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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 451 records · Page 25
All sourcesNASA NTRSDOE OSTI
DOE OSTI2021

In silico trials predict that combination strategies for enhancing vesicular stomatitis oncolytic virus are determined by tumor aggressivity

Background Immunotherapies, driven by immune-mediated antitumorigenicity, offer the potential for significant improvements to the treatment of multiple cancer types. Identifying therapeutic strategies that bolster antitumor immunity while limiting immune suppression is critical to selecting treatment combinations and schedules that offer durable therapeutic benefits. Combination oncolytic virus (OV) therapy, wherein complementary OVs are administered in succession, offer such promise, yet their translation from preclinical studies to clinical implementation is a major challenge. Overcoming this obstacle requires answering fundamental questions about how to effectively design and tailor schedules to provide the most benefit to patients. Methods We developed a computational biology model of combined oncolytic vaccinia (an enhancer virus) and vesicular stomatitis virus (VSV) calibrated to and validated against multiple data sources. We then optimized protocols in a cohort of heterogeneous virtual individuals by leveraging this model and our previously established in silico clinical trial platform. Results Enhancer multiplicity was shown to have little to no impact on the average response to therapy. However, the duration of the VSV injection lag was found to be determinant for survival outcomes. Importantly, through treatment individualization, we found that optimal combination schedules are closely linked to tumor aggressivity. We predicted that patients with aggressively growing tumors required a single enhancer followed by a VSV injection 1 day later, whereas a small subset of patients with the slowest growing tumors needed multiple enhancers followed by a longer VSV delay of 15 days, suggesting that intrinsic tumor growth rates could inform the segregation of patients into clinical trials and ultimately determine patient survival. These results were validated in entirely new cohorts of virtual individuals with aggressive or non-aggressive subtypes. Conclusions Based on our results, improved therapeutic schedules for combinations with enhancer OVs can be studied and implemented. Our results further underline the impact of interdisciplinary approaches to preclinical planning and the importance of computational approaches to drug discovery and development.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1987

Focus of attention in systems for visual monitoring of experiments

The problem of designing a computerized experiment monitoring system for use in a space station or elsewhere is examined. It is shown that the essential challenge of such a system - attaining a reasonable expected running time - can be attacked using the concept of focus of attention and by exploiting parallelism. The use of the Contract Net Protocol for the latter purpose is discussed. The use of ideas from information science to help focus a programs's efforts on those computations likely to bring results is addressed, and the incorporation of those ideas into a design in order to aid the system in deciding upon the best course of action is considered.

Blank, G. E.↗
NASA NTRS1992

Spreadsheet Analysis Of Queuing In A Computer Network

Method of analyzing responses of computer network based on simple queuing-theory mathmatical models via spreadsheet program. Effects of variations in traffic, capacities of channels, and message protocols assessed.

Galant, David C.↗
NASA NTRS2014

Monitoring for Renal Stone Recurrence in Astronauts With History of Stone

After an initial stone episode persons are at increased risk for future stone formation. A systematic approach is required to monitor the efficacy of treatment and preventive measures, and to assess the risk of developing new stones. This is important for persons working in critical jobs or austere environments, such as astronauts. A literature review of the current standards of care for renal stone monitoring and imaging was done. Military and civil aviation standards were also reviewed, as well as the medical precedents from the space program. Additionally, a new, more effective, renal stone ultrasound protocol has been developed. Using this work, a monitoring algorithm was proposed that takes into consideration the unique mission and operational environment of spaceflight. The approach to imaging persons with history of renal stones varies widely in the literature. Imaging is often done yearly or biannually, which may be too long for mission critical personnel. In the proposed algorithm astronauts with a history of renal stone, who may be under consideration for assignment, are imaged by a detailed, physiciandriven, ultrasound protocol. Unassigned personnel are monitored by yearly ultrasound and urine studies. Any positive ultrasound study is then followed by low-dose renal computed tomography scan. Other criteria are also established. The proposed algorithm provides a balanced approach between efficacy and reduced radiation exposure for the monitoring of astronauts with a renal stone history. This may eventually allow a transition from a risk-averse, to a risk-modifying approach that can enable continued service of individuals with history of renal stone that have adequately controlled risk factors.

