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At least 451 records · Page 25

COVID-19 Biomarkers and Advanced Sensing Technologies for Point-of-Care (POC) Diagnosis

COVID-19, also known as SARS-CoV-2 is a novel, respiratory virus currently plaguing humanity. Genetically, at its core, it is a single-strand positive-sense RNA virus. It is a beta-type Coronavirus and is distinct in its structure and binding mechanism compared to other types of coronaviruses. Testing for the virus remains a challenge due to the small market available for at-home detection. Currently, there are three main types of tests for biomarker detection: viral, antigen and antibody. Reverse Transcription-Polymerase Chain Reaction (RT-PCR) remains the gold standard for viral testing. However, the lack of quantitative detection and turnaround time for results are drawbacks. This manuscript focuses on recent advances in COVID-19 detection that have lower limits of detection and faster response times than RT-PCR testing. The advancements in sensing platforms have amplified the detection levels and provided real-time results for SARS-CoV-2 spike protein detection with limits as low as 1 fg/mL in the Graphene Field Effect Transistor (FET) sensor. Additionally, using multiple biomarkers, detection levels can achieve a specificity and sensitivity level comparable to that of PCR testing. Proper biomarker selection coupled with nano sensing detection platforms are key in the widespread use of Point of Care (POC) diagnosis in COVID-19 detection.

60 APPLIED LIFE SCIENCES↗

Propagating information content: an example with advection

The mathematical algorithm to derive geophysical information from remote sensing observations is called a retrieval. The mathematics of many retrieval problems are ill-posed, and thus a priori information is used to help constrain the derived geophysical variable to realistic values. One quantity of interest, therefore, is the information content of the observation. Perfect information content in the observation would be achieved if the retrieval were able to capture any perturbation in the desired geophysical variable with the proper magnitude. Many new data products can be derived by combining geophysical variables retrieved from multiple different remote sensors. This paper explores, for the first time, how to derive the information content of these derived products. The approach uses traditional error propagation techniques to derive the uncertainty of the derived field twice, both when the observations are used in the retrieval and also when only the a priori information from each remote sensor is propagated. These two uncertainties are then used to provide an estimate of the information content of the derived geophysical variable. This study demonstrates how to propagate the uncertainties from six different instruments to provide the information content for water vapor and temperature advection. A multi-month analysis demonstrates that, in a mean sense, the information content for temperature advection is nearly unity for all heights below 700 m while, the information content for water vapor advection is somewhat more variable but still larger than 0.6 in the convective boundary layer.

Turner, David D. [National Oceanic and Atmospheric↗

TRICCS: A proposed teleoperator/robot integrated command and control system for space applications

Robotic systems will play an increasingly important role in space operations. An integrated command and control system based on the requirements of space-related applications and incorporating features necessary for the evolution of advanced goal-directed robotic systems is described. These features include: interaction with a world model or domain knowledge base, sensor feedback, multiple-arm capability and concurrent operations. The system makes maximum use of manual interaction at all levels for debug, monitoring, and operational reliability. It is shown that the robotic command and control system may most advantageously be implemented as packages and tasks in Ada.

Will, R. W.↗

Six-Axis Superconducting Accelerometer

Sensitivity and short-term stability high. Design combines superconductivity and magnetic levitation to achieve linear-acceleration sensitivity greater than conventional linear accelerometers, and short-term angular stability better than conventional gyroscopes. Improved accelerometer used to increase precision in inertial navigation and surveying, as sensitive multiple-axis seismic sensor, as component of tensor gravity gradiometer, or to sense accelerations of stabilized platforms or spacecraft.

Paik, Ho Jung↗

Advanced solidstate array spectroradiometer - Sensor and calibration improvements

The advanced solid-state array spectroradiometer (ASAS), an airborne imaging spectrometer with 30 spectral channels extending from 450-880 nm, is described. Modifications to the sensor mounting technique changed the ASAS from a fixed nadir viewing instrument to a sensor capable of multiple direction observations of surface bidirectional reflectance distribution functions. The system was flown on the NASA Ames C130 aircraft to obtain surface bidirectional reflectance measurements of vegetation; it demonstrated excellent reliability and radiometric stability.

