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At least 469 records · Page 26

Optimal Bayesian supervised domain adaptation for RNA sequencing data

Abstract Motivation When learning to subtype complex disease based on next-generation sequencing data, the amount of available data is often limited. Recent works have tried to leverage data from other domains to design better predictors in the target domain of interest with varying degrees of success. But they are either limited to the cases requiring the outcome label correspondence across domains or cannot leverage the label information at all. Moreover, the existing methods cannot usually benefit from other information available a priori such as gene interaction networks. Results In this article, we develop a generative optimal Bayesian supervised domain adaptation (OBSDA) model that can integrate RNA sequencing (RNA-Seq) data from different domains along with their labels for improving prediction accuracy in the target domain. Our model can be applied in cases where different domains share the same labels or have different ones. OBSDA is based on a hierarchical Bayesian negative binomial model with parameter factorization, for which the optimal predictor can be derived by marginalization of likelihood over the posterior of the parameters. We first provide an efficient Gibbs sampler for parameter inference in OBSDA. Then, we leverage the gene-gene network prior information and construct an informed and flexible variational family to infer the posterior distributions of model parameters. Comprehensive experiments on real-world RNA-Seq data demonstrate the superior performance of OBSDA, in terms of accuracy in identifying cancer subtypes by utilizing data from different domains. Moreover, we show that by taking advantage of the prior network information we can further improve the performance. Availability and implementation The source code for implementations of OBSDA and SI-OBSDA are available at the following link. https://github.com/SHBLK/BSDA. Supplementary information Supplementary data are available at Bioinformatics online.

Biochemistry & Molecular Biology↗

A Microstrip Patch-Fed Short Backfire Antenna for the Tracking and Data Relay Satellite System-Continuation (TDRSS-C) Multiple Access (MA) Array

Short Backfire Antennas (SBAs) are widely utilized for mobile satellite communications, tracking, telemetry, and wireless local area network (WLAN) applications due to their compact structure and excellent radiation characteristics [1-3]. Typically, these SBA s consist of an excitation element (i.e., a half-wavelength dipole), a reflective bottom plane, a planar sub-reflector located above the "exciter", and an outer circular rim. This configuration is capable of achieving gains on the order of 13-15 dBi, but with relatively narrow bandwidths (approx.3%-5%), making it incompatible with the requirements of the next generation enhanced Tracking and Data Relay Satellite System-Continuation (TDRSS-C) Multiple Access (MA) array [1]. Several attempts have been made to enhance the bandwidth performance of the common dipole-fed SBA by employing various other feeding mechanisms (e.g., waveguide, slot) with moderate success [4-5]. In this paper, a novel method of using a microstrip patch is employed for the first time to excite an SBA. The patch element is fed via two H-shaped slots electromagnetically coupled to a broadband hybrid coupler to maintain a wide bandwidth, as well as provide for dual circular polarization capabilities.

Nessel, James A.↗

Benefits of Sharing Information from Commercial Airborne Forward-Looking Sensors in the Next Generation Air Transportation System

The air transportation system of the future will need to support much greater traffic densities than are currently possible, while preserving or improving upon current levels of safety. Concepts are under development to support a Next Generation Air Transportation System (NextGen) that by some estimates will need to support up to three times current capacity by the year 2025. Weather and other atmospheric phenomena, such as wake vortices and volcanic ash, constitute major constraints on airspace system capacity and can present hazards to aircraft if encountered. To support safe operations in the NextGen environment advanced systems for collection and dissemination of aviation weather and environmental information will be required. The envisioned NextGen Network Enabled Weather (NNEW) infrastructure will be a critical component of the aviation weather support services, providing access to a common weather picture for all system users. By taking advantage of Network Enabled Operations (NEO) capabilities, a virtual 4-D Weather Data Cube with aviation weather information from many sources will be developed. One new source of weather observations may be airborne forward-looking sensors, such as the X-band weather radar. Future sensor systems that are the subject of current research include advanced multi-frequency and polarimetric radar, a variety of Lidar technologies, and infrared imaging spectrometers.

