Results for “Proliferation” — Page 26

NASA NTRSDate not supplied

NASA’s Goddard Space Flight Center’s Distributed Systems Missions Architecture

Space and Earth Science are being transformed by applying a distributed approach to missions, where the fusion of data from components, systems, instruments, models, and observation locations works in concert with timely responses and feedback mechanisms to multiply the knowledge obtained. Additionally, a disaggregated approach allows for a distributed cost and schedule that can be shared across multiple organizations to enable the greater mission. With the advances in reduced size, weight, and power for space-worthy components leading to the revolution in smaller spacecraft, the cost and timeliness proposition for launching multiple space assets has also greatly improved. Thus, the aerospace industry is undergoing a paradigm shift toward a proliferation of small satellites as a networked approach to meet mission objectives. This paper will describe the impetus, goal, and path to provide an openly available framework as a unifying catalyst for broad-ranging Distributed Systems Missions (DSMs) contributors.

Distributed Systems↗

NASA NTRS2022

Lunar Landing and Operations Policy Analysis

Just within the next four years, we expect to see at least 22 lunar surface missions. Half of these missions will occur in the Moon’s south polar region. Due to this upcoming proliferation of actors and activities at or near the lunar south pole, and due to the potential close proximity of operations, NASA and other operators will face challenges never faced before. NASA’s Deputy Administrator and Associate Administrator of the Science Mission Directorate (SMD) tasked the Office of Technology, Policy, and Strategy (OTPS) with answering two questions related to the Artemis campaign: (1) what technical and policy considerations should NASA take into account in the selection of lunar landing and operations sites, and (2) what technical and policy considerations should NASA take into account when implementing tools such as safety zones in order to protect these operations and U.S. interests? In addition to the challenges inherent in lunar operations, NASA subject-matter experts (SMEs) are concerned about certain challenges to NASA operations that may require policy solutions. The goal of this report is to provide options and recommendations to NASA leadership and program planners so that they can consider policy measures to respond to those challenges. This report also describes options for transparency, coordination, and implementation to increase the effectiveness of these measures.

lunar policy↗

NASA NTRS2023

Lunar Landing and Operations Policy Analysis

At least 22 lunar missions are planned in the next four years. Half of these missions will occur in the Moon’s south polar region. Due to this upcoming proliferation of actors and activities at or near the lunar south pole, and due to the potential close proximity of operations, NASA and other operators will face challenges never faced before. NASA’s Deputy Administrator and Associate Administrator of the Science Mission Directorate tasked the Office of Technology, Policy, and Strategy with answering two questions related to the Artemis campaign: (1) what technical and policy considerations should NASA take into account in the selection of lunar landing and operations sites, and (2) what technical and policy considerations should NASA take into account when implementing tools such as safety zones in order to protect these operations and U.S. interests? We present policy tools (options and recommendations) to NASA leadership and program planners so that they can consider policy measures to respond to challenges inherent in landing and operating at the lunar South Pole—this answers question one. We also describe a set of options (transparency, coordination, and implementation) to increase the effectiveness of these tools—this answers question two.

Lunar policy↗

NASA NTRS2022

Unlocking the Spacecraft and Human Habitat Microbiome to Enable the Next Generation of Space Exploration