Huegel, Frederick G.↗

A model for a space shuttle safing and failure-detection expert

The safing and failure-detection expert (SAFE) is a prototype for a malfunction detection, diagnosis, and safing system for the atmospheric revitalization subsystem (ARS) in the Space Shuttle orbiter. SAFE, whose knowledge was extracted from expert-provided heuristics and documented procedures, automatically manages all phases of failure handling: detection, diagnosis, testing procedures, and recovery instructions. The SAFE architecture allows it to handle correctly sensor failures and multiple malfunctions. Since SAFE is highly interactive, it was used as a test bed for the evaluation of various advanced human-computer interface (HCI) techniques. The use of such expert systems in the next generation of space vehicles would increase their reliability and autonomy to levels not achievable before.

Zeilingold, Daphna↗

Failure detection and fault management techniques for flush airdata sensing systems

A high-angle-of-attack flush airdata sensing system was installed and flight tested on the F-18 High Alpha Research Vehicle at NASA-Dryden. This system uses a matrix of pressure orifices arranged in concentric circles on the nose of the vehicle to determine angles of attack, angles of sideslip, dynamic pressure, and static pressure as well as other airdata parameters. Results presented use an arrangement of 11 symmetrically distributed ports on the aircraft nose. Experience with this sensing system data indicates that the primary concern for real-time implementation is the detection and management of overall system and individual pressure sensor failures. The multiple port sensing system is more tolerant to small disturbances in the measured pressure data than conventional probe-based intrusive airdata systems. However, under adverse circumstances, large undetected failures in individual pressure ports can result in algorithm divergence and catastrophic failure of the entire system. How system and individual port failures may be detected using chi sq. analysis is shown. Once identified, the effects of failures are eliminated using weighted least squares.

Whitmore, Stephen A.↗

The polarization lidar technique for cloud research - A review and current assessment

The development of the polarization lidar technique is reviewed, and the current capabilities and limitations of the technique for the cloud research are discussed. At present, polarization lidar is a key component of climate-research programs designed to characterize the properties of cirrus clouds and is an integral part of multiple remote-sensor studies of mixed-phase cloud systems such as winter mountain storms, making it possible to discriminate between cloud phases and to identify some particle types and orientations. Recent theoretical approaches involving ice crystal ray-tracing and cloud microphysical-model simulations are expected to increase the utility of the polarization lidar technique.

Sassen, Kenneth↗

The use of interactive computer vision and robot hand controllers for enhancing manufacturing safety

Current available robotic systems provide limited support for CAD-based model-driven visualization, sensing algorithm development and integration, and automated graphical planning systems. This paper describes ongoing work which provides the functionality necessary to apply advanced robotics to automated manufacturing and assembly operations. An interface has been built which incorporates 6-DOF tactile manipulation, displays for three dimensional graphical models, and automated tracking functions which depend on automated machine vision. A set of tools for single and multiple focal plane sensor image processing and understanding has been demonstrated which utilizes object recognition models. The resulting tool will enable sensing and planning from computationally simple graphical objects. A synergistic interplay between human and operator vision is created from programmable feedback received from the controller. This approach can be used as the basis for implementing enhanced safety in automated robotics manufacturing, assembly, repair and inspection tasks in both ground and space applications. Thus, an interactive capability has been developed to match the modeled environment to the real task environment for safe and predictable task execution.

Marzwell, Neville I.↗

Space Acceleration Measurement System-II: Microgravity Instrumentation for the International Space Station Research Community

The International Space Station opens for business in the year 2000, and with the opening, science investigations will take advantage of the unique conditions it provides as an on-orbit laboratory for research. With initiation of scientific studies comes a need to understand the environment present during research. The Space Acceleration Measurement System-II provides researchers a consistent means to understand the vibratory conditions present during experimentation on the International Space Station. The Space Acceleration Measurement System-II, or SAMS-II, detects vibrations present while the space station is operating. SAMS-II on-orbit hardware is comprised of two basic building block elements: a centralized control unit and multiple Remote Triaxial Sensors deployed to measure the acceleration environment at the point of scientific research, generally within a research rack. Ground Operations Equipment is deployed to complete the command, control and data telemetry elements of the SAMS-II implementation. Initially, operations consist of user requirements development, measurement sensor deployment and use, and data recovery on the ground. Future system enhancements will provide additional user functionality and support more simultaneous users.