Schaffner, Philip R.↗

NASA Electric Vertical Takeoff and Landing (eVTOL) Aircraft Technology for Public Services – A White Paper

History has shown that our personal life is highly dependent on the technology that people have developed. A strategic scan of the aerospace environment at the beginning of the 21st century strongly suggests that the world might be approaching a new age of airpower—the era of electrified/hybrid aircraft propulsion. Undeniably, starting from the Montgolfier Brothers balloon flight in 1783, to the Wright Brothers piston engine flight in 1903, and the jet engine of the 1960s, or the space age of today, one can say that leaps in propulsion technology have marked the different ages of human flight. The technological advancements, brought at the beginning of 21st century by the revolution in data exchange, computational power, sensors, wireless communication, internet, and autonomy, contributed to the vision of this new age of propulsion we are approaching. Historically, conventional vertical takeoff and landing (VTOL) aircraft have been equipped with propulsion units relying on complex internal combustion machines (turbines, piston engines, for example), and complex mechanical arrangements (gearboxes, shafts, variable pitch propeller). By contrast, electric VTOL aircraft (eVTOL)1 rely on simpler propulsion units (electric motors and in some cases fixed-pitch propellers). This promotes redundancy and improves tolerance to failures, in turn improving safety. The use of simpler electric propulsion units should also allow significant acquisition and operating cost reductions. Whether full-electric (relying solely on batteries) or hybrid-electric (relying on a combination of batteries, fuel-powered engines, and generators.), eVTOLs are also expected to generate less noise and air pollution than conventional aircraft with similar payloads. According to the 2019 Annual Review of IATA (International Air Transport Association) [ref.1], due to an expected increase in air transport traffic by 5% every year and a doubling of air transport passenger numbers to 8.2 billion by 2037 significant challenges are posed to the aviation industry. Furthermore, this report does not factor in the expected demand for short-range (intra-city) air transportation, which is in development and yet to be operational. The increased demand to fly creates a responsibility to expand in a sustainable manner and an endeavor to develop more environmentally-friendly aircraft. eVTOL aircraft, either piloted or autonomous, is gathering considerable interest worldwide. Modern and novel full-electric or hybrid-electric eVTOL configurations enable a new paradigm shift in air transportation as the aviation industry remains committed to its goals of carbon-neutral growth from 2020 onwards and cutting CO2 emissions to half 2005 levels by 2050. While electric power has been used for decades, recent developments in mobile electric/hybrid propulsion coupled with advanced materials and autonomous systems may create the possibility to transition into the next age of air mobility propelled by electric/hybrid VTOL aircraft technology. Although eVTOL aircraft might seem like an incremental improvement or even a counterintuitive regression with regard to past VTOL development, it has in fact the potential to transform air mobility across a wide range of government applications. Previous transformations in aviation generated dramatic leaps in performance, but the cost was commensurate with performance, limiting quantity produced. This next age appears to take a different approach. Performance may not increase, but at this moment technology is poised for future urban mobility that will spawn commercial passenger drone services, that is, autonomous (pilotless) air taxis and thereby add a new dimension to the urban transportation mix of the future [ref. 2]. Advances in electric propulsion, autonomous flight technology, and 5G communication networks will enable this fast new-growing market to become a reality. It is now time to envision the introduction of electric/hybrid eVTOL aircraft for Public Services2. We believe that in the next decades eVTOL aircraft will have the potential to become an essential tool to Public Service agencies around the world in applications such as firefighting, public safety, search and rescue, disaster relief and law enforcement. This is due to several major factors. • First, with the increasing popularity of small, unmanned aircraft vehicles (UAVs) or drones, many companies today are focusing on the development of passenger UAVs designed to accommodate up to five passengers or equivalent cargo payload. Many such configurations are electric or hybrid-electric designs with VTOL capabilities. Several of these projects have started a flight test program and many more are expected to be in the