Reyes, David P.↗
DOE OSTI2020

Robust Method to Identify Groundwater Affected By Redox Conditions at Los Alamos National Laboratory Legacy Cleanup Site - 20497

To facilitate the mission of the Department of Energy's (DoE's) Environmental Management Program at Los Alamos National Laboratory (LANL), a significant number of groundwater monitoring wells with depths ranging from 152-396 meter were completed for characterization and monitoring. Groundwater at Los Alamos tends to be oxygen saturated with very low concentrations of organic matter. Drilling fluids can introduce residual carbon causing an increase in microbial activity and local reducing conditions around the well, potentially impacting representativeness of groundwater data quality for redox sensitive constituents. We assert that the redox state of the wells can robustly be identified by aqueous solution concentrations of iron and manganese. An automated review process has been built into a computer-based data management system enabling an efficient screening process for identifying reducing conditions that are not caught using standard data-validation protocol, and ensures that important data quality issues are thoroughly identified and addressed in an efficient and timely manner. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2026

Exact and Fixed-Point Grover Search with Qudits

Grover's algorithm provides a quadratic speedup for searching unstructured databases and is traditionally implemented with qubits in Hilbert spaces whose dimensions are powers of two. With the advent of quantum platforms utilizing qudits---quantum systems with more than two levels---there is a need to generalize Grover search to these architectures, including heterogeneous systems with qudits of varying dimensions. Here, we present a unified framework for qudit-based Grover search, detailing the construction of oracles and diffusion operators with and without ancilla qubits and generalizing deterministic and fixed-point search variants that ensure exact or bounded success probabilities. We analyze phase-matching techniques and provide explicit circuit decompositions suitable for diverse hardware platforms. We also compare the corresponding trajectories on the Bloch sphere to provide an intuitive visualization of how the different phase choices amplify the target state. These results facilitate flexible, hardware-oriented protocols for implementing Grover search on qudit processors, potentially reducing circuit depth and enhancing success probabilities, thereby offering a practical toolkit for quantum computation and sensing applications leveraging multilevel quantum systems.

Roy, Tanay [Fermilab] (ORCID:000000019442862X)↗
DOE OSTI2022

Cyber–physical vulnerability and resiliency analysis for DER integration: A review, challenges and research needs

High penetration of renewable and sustainable Distributed Energy Resources (DER) into the traditional distribution system requires a well-coordinated control strategy for the improvement of system-wide reliability and resiliency. Implementation of such a holistic control architecture requires a flexible, near real-time, and bi-directional communication framework for facilitating the participation of various agents in a multi-vendor heterogeneous smart grid. While the sustainability of energy generation is ensured, this exposes the smart grid to extrinsic cyber threats, and appropriate defense mechanism(s) must be deployed to guarantee continued reliability and resiliency of the power grid. Further, the comprehensive literature review presented in this paper discusses the latest trends in the DER control schemes with fast communication requirements and their accompanying cyber–physical vulnerabilities. These control schemes are compared and contrasted for various traits. A three-level DER system architecture has been depicted, facilitating the deployment of these control schemes. The current developments of standard communication protocols, key security mechanisms, and best practices along major standards and guidelines are explored. The impacts of different attack types with miscellaneous DER functions based on various control schemes and associated mitigation solutions are also provided. Finally, challenges and future research directions for limiting cyber-power susceptibility to enhance resiliency are summarized. The work presented here will help us enabling a cyber-resilient and sustainable smart electric grid.

24 POWER TRANSMISSION AND DISTRIBUTION↗
DOE OSTI2022

January 2022 Operational Highlights

The Indexing Lab is now complete and includes classified and unclassified computers, safes and work stations. Staff capture metadata and catalog materials, including classified reports, directors’ correspondence and Rocky Flats materials to ensure the holdings are discoverable and retrievable. Access protocols were updated for products related to the LANL Annual Assessment in the Online Vault (OLV) classified repository. The Annual Assessment is a yearly analysis of the weapons systems in the nation’s nuclear stockpile. The Standardization Quality Assessment (SQA) for the Online Vault (OLV) classified repository was completed and contained no findings. Beta testing, or customer validation, began for the metrics database that generates metrics reports and visualizations from NSRC customer projects.

97 MATHEMATICS AND COMPUTING↗
NASA NTRS1986

Operation of the HP2250 with the HP9000 series 200 using PASCAL 3.0

A computer program has been written to provide an interface between the HP Series 200 desktop computers, operating under HP Standard Pascal 3.0, and the HP2250 Data Acquisition and Control System. Pascal 3.0 for the HP9000 desktop computer gives a number of procedures for handling bus communication at various levels. It is necessary, however, to reach the lowest possible level in Pascal to handle the bus protocols required by the HP2250. This makes programming extremely complex since these protocols are not documented. The program described solves those problems and allows the user to immediately program, simply and efficiently, any measurement and control language (MCL/50) application with a few procedure calls. The complete set of procedures is available on a 5 1/4 inch diskette from Cosmic. Included in this group of procedures is an Exerciser which allows the user to exercise his HP2250 interactively. The exerciser operates in a fashion similar to the Series 200 operating system programs, but is adapted to the requirements of the HP2250. The programs on the diskette and the user's manual assume the user is acquainted with both the MCL/50 programming language and HP Standard Pascal 3.0 for the HP series 200 desktop computers.

