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At least 469 records · Page 26

Argon-isotopic Age Dating Analyses for Eastern Snake River Plain Volcanic Rock Samples

Argon-isotopic age dating analyses were conducted on 25 volcanic rock samples obtained from 22 boreholes and collected at three surface locations in the Eastern Snake River Plain (ESRP). The analyses were conducted to reduce uncertainties for characterizing volcanic hazards at Idaho National Laboratory (INL) as part of the Senior Seismic Hazard Analysis Committee (SSHAC) Level 3 Probabilistic Volcanic Hazards Assessment (PVHA). Results of the argon-isotopic age dating analyses will be used to estimate the recurrence of basaltic and silicic volcanism and for assessing the spatial and temporal distributions of volcanic events in the ESRP.

58 - GEOSCIENCES↗

230 Th/ 234 U Model Age of International Atomic Energy Agency Sample 27107-14-04 Measured at Los Alamos National Laboratory

This report details the uranium age-dating of International Atomic Energy Agency (IAEA) bulk environmental cotton swipe sample 27107-14-04 at Los Alamos National Laboratory (LANL). The 230 Th/ 234 U radiochronometer was used to determine sample model age requiring the following analyses: U assay, U isotope composition, Th assay and Th isotope composition. Sample 27107-14-04 was received at LANL on November 3, 2025, along with cotton swipe blank 30124-24-20.

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗

Emergency vacuum repairs in an aging accelerator: Case studies and lessons learned

Jefferson Lab operates the CEBAF electron accelerator at energies to 12 GeV for the Department of Energy Nuclear Physics program. The CEBAF injector beamline was designed and built in the early 1990s. Although we’ve upgraded and replaced many of the vacuum systems, we still have unique original components installed which operate daily. Over the past 3 years, we have had several vacuum leaks in ageing components leading to emergency repairs on a tight timeline. I’ll discuss the nature of these vacuum component failures, the difficulties in repair due to their ages, the lessons we’ve learned, and how we hope to minimize similar failures going forward.

Stutzman, Marcy [Thomas Jefferson National Acceler↗

Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring

Despite the highly effective impact of antiretroviral therapy (ART) in reducing mother-to-child transmission of human immunodeficiency virus (HIV), there are concerns of long-term impacts of ART on the health of the offspring. The implications of perinatal exposure to antiviral drugs on the gut bacterial population and metabolic function in the offspring is unclear but may influence health outcomes given the various reported effects of the microbiome in human health. This study aims to gain insight into the potential effect ofin uteroand lactational exposure to ART on gut microbiota populations and short‐chain fatty acids (SCFAs) production in aged rat offspring. Pregnant rats were administered a combination of antiretroviral drugs (abacavir/dolutegravir/lamivudine) at two different dose levels during gestation and throughout lactation, and the fecal bacterial abundance and SCFA levels of the offspring were analyzed when they reached 12 months of age. Our results showed dose-dependent and sex-based differences in fecal microbial abundance at various taxonomic levels. Specifically, we found a decline inFirmicutesin males, and an increase inActinobacteriaamong males and females. Furthermore, a sex-specific distribution reorganization ofLactobacillus,Bifidobacterium, andAkkermansiawas identified. No significant difference in the concentration of prominent SCFAs and IgA levels were identified. These findings provide preliminary information indicating the need to evaluate perinatal effects of ART more comprehensively on the gut bacterial and metabolic function in future studies, and their potential role in offspring health outcomes.

Research & Experimental Medicine↗

Chemical contributions to silicon anode calendar aging are dominant over mechanical contributions

Silicon (Si) anodes are a promising candidate for increasing the energy density of lithium (Li)-ion batteries for electric vehicles. However, they have recently been identified as having poor calendar life that is insufficient for commercial needs, in addition to the well-known issue of their poor cycle life resulting from large volume expansion. Here, a specially designed protocol with variable rest periods between intermittent cycling is used to evaluate the impact of the mechanical disruption of Si and solid electrolyte interphase (SEI) from cycling on calendar aging measurements. Si was found to undergo more mechanical degradation during calendar aging with intermittent cycling than graphite. However, Si anode capacity fade was still dominated by time, especially for rest periods greater than or equal to 1 month between cycling. Postmortem dQ/dV half-cell analysis indicated this was mainly due to Li inventory loss and an increase in electrode resistance. Isothermal microcalorimetry further demonstrated that Si passivation is more disrupted than graphite passivation with intermittent cycling and suggested that there may be a chemical buildup of a detrimental species in the electrolyte, leading to a large spike in heat after the Si and SEI are disrupted by cycling.