experimental and development phase in 2020. Such revolutionary vehicles could be in commercial operations by 2030. These eVTOL systems could be ready for selected Public Services missions even sooner. • Second, although these advanced eVTOL vehicles under development still need access to fuel (hybrid) and/or electric charging capability, they can take off and land from almost anywhere. Therefore, such vehicles, both manned and unmanned can be successfully integrated for the critical missions of the Public Services with extra deployment flexibilities. • Third, advancement in electric propulsion systems in the automotive industry together with NASA’s leading efforts in electrification of aircraft propulsion systems, FAA’s ongoing active eVTOL certification programs, and EASA’s proposed framework for the certification of electric/hybrid small category VTOL aircraft in Europe [ref. 3] will help accelerate industry electric propulsion system development and integration. • Finally, eVTOL vehicles could be deployed for Public Services sooner than air taxi or other commercial applications, since Public Services missions may be more easily approved based on specific mission criteria, localized airworthiness authority for public-use aircraft3, and are normally operating under centralized airspace management and control by the theater command. Moreover, public perception and acceptance are generally less of a concern when operations save lives and benefit the wider community. The prioritized introduction of eVTOL aircraft in Public Services is ambitious, but we believe it is achievable in the coming decades if fundamental enablers (people and technologies) are engaged in defining the objectives and needs of these missions. The revolution that is currently taking place in eVTOL aircraft represents an unprecedented opportunity to develop a safer, more affordable, more available and more environmentally friendly future of vertical flight. To ensure that these novel aircraft meet the future expectations of Public Services, it is essential to take a collaborative and multi-disciplinary approach to their development, across engineering disciplines, policy-making, program management, business case development, manufacturing, and flight demonstrations. It should be noted that the term eVTOL (in the near term) used throughout this publication implies aircraft capable of transporting up to 5 persons which may or may not include a pilot if operated fully autonomously, assuming an average of 200 pounds (91 kg) per person or equivalent payload and a range up to 60 miles plus a suitable reserve. Hybrid or hydrogen powered eVTOLs would have greater range. For example, a “3-seat” eVTOL aircraft may only be able to carry two fully equipped firemen, and payload capacity is more relevant when used for the supply mission. Moreover, this paper concentrates on the “last-mile” solutions with a deployment time of no more than 6 hours. Although not specifically discussed in this document, it is understood that the future of Transformative Vertical Flight in general and Public Services, in particular, will also involve smaller UAVs that will undoubtedly play a crucial role in future aerial operations. For example, smaller unmanned aircraft may be used to dispatch medical supplies, portable filtration systems or perform the Search task of future Search and Rescue (SAR) operations. Close collaboration between the aircraft industry, the Civil Aviation Authorities (CAA), e.g., Federal Aviation Administration (FAA), European Aviation Safety Agency (EASA), Transport Canada Civil Aviation (TCCA) and the Department of Defense (DoD) certifiers, will help identify Public Services requirements, define expectations and limit development cost and timescales. Take the US Air Force Agility Prime as an example, the majority of the eVTOL application opportunities and mission elements identified are in line with the NASA TVF WG-4 objectives and use cases. Together, it forms a strong partnership to accelerate the development, certification, and practical deployment for public service missions. The US Air Force Agility Prime has been a collaboration partner on this white paper, and provided valuable input and recommendations. Most of the eVTOL public service mission elements discussed in this paper and additional use cases envisioned by the NASA TVF WG-4 team are shared by the Agility Prime program. The focus and efforts of the Agility Prime in product and system development, industry and government partnership, accelerated certifications as well as early test and deployment are totally in sync with the path forward recommended by this white paper. This kind of collaboration and partnership will help enable the practical use of the eVTOL for public service missions, benefit the eVTOL public acceptance, and accelerate the eVTOL industry revolution.