Sutliff, Thomas J.↗

New Developments in Quaternion Estimation from Vector Observations

This paper contains a critical comparison of estimators minimizing Wahba's loss function. Some new results are presented for the QUaternion ESTimator (QUEST) and EStimators of the Optimal Quaternion (ESOQ and ESOQ2) to avoid the computational burden of sequential rotations in these algorithms. None of these methods is as robust in principle as Davenport's q method or the Singular Value Decomposition (SVD) method, which are significantly slower. Robustness is only an issue for measurements with widely differing accuracies, so the fastest estimators, the modified ESOQ and ESOQ2, are well suited to sensors that track multiple stars with comparable accuracies. More robust forms of ESOQ and ESOQ2 are developed that are intermediate in speed.

Markley, F. Landis↗

Ocean Color Optical Property Data Derived from OCTS and POLDER: A Comparison Study

We describe our efforts in studying and comparing the ocean color data derived from the Japanese Ocean Color and Temperature Scanner (OCTS) and the French Polarization and Directionality of the Earth's Reflectances (POLDER). OCTS and POLDER were both on board Japan's Sun-synchronous Advanced Earth Observing Satellite (ADEOS-1) from August 1996 to June 1997, collecting about 10 months of global ocean color data. This provides a unique opportunity for developing methods and strategies for the merging of ocean color data from multiple ocean color sensors. In this paper, we describe our approach in developing consistent data processing algorithms for both OCTS and POLDER and using a common in situ data set to vicariously calibrate the two sensors. Therefore, the OCTS and POLDER-measured radiances are effectively bridged through common in situ measurements. With this approach in processing data from two different sensors, the only differences in the derived products from OCTS and POLDER are the differences inherited from the instrument characteristics. Results show that there are no obvious bias differences between the OCTS and POLDER-derived ocean color products, whereas the differences due to noise, which stem from variations in sensor characteristics, are difficult to correct. It is possible, however, to reduce noise differences with some data averaging schemes. The ocean color data from OCTS and POLDER can therefore be compared and merged in the sense that there is no significant bias between two.

Wang, Menghua↗

Non-Systematic Errors of Monthly Oceanic Rainfall Derived From TMI

A major objective of the Tropical Rainfall Measuring Mission (TRMM) is to produce a multi-year time series of monthly rainfall over 50 latitude by 50 longitude boxes with an uncertainty of 1 mm/day for low rain rates and 10% for high rain rates. Based on some simple assumptions about the error structure, we compute the non-systematic errors of monthly oceanic rainfall over the same space/time domain derived from data taken by the Special Sensor Microwave Imager (SSM/I) on board the Defense Meteorological Satellite Program (DMSP) satellites and TRMM Microwave Imager (TMI). The mean rain rates over a two-year period (1998-1999) are calculated to be 3.0, 2.85, 2.94 mm/day for SSM/I onboard the DMSP F-13, F-14 and TMI, respectively. Assuming that the non-systematic errors for each sensor are independent, the errors are calculated to be 22.2%, 22.4% and 19.7% for F-13, F-14 and for TMI, respectively. The non-systematic error for the TMI is smaller than that for either F-13 or F-14 SSM/I at the low rain rates but is comparable at rain rates higher than about 5 mm/day. The TRMM objective of 1 mm/day for non-systematic error is met by TMI for rain rates up to 5-6 mm/day. For higher rain rates, the nonsystematic error is in the 15% range. The goal of a 10% error for high rain rates may be realized by a combination of sensor measurements from multiple satellites, such as that advocated by the Global Precipitation Mission (GPM).

