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At least 451 records · Page 25

Positron emission tomography harmonization in the Alzheimer's Disease Neuroimaging Initiative: A scalable and rigorous approach to multisite amyloid and tau quantification

Abstract INTRODUCTION A key goal of the Alzheimer's Disease NeuroImaging Initiative (ADNI) positron emission tomography (PET) Core is to harmonize quantification of β‐amyloid (Aβ) and tau PET image data across multiple scanners and tracers. METHODS We developed an analysis pipeline (Berkeley PET Imaging Pipeline, B‐PIP) for ADNI Aβ and tau PET images and applied it to PET data from other multisite studies. Steps include image pre‐processing, refacing, magnetic resonance imaging (MRI)/PET co‐registration, visual quality control (QC), quantification of tracer uptake, and standardization of Aβ and tau standardized uptake value ratios (SUVrs) across tracers. RESULTS Measurements from 10,105 cross‐sectional and longitudinal Aβ and tau PET scans acquired in several studies between 2010 and 2024 can be processed, harmonized, and directly merged across tracers and cohorts. DISCUSSION The B‐PIP developed in ADNI is a scalable image harmonization approach used in several observational studies and clinical trials that facilitates rigorous Aβ and tau PET quantification and data sharing. Highlights Quantitative results from ADNI Aβ and tau PET data are generated using a rigorous, scalable image processing pipeline This pipeline has been applied to PET data from several other large, multisite studies and trials Quantitative outcomes are harmonizable across studies and are shared with the scientific community

Neurosciences & Neurology↗

Test Cases for the Benchmark Active Controls: Spoiler and Control Surface Oscillations and Flutter

As a portion of the Benchmark Models Program at NASA Langley, a simple generic model was developed for active controls research and was called BACT for Benchmark Active Controls Technology model. This model was based on the previously-tested Benchmark Models rectangular wing with the NACA 0012 airfoil section that was mounted on the Pitch and Plunge Apparatus (PAPA) for flutter testing. The BACT model had an upper surface spoiler, a lower surface spoiler, and a trailing edge control surface for use in flutter suppression and dynamic response excitation. Previous experience with flutter suppression indicated a need for measured control surface aerodynamics for accurate control law design. Three different types of flutter instability boundaries had also been determined for the NACA 0012/PAPA model, a classical flutter boundary, a transonic stall flutter boundary at angle of attack, and a plunge instability near M = 0.9. Therefore an extensive set of steady and control surface oscillation data was generated spanning the range of the three types of instabilities. This information was subsequently used to design control laws to suppress each flutter instability. There have been three tests of the BACT model. The objective of the first test, TDT Test 485, was to generate a data set of steady and unsteady control surface effectiveness data, and to determine the open loop dynamic characteristics of the control systems including the actuators. Unsteady pressures, loads, and transfer functions were measured. The other two tests, TDT Test 502 and TDT Test 5 18, were primarily oriented towards active controls research, but some data supplementary to the first test were obtained. Dynamic response of the flexible system to control surface excitation and open loop flutter characteristics were determined during Test 502. Loads were not measured during the last two tests. During these tests, a database of over 3000 data sets was obtained. A reasonably extensive subset of the data sets from the first two tests have been chosen for Test Cases for computational comparisons concentrating on static conditions and cases with harmonically oscillating control surfaces. Several flutter Test Cases from both tests have also been included. Some aerodynamic comparisons with the BACT data have been made using computational fluid dynamics codes at the Navier-Stokes level (and in the accompanying chapter SC). Some mechanical and active control studies have been presented. In this report several Test Cases are selected to illustrate trends for a variety of different conditions with emphasis on transonic flow effects. Cases for static angles of attack, static trailing-edge and upper-surface spoiler deflections are included for a range of conditions near those for the oscillation cases. Cases for trailing-edge control and upper-surface spoiler oscillations for a range of Mach numbers, angle of attack, and static control deflections are included. Cases for all three types of flutter instability are selected. In addition some cases are included for dynamic response measurements during forced oscillations of the controls on the flexible mount. An overview of the model and tests is given, and the standard formulary for these data is listed. Some sample data and sample results of calculations are presented. Only the static pressures and the first harmonic real and imaginary parts of the pressures are included in the data for the Test Cases, but digitized time histories have been archived. The data for the Test Cases are also available as separate electronic files.

Bennett, Robert M.↗

Overcoming Dimensionality Barriers in Satellite Data to Elucidate SPECTRAL-SPATIAL-TEMPORAL Trends in the Ocean

The weighted harmonic mean of spectral wavelengths can be used as an index of optical water types that share similar spectral signatures.This technique can be translated to relate spectral shape between sensors of varying spectral resolution.The output along a continuum of color values enables spatio-temporal analysis of subtle spectral shifts.Directional trends in absorption and backscatter data lend a hidden context to changes in water color. Conceptualization of multiple data dimensions is imperative as passive/active sensors grow increasingly sophisticated in nature.

Vandermeulen, Ryan↗

Venus gravity - A harmonic analysis and geophysical implications

An improved theoretical model of Venusian global gravity has been obtained by fitting a tenth degree spherical harmonic series to 78 orbital arcs of Doppler tracking data from the Pioneer Venus Orbiter. Maps of the free-air anomaly and its formal error are presented. Isostatic anomaly and 'Geoid' maps are also presented, and their geophysical implications are discussed in details. Comparison with equivalent resolution topographic models reveals a strong correlation between long wavelength gravity and the topography of Venus. Analysis of the second degree harmonics showed two aspects of the orientation of the inertial axes of Venus: (1) a significant (about three degrees) departure of the axis of greatest inertia from the rotational axis; and (2) a near alignment of the axis of least inertia with the location of the subterrestrial point at the time of the next inferior conjunction with earth (December 16, 2101). A series of contour maps of the Venusian free-air anomalies is provided.