25 ENERGY STORAGE↗

Transmural Remodeling of Cardiac Microstructure in Aged Spontaneously Hypertensive Rats by Diffusion Tensor MRI

The long-standing high blood pressure (also known as hypertension) overworks the heart. Microstructural remodeling is a key factor of hypertensive heart disease progression. Diffusion tensor magnetic resonance imaging (DT-MRI) is a powerful tool for the rapid noninvasive nondestructive delineation of the cardiomyocyte organization. The spontaneously hypertensive rat (SHR) is a well-established model of genetic hypertension. The goal of this study was to employ high-resolution DT-MRI and the SHR animal model to assess the transmural layer-specific remodeling of myocardial microstructure associated with hypertension. Ex vivo experiments were performed on excised formalin-fixed hearts of aged SHRs (n = 4) and age-matched controls (n = 4). The DT-MRI-derived fractional anisotropy (FA), longitudinal diffusivity (λ L ), transversal diffusivity (λ T ), and mean diffusivity (MD) served as the readout parameters investigated at three transmural zones (i.e., endocardium, mesocardium, and epicardium). The helix angles (HAs) of the aggregated cardiomyocytes and the orientation of laminar sheetlets were also studied. Compared with controls, the SHRs exhibited decreased epicardial FA, while FA changes in the other two transmural regions were insignificant. No substantial differences were observed in the diffusivity parameters and the transmural course of HAs between the two groups. A consistent distribution pattern of laminar sheetlet orientation was not identified for either group. Our findings are in line with the known cellular microstructure from early painstaking histological studies. Biophysical explanations of the study outcomes are provided. In conclusion, our experimental findings indicate that the epicardial microstructure is more vulnerable to high blood pressure leading to more pronounced changes in this region during remodeling. DT-MRI is well-suited for elucidating these alterations. The revealed transmural nonuniformity of myocardial reorganization may shed light on the mechanisms of the microstructure-function relationship in hypertension progression. Our results provide insights into the management of patients with systemic arterial hypertension, thus prevent the progression toward heart failure. The findings of this study should be acknowledged by electromechanical models of the heart that simulate the specific cardiac pathology.

60 APPLIED LIFE SCIENCES↗

Effect of Part Size, Displacement Rate, and Aging on Compressive Properties of Elastomeric Parts of Different Unit Cell Topologies Formed by Vat Photopolymerization Additive Manufacturing

Due to its ability to achieve geometric complexity at high resolution and low length scales, additive manufacturing (AM) has increasingly been used for fabricating cellular structures (e.g., foams and lattices) for a variety of applications. Specifically, elastomeric cellular structures offer tunability of compliance as well as energy absorption and dissipation characteristics. However, there are limited data available on compression properties for printed elastomeric cellular structures of different designs and testing parameters. In this work, the authors evaluate how unit cell topology, part size, the rate of compression, and aging affect the compressive response of polyurethane-based simple cubic, body-centered, and gyroid structures formed by vat photopolymerization AM. Finite element simulations incorporating hyperelastic and viscoelastic models were used to describe the data, and the simulated results compared well with the experimental data. Of the designs tested, only the parts with the body-centered unit cell exhibited differences in stress–strain responses at different part sizes. Of the compression rates tested, the highest displacement rate (1000 mm/min) often caused stiffer compressive behavior, indicating deviation from the quasi-static assumption and approaching the intermediate rate response. The cellular structures did not change in compression properties across five weeks of aging time, which is desirable for cushioning applications. This work advances knowledge on the structure–property relationships of printed elastomeric cellular materials, which will enable more predictable compressive properties that can be traced to specific unit cell designs.

