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At least 469 records · Page 26

EpiK: A Knowledge Base for Epidemiological Modeling and Analytics of Infectious Diseases

Computational epidemiology seeks to develop computational methods to study the distribution and determinants of health-related states or events (including disease), and the application of this study to the control of diseases and other health problems. Recent advances in computing and data sciences have led to the development of innovative modeling environments to support this important goal. The datasets used to drive the dynamic models as well as the data produced by these models presents unique challenges owing to their size, heterogeneity and diversity. These datasets form the basis of effective and easy to use decision support and analytical environments. As a result, it is important to develop scalable data management systems to store, manage and integrate these datasets. In this paper, we develop EpiK —a knowledge base that facilitates the development of decision support and analytical environments to support epidemic science. An important goal is to develop a framework that links the input as well as output datasets to facilitate effective spatio-temporal and social reasoning that is critical in planning and intervention analysis before and during an epidemic. The data management framework links modeling workflow data and its metadata using a controlled vocabulary. The metadata captures information about storage, the mapping between the linked model and the physical layout, and relationships to support services. EpiK is designed to support agent-based modeling and analytics frameworks—aggregate models can be seen as special cases and are thus supported. We use semantic web technologies to create a representation of the datasets that encapsulates both the location and the schema heterogeneity. The choice of RDF as a representation language is motivated by the diversity and growth of the datasets that need to be integrated. A query bank is developed—the queries capture a broad range of questions that can be posed and answered during a typical case study pertaining to disease outbreaks. The queries are constructed using SPARQL Protocol and RDF Query Language (SPARQL) over the EpiK. EpiK can hide schema and location heterogeneity while efficiently supporting queries that span the computational epidemiology modeling pipeline: from model construction to simulation output. As a result, we show that the performance of benchmark queries varies significantly with respect to the choice of hardware underlying the database and resource description framework (RDF) engine.

60 APPLIED LIFE SCIENCES↗

Cyberbiosecurity and Public Health in the Age of COVID-19

Cyberbiosecurity, the aspect of biosecurity involving the digital representation of biological data, had already been emerging as a matter of public concern even prior to the onset of the COVID-19 pandemic. Key issues of concern include, among others, the privacy of patient data, the security of public health databases, the integrity of diagnostic test data, the integrity of public biological databases, the security implications of automated laboratory systems and the security of proprietary biological engineering advances. With the onset of the COVID-19 pandemic, and the importance of digital resources in combatting it, concern about the potential for cyber attacks by state-based or non-state actors has been elevated. To illuminate the challenges, we focus on the cyber vulnerabilities that need to be addressed in public health activities such as disease surveillance and outbreak management. In particular, we examine cyber issues raised by the accelerated pace of development for COVID mitigations, treatments, and vaccines.

cybersecurity, biosecurity↗

Medics: Medical Decision Support System for Long-Duration Space Exploration

The Autonomous Medical Operations (AMO) group at NASA Ames is developing a “medical decision support system” to enable astronauts on long-duration exploration missions to operate autonomously. The system will support clinical actions by providing medical interpretation advice and procedural recommendations during emergent care and clinical work performed by crew. The current state of development of the system, called MedICS (Medical Interpretation Classification and Segmentation) includes two separate aspects: a set of machine learning diagnostic models trained to analyze organ images and patient health records, and an interface to ultrasound diagnostic hardware and to medical repositories. Three sets of images of different organs and medical records were utilized for training machine learning models for various analyses, as follows: 1. Pneumothorax condition (collapsed lung). The trained model provides a positive or negative diagnosis of the condition. 2. Carotid artery occlusion. The trained model produces a diagnosis of 5 different occlusion levels (including “normal”). 3. Ocular retinal images. The model extracts optic disc pixels (image segmentation). This is a precursor step for advanced autonomous fundus clinical evaluation algorithms to be implemented in FY20. 4. Medical health records. The model produces a differential diagnosis for any particular individual, based on symptoms and other health and demographic information. A probability is calculated for each of 25 most common conditions. The same model provides the likelihood of survival. All results are provided with a confidence level. Item 1 images were provided by the US Army and were part of a data set for the clinical treatment of injured battlefield soldiers. This condition is relevant to possible space mishaps, due to pressure management issues. Item 2 images were provided by Houston Methodist Hospital, and item 3 health records were acquired from the MIT laboratory of computational physiology. The machine learning technology utilized is deep multilayer networks (Deep Learning), and new models will continue to be produced, as relevant data is made available and specific health needs of astronaut crews are identified. The interfacing aspects of the system include a GUI for running the different models, and retrieving and storing data, as well as support for integration with an augmented reality (AR) system deployed at JSC by Tietronix Software Inc. (HoloLens). The AR system provides guidance for the placement of an ultrasound transducer that captures images to be sent to the MedICS system for diagnosis. The image captured and the associated diagnosis appear in the technician’s AR visual display.

