It appears that atrophic muscles exhibit increased susceptibility to eccentric damage because lesions are produced during nonstressful voluntary movements upon return to weightbearing. The EC-like lesions are absent in the unweighted conditions, but appear in HSU rats 15-60 minutes after reloading and in space-flown rates about 4 hrs after landing. By 12 hours, many EC-like lesioned sarcomeres are fully covered by longitudinal patches of Z line-like material which increases in density by 48 hours, producing the so-called "Z line streaming" morphology. In this case, Z line streaming is indicative of rapid repair of damaged sarcomeres rather than the onset of sarcomere breakdown. Immunoelectron microscopy is necessary to determine the composition of this dense material. By 9 days of reloading at 1 gravity, sarcomeres have regained normal structure, except for very rare persistence of faint Z patches. The morphological data indicate that Z patches serve at least two functions: 1) to permit contractile force to be transmitted across the damaged sarcomeres and 2) to provide a scaffold upon which sarcomeres are reconstructed in an active functional muscle.

NASA Discipline Number 00-00↗
NASA NTRS2001

Determining flexor-tendon repair techniques via soft computing

An SC-based multi-objective decision-making method for determining the optimal flexor-tendon repair technique from experimental and clinical survey data, and with variable circumstances, was presented. Results were compared with those from the Taguchi method. Using the Taguchi method results in the need to perform ad-hoc decisions when the outcomes for individual objectives are contradictory to a particular preference or circumstance, whereas the SC-based multi-objective technique provides a rigorous straightforward computational process in which changing preferences and importance of differing objectives are easily accommodated. Also, adding more objectives is straightforward and easily accomplished. The use of fuzzy-set representations of information categories provides insight into their performance throughout the range of their universe of discourse. The ability of the technique to provide a "best" medical decision given a particular physician, hospital, patient, situation, and other criteria was also demonstrated.

Therapy, Computer-Assisted/methods↗
NASA NTRS2000

A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse

We have studied the efficiency of DNA double strand break (DSB) rejoining in primary cells from mouse strains that show large differences in in vivo radiosensitivity and tumor susceptibility. Cells from radiosensitive, cancer-prone BALB/c mice showed inefficient end joining of gamma ray-induced DSBs as compared with cells from all of the other commonly used strains and F1 hybrids of C57BL/6 and BALB/c mice. The BALB/c repair phenotype was accompanied by a significantly reduced expression level of DNA-PKcs protein as well as a lowered DNA-PK activity level as compared with the other strains. In conjunction with published reports, these data suggest that natural genetic variation in nonhomologous end joining processes may have a significant impact on the in vivo radiation response of mice.

Non-NASA Center↗
NASA NTRS2005

Repairs In Space

Four thermal protection repair technologies will be carried by the STS-114 mission on Discovery when the space shuttle program resumes flights as early as mid-May. Three of the concepts will be tested in orbit and the fourth kept in reserve.

Covault, Craig↗
NASA NTRS2005

An emergency response team for membrane repair

On demand, rapid Ca(2+)-triggered homotypic and exocytic membrane-fusion events are required to repair a torn plasma membrane, and we propose that this emergency-based fusion differs fundamentally from other rapid, triggered fusion reactions. Emergency fusion might use a specialized protein and organelle emergency response team that can simultaneously promote impromptu homotypic fusion events between organelles and exocytic fusion events along the vertices between these fusion products and the plasma membrane.

Review↗
NASA NTRS2005

Welding in Space: Lessons Learned for Future In Space Repair Development

Welds have been made in the harsh environment of space only twice in the history of manned space flight. The United States conducted the M5 12 experiment on Skylab and the former Soviet Union conducted an Extravehicular Activity. Both experiments demonstrated electron beam welding. A third attempt to demonstrate and advance space welding was made by the Marshall Space Flight Center in the 90's but the experiment was demanifested as a Space Shuttle payload. This presentation summarizes the lessons learned from these three historical experiences in the areas of safety, design, operations and implementation so that welding in space can become an option for in space repair applications.

Russell, C. K.↗
NASA NTRS2004

G2 Chromatid Damage and Repair Kinetics in Normal Human Fibroblast Cells Exposed to Low-or High-LET Radiation

Radiation-induced chromosome damage can be measured in interphase using the Premature Chromosome Condensation (PCC) technique. With the introduction of a new PCC technique using the potent phosphatase inhibitor calyculin-A, chromosomes can be condensed within five minutes, and it is now possible to examine the early damage induced by radiation. Using this method, it has been shown that high-LET radiation induces a higher frequency of chromatid breaks and a much higher frequency of isochromatid breaks than low-LET radiation. The kinetics of chromatid break rejoining consists of two exponential components representing a rapid and a slow time constant, which appears to be similar for low- and high- LET radiations. However, after high-LET radiation exposures, the rejoining process for isochromatid breaks influences the repair kinetics of chromatid-type breaks, and this plays an important role in the assessment of chromatid break rejoining in the G2 phase of the cell cycle.

Kawata, T.↗