Chiu, Long S.↗

The Athena Microscopic Imager Investigation

The Athena science payload on the Mars Exploration Rovers (MER) includes the Microscopic Imager (MI) [1]. The MI is a fixed-focus camera mounted on the end of an extendable instrument arm, the Instrument Deployment Device (IDD; see Figure 1).The MI was designed to acquire images at a spatial resolution of 30 microns/pixel over a broad spectral range (400 - 700 nm; see Table 1). Technically, the microscopic imager is not a microscope: it has a fixed magnification of 0.4 and is intended to produce images that simulate a geologist s view through a common hand lens. In photographers parlance, the system makes use of a macro lens. The MI uses the same electronics design as the other MER cameras [2, 3] but has optics that yield a field of view of 31 31 mm across a 1024 1024 pixel CCD image (Figure 2). The MI acquires images using only solar or skylightillumination of the target surface. A contact sensor is used to place the MI slightly closer to the target surface than its best focus distance (about 66 mm), allowing concave surfaces to be imaged in good focus. Because the MI has a relatively small depth of field (3 mm), a single MI image of a rough surface will contain both focused and unfocused areas. Coarse focusing will be achieved by moving the IDD away from a rock target after the contact sensor is activated. Multiple images taken at various distances will be acquired to ensure good focus on all parts of rough surfaces. By combining a set of images acquired in this way, a completely focused image can be assembled. Stereoscopic observations can be obtained by moving the MI laterally relative to its boresight. Estimates of the position and orientation of the MI for each acquired image will be stored in the rover computer and returned to Earth with the image data. The MI optics will be protected from the Martian environment by a retractable dust cover. The dust cover includes a Kapton window that is tinted orange to restrict the spectral bandpass to 500-700 nm, allowing color information to be obtained by taking images with the dust cover open and closed. The MI will image the same materials measured by other Athena instruments (including surfaces prepared by the Rock Abrasion Tool), as well as rock and soil targets of opportunity. Subsets of the full image array can be selected and/or pixels can be binned to reduce data volume. Image compression will be used to maximize the information contained in the data returned to Earth. The resulting MI data will place other MER instrument data in context and aid in petrologic and geologic interpretations of rocks and soils on Mars.

K E Herkenhoff↗

A Glass Can Be Half Full: Even in Microgravity

When conducting physical science research in space, the smallest vibration or disturbance can disrupt sensitive experiments. Back in the 1990s we developed an instrument, the Space Acceleration Measurement System (SAMS) that flew on the shuttle to monitor the vibration environment - but it wasn't very flexible. It could only measure vibrations for three users and only at fixed frequency ranges, and it had to be disassembled after each two-week mission to be readied for reuse. Then the International Space Station came along. Our researchers needed a second-generation system, the SAMS-II, which would measure acceleration and vibrations for multiple payloads conducting experiments throughout the life of the station. Measurement requirements were all over the map with a variety of frequencies that needed measuring over a broad dynamic range, so it was essential to develop a robust system that would be flexible enough to accommodate all the particular users. We came up with a concept using the Space Station's Ethernet as the means to talk between multiple remote triaxial sensor systems and a remote controller box. Ultimately, our job was to acquire data within the existing constraints of the station and to quickly and effectively get that information to the scientists. In 1994 we had a $2.1-million budget and a four-year development schedule aimed at achieving these goals. Technical risks were few and primarily resulted from uncertainty of ISS capabilities. At that point, we didn't worry about a thing programmatically; our cup runneth over.

Sutliff, Thomas↗

Advanced Resistive Exercise Device (ARED) Flight Software (FSW): A Unique Approach to Exercise in Long Duration Habitats

ARED flight instrumentation software is associated with an overall custom designed resistive exercise system that will be deployed on the International Space Station (ISS). This innovative software application fuses together many diverse and new technologies into a robust and usable package. The software takes advantage of touchscreen user interface technology by providing a graphical user interface on a Windows based tablet PC, meeting a design constraint of keyboard-less interaction with flight crewmembers. The software interacts with modified commercial data acquisition (DAQ) hardware to acquire multiple channels of sensor measurment from the ARED device. This information is recorded on the tablet PC and made available, via International Space Station (ISS) Wireless LAN (WLAN) and telemetry subsystems, to ground based mission medics and trainers for analysis. The software includes a feature to accept electronically encoded prescriptions of exercises that guide crewmembers through a customized regimen of resistive weight training, based on personal analysis. These electronically encoded prescriptions are provided to the crew via ISS WLAN and telemetry subsystems. All personal data is securely associated with an individual crew member, based on a PIN ID mechanism.