Colombano, Silvano↗

Physics-Guided Deep Learning for Complex System Health Management and Decision Making

The landscape of complex engineered systems is rapidly evolving, from smart manufacturing facilities to next-generation transportation vehicles. As these systems become increasingly sophisticated and interconnected, the need for advanced health management systems grows ever more critical. These systems must go beyond simple monitoring, actively predicting potential failures before they occur. This paradigm shift from fixed maintenance schedules to condition-based predictions is key to optimizing system performance, enhancing safety, and paving the way for autonomous decision-making across various industries. Whether in industrial processes, energy systems, or advanced transportation, the ability to anticipate and prevent failures is becoming a cornerstone of operational excellence. To accurately predict the future health of any complex system, knowledge of its current health state and future operational conditions is essential. Recent advancements in data-driven algorithms have generated growing interest in artificial intelligence for industrial applications. However, the limitations of pure data-driven methods, particularly in industries where data acquisition is costly and limited, have become apparent. This has led to a focus on blending physics with data-driven algorithms, mitigating the drawbacks of both approaches while emphasizing their respective advantages. This research proposes a novel framework for integrating physics-based performance models with deep learning algorithms for the prognostics of complex safety-critical systems. In this approach, physics-based models serve as a blueprint, capturing fundamental system behaviors, while deep learning algorithms, leveraging real-world sensor data, fill in gaps and identify subtle patterns indicative of potential problems. This hybrid methodology, utilizing techniques such as Physics-Informed Neural Networks (PINNs), offers a powerful solution for predicting system health. By fusing domain knowledge with data-driven insights, this approach promises more accurate, adaptable, and reliable models for health prediction. The resulting framework is versatile, applicable across various sectors including aerospace, manufacturing, and energy systems, ultimately contributing to safer, more efficient operations in our increasingly complex technological landscape.

Diagnostics↗

Integrated Pest Management (IPM) for Early Detection Algal Crop Protection. Final Report

During large-scale, outdoor algal biomass growth, production strain(s) are subject to attack by pathogens, predators, and non-productive competitors, compromising the biomass yield. The project team at UCSD developed and demonstrated the effectiveness of Volatile Organic Compound, VOC, analysis via mass spectrometry (MS) as an early detection system for the presence of production algal ponds infection. The MS detection can then trigger high-resolution melt analysis (HRMA) and enhanced quantitative PCR (qPCR) to identify predatory or pathogenic species precisely. This study gathered the foundational data informing how wholly automated systems monitor the health of production ponds. By detecting the presence of low molecular weight VOCs in the air space above ponds, the instrument was able to mimic “sniffing” the health of the algae pond. This early warning system will be free growers from time-consuming and costly regular surveillance of ponds with the current techniques, such as qPCR and flow-cam assays, which are slower, less sensitive, and not easily fully automated, resulting in increased production efficiency through the reduction of crop loss. This project demonstrated that Chemical Ionization Mass Spectrometry, CIMS, could serve as a real-time monitor of ponds health tracking up to 100 different VOCs simultaneously for continuous periods up to 60 days without interruption, signaling infection within an algal crop 24 to 36 hours prior to techniques such as qPCR and microscopy. While mass spectrometry is an expensive tool, this simple VOC sampling system proved not only to be sensitive and robust but could to multiplexed to monitor several ponds, lowering the overall cost serially. This technology demonstrated a reduction in biomass production cost by approximately 50% compared to growers not employing any detection methodology.