Planetary protection is the discipline that prevents harmful contamination of the solar system during exploration activities. The current international guidelines and NASA policy addressing biological contamination on spacecraft surfaces contains prescriptive guidelines of spore requirements (e.g., 300 spores/m2, 5×105 spores per spacecraft) applicable to spacecraft bound for Mars. To verify these requirements spacecraft engineers sample spacecraft surfaces throughout the assembly, test and launch operations phase of the mission using damp water cotton swabs and polyester wipes. After sampling, the potential biological contamination is enumerated using a series of traditional microbiology techniques to include sonication, heat shocking at 80°C for 15min to select for spores, and growth on tryptic soy agar at 32°C for 72 hours. To enable crewed missions to Mars and robotic exploration of the Ocean Worlds a risk informed decision making / performance-based approach to assess biological contamination offers a promising solution in the trade space. Recognizing the need for a performance-based approach, NASA’s new Planetary Protection policies now incorporate the agility for missions to be able to leverage a performance or prescriptive approach. One of top contenders in the option space is a coupled quantitative, descriptive and functional based approach to be able to assess the quantity, types and capabilities of the biological contamination present on spacecraft surfaces. A tailored, mission by mission assurance case could then be formulated by building an argument around the target body, projected capabilities surrounding the types of organisms their potential for survival and proliferation, and ability to be transported on the target body to contaminate an area of biological interest. A performance-based requirement would then be used to demonstrate the mission’s compliance in protecting the planetary environment safety objectives. This symposium talk will showcase the background and need case for NASA to develop such a capability as well as provide an update on the efforts underway in developing a transparent and responsible performance-based approach to biological contamination assessments on spacecraft surfaces.

Habitat Microbiome↗

NASA NTRSDate not supplied

Analysis of Electrical Grid Capacity in Major U.S. Metropolitan Areas for Urban Air Mobility

A wide range of challenges must be overcome to conduct Urban Air Mobility (UAM) operations at scale with electric vertical takeoff and landing aircraft as envisioned. This paper documents an analysis of one potential infrastructure challenge for UAM: available electrical grid power capacity. The success of UAM depends on the availability of electricity, which will be increasingly impacted by the proliferation of ground electric vehicles (EVs) over time. Under the worst-case assumption that each U.S. Metropolitan Statistical Area (MSA) can only access and utilize the electricity generated by power plants within its boundaries, it is estimated that the maximum number of UAM aircraft that can charge simultaneously in the 25 most populous MSAs will decrease by about 61% from about 129,000 in the year 2021 to about 51,000 in the year 2050, due to the projected increase in ground EVs. Also, it is estimated that the number of these MSAs that may lack any available electrical grid power capacity for UAM operations will increase from zero MSAs in 2021 to eleven MSAs in 2050—including three MSAs that prospective UAM operators have announced as target markets (Los Angeles, Miami, and Orlando)—unless electricity demand for other purposes is reduced.

electrical grid↗

NASA NTRSDate not supplied

Analysis of Electrical Grid Capacity in Major U.S. Metropolitan Areas for Urban Air Mobility

A wide range of challenges must be overcome to conduct Urban Air Mobility (UAM) operations at scale with electric vertical takeoff and landing aircraft as envisioned. This paper documents an analysis of one potential infrastructure challenge for UAM: available electrical grid power capacity. The success of UAM depends on the availability of electricity, which will be increasingly impacted by the proliferation of ground electric vehicles (EVs) over time. Under the worst-case assumption that each U.S. Metropolitan Statistical Area (MSA) can only access and utilize the electricity generated by power plants within its boundaries, it is estimated that the maximum number of UAM aircraft that can charge simultaneously in the 25 most populous MSAs will decrease by about 61% from about 129,000 in the year 2021 to about 51,000 in the year 2050, due to the projected increase in ground EVs. Also, it is estimated that the number of these MSAs that may lack any available electrical grid power capacity for UAM operations will increase from zero MSAs in 2021 to eleven MSAs in 2050—including three MSAs that prospective UAM operators have announced as target markets (Los Angeles, Miami, and Orlando)—unless electricity demand for other purposes is reduced.

electrical grid↗

NASA NTRS2023

Dual Genes of Muscle Cell Senescence: Unraveling the Radiation-Induced Roles of HDAC4 and MORC2a