Johnny T. Doo↗

NASA 26 GHz Polar Subnet in 2020+

The next generation Earth observing satellites will face challenges in supporting high rate space communications from the increasingly sophisticated instruments. Emerging applications will need space-to-ground links with data rates forecasted to be in the 1-20 Gbps range. To meet these challenges, NASA is designing and integrating a 26 GHz Polar Subnet to support space communication needs in 2020 and beyond. This paper describes the current effort of the Space Communications and Navigation Program's Near Earth Network (NEN), managed out of Goddard Space Flight Facility (GSFC), to deploy a 26 GHz Polar Subnet including the implementation, topology, capabilities, architecture design, operations and key design trades.

Baldwin, Philip↗

Toward an Integrated Product of Higher Accuracy and Longer Time Span: Improvement of the Upcoming NASA GEWEX SRB Data Release 4 over Release 3 Based on Validation Against Surface-Based Measurements

The NASA Global Energy and Water Exchanges (GEWEX) Surface Radiation Budget (SRB) is moving toward its next generation, the Release 4 Integrated Product (Rel. 4-IP), and its shortwave algorithm preliminary results as of this writing span 34 years continuously from July 1983 to June 2017 on a quasi-equal-area grid system with 44,016 gridboxes ranging from 1 longitude times 1 latitude around the Equator to 120 longitude times 1 latitude. The data are in the form of 3-hourly, 3-hourly-monthly, daily and monthly means. The Baseline Surface Radiation Network (BSRN) is a project of the Data and Assessments Panel from the GEWEX under the umbrella of the World Climate Research Programme (WCRP). Currently in the archive there are data from 67 sites located in all seven continents spanning from 1992 to the very present. The original BSRN records are at 1-, 2-, 3- or 5-minute intervals, and sophisticated quality-control procedures have been developed to eliminate erroneous records before hourly, daily and monthly means are computed. The Pacific Marine Environmental Laboratory (PMEL) arrays of buoys in the tropical oceans, TAO/TRITON (Pacific Ocean), RAMA (Indian Ocean) and PITARA (Atlantic Ocean), measure shortwave downward fluxes using pyranometers. These buoys transmit measured data to shore in real-time via the Argos satellite system. And these buoys are major components of the CLIVAR climate analysis project and the GOOS, GCOS, and GEOSS observing systems. So far there are data from 64 buoys and the earliest data start from 2000. We have extensively validated the Rel. 4-IP preliminary results against the BSRN and PMEL 3-hourly, daily and monthly means. In this paper, we will show that the new results not only temporally span 10 years longer than its predecessor, Release 3, but agree significantly better with the BSRN data over the land and PMEL data over the ocean.

Taiping Zhang↗

Compact and Low-cost Microinverter for Residential Systems

Concerns regarding climate change from the use of fossil fuels have expedited the growth of renewable energy sources. One such form of renewables, solar energy, is already playing and will continue to play a major role in meeting U.S clean energy targets. Expanding solar power usage in residential networks is a critical step in the decarbonization and clean electricity movement. To achieve a carbon-free grid by promoting solar power to the general public, an aggressive cost reduction in solar power systems is essential. The power density of the equipment used in the solar power system is necessary to solve the challenges of solar power installation. This project aims to research, explore, and assess the possibility of reducing the microinverter cost and volume to achieve the next generation microinverters (NGMs) targets for residential solar photovoltaic applications.

14 SOLAR ENERGY↗

A Plan for Revolutionary Change in Gas Turbine Engine Control System Architecture

The implementation of Distributed Engine Control technology on the gas turbine engine has been a vexing challenge for the controls community. A successful implementation requires the resolution of multiple technical issues in areas such as network communications, power distribution, and system integration, but especially in the area of high temperature electronics. Impeding the achievement has been the lack of a clearly articulated message about the importance of the distributed control technology to future turbine engine system goals and objectives. To resolve these issues and bring the technology to fruition has, and will continue to require, a broad coalition of resources from government, industry, and academia. This presentation will describe the broad challenges facing the next generation of advanced control systems and the plan which is being put into action to successfully implement the technology on the next generation of gas turbine engine systems.

Culley, Dennis E.↗

The X-windows interactive navigation data editor

A new computer program called the X-Windows Interactive Data Editor (XIDE) was developed and demonstrated as a prototype application for editing radio metric data in the orbit-determination process. The program runs on a variety of workstations and employs pull-down menus and graphical displays, which allow users to easily inspect and edit radio metric data in the orbit data files received from the Deep Space Network (DSN). The XIDE program is based on the Open Software Foundation OSF/Motif Graphical User Interface (GUI) and has proven to be an efficient tool for editing radio metric data in the navigation operations environment. It was adopted by the Magellan Navigation Team as their primary data-editing tool. Because the software was designed from the beginning to be portable, the prototype was successfully moved to new workstation environments. It was also itegrated into the design of the next-generation software tool for DSN multimission navigation interactive launch support.

Rinker, G. C.↗

A Common Communications, Navigation and Surveillance Infrastructure for Accommodating Space Vehicles in the Next Generation Air Transportation System