09 BIOMASS FUELS↗

Development of Acoustic Model-Based Iterative Reconstruction Technique for Thick-Concrete Imaging

Ultrasound signals have been used extensively for non-destructive evaluation (NDE). However, typical reconstruction techniques, such as the synthetic aperture focusing technique (SAFT), are limited to quasi-homogenous thin media. New ultrasonic systems and reconstruction algorithms are in need for one-sided NDE of non-homogenous thick objects. An application example space is imaging of reinforced concrete structures for commercial nuclear power plants (NPPs). These structures provide important foundation, support, shielding, and containment functions. Identification and management of aging and degradation of concrete structures is fundamental to the proposed long-term operation of NPPs. Another example is geothermal and oil/gas production wells. These multi-layered structures are composed of steel, cement, and several types of soil and rocks. Ultrasound systems with greater penetration range and image quality will allow for better monitoring of the well's health and prediction of high-pressure hydraulic fracturing of the rock. These application challenges need to be addressed with an integrated imaging approach, where the application, hardware, and reconstruction software are highly integrated and optimized. Therefore, we are developing an ultrasonic system with Model-Based Iterative Reconstruction (MBIR) as the image reconstruction backbone. As the first implementation of MBIR for ultrasonic signals, this paper document the first implementation of the algorithm and show reconstruction results for synthetically generated data.

concrete NDE↗

Development of Acoustic Model-Based Iterative Reconstruction Technique for Thick-Concrete Imaging

Ultrasound signals have been used extensively for non-destructive evaluation (NDE). However, typical reconstruction techniques, such as the synthetic aperture focusing technique (SAFT), are limited to quasi-homogenous thin media. New ultrasonic systems and reconstruction algorithms are in need for one-sided NDE of non-homogenous thick objects. An application example space is imaging of reinforced concrete structures for commercial nuclear power plants (NPPs). These structures provide important foundation, support, shielding, and containment functions. Identification and management of aging and degradation of concrete structures is fundamental to the proposed long-term operation of NPPs. Another example is geothermal and oil/gas production wells. These multi-layered structures are composed of steel, cement, and several types of soil and rocks. Ultrasound systems with greater penetration range and image quality will allow for better monitoring of the well s health and prediction of high-pressure hydraulic fracturing of the rock. These application challenges need to be addressed with an integrated imaging approach, where the application, hardware, and reconstruction software are highly integrated and optimized. Therefore, we are developing an ultrasonic system with Model-Based Iterative Reconstruction (MBIR) as the image reconstruction backbone. As the first implementation of MBIR for ultrasonic signals, this paper document the first implementation of the algorithm and show reconstruction results for synthetically generated data.

Almansouri, Hani↗

Solutions Network Formulation Report. Integrating Salinity Measurements from Aquarius into the Harmful Algal Blooms Observing System

This Candidate Solution suggests the use of Aquarius sea surface salinity measurements to improve the NOAA/NCDDC (National Oceanic and Atmospheric Administration s National Coastal Data Development Center) HABSOS (Harmful Algal Blooms Observing System) DST (decision support tool) by enhancing development and movement forecasts of HAB events as well as potential species identification. In the proposed configuration, recurring salinity measurements from the Aquarius mission would augment HABSOS sea surface temperature and in situ ocean current measurements. Thermohaline circulation observations combined with in situ measurements increase the precision of HAB event movement forecasting. These forecasts allow coastal managers and public health officials to make more accurate and timely warnings to the public and to better direct science teams to event sites for collection and further measurements.