Perry, John↗
NASA NTRS1982

An application of distributed processing - In the TDRSS ground communication fault isolation and monitoring system

A computer interface has been designed for the Fault Isolation and Monitoring System, a system providing qualitative and quantitative assessment of the communications between the Tracking and Data Relay Satellite System Ground Segment and NASA's Network Control Center. The functional requirements for the interface and the design philosophy are discussed, as are the methods and protocol used to implement the operator support software required to configure the monitoring system and to display and report the results of the analysis. The system relies on the use of intelligent terminals, with the human interface removed from the host computer.

Waddell, R. L., Jr.↗
DOE OSTI2021

Quantum Machine-Learning for Eigenstate Filtration in Two-Dimensional Materials

Quantum machine-learning algorithms have emerged to be a promising alternative to their classical counterparts as they leverage the power of quantum computers. Such algorithms have been developed to solve problems like electronic structure calculations of molecular systems and spin models in magnetic systems. However, the discussion in all these recipes focuses specifically on targeting the ground state. Herein we demonstrate a quantum algorithm that can filter any energy eigenstate of the system based on either symmetry properties or a predefined choice of the user. The workhorse of our technique is a shallow neural network encoding the desired state of the system with the amplitude computed by sampling the Gibbs–Boltzmann distribution using a quantum circuit and the phase information obtained classically from the nonlinear activation of a separate set of neurons. We show that the resource requirements of our algorithm are strictly quadratic. To demonstrate its efficacy, we use state filtration in monolayer transition metal dichalcogenides which are hitherto unexplored in any flavor of quantum simulations. We implement our algorithm not only on quantum simulators but also on actual IBM-Q quantum devices and show good agreement with the results procured from conventional electronic structure calculations. We thus expect our protocol to provide a new alternative in exploring the band structures of exquisite materials to usual electronic structure methods or machine-learning techniques that are implementable solely on a classical computer.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS1977

An experiment protocol for a search for radio signals of extraterrestrial intelligent origin in the presence of man-made radio frequency sources

Some aspects of signal extraction in a microwave search for evidence of extraterrestrial intelligence are examined. Parametric relations are summarized which are applicable to a microwave search of constrained duration that employs FFT spectrum-analyzer receivers, with sensitivity enhancement by spectrum accumulation and detection by a threshold criterion. Three types of natural and man-made false alarms are identified, the probability of false alarm in a single data channel is computed, and the implications of false alarms for a constant-beamwidth sky survey are considered. It is shown that the key to an efficient search is the prompt and unambiguous elimination of false alarms. An experimental protocol is suggested which eliminates spurious signals primarily through procedural techniques involving antenna repointing, delayed repeated observations, and storage of particular historical parameters for suspect signals.

Edelson, R. E.↗
NASA NTRS1996

Simulations of light effects on the human circadian pacemaker: implications for assessment of intrinsic period

The sensitivity of the human circadian system to light has been the subject of considerable debate. Using computer simulations of a recent quantitative model for the effects of light on the human circadian system, we investigated these effects of light during different experimental protocols. The results of the simulations indicate that the nonuniform distribution over the circadian cycle of exposure to ordinary room light seen in classical free-run studies, in which subjects select their exposure to light and darkness, can result in an observed period of approximately 25 h, even when the intrinsic period of the subject's endogenous circadian pacemaker is much closer to 24 h. Other simulation results suggest that accurate assessment of the true intrinsic period of the human circadian pacemaker requires low ambient light intensities (approximately 10-15 lx) during scheduled wake episodes, desynchrony of the imposed light-dark cycle from the endogenous circadian oscillator, and a study length of at least 20 days. Although these simulations await further experimental substantiation, they highlight the sensitivity to light of the human circadian system and the potential confounding influence of light on the assessment of the intrinsic period of the circadian pacemaker.