Suborbital space flight and space tourism are new potential markets that could significantly impact the National Airspace System (NAS). Numerous private companies are developing space flight capabilities to capture a piece of an emerging commercial space transportation market. These entrepreneurs share a common vision that sees commercial space flight as a profitable venture. Additionally, U.S. space exploration policy and national defense will impose significant additional demands on the NAS. Air traffic service providers must allow all users fair access to limited airspace, while ensuring that the highest levels of safety, security, and efficiency are maintained. The FAA's Next Generation Air Transportation System (NextGen) will need to accommodate spacecraft transitioning to and from space through the NAS. To accomplish this, space and air traffic operations will need to be seamlessly integrated under some common communications, navigation and surveillance (CNS) infrastructure. As part of NextGen, the FAA has been developing the Automatic Dependent Surveillance Broadcast (ADS-B) which utilizes the Global Positioning System (GPS) to track and separate aircraft. Another key component of NextGen, System-Wide Information Management/ Network Enabled Operations (SWIM/NEO), is an open architecture network that will provide NAS data to various customers, system tools and applications. NASA and DoD are currently developing a space-based range (SBR) concept that also utilizes GPS, communications satellites and other CNS assets. The future SBR will have very similar utility for space operations as ADS-B and SWIM has for air traffic. Perhaps the FAA, NASA, and DoD should consider developing a common space-based CNS infrastructure to support both aviation and space transportation operations. This paper suggests specific areas of research for developing a CNS infrastructure that can accommodate spacecraft and other new types of vehicles as an integrated part of NextGen.

VanSuetendael, RIchard↗

Enabling a Larger Deep Space Mission Suite: A Deep Space Network Queuing Antenna for Demand Access

The advent of deep space small spacecraft, as exemplified by the Mars Cubesat One (MarCO), Lunar Trailblazer, Janus, the Escape and Plasma Acceleration and Dynamics Explorers (EscaPADE), and the thirteen Artemis 1 missions, opens the possibility that a much larger number of deep space spacecraft may be launched over the next 10 years and beyond. While scientifically exciting, the prospect of a (much) larger mission suite raises significant challenges for the current approach to ground stations and mission operations. We have been investigating an integrated approach for ground stations and missions operations to enable new modes of operation while maintaining the capabilities of the current operational techniques. This integrated approach is built around three core capabilities: (1) A queuing antenna that enables monitoring the status of a much larger number of spacecraft, and allows spacecraft to transmit requests for telemetry with NASA’s Deep Space Network (DSN); (2) a flexible scheduling system that expands the current DSN scheduling services to enable allocating time on DSN antennas in near real-time; and (3) a cloud-based ground data system that can be spun up and down according to how tracks are assigned by the flexible scheduling system. We shall show that an 18 meter DSN queuing antenna equipped with cyrogenic receivers would enable use of the DSN Demand Access Service for small spacecraft throughout the inner Solar System, thus providing service to a large mission suite. We first discuss the architecture of the queuing antenna and its supporting systems, including, for instance, the service required to generate the schedule for the queueing antenna (which dictates how it slews to monitor multiple spacecraft in a day of operations). Next, we describe the signaling scheme used to encode a request, which is inherited from the already operational DSN Beacon Tone Service, and describe two alternative ways to detect the incoming tone at the ground station, one based on maximum likelihood estimation (MLE), and another one based on Fast-Fourier Transfer (FFT) processing. We then use these results to estimate the maximum range at which a request can be reliably detected as a function of the spacecraft and ground station communication capabilities. Finally, the last part of this part of this paper briefly describes the prototyping effort undertaken at Morehead State University (MSU) and JPL to demonstrate the viability of this new DSN demand access. In particular, we describe the suite of tests conducted using MSU’s 21 meter ground station to validate its use a queuing antenna.

Mattle, Emily↗

Hydroboost

HydroBoost is the most realistic revenue optimization tool for the hybridization of hydropower and battery energy storage systems to date. The innovative representation of how operators actually schedule hydropower in practice results in more realistic predictions of revenue and operations. Unlike other optimization tools, HydroBoost generates forecast energy prices with uncertainty to use in the optimization. This allows HydroBoost to give users a range of potential revenue with an upper bound using the perfect foresight pricing and a lower bound using a naive persistence forecast model. Additional forecast can be generated and used in the optimization, such as additive models, random forest, and neural networks to give further insight into potential revenue. HydroBoost has been designed to be applicable for both run-of-river and reservoir storage sites. The primary focus is on the day-ahead market and requires year-long data with an hour time-step. All time-series input and constraints are contained in an Excel worksheet for convince. The user will run the forecasting generation first with a Python script to give the optimization model the necessary requirements. Next the optimization is ran using Julia and results are generated and stored into a directory as csv files. HydroBoost includes an additional module to generate figures based on the results of the optimization simulation. The results help analyze the results and users to draw insights into how the hydro and battery systems are operated and the revenue each is producing. Additionally, the difference between the perfect foresight model and models that include forecast can easily be inspected.