Anderson, Daniel↗

Lac du Flambeau - Climate Change Resilience Initiative (Final Report)

The goals of this project were to create a comprehensive Environmental Resiliency Plan and to increase the capacity of all Lac du Flambeau Tribal Program Managers to incorporate environmental impact thinking into the everyday management of their departments. Environmental Resiliency Planning utilized current Tribal documents, which include the Integrated Resource Management Plan (IRMP), the Lac du Flambeau Tribal Emergency Management Plan (EMP), and the Lac du Flambeau Strategic Energy Plan, as guidance throughout the process. A vulnerability assessment initiated our technical process and allowed us to identify, quantify, and prioritize (or rank) the vulnerabilities in our system. This set the stage for a reduction and resilience plan as well as providing insight for revisions of existing management plans such as the Energy and Integrated Resources Management Plans

54 ENVIRONMENTAL SCIENCES↗

Probabilistic Structural Health Monitoring of the Orbiter Wing Leading Edge

A structural health monitoring (SHM) system can contribute to the risk management of a structure operating under hazardous conditions. An example is the Wing Leading Edge Impact Detection System (WLEIDS) that monitors the debris hazards to the Space Shuttle Orbiter s Reinforced Carbon-Carbon (RCC) panels. Since Return-to-Flight (RTF) after the Columbia accident, WLEIDS was developed and subsequently deployed on board the Orbiter to detect ascent and on-orbit debris impacts, so as to support the assessment of wing leading edge structural integrity prior to Orbiter re-entry. As SHM is inherently an inverse problem, the analyses involved, including those performed for WLEIDS, tend to be associated with significant uncertainty. The use of probabilistic approaches to handle the uncertainty has resulted in the successful implementation of many development and application milestones.

Yap, Keng C.↗

Sandia National Laboratories Facilities Management and Operations Center Design Standards Manual

At Sandia National Laboratories in New Mexico (SNL/NM), the design, construction, operation, and maintenance of facilities is guided by industry standards, a graded approach, and the systematic analysis of life cycle benefits received for costs incurred. The design of the physical plant must ensure that the facilities are "fit for use," and provide conditions that effectively, efficiently, and safely support current and future mission needs. In addition, SNL/NM applies sustainable design principles, using an integrated whole-building design approach, from site planning to facility design, construction, and operation to ensure building resource efficiency and the health and productivity of occupants. The safety and health of the workforce and the public, any possible effects on the environment, and compliance with building codes take precedence over project issues, such as performance, cost, and schedule. These design standards generally apply to all disciplines on all SNL/NM projects. Architectural and engineering design must be both functional and cost-effective. Facility design must be tailored to fit its intended function, while emphasizing low-maintenance, energy-efficient, and energy-conscious design. Design facilities that can be maintained easily, with readily accessible equipment areas, low maintenance, and quality systems. To promote an orderly and efficient appearance, architectural features of new facilities must complement and enhance the existing architecture at the site. As an Architectural and Engineering (A/E) professional, you must advise the Project Manager when this approach is prohibitively expensive. You are encouraged to use professional judgment and ingenuity to produce a coordinated interdisciplinary design that is cost-effective, easily contractible or buildable, high-performing, aesthetically pleasing, and compliant with applicable building codes. Close coordination and development of civil, landscape, structural, architectural, fire protection, mechanical, electrical, telecommunications, and security features is expected to ensure compatibility with planned functional equipment and to facilitate constructability. If portions of the design are subcontracted to specialists, delivery of the finished design documents must not be considered complete until the subcontracted portions are also submitted for review. You must, along with support consultants, perform functional analyses and programming in developing design solutions. These solutions must reflect coordination of the competing functional, budgetary, and physical requirements for the project. During design phases, meetings between you and the SNL/NM Project Team to discuss and resolve design issues are required. These meetings are a normal part of the design process. For specific design-review requirements, see the project-specific Design Criteria. In addition to the design requirements described in this manual, instructive information is provided to explain the sustainable building practice goals for design, construction, operation, and maintenance of SNL/NM facilities. Please notify SNL/NM personnel of design best practices not included in this manual, so they can be incorporated in future updates. You must convey all documents describing work to the SNL/NM Project Manager in both hard copy and in an electronic format compatible with the SNL/NM-prescribed CADD and other software packages, and in accordance with a SNL/NM approved standard format. Print all hard copy versions of submitted documents (excluding drawings and renderings) double-sided when practical.

