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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 469 records · Page 26
All sourcesNASA NTRSDOE OSTI
NASA NTRS2017

Method of Stamping Surface-Enhance Raman Spectroscopy for Label-Free, Multiplexed, Molecular Sensing and Imaging

The present disclosure relates the use of a stamping surface enhanced Raman scattering (S-SERS) technique with nanoporous gold disk (NPGD) plasmonic substrates to produce a label-free, multiplexed molecular sensing and imaging technique. A NPGD SERS substrate is stamped onto a surface containing one or more target molecules, followed by SERS measurement of the target molecules located between the surface and SERS substrate. The target molecules may be deposited on the surface, which may be a carrier substrate such as polydimethylsiloxane (PDMS).

Shih, Wei-Chuan↗
NASA NTRSDate not supplied

Lunar Dust Capture Using a Novel, Multiplexed Inertial Filter

Multiplexed inertial filtration is new. It holds promise to capture and contain lunar dust with less pressure drop. Even when the filter contains significant amounts of captured lunar dust, the pressure drop remains relatively low. State of the art vacuum cleaners use a system with 4 different filter: they can contain large amounts of lunar dust and maintain low pressure drop, but because they require 4 filters, the system size is relatively large. State of the are miniature vacuum cleaners are small, but the single in-line depth filter clogs easily. The goal of this CIF project is to develop a lunar dust vacuum cleaner <1000 cc in size, with high capacity and low dP.

Lunar Soil↗
DOE OSTI2014

Increasing throughput of multiplexed electrical bus in pipe-lined architecture

Techniques are disclosed for increasing the throughput of a multiplexed electrical bus by exploiting available pipeline stages of a computer or other system. For example, a method for increasing a throughput of an electrical bus that connects at least two devices in a system comprises introducing at least one signal hold stage in a signal-receiving one of the two devices, such that a maximum frequency at which the two devices are operated is not limited by a number of cycles of an operating frequency of the electrical bus needed for a signal to propagate from a signal-transmitting one of the two devices to the signal-receiving one of the two devices. Preferably, the signal hold stage introduced in the signal-receiving one of the two devices is a pipeline stage re-allocated from the signal-transmitting one of the two devices.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2013

Design of Smart Charging Infrastructure Hardware and Firmware Design of the Various Current Multiplexing Charging System

Currently, when Electric Vehicles (EVs) are charging, they only have the option to charge at a selected current or not charge. When during the day there is a power shortage, the charging infrastructure should have the options to either shut off the power to the charging stations or to lower the power to the EVs in order to satisfy the needs of the grid. There is a need for technology that controls the current being disbursed to these electric vehicles. This paper proposes a design for a smart charging infrastructure capable of providing power to several EVs from one circuit by multiplexing power and providing charge control. The smart charging infrastructure includes the server and the smart charging station. With this smart charging infrastructure, the shortage of energy in a local grid could be solved by our EV management system

Chung, Ching-Yen↗
DOE OSTI2018

Time-division multiplexing data bus

A two-to-one multiplexor comprises a first data input configured to hold data provided from a first preceding asynchronous pipeline stage and a second data input configured to hold data provided from a second preceding asynchronous pipeline stage, a 4-phase bundled data protocol facilitating communication between the first and the second data inputs and the first and second preceding asynchronous pipeline stage, an arbitration unit connected to the first data input and the second data input, and configured to select which of the data from the first and the second data inputs is released, a request release unit, and a reset unit wherein the arbitration unit, the request release unit, and the reset unit implement and complete a second 4-phase bundled data protocol facilitating communication with a succeeding asynchronous pipeline stage for transmission of the data chosen by the arbitration unit thereby providing asynchronous multiplexing of the data.

Hoff, James R.↗
DOE OSTI2019

Conflux – An Asynchronous 2-to-1 Multiplexor for Time-Division Multiplexing and Clock-less, Token-less Readout

This paper describes an independent, self-arbitrating asynchronous two-to-one multiplexor called Conflux. Conflux can be used to implement clock-less and token-less Time-Division Multiplexing between two sources. This capability can then be used to create a clock-less and token-less aggregate data bus which can be used as a complete asynchronous readout architecture for a chip, a part of a chip or an entire multi-chip system. Conflux utilizes a classic, four-phased asynchronous handshake on both of its input ports as well as on its output port. Asynchronous Request is bundled with Data to ensure consistent propagation delay. The Request is also differential to account for propagation delay differences between Logical Ones and Zeros. Arbitration between the two Conflux input streams is accomplished by three Set-Reset latches. Finally, Conflux cells were used successfully to implement the readout architecture of the FCP130 prototype chip. Tests indicate single Conflux stage delays of 1.8ns and a bandwidth of approximately 20 Gbps in 130nm CMOS.