Mangieri, Mark↗

MER-DIMES : a planetary landing application of computer vision

During the Mars Exploration Rovers (MER) landings, the Descent Image Motion Estimation System (DIMES) was used for horizontal velocity estimation. The DIMES algorithm combines measurements from a descent camera, a radar altimeter and an inertial measurement unit. To deal with large changes in scale and orientation between descent images, the algorithm uses altitude and attitude measurements to rectify image data to level ground plane. Feature selection and tracking is employed in the rectified data to compute the horizontal motion between images. Differences of motion estimates are then compared to inertial measurements to verify correct feature tracking. DIMES combines sensor data from multiple sources in a novel way to create a low-cost, robust and computationally efficient velocity estimation solution, and DIMES is the first use of computer vision to control a spacecraft during planetary landing. In this paper, the detailed implementation of the DIMES algorithm and the results from the two landings on Mars are presented.

landing systems↗

Titan Orbiter Aerorover Mission with Enceladus Science (TOAMES)

Cassini and Huygens have made exciting discoveries at Titan and Enceladus, and at the same time made us aware of how little we understand about these bodies. For example, the source, and/or recycling mechanism, of methane in Titan's atmosphere is still puzzling. Indeed, river beds (mostly dry) and lakes have been spotted, and occasional clouds have been seen, but the physics to explain the observations is still mostly lacking, since our "image" of Titan is still sketchy and quite incomplete. Enceladus, only -500 km in extent, is even more puzzling, with its fiery plumes of vapor, dust and ice emanating from its south polar region, "feeding" Saturn's E ring. Long term variability of magnetospheric plasma, neutral gas, E-ring ice grain density, radio emissions, and corotation of Saturn's planetary magnetic field in response to Enceladus plume activity are of great interest for Saturn system science. Both Titan and Enceladus are bodies of considerable astrobiological interest in view of high organic abundances at Titan and potential subsurface liquid water at Enceladus. We propose to develop a new mission to Titan and Enceladus, the Titan Orbiter Aerorover Mission with Enceladus Science (TOAMES), to address these questions using novel new technologies. TOAMES is a multi-faceted mission that starts with orbit insertion around Saturn using aerobraking with Titan's extended atmosphere. We then have an orbital tour around Saturn (for 1-2 years) and close encounters with Enceladus, before it goes into orbit around Titan (via aerocapture). During the early reconnaissance phase around Titan, perhaps 6 months long, the orbiter will use altimetry, radio science and remote sensing instruments to measure Titan's global topography, subsurface structure and atmospheric winds. This information will be used to determine where and when to release the Aerorover, so that it can navigate safely around Titan and identify prime sites for surface sampling and analysis. In situ instruments will sample the upper atmosphere which may provide the seed population for the complex organic chemistry on the surface. The Aerorover will probably use a "hot air" Montgolfier balloon concept using the waste heat from the MMRTG 1-2 kwatts. New technologies will need to be developed and miniaturization will be required to maintain functionality while controlling mass, power and cost. Duty cycling will be used. The Aerorover will have all the instruments needed to sample Titan's atmosphere and surface with possible methane lakes-rivers. It will e.g., use multi-spectral imagers and for last 6 months of mission, balloon payload will land on surface at predetermined site to take core samples of the surface and use seismometers to help probe the interior. All remote (and active) sensors on the orbiter will share a - 1 meter telescope, called MIDAS (Multiple Instrument Distributed Aperture Sensor). MIDAS observations in stable orbit at Titan can provide full global maps of Titan's surface and could additionally provide long term observations of the Saturn system including Enceladus for extended mission phases over many years, potentially for decades. Experience from the Hubble Space Telescope has shown strong public interest and commitment to exciting generational missions.

Sittler, Edward C.↗