As the human race ventures further into space and plans missions to explore the Moon and the expanse that lies ahead, addressing health challenges that may hinder exploration becomes an imperative task. However, limited research exists on the molecular mechanisms within skeletal muscle cells in response to long-term radiation-induced oxidative stress. Upon analyzing GLDS-426 from the GeneLab Repository, upregulation of the DNA damage response gene HDAC4 in space radiation conditions with 1G was observed, where radiation-induced oxidative stress increased DNA damage. DNA damage response gene MORC2a was found to be downregulated in space radiation conditions in 1G with a culture treatment of nanoceria, an antioxidant that alleviates the effects of oxidative stress and causes less DNA damage. Literature review further indicated that MORC2a recruits HDAC4 at the promoter to prevent the transcription of p21. Upregulation of p21 has been linked to cell senescence and muscle atrophy on Earth, but no research has studied its changes in radiation conditions. To address the knowledge gap regarding the HDAC4/MORC2a pathway impact on p21 expression in radiation, our experiment aims to silence HDAC4 and MORC2a in the Mus musculus C2C12 cell culture line. These cultures will be exposed to radiation to assess the effects on cellular senescence (Aim 1). Additionally, we will silence p21 and subject the cell cultures to radiation to measure muscle cell proliferation (Aim 2). Muscle atrophy in future long-term space missions can contribute to the risk of degenerative diseases and hinder the completion of tasks in space. Furthermore, exploring the impact of these genes on muscle atrophy may provide therapeutic insights for individuals experiencing skeletal muscle degeneration and elderly individuals affected by sarcopenia.

GL4HS↗

NASA NTRSDate not supplied

Gene Expression of Peripheral Blood Mononuclear Cells of Crew Members During Long-Duration Space Missions Indicate Dysregulation of Immunological and Cell Survival Mechanisms

Lymphocytes are naturally exposed to genotoxic stresses. DNA damage occurs during the entire lymphocyte’s life span and is induced mainly by reactive oxygen species (ROS), replication fork collapse, or telomere shortening during the immune response or intense cell proliferation phases. Strong evidence for the influence of immune function on DNA repair comes from studies of SCID disease. SCID mice not only have a deficient V(D)J recombination but are also unable to repair double strand breaks, leading to increased radiation sensitivity. The leukocytes’ transcriptome of 8 ISS crew members revels a dysregulated immune function and activation of cellular survival pathways in response to space environment. We have performed PCR analysis in peripheral mononuclear cells from the same crew members. A list of 62 genes were carefully selected addressing immunological and cell survival pathways. Differentially expressed genes indicated changes in chemokine receptor activity, chemokine binding, toll-like receptors, adhesion molecules and cellular response to DNA damage.

Maria Moreno-Villanueva↗

NASA NTRSDate not supplied

The Effects of Freestream Turbulence on Wing-Gust Interactions

There is a growing interest in the experimental study of discrete vertical gusts motivated by the proliferation of small Uncrewed Air Systems. However, gusts are not the only unsteady flow disturbances that these vehicles are expected to encounter. Freestream turbulence is also a serious consideration. Previous work has indicated that freestream turbulence has significant effects on the flow around airfoils, so this work investigates the interaction of these two unsteady flow disturbances. Airfoils are pitched to mimic the flow angle change caused by a gust at different levels of incoming freestream turbulence. The lift generated during the gust encounters with elevated incoming freestream turbulence show that the effects on the performance of the airfoil are dependent on the turbulence intensity. Low turbulence intensity has beneficial effects, delaying stall and increasing the maximum lift, whereas higher freestream turbulence intensity delays stall without a corresponding increase in the maximum lift. A preliminary investigation of 15-trial ensemble-averaged flow fields suggests that freestream turbulence dominates the flow, but the flow features associated with the dynamic lift seen in the "clean" case are still somewhat present. However, lift curves and flow fields from individual trials indicates that the turbulence increases the unsteadiness in the interaction, but the general trends are dominated by the gust interaction. Further work is still needed to better determine the flow physics of these interactions and the interplay between repeatable and stochastic flow phenomena.