Phillips, TylerB. [Idaho National Laboratory (INL)↗

Modeling Deformable Linear Objects for Autonomous Robotic Outfitting of Lunar Surface Systems

This paper presents structural models of deformable linear objects (DLOs). DLOs are a subclass of deformable objects that encompasses common outfitting elements such as cables and ropes. Models are validated through hardware experiments, and integration in a robotic autonomy architecture for space environments is discussed. A persistent human presence on the lunar surface is one of the next major milestones in space exploration. This requires the development of robust extraplanetary construction technologies including structures and materials modeling and robotic systems. Previous robotic construction technology development has primarily focused on structural assembly, with significantly less focus on robotically performed outfitting tasks to instantiate subsystems providing power, data, life support, etc. These tasks involve manipulation of highly flexible elements, which are difficult to model, such as cable harnesses, ropes, and hoses. Robotic manipulation of DLOs, especially cable harnesses, is an active area of research as cable harnesses are essential for providing power and data to space assets. DLO models that can be used for robot manipulator trajectory generation are necessary for autonomous operation of lunar infrastructure. There are many proposed methods for modeling DLOs, and they primarily fall into three types: 1) discrete model-based, 2) continuum model-based, and 3) Neural Network-based. These types each have pros and cons, and the tradeoff between model accuracy and computational speed informs which type should be used. An understanding of this trade-off is imperative for real-time control of autonomous systems. High computational requirements reduce the speed of the model, making real-time control difficult, while accuracy is critical to preventing collisions. Discrete models, such as a mass-spring multibody representation, require relatively few calculations, and accuracy is directly tied to the step size of the discretization. Continuum models, such as a B-spline representation or a Cosserat rod model (a mix of continuous and discrete), are more informed of the structural properties of the cable and are much more accurate than a rigid body mass-spring model, but at significant computational cost. A Neural Network approach can provide an online solution with very few computational steps, but properly generating training data can be difficult and validation for an in-space application is not trivial. This paper explores the trade-off between different modeling approaches and compares accuracy and computational speed/complexity of the three types mentioned above. Model accuracy is evaluated using a cable in a static configuration. True cable shape is obtained using a depth camera for RGB images and point-cloud segmentation. The purpose of this experiment is to evaluate the trade-offs of different approaches to the DLO modeling problem. Understanding the tradeoffs between different cable modeling techniques paves the way for developing robotic control and planning architectures necessary for real-time manipulation of DLOs for lunar infrastructure outfitting. Real-time control is required for robotic systems to be able to actively manipulate a cable in a harsh environment where model and sensor errors compound, and environmental conditions can cause significant disturbances. Cable routing must be performed in areas with high density of objects/obstacles: through truss structures, near solar panels or mirror arrays, next to bundles of electrical equipment. Understanding the best way to plan and manipulate a cable without disrupting the environment or damaging the cable is imperative to robotic outfitting operations on the lunar surface.

Amy M Quartaro↗

Direct Data Distribution From Low-Earth Orbit

NASA Lewis Research Center (LeRC) is developing the space and ground segment technologies necessary to demonstrate a direct data distribution (1)3) system for use in space-to-ground communication links from spacecraft in low-Earth orbit (LEO) to strategically located tracking ground terminals. The key space segment technologies include a K-band (19 GHz) MMIC-based transmit phased array antenna, and a multichannel bandwidth- and power-efficient digital encoder/modulate with an aggregate data rate of 622 Mb/s. Along with small (1.8 meter), low-cost tracking terminals on the ground, the D3 system enables affordable distribution of data to the end user or archive facility through interoperability with commercial terrestrial telecommunications networks. The D3 system is applicable to both government and commercial science and communications spacecraft in LEO. The features and benefits of the D3 system concept are described. Starting with typical orbital characteristics, a set of baseline requirements for representative applications is developed, including requirements for onboard storage and tracking terminals, and sample link budgets are presented. Characteristics of the transmit array antenna and digital encoder/modulator are described. The architecture and components of the tracking terminal are described, including technologies for the next generation terminal. Candidate flights of opportunity for risk mitigation and space demonstration of the D3 features are identified.