42 ENGINEERING↗

RuralAI in Tomato Farming: Integrated Sensor System, Distributed Computing, and Hierarchical Federated Learning for Crop Health Monitoring

Precision horticulture is evolving due to scalable sensor deployment and machine learning (ML) integration. These advancements boost the operational efficiency of individual farms, balancing the benefits of analytics with autonomy requirements. However, given concerns that affect wide geographic regions (e.g., climate change), there is a need to apply models that span farms. Federated learning (FL) has emerged as a potential solution. FL enables decentralized ML across different farms without sharing private data. Traditional FL assumes simple two-tier network topologies and, thus, falls short of operating on more complex networks found in real-world agricultural scenarios. Networks vary across crops and farms and encompass various sensor data modes, extending across jurisdictions. New hierarchical FL (HFL) approaches are needed for more efficient and context-sensitive model sharing, accommodating regulations across multiple jurisdictions. Here, we present the RuralAI architecture deployment for tomato crop monitoring, featuring sensor field units for soil, crop, and weather data collection. HFL with personalization is used to offer localized and adaptive insights. Model management, aggregation, and transfers are facilitated via a flexible approach, enabling seamless communication between local devices, edge nodes, and the cloud.

60 APPLIED LIFE SCIENCES↗

An iterative learning and inference approach to managing dynamic cyber-vulnerabilities of complex systems

As modern systems become increasingly reliant on cyber-technologies and continue to be integrated with physical systems, managing risks from deliberate and non-deliberate sources is a significant research challenge. Unlike strictly physical systems, cyber-enabled physical systems are influenced by dynamic and evolving technologies, environments, and attack mechanisms. As a result, vulnerabilities are rapidly changing and difficult to detect and manage. While there is recent interest in the dynamic properties of performance through resilience analysis, limited research addresses the dynamic nature of cyber-system vulnerability. This paper presents a dynamic iterative learning approach to evaluate the state of health for systems as related to cyber-vulnerabilities. These time-varying system health characteristics may not be visible, but can be inferred using observable characteristics. The approach recognizes that multiple types of vulnerabilities need to be included in a holistic system health assessment. The methods are applied to the Common Vulnerability Scoring System database containing over 100,000 documented cybersecurity vulnerabilities. This work is the first to acknowledge the dynamic properties of cyber-vulnerability, while also inferring system health using observable data and hidden states of system health. This work will be of interest to managers of large-scale cyber-enabled physical systems who are seeking to prioritize system health investments.

Chatterjee, Samrat↗

Space Station Freedom environmental database system (FEDS) for MSFC testing

The Water Recovery Test (WRT) at Marshall Space Flight Center (MSFC) is the first demonstration of integrated water recovery systems for potable and hygiene water reuse as envisioned for Space Station Freedom (SSF). In order to satisfy the safety and health requirements placed on the SSF program and facilitate test data assessment, an extensive laboratory analysis database was established to provide a central archive and data retrieval function. The database is required to store analysis results for physical, chemical, and microbial parameters measured from water, air and surface samples collected at various locations throughout the test facility. The Oracle Relational Database Management System (RDBMS) was utilized to implement a secured on-line information system with the ECLSS WRT program as the foundation for this system. The database is supported on a VAX/VMS 8810 series mainframe and is accessible from the Marshall Information Network System (MINS). This paper summarizes the database requirements, system design, interfaces, and future enhancements.

Story, Gail S.↗

An Architecture for Intelligent Systems Based on Smart Sensors

Based on requirements for a next-generation rocket test facility, elements of a prototype Intelligent Rocket Test Facility (IRTF) have been implemented. A key component is distributed smart sensor elements integrated using a knowledgeware environment. One of the specific goals is to imbue sensors with the intelligence needed to perform self diagnosis of health and to participate in a hierarchy of health determination at sensor, process, and system levels. The preliminary results provide the basis for future advanced development and validation using rocket test stand facilities at Stennis Space Center (SSC). We have identified issues important to further development of health-enabled networks, which should be of interest to others working with smart sensors and intelligent health management systems.