Unsteady Aerodynamics↗

NASA NTRSDate not supplied

Harnessing Large Language Models for Scientific Endeavors

The rapid proliferation of Large Language Models (LLMs) such as GPT, Bard, and Llama has revolutionized various sectors, including the scientific community. These models, with their potential to automate and augment tasks, are increasingly being recognized as both a valuable asset and a potential challenge in the realm of scientific research and data management. However, the current LLMs, primarily trained on general corpora, exhibit a limited understanding of scientific concepts and terminologies due to the lack of scientific corpus in their training data. Recognizing this gap, several groups are now advocating for the development of LLMs specifically tailored for scientific applications. A notable initiative in this direction is the Large Language Model effort initiated by NASA's CSDO. This endeavor aims to align LLM efforts across NASA’s Science Mission Directorate, develop a science-specific corpus and validation test set for model training, and create an encoder-only model for various downstream tasks. Moreover, the initiative also plans to develop a decoder-only model to explore the potential benefits and risks associated with a generative LLM for science. Lastly, the project aims to create a science evaluation suite, encompassing various categories of downstream scientific tasks, to serve as a benchmark for assessing the value of any LLM for future use. This presentation will provide an overview and current status of this ongoing initiative, highlighting its potential to reshape the use of LLMs in the scientific domain.

Rahul Ramachandran↗

NASA NTRSDate not supplied

The Crustal Dynamics Data Information System (CDDIS) – Updates and Future Developments

As earth observing services and techniques have flourished, data and products have exponentially grown, like the proliferation of Global Navigation Satellite System (GNSS) stations capable of providing real-time data, Satellite Laser Ranging (SLR) stations shifting to kHz lasers, and Very-Long-Baseline Interferometry (VLBI)’s implementation of VLBI Global Observing System (VGOS) telescopes. The CDDIS is continually evolving to fulfill the new storage, quality check, and latency requirements that these changes bring, as well as meet new standards such as the shift toward FAIR and open science. These have shaped how the CDDIS develops new software and resources. Beginning next year, the CDDIS will begin to transition their data and products to the Amazon Web Services (AWS) cloud, beginning with DORIS data. This poster will highlight the CDDIS’s recently updated processing system, new data and products available, and future work.

Justine Woo↗

NASA NTRS2024

Gene Expression of Peripheral Blood Mononuclear Cells of Crew Members During Long-Duration Space Missions Indicate Dysregulation of Immunological and Cell Survival Mechanisms

Lymphocytes are naturally exposed to genotoxic stresses. DNA damage occurs during the entire lymphocyte’s life span and is induced mainly by reactive oxygen species (ROS), replication fork collapse, or telomere shortening during the immune response or intense cell proliferation phases. Strong evidence for the influence of immune function on DNA repair comes from studies of SCID disease. SCID mice not only have a deficient V(D)J recombination but are also unable to repair double strand breaks, leading to increased radiation sensitivity. The leukocytes’ transcriptome of 8 ISS crew members revels a dysregulated immune function and activation of cellular survival pathways in response to space environment. We have performed PCR analysis in peripheral mononuclear cells from the same crew members. A list of 62 genes were carefully selected addressing immunological and cell survival pathways. Differentially expressed genes indicated changes in chemokine receptor activity, chemokine binding, toll-like receptors, adhesion molecules and cellular response to DNA damage.

María Moreno-Villanueva↗

NASA NTRSDate not supplied

A Novel Bone Marrow Single Cell Atlas of Mechanotransduction in Microgravity, Normal Gravity, Exercise, and Hindlimb Unloading for WT and CDKN1A-Null Regenerative Mice