Budinger, James M.↗

Proceedings of the Space Station Freedom Clinical Experts Seminar

These are the proceedings of the Space Station Freedom Health Maintenance Facility 1990 Clinical Experts Seminar held August 27-29, 1990, at the Nassau Bay Hilton, Houston, Texas. Contained within are the agenda, list of medical consultants, executive summary, individual presentations, and the comments generated from the working groups. Issues include the adequacy of current Health Maintenance Facility for Space Station Freedom; impact of having, or not having, an ACRV or physician on board Space Station Freedom; new and developing technologies, techniques, and medications and their impact on the evolving Space Station Freedom, considerations surrounding x-ray, ultrasound, lab, decontamination, blood transfusion, nutrition, safe-haven, computer/telemedicine; suggestions as to how to train the Crew Medical Officer; and, how the consultant network will interface over the next several years.

Billica, Roger P.↗

VLBI2010 Imaging and Structure Corrections

Simulations show that the next generation VLBI system is generally well suited for imaging extragalactic radio sources. In addition to revealing the morphology of the sources, simulated VLBI2010 images may also be used to generate structure correction maps, which characterize the impact of source structure on the VLBI measurements. By comparing structure corrections for a set of simulated images based on Monte-Carlo generated visibilities with theoretical structure corrections derived from the model, we assess the accuracy of VLBI2010 structure corrections. In the most favorable case (32-station network, source at declination +40 deg.), statistics demonstrate that the structure corrections obtained from simulated images are statistically close to the theoretical model ones, which seems very promising for the VLBI2010 system.

Collioud, Arnaud↗

Metric Tracking Services in the Era of Optical Communications

The Space Communications and Navigation program, at the National Aeronautics and Space Administration, is developing free-space optical communications technology to facilitate the next generation of space missions in near-Earth, Lunar, and planetary space. A discussion of optimetric observation performance and hardware-in-the-loop test results are presented. Simulation of orbit-determination for LEO and Lunar spacecraft relying on optimetric tracking extends raw observation accuracy to realizable orbit-determination performance. Potential science and operational applications are reviewed, along with NASA's approach for developing optimetric technology. Current investments in developing optimetric hardware and plans for NASA's future optical communications network define the path for a future operational optimetric capability in the 2020's and beyond.

optimetrics↗

Baryon Number Violation Search

Understanding the fundamental forces and symmetries of nature has long been a central goal of particle physics. While the Standard Model (SM) provides a successful framework, it does not guarantee the conservation of baryon number B or lepton number L, thus motivating searches for their violation. Proton decay, a fundamental process violating B, has been at the forefront of experimental searches for decades.The discovery of the weak neutral current in 1973 unified the electromagnetic and weak forces and inspired the creation of Grand Unified Theories (GUTs) that also unify the strong force. In 1974, the first-ever GUT, proposed by Georgi and Glashow, naturally predicted proton decay. This prediction led to an experimental push to validate these theories, and a large underground detector boom was born. Initially designed for proton decay searches, these detectors later proved invaluable to neutrino physics.Although no evidence for proton decay has yet been observed, next-generation large detectors, such as the Deep Underground Neutrino Experiment (DUNE), offer the opportunity to improve on current experimental limits. Utilizing its Liquid Argon Time Projection Chamber (LArTPC) technology, DUNE is positioned to probe rare processes such as proton decay with increased sensitivity.This thesis presents a sensitivity study for the dominant proton decay mode predicted by Supersymmetric GUTs, p → K+ν, utilizing machine learning approaches. Two methods are explored in this thesis: a Boosted Decision Tree (BDT) analysis and a Graphical Neural Network (GNN) analysis with NuGraph. A lifetime limit of 5.36 ± 0.69 × 1033 years for 400 kt-yrs is found using the BDT, while the GNN achieves a lifetime limit of 6.19±1.26×1033 years for 400-kt-yrs. The NuGraph result offers better sensitivity compared to the current limit set by Super-Kamiokande of 5.90 × 1033 while the BDT result offers a slightly lower sensitivity.Additionally, this thesis discusses cross-section work, a first-ever foray into proton decay and atmospheric neutrinos in a vertical drift (VD) DUNE detector, and extensive hardware contributions to the DUNE Far Detector (FD) 1 Module-0, ProtoDUNE-2, which serves as a testbed for the final detector design and installation.

Stokes, Tyler D. [Louisiana State U.] (ORCID:00000↗