Schmalzel, John↗

Piloted Evaluation of a Fault Recovery System for an Aircraft with Distributed Electric Propulsion

Electrified aircraft powertrains contain multiple tightly coupled subsystems, making them much more complex than traditional aircraft propulsion systems, both in terms of integration and control. Electrification enables aircraft to have multiple distributed thrust-producing fans that the flight control system can utilize for enhanced maneuverability, further increasing the control complexity. The SUbsonic Single Aft eNgine (SUSAN) Electrofan is a NASA concept aircraft that leverages this technology. SUSAN is a series/parallel partial hybrid electric single-aisle transport aircraft that takes advantage of its electrified powertrain to provide fuel burn and emissions benefits when compared to the state-of-the-art. Achieving these benefits requires an appropriately designed control architecture that coordinates the various powertrain and flight control subsystems. As such, the SUSAN aircraft is designed with a high level of automation, allowing it to properly manage coupled subsystems and react rapidly to failures and anomalies. To do this effectively, algorithms that perform component health management, fault detection, isolation, and accommodation, and continuous optimization, must be developed, tested, validated, and implemented. This paper describes a piloted evaluation of such an algorithm in scenarios with multiple fan failures, performed in a flight simulator, demonstrating failure recovery and continued safe operation up to the limits of the powertrain. These scenarios are subsequently related to certification requirements.

Electrified Aircraft Propulsion↗

Piloted Evaluation of a Fault Recovery System for an Aircraft with Distributed Electric Propulsion

Electrified aircraft powertrains contain multiple tightly coupled subsystems, making them much more complex than traditional aircraft propulsion systems, both in terms of integration and control. Electrification enables aircraft to have multiple distributed thrust-producing fans that the flight control system can utilize for enhanced maneuverability, further increasing the control complexity. The SUbsonic Single Aft eNgine (SUSAN) Electrofan is a NASA concept aircraft that leverages this technology. SUSAN is a series/parallel partial hybrid electric single-aisle transport aircraft that takes advantage of its electrified powertrain to provide fuel burn and emissions benefits when compared to the state-of-the-art. Achieving these benefits requires an appropriately designed control architecture that coordinates the various powertrain and flight control subsystems. As such, the SUSAN aircraft is designed with a high level of automation, allowing it to properly manage coupled subsystems and react rapidly to failures and anomalies. To do this effectively, algorithms that perform component health management, fault detection, isolation, and accommodation, and continuous optimization, must be developed, tested, validated, and implemented. This paper describes a piloted evaluation of such an algorithm in scenarios with multiple fan failures, performed in a flight simulator, demonstrating failure recovery and continued safe operation up to the limits of the powertrain. These scenarios are subsequently related to certification requirements.

Electrified Aircraft Propulsion↗

Piloted Evaluation of a Fault Recovery System for an Aircraft with Distributed Electric Propulsion

Electrified aircraft powertrains contain multiple tightly coupled subsystems, making them much more complex than traditional aircraft propulsion systems, both in terms of integration and control. Electrification enables aircraft to have multiple distributed thrust-producing fans that the flight control system can utilize for enhanced maneuverability, further increasing the control complexity. The SUbsonic Single Aft eNgine (SUSAN) Electrofan is a NASA concept aircraft that leverages this technology. SUSAN is a series/parallel partial hybrid electric single-aisle transport aircraft that takes advantage of its electrified powertrain to provide fuel burn and emissions benefits when compared to the state-of-the-art. Achieving these benefits requires an appropriately designed control architecture that coordinates the various powertrain and flight control subsystems. As such, the SUSAN aircraft is designed with a high level of automation, allowing it to properly manage coupled subsystems and react rapidly to failures and anomalies. To do this effectively, algorithms that perform component health management, fault detection, isolation, and accommodation, and continuous optimization, must be developed, tested, validated, and implemented. This paper describes a piloted evaluation of such an algorithm in scenarios with multiple fan failures, performed in a flight simulator, demonstrating failure recovery and continued safe operation up to the limits of the powertrain. These scenarios are subsequently related to certification requirements.

Electrified Aircraft Propulsion↗