43 PARTICLE ACCELERATORS↗
DOE OSTI2020

Multiplexed binary assembly and quantitative tracking of bacterial populations

Compositions and methods for tracking combinations of mutations in populations by coupling DNA assembly and paired-end sequencing technology with high-throughput sequencing. This allows for an unlimited number of mutation sites in a population of microorganisms to be identified, and allows sites to be sequenced across several replicates. Unique identifiers (DNA barcodes) can be used to measure fitness data by sequencing of the barcodes multiplexed with the mutation sites with high-throughput short sequencing read technology, allowing selections to be rapidly performed on populations of known combinatorial genotypes.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Multiplexing-Based Flyback Converter for Multi-Port USB Power Delivery with True Power-Sharing

Universal serial bus power delivery (USB-PD) chargers are more attractive to consumers with multiple output ports. Existing multiple port charger designs take multi-stage approach thus increase power loss and charger size. Also, ports are normally designed with different power capability thus the high-power port becomes under-used if the connected device is fully charged while the other lower power ports cannot take over the unused power. This is mainly limited by the power architecture design. This paper addresses this issue by presenting a multiplexing based multi-port quasi-resonant flyback converter. The design achieves true power-sharing with high efficiency, small size, and simple analog implementation. This paper discusses the operating principle and design considerations. A GaN-based 60 W dual port charger verifies the proposed scheme while achieving 76% size reduction and 1% efficiency improvement than state-of-the-art.

Xue, Lincoln↗
DOE OSTI2023

Chip Development Toward 12 bit 10 GSPS Cryogenic ADC for Multiplexed Quantum Readout

This presentation presents the background and plan for the development toward a 12 bit 10 GSPS cryogenic ADC for multiplexed quantum readout. It covers the first two chips that have been taped out and tested. It includes results for those chips and provides some context to plans for the upcoming chip tapeout and the final one to come later.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2016

Challenges in the implementation of dense wavelength division multiplexed (DWDM) optical interconnects using resonant silicon photonics (invited)

In this study, small silicon photonics micro-resonator modulators and filters hold the promise for multi-terabit per-second interconnects at energy consumptions well below 1 pJ/bit. To date, no products exist and little known commercial development is occurring using this technology. Why? In this talk, we review the many challenges that remain to be overcome in bringing this technology from the research labs to the field where they can overcome important commercial, industrial, and national security limitations of existing photonic technologies.

36 MATERIALS SCIENCE↗
DOE OSTI2025

The evolution of analytical techniques for multiplex analysis of protein biomarkers

Introduction: The landscape of biomarker development has evolved with advanced analytical technologies, particularly affinity- and mass spectrometry-based techniques. These advancements have deepened our understanding of disease mechanisms, enabling the development of precise diagnostic tools and personalized medicine. Protein biomarkers, which play pivotal roles in biological processes, have become invaluable in diagnosing and monitoring diseases, aided by their presence in various biological samples and the availability of established detection methods. Areas covered: This review covers the role of protein biomarkers in clinical practice, the development and dimensionality of protein biomarkers, advancements in detection technologies, a comparison of these technologies, and future directions in biomarker discovery and disease mechanism elucidation. Expert opinion: Advances in biomarker technologies have the potential to transform diagnostics and personalized treatment but face challenges such as high costs and technical complexity. Enhancing reproducibility and integrating multi-omics approaches may offer better insights. In conclusion, the field should evolve toward high-throughput, automated methods, continuously adapting research, and clinical practices.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2014

All-diamond optical assemblies for a beam-multiplexing X-ray monochromator at the Linac Coherent Light Source

A double-crystal diamond (111) monochromator recently implemented at the Linac Coherent Light Source (LCLS) enables splitting of the primary X-ray beam into a pink (transmitted) and a monochromatic (reflected) branch. The first monochromator crystal, with a thickness of ~100 µm, provides sufficient X-ray transmittance to enable simultaneous operation of two beamlines. This article reports the design, fabrication and X-ray characterization of the first and second (300 µm-thick) crystals utilized in the monochromator and the optical assemblies holding these crystals. Each crystal plate has a region of about 5 × 2 mm with low defect concentration, sufficient for use in X-ray optics at the LCLS. The optical assemblies holding the crystals were designed to provide mounting on a rigid substrate and to minimize mounting-induced crystal strain. The induced strain was evaluated using double-crystal X-ray topography and was found to be small over the 5 × 2 mm working regions of the crystals.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2020

Multiplexed Knockouts in the Model Diatom Phaeodactylum by Episomal Delivery of a Selectable Cas9

Marine diatoms are eukaryotic microalgae that play significant ecological and biogeochemical roles in oceans. They also have significant potential as organismal platforms for exploitation to address biotechnological and industrial goals. In order to address both modes of research, sophisticated molecular and genetic tools are required. We presented here new and improved methodologies for introducing CRISPRCas9 to the model diatom Phaeodactylum tricornutum cells and a streamlined protocol for genotyping mutant cell lines with previously unknown phenotypes. First, bacterialconjugation was optimized for the delivery of Cas9 by transcriptionally fusing Cas9 to a selectable marker by the 2A peptide. An episome cloning strategy using both negative and positive selection was developed to streamline CRISPR-episome assembly. Next, cell line picking and genotyping strategies, that utilize manual sequencing curation, TIDE sequencing analysis, and a T7 endonuclease assay, were developed to shorten the time required to generate mutants. Following this new experimental pipeline, both singlegene and two-gene knockout cell lines were generated at mutagenesis efficiencies of 48% and 25%, respectively. Lastly, a protocol for precise gene insertions via CRISPRCas9 targeting was developed using particle-bombardment transformation methods. Overall, the novel Cas9 episome design and improved genotyping methods presented here allow for quick and easy genotyping and isolation of Phaeodactylum mutant cell lines (less than 3 weeks) without relying on a known phenotype to screen for mutants.

59 BASIC BIOLOGICAL SCIENCES↗