Mechanical loading of adult stem cell progenitors is a key factor in modulating their proliferation, differentiation, and tissue regenerative potential, with loading generally promoting tissue formation and unloading mediating tissue loss. To address the role of mechanotransduction in maintaining stem cell-based tissue regenerative health, we generated a single cell transcriptomic atlas mapping responses of femur bone marrow mesenchymal and hematopoietic lineages to a range of altered mechanical loading conditions, both in WT B1629SF2/J mice as well as the p21/CDKN1A-null regenerative mice. We selected the femur marrow compartment as a model because of the diversity and high numbers of stem cell progenitor stages present, and because it undergoes static and cyclic hydrostatic pressure loading associated with weight-bearing and ambulation. Our study included normally loaded mice at 1g, unloading in microgravity during spaceflight as well as tail suspension hindlimb unloading, and voluntary running wheel exercise. Basal, one-year natural aging, and habitat controls were also conducted. Overall, the atlas encompasses 18 different experimental conditions with N=3 mice per condition and includes more than 500,000 single cell expressomes. Key specific findings include: increased mature reticulocyte populations in aging and unloading mice compared to active mice; greater hematopoietic and mesenchymal differentiating progenitors cluster identification in CDKN1A-null samples, especially the exercise model; distinct pseudotime cell trajectory shifts in the hematopoietic lineage for spaceflight and unloaded mice; and shifts in monocytic cell populations toward osteoclastic bone degenerative lineages in unloading and spaceflight samples. Overall mechanical loading shows increased marrow progenitor population differentiation while unloading is associated with increased CDKN1A expression and maintenance of marrow population stemness. Deletion of CDKN1A appears to remove a negative check on progenitor lineages commitment to differentiation. Finally, the Bone Marrow Mechanotransduction Single Cell Atlas will serve as a reference tool for studying marrow regenerative responses across a range of mechanical environments as they relate to CDKN1A status.

single-cell↗

NASA NTRSDate not supplied

Mechanical Unloading Effects Hematopoiesis and Subsequent Red Blood Cell Life Cycle Evaluated at Singe Cell Resolution

Red blood cell formation or erythropoiesis in the bone marrow and exit into circulation are known to be affected by mechanical loading. Specifically, space anemia is a condition observed during prolonged microgravity unloading in which the red blood cell (RBC) mass in circulation is reduced. However, the mechanisms causing space anemia are yet to be clearly established, but may include increased hemolysis of RBC in circulation, decreased RBC production or a combination of both factors. The presentation of space anemia is comparable to chronic anemia conditions associated with aging, disuse, and poor health. Molecular dysregulation in the RBC's life cycle is poorly defined and is a significant concern in the context of disuse anemia as mechanotransduction significantly alters of gene expression, protein synthesis and cell signaling pathways. Our study analyzes mouse single cell RNA sequencing libraries from the bone marrow, circulating blood, and spleen and integrates the RBC lineage populations from the tissues into a RBC life cycle atlas. This study also probes how age at time of spaceflight contributes to the molecular signature of space anemia. The overarching objective of the study is to develop a mechanistic understanding of space anemia and translate the findings to a better understanding of aging, disuse, and poor health-related anemia to defining the role of mechanical loading in health and devise potential therapeutic interventions. Important findings of our study are: 1) that mechanical unloading in microgravity alters the proportion of developmental RBC lineage cells, skewing toward progenitor, indicating that fewer RBCs may be present in blood; 2) that late reticulocyte number is elevated in the bone marrow of older animals, suggesting a failure to enter circulation; and 3) that the molecular signature of the circulating RBCs is not significantly altered in microgravity. However, expression markers for eryptosis and erythrophagocytosis are elevated in circulating and spleen RBCs, suggesting spaceflight may shorten the lifetime of RBCs after exit from the marrow. In conclusion our results suggest early stages of erythropoiesis proliferation and differentiation in the marrow are key factors in space anemia and mechanical loading may be a necessary step of RBC entry in circulation.

blood↗

NASA NTRSDate not supplied

Lunar Optical Communications

Numerous studies have shown that NASA’s Deep Space Network (DSN) is woefully inadequate to support the current pace of space exploration. Proposals are on the table for extensive infrastructure build-out using RF communications, which is ultimately bandwidth constrained. Optical communication offers unregulated, near-infinite bandwidth that can easily support the needs of humans at the Moon and beyond. Although not part of the proposed lunar network architecture, optical communication systems should be considered; these systems are operational now, quickly proliferating near Earth space (e.g. StarLink), and offer very high bandwidths.