36 MATERIALS SCIENCE↗

A Deep Study of an Intermediate-age Open Cluster SAI 35 (Juchert 20) Using Ground-based Imaging and Gaia EDR3 Astrometry

We present a CCD UBVI photometric study of poorly studied intermediate-age open cluster SAI 35 (Juchert 20) for the first time. To accomplish this study, we also used LAMOST DR5, Two Micron All Sky Survey, and Gaia EDR3 databases. We identified 214 most probable cluster members with membership probability higher than 50%. The mean proper motion of the cluster is found as μ{sub α}cos δ=1.10±0.01 and μ {sub δ} = −1.66 ± 0.01 mas yr{sup −1}. We find the normal interstellar extinction law using the various two-color diagrams. The age, distance, reddening, and radial velocity of the cluster are estimated to be 360 ± 40 Myr, 2.9 ± 0.15 kpc, 0.72 ± 0.05 mag, and −91.62 ± 6.39 km s{sup −1}, respectively. The overall mass function slope for main-sequence stars is found to be 1.49 ± 0.16 within the mass range 1.1–3.1 M {sub ⊙}, which is in agreement with Salpeter’s value within uncertainty. The present study demonstrates that SAI 35 is dynamically relaxed. Galactic orbital parameters are determined using Galactic potential models. We found that this object follows a circular path around the Galactic center.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

MicroRNAs as diagnostic and prognostic biomarkers of age-related macular degeneration: advances and limitations

A main cause of vision loss in the elderly is age-related macular degeneration (AMD). Among the cellular, biochemical, and molecular changes linked to this disease, inflammation and angiogenesis appear as being crucial in AMD pathogenesis and progression. There are two forms of the disease: dry AMD, accounting for 80–90% of cases, and wet AMD. The disease usually begins as dry AMD associated with retinal pigment epithelium and photoreceptor degeneration, whereas wet AMD is associated with choroidal neovascularization resulting in severe vision impairment. The new vessels are largely malformed, leading to blood and fluid leakage within the disrupted tissue, which provokes inflammation and scar formation and results in retinal damage and detachment. MicroRNAs are dysregulated in AMD and may facilitate the early detection of the disease and monitoring disease progression. Two recent reviews of microRNAs in AMD had indicated weaknesses or limitations in four earlier investigations. Studies in the last three years have shown considerable progress in overcoming some of these concerns and identifying specific microRNAs as biomarkers for AMD. Further large-scale studies are warranted using appropriate statistical methods to take into account gender and age disparity in the study populations and confounding factors such as smoking status.

60 APPLIED LIFE SCIENCES↗

Aneuploidy induces premature aging in yeast due to defects in Ribosome Quality Control [RNASeqData]

Premature aging is a hallmark of Down syndrome, caused by trisomy of human chromosome 21; but the reason is unclear and difficult to study in humans. We used an aneuploid model in wild yeast to show that chromosome amplification disrupts nutrient-induced cell-cycle arrest, quiescence entry, and healthy aging, across genetic backgrounds and amplified chromosomes. We discovered that these defects are due in part to aneuploidy-induced dysfunction in Ribosome Quality Control (RQC). Aneuploids entering quiescence display aberrant ribosome profiles, accumulate RQC intermediates, and harbor an increased load of protein aggregates. Although they have normal proteasome capacity, aneuploids show signs of ubiquitin dysregulation, which impacts cyclin abundance to disrupt arrest. Remarkably, inducing ribosome stalling in euploids produces similar aberrations, while up-regulating limiting RQC subunits or proteins in ubiquitin metabolism alleviates many of the aneuploid defects. Our results raise major implications for other aneuploidy disorders including Down syndrome.

aneuploidy↗

Aneuploidy induces premature aging in yeast due to defects in Ribosome Quality Control [MoBYSeqData]

Premature aging is a hallmark of Down syndrome, caused by trisomy of human chromosome 21; but the reason is unclear and difficult to study in humans. We used an aneuploid model in wild yeast to show that chromosome amplification disrupts nutrient-induced cell-cycle arrest, quiescence entry, and healthy aging, across genetic backgrounds and amplified chromosomes. We discovered that these defects are due in part to aneuploidy-induced dysfunction in Ribosome Quality Control (RQC). Aneuploids entering quiescence display aberrant ribosome profiles, accumulate RQC intermediates, and harbor an increased load of protein aggregates. Although they have normal proteasome capacity, aneuploids show signs of ubiquitin dysregulation, which impacts cyclin abundance to disrupt arrest. Remarkably, inducing ribosome stalling in euploids produces similar aberrations, while up-regulating limiting RQC subunits or proteins in ubiquitin metabolism alleviates many of the aneuploid defects. Our results raise major implications for other aneuploidy disorders including Down syndrome.