Non-NASA Center↗
NASA NTRS2004

Portable Electromyograph

A portable electronic apparatus records electromyographic (EMG) signals in as many as 16 channels at a sampling rate of 1,024 Hz in each channel. The apparatus (see figure) includes 16 differential EMG electrodes (each electrode corresponding to one channel) with cables and attachment hardware, reference electrodes, an input/output-and-power-adapter unit, a 16-bit analog-to-digital converter, and a hand-held computer that contains a removable 256-MB flash memory card. When all 16 EMG electrodes are in use, full-bandwidth data can be recorded in each channel for as long as 8 hours. The apparatus is powered by a battery and is small enough that it can be carried in a waist pouch. The computer is equipped with a small screen that can be used to display the incoming signals on each channel. Amplitude and time adjustments of this display can be made easily by use of touch buttons on the screen. The user can also set up a data-acquisition schedule to conform to experimental protocols or to manage battery energy and memory efficiently. Once the EMG data have been recorded, the flash memory card is removed from the EMG apparatus and placed in a flash-memory- card-reading external drive unit connected to a personal computer (PC). The PC can then read the data recorded in the 16 channels. Preferably, before further analysis, the data should be stored in the hard drive of the PC. The data files are opened and viewed on the PC by use of special- purpose software. The software for operation of the apparatus resides in a random-access memory (RAM), with backup power supplied by a small internal lithium cell. A backup copy of this software resides on the flash memory card. In the event of loss of both main and backup battery power and consequent loss of this software, the backup copy can be used to restore the RAM copy after power has been restored. Accessories for this device are also available. These include goniometers, accelerometers, foot switches, and force gauges.

De Luca, Gianluca↗
DOE OSTI2024

Synergizing human expertise and AI efficiency with language model for microscopy operation and automated experiment design

With the advent of large language models (LLMs), in both the open source and proprietary domains, attention is turning to how to exploit such artificial intelligence (AI) systems in assisting complex scientific tasks, such as material synthesis, characterization, analysis and discovery. Here, we explore the utility of LLMs, particularly ChatGPT4, in combination with application program interfaces (APIs) in tasks of experimental design, programming workflows, and data analysis in scanning probe microscopy, using both in-house developed APIs and APIs given by a commercial vendor for instrument control. We find that the LLM can be especially useful in converting ideations of experimental workflows to executable code on microscope APIs. Beyond code generation, we find that the GPT4 is capable of analyzing microscopy images in a generic sense. At the same time, we find that GPT4 suffers from an inability to extend beyond basic analyses for more in-depth technical experimental design. We argue that an LLM specifically fine-tuned for individual scientific domains can potentially be a better language interface for converting scientific ideations from human experts to executable workflows. Such a synergy between human expertise and LLM efficiency in experimentation can open new doors for accelerating scientific research, enabling effective experimental protocols sharing in the scientific community.

97 MATHEMATICS AND COMPUTING↗
NASA NTRS1987

Reliable communication in the presence of failures

The design and correctness of a communication facility for a distributed computer system are reported on. The facility provides support for fault-tolerant process groups in the form of a family of reliable multicast protocols that can be used in both local- and wide-area networks. These protocols attain high levels of concurrency, while respecting application-specific delivery ordering constraints, and have varying cost and performance that depend on the degree of ordering desired. In particular, a protocol that enforces causal delivery orderings is introduced and shown to be a valuable alternative to conventional asynchronous communication protocols. The facility also ensures that the processes belonging to a fault-tolerant process group will observe consistant orderings of events affecting the group as a whole, including process failures, recoveries, migration, and dynamic changes to group properties like member rankings. A review of several uses for the protocols is the ISIS system, which supports fault-tolerant resilient objects and bulletin boards, illustrates the significant simplification of higher level algorithms made possible by our approach.

Birman, Kenneth P.↗
NASA NTRS1992

The role of HiPPI switches in mass storage systems: A five year prospective

New standards are evolving which provide the foundation for novel multi-gigabit per second data communication structures. The lowest layer protocols are so generalized that they encourage a wide range of application. Specifically, the ANSI High Performance Parallel Interface (HiPPI) is being applied to computer peripheral attachment as well as general data communication networks. This paper introduces the HiPPI standards suite and technology products which incorporate the standards. The use of simple HiPPI crosspoint switches to build potentially complex extended 'fabrics' is discussed in detail. Several near term applications of the HiPPI technology are briefly described with additional attention to storage systems. Finally, some related standards are mentioned which may further expand the concepts above.

Gilbert, T. A.↗
NASA NTRS1991

The role of HiPPI switches in mass storage systems: A five year prospective

New standards are evolving which provide the foundation for multi-gigabit per second data communication structures. The lowest layer protocols are so generalized that they encourage a wide range of application. Specifically, the ANSI High Performance Parallel Interface (HiPPI) is being applied to computer peripheral attachment as well as general data communication networks. The HiPPI Standards suite and technology products which incorporate the standards are introduced. The use of simple HiPPI crosspoint switches to build potentially complex extended 'fabrics' is discussed in detail. Several near term applications of the HiPPI technology are briefly described with additional attention to storage systems. Finally, some related standards are mentioned which may further expand the concepts above.

Gilbert, T. A.↗