lunar↗

NASA NTRSDate not supplied

The Crustal Dynamics Data Information System (CDDIS) – Updates and Future Developments

As earth observing services and techniques have flourished, data and products have exponentially grown, like the proliferation of GNSS stations capable of providing real-time data, SLR stations shifting to kHz lasers, and VLBI’s implementation of VGOS telescopes. The CDDIS is continually evolving to fulfill the new storage, quality check, and latency requirements that these changes bring, as well as meet new standards such as the shift toward FAIR and open science. These have shaped how the CDDIS develops new software and resources. Beginning next year, the CDDIS will begin to transition their data and products to the AWS cloud, beginning with DORIS data. This poster will highlight the CDDIS’s recently updated processing system, new data and products available, and future work.

Justine Woo↗

NASA NTRSDate not supplied

The Space Superhighway: Enabling Active Debris Remediation Through an In-Space Logistics Infrastructure

The Space Superhighway is a future space infrastructure concept intended to support civil, commercial, and national security space interests by providing In-Space Servicing, Assembly, and Manufacturing (ISAM) services across low Earth orbit (LEO), geosynchronous orbit (GEO), and cislunar space. This concept was originally developed by an interagency working group and commissioned by the Executive Office of the President. The Space Superhighway is comprised of three primary components: regional hubs, a sustainable transportation network, and Earth-to-orbit logistics. This study establishes methods which may be used to quantify the cost-savings from use of the Space Superhighway infrastructure and interrogates the effects of the use of this logistics network on a specific use case – removal of 26 pieces of large space debris within LEO. Through application of the established methods and assuming an emplaced Space Superhighway infrastructure with no cost implications related to deployment of infrastructure-related spacecraft, this study found that the cost to use an established Space Superhighway infrastructure to remove the targeted debris may be cheaper than removal of the targeted debris through traditional methods when the ΔV between a regional hub hosting propellant and the debris field is less than 1500 m/s. Through determining optimized locations of regional hubs within LEO, this study estimates that such a ΔV is within expectations for a LEO environment supported by a fully evolved Space Superhighway logistics infrastructure. This study provides a blueprint for future Space Superhighway value proposition studies for other use cases which, when combined, may provide the ultimate benefit and justification for the proliferation of an interconnected Space Superhighway.

Space Superhighway↗

NASA NTRSDate not supplied

The Space Superhighway: Enabling Active Debris Remediation Through an In-Space Logistics Infrastructure

The Space Superhighway is a future space infrastructure concept intended to support civil, commercial, and national security space interests by providing In-Space Servicing, Assembly, and Manufacturing (ISAM) services across low Earth orbit (LEO), geosynchronous orbit (GEO), and cislunar space. This concept was originally developed by an interagency working group and commissioned by the Executive Office of the President. The Space Superhighway is comprised of three primary components: regional hubs, a sustainable transportation network, and Earth-to-orbit logistics. This study establishes methods which may be used to quantify the cost-savings from use of the Space Superhighway infrastructure and interrogates the effects of the use of this logistics network on a specific use case – removal of 26 pieces of large space debris within LEO. Through application of the established methods and assuming an emplaced Space Superhighway infrastructure with no cost implications related to deployment of infrastructure-related spacecraft, this study found that the cost to use an established Space Superhighway infrastructure to remove the targeted debris may be cheaper than removal of the targeted debris through traditional methods when the ΔV between a regional hub hosting propellant and the debris field is less than 1500 m/s. Through determining optimized locations of regional hubs within LEO, this study estimates that such a ΔV is within expectations for a LEO environment supported by a fully evolved Space Superhighway logistics infrastructure. This study provides a blueprint for future Space Superhighway value proposition studies for other use cases which, when combined, may provide the ultimate benefit and justification for the proliferation of an interconnected Space Superhighway.

Space Superhighway↗