aneuploidy↗

Premature aging in aneuploid yeast is influenced by aneuploidy-induced defects in Ribosome Quality Control [RiboSeq]

Premature aging is a hallmark of Down syndrome, caused by trisomy of human chromosome 21; but the reason is unclear and difficult to study in humans. We used an aneuploid model in wild yeast to show that chromosome amplification disrupts nutrient-induced cell-cycle arrest, quiescence entry, and healthy aging, across genetic backgrounds and amplified chromosomes. We discovered that these defects are due in part to aneuploidy-induced dysfunction in Ribosome Quality Control (RQC). Aneuploids entering quiescence display aberrant ribosome profiles, accumulate RQC intermediates, and harbor an increased load of protein aggregates. Although they have normal proteasome capacity, aneuploids show signs of ubiquitin dysregulation, which impacts cyclin abundance to disrupt arrest. Remarkably, inducing ribosome stalling in euploids produces similar aberrations, while up-regulating limiting RQC subunits or proteins in ubiquitin metabolism alleviates many of the aneuploid defects. Our results raise major implications for other aneuploidy disorders including Down syndrome.

aneuploidy↗

Status of INL Aged A709 Mechanical Testing

A709 was selected to be qualified in Section III, Division 5 of the American Society of Mechanical Engineers Boiler and Pressure Vessel Code. Idaho National Laboratory (INL), Argonne National Laboratory and Oak Ridge National Laboratory are collaborating to develop and qualify A709 plate. Aging A709 to form beneficial precipitates prior to service is investigated. One tensile test, five creep-rupture tests, and eight cyclic tests have been completed on aged A709. Two creep-rupture tests are in progress.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

A Lunar Farside Low Radio Frequency Array for Dark Ages 21-cm Cosmology

An array of low-frequency dipole antennas on the lunar farside surface will probe a unique, unexplored epoch in the early Universe called the Dark Ages. It begins at Recombination when neutral hydrogen atoms formed, first revealed by the cosmic microwave background. This epoch is free of stars and astrophysics, so it is ideal to investigate high energy particle processes including dark matter, early Dark Energy, neutrinos, and cosmic strings. A NASA-funded study investigated the design of the instrument and the deployment strategy from a lander of 128 pairs of antenna dipoles across a 10 kmx10 km area on the lunar surface. The antenna nodes are tethered to the lander for central data processing, power, and data transmission to a relay satellite. The array, named FARSIDE, would provide the capability to image the entire sky in 1400 channels spanning frequencies from 100 kHz to 40 MHz, extending down two orders of magnitude below bands accessible to ground-based radio astronomy. The lunar farside can simultaneously provide isolation from terrestrial radio frequency interference, the Earth's auroral kilometric radiation, and plasma noise from the solar wind. It is thus the only location within the inner solar system from which sky noise limited observations can be carried out at sub-MHz frequencies. Through precision calibration via an orbiting beacon and exquisite foreground characterization, the farside array would measure the Dark Ages global 21-cm signal at redshifts z~35-200. It will also be a pathfinder for a larger 21-cm power spectrum instrument by carefully measuring the foreground with high dynamic range.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

On Soft Mathematical Models of Subjective Time Acceleration with Age

It is a commonplace perception that speed of time subjectively experienced by humans significantly differs from chronological (objective) time and shows a great deal of variability. An often cited example is the phenomenon of the time acceleration with age - subjectively, the time passes faster as we get older. While the exact mechanisms behind it are not yet fully established, here we consider three 'soft' (conceptual) mathematical models that might be applicable to the speeding time phenomenon: two proportionality theories widely discussed in the past and the original model that takes into account the novelty of experience effect. Furthermore, the latter is found the most plausible, as not only it satisfactorily describes the decadal subjective time acceleration, but also offers a reasonable explanation of the human life experience accumulation with age.

acceleration↗

Analysis of Material Properties of Aged Rigid Polyurethane Foam

Foams are classified as either rigid or flexible and are commonly used in applications such as pipe insulation, carpet fibers, and chair foam cushions. Polyurethane foams are excellent thermal insulators, have excellent mechanical properties, and are chemically inert. With the addition of fire protective additives, polyurethane foams have the ability to intumescence when exposed to high temperatures. For the future storage of the 9977 nuclear shipping packages, the material properties of the General Plastics 3716 rigid polyurethane foam were evaluated for long term performance by comparing aged samples to unaged samples. General Plastics 3716 rigid polyurethane foam was aged from November 2014 to June 2019 at varying temperatures of: 160 deg. F, 160 deg. F + 50% relative humidity (RH), 185 deg. F, 215 deg. F, and 250 deg. F. The foam was then analyzed via Fourier Transform Infrared Spectroscopy (FTIR), 3D Optical Microscope, Thermal Gravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC). FTIR and Optical Microscope: No significant change to chemical or physical structure was evident by FTIR or optical microscope analysis. DSC: Decrease of heat capacity over time for all oven temperatures except a slight increase for the 185 deg. F conditioned foams. Largest decrease evident with foams conditioned at 250 deg. F. A slight increase in heat capacity for humid samples. Similar trends in heat capacities at 71 deg. C and 102 deg. C. TGA: As conditioning temperature increased, a decline was evident in the average percent weight loss, onset temperature, and first derivative peak temperature. No significant effect due to humidity except for a decrease in first derivative peak temperature. Unaged samples exhibited strong intumescence. Foams conditioned at 160 deg. F exhibited slight intumescence. Results suggest fire protective additives decomposed at higher temperatures, which contributed to a lower average percent mass loss in higher temperature conditioning. Further thermal degradation testing would be beneficial to evaluate the ability of the conditioned foams to intumesce. Evaluate irradiation dose rate effects on conditioned foam. Possible conditioning in an environment with a known humidity or analyzing a new aliquot of sample for each trial to achieve a more representative heat capacity calculation.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Ageing Studies of Mega Battery Packs for Grid Storage Applications Using Physics Based Modeling

The lower Levelized Cost of Electricity (LCOE) from wind and solar photovoltaics has enabled for greater integration of variable energy resources with energy storage tech-nologies such as larger centralized lithium-ion battery megapacks (with 1MWh total energy and 500V rating) to provide utility-scale services to grid operators. The daily cycling of standalone lithium-ion grid storage will reduce the battery cells' capacity due to several degradation mechanisms. A comprehensive physics-based Python tm framework called Liionpack was developed to estimate these megapacks' remaining life and ageing. The study includes various degradation mechanisms coupled to the electrochemical-thermal model at the pack level. The effect of the inhomogeneities from cell-to-cell thermodynamic and kinetic properties for different working conditions including temperature and charge/discharge protocols on the ageing of a megapack are presented here.

Karra, Vikrant↗

Leveraging Hydropower Multi-Sensor Data for Inference and Age-Informed Modeling

Increased demand of operational flexibility such as faster ramp up/down in generation, and more frequent start/stops are putting hydropower plants and their associated components in unprecedented stress. Consequently, these plants are at the high risk of extended and more frequent outage to accommodate unscheduled, and unexpected maintenance. Therefore, hydropower plants are in critical need of data driven and age-informed analysis for their regular and unscheduled operation. Yet not all hydropower plants are exhaustively equipped with sensors and/or measurement streams for their respective components – demanding solutions on how to detect, identify, and locate the cause of any event from the unobservable. Idaho National Laboratory (INL) analyzed the anonymized measurements and event records from the Hydropower Research Institute (HRI) to address this issue, as part of the Water Power Technologies Office (WPTO) funded one year multi-lab project. First, we investigated how time series of multiple sensor measurements can be leveraged to identify an event “root cause” as well as to develop an inference (i.e., estimate the unobservable) problem. INL also investigated how individual hydropower components’ reaction or response times vary across the pre-event, during event, and post-event conditions – enabling the hydropower dynamic models to be age-informed. Finally, the impact of clustering multi-sensor time series on short-term vibration prediction is analyzed. INL will present key findings from these analyses and recommend next steps for stakeholder adoption.

13 HYDRO ENERGY↗