Mottinger, N. A.↗

High resolution analysis of satellite gradiometry

Satellite gravity gradiometry is a technique now under development which, by the middle of the next decade, may be used for the high resolution charting from space of the gravity field of the earth and, afterwards, of other planets. Some data analysis schemes are reviewed for getting detailed gravity maps from gradiometry on both a global and a local basis. It also presents estimates of the likely accuracies of such maps, in terms of normalized spherical harmonics expansions, both using gradiometry alone and in combination with data from a Global Positioning System (GPS) receiver carried on the same spacecraft. It compares these accuracies with those of current and future maps obtained from other data (conventional tracking, satellite-satellite tracking, etc.), and also with the spectra of various signals of geophysical interest.

Colombo, O. L.↗

Gaussian statistics of the cosmic microwave background: Correlation of temperature extrema in the COBE DMR two-year sky maps

We use the two-point correlation function of the extrema points (peaks and valleys) in the Cosmic Background Explorer (COBE) Differential Microwave Radiometers (DMR) 2 year sky maps as a test for non-Gaussian temperature distribution in the cosmic microwave background anisotropy. A maximum-likelihood analysis compares the DMR data to n = 1 toy models whose random-phase spherical harmonic components a(sub lm) are drawn from either Gaussian, chi-square, or log-normal parent populations. The likelihood of the 53 GHz (A+B)/2 data is greatest for the exact Gaussian model. There is less than 10% chance that the non-Gaussian models tested describe the DMR data, limited primarily by type II errors in the statistical inference. The extrema correlation function is a stronger test for this class of non-Gaussian models than topological statistics such as the genus.

Kogut, A.↗

Likelihood Methods for CMB Experiments

A great deal of experimental effort is currently being devoted to the precise measurements of the cosmic microwave background (CMB) sky in temperature and polarization. Satellites, balloon-borne, and ground-based experiments scrutinize the CMB sky at multiple scales, and therefore enable to investigate not only the evolution of the early Universe, but also its late-time physics with unprecedented accuracy. The pipeline leading from time ordered data as collected by the instrument to the final product is highly structured. Moreover, it has also to provide accurate estimates of statistical and systematic uncertainties connected to the specific experiment. In this paper, we review likelihood approaches targeted to the analysis of the CMB signal at different scales, and to the estimation of key cosmological parameters. We consider methods that analyze the data in the spatial (i.e., pixel-based) or harmonic domain. We highlight the most relevant aspects of each approach and compare their performance.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Data use investigation for the magnetic field satellite (MAGSAT) mission: Geomagnetic field forecasting and fluid dynamics of the core

MAGSAT data were used to construct a variety of spherical harmonic models of the main geomagnetic field emanating from Earth's liquid core at poch 1980. These models were used to: (1) accurately determine the radius of Earth's core by a magnetic method, (2) calculate estimates, of the long-term ange of variation of geomagnetic Gauss coefficients; (3) establish a preferred truncation level for current spherical harmonic models of the main geomagnetic field from the core; (4) evaluate a method for taking account of electrical conduction in the mantle when the magnetic field is downward continued to the core-mantle boundary; and (5) establish that upwelling and downwelling of fluid motion at the top of the core is probably detectable, observationally. A fluid dynamics forecast model was not produced because of insufficient data.

Benton, E. R.↗

Magnetic Field Measurements of First Pre-series Full -Length 4.2 m Quadrupole MQXFA03 Using PCB Rotating Coils for the Hi Hi-Lumi LHC Project

The U.S. Hi-Lumi LHC Accelerator Upgrade Project (AUP) and CERN have joined efforts to develop high field quad-rupoles for the Hi-Lumi LHC upgrade. The US national laborato-ries in the AUP project will deliver 10 magnets and each cryostat has two 4.2 m high gradient quadrupoles in it. These magnets are made of Nb3Sn conductors, with large aperture (150 mm) and in-tegrated gradient of 556.9 T. This paper reports on magnetic measurements performed during the vertical test at Brookhaven National Laboratory (BNL) in 2019-2020. A warm measurement Z-Scan (+/- 15 A) with 42 Z-positions before cool-down was per-formed at BNL. The results were directly compared to field data measured at LBNL during magnet assembly. Measured harmonics and magnetic center offsets (ΔX and ΔY) have provided timely and informative diagnostics on the magnet structure’s shape at both warm and cold temperatures. A new centering fixture was de-signed and added to better center the warm bore tube which con-tains the rotating coil probe. After the quench training to 16.47 kA was achieved, a complete set of cold measurements (Z-Scan at 16.47 kA and I-Scan from 960 A to 16.47 kA and back to 960 A) was made. Periodic axial variation of allowed and nonallowed harmonics was observed which is related to the coil radial and/or mid-plane variations along the magnet axis. Overall, the average harmonics in the straight section are within the required field boundaries.

43 PARTICLE ACCELERATORS↗

A harmonic analysis of lunar gravity

An improved model of lunar global gravity has been obtained by fitting a sixteenth-degree harmonic series to a combination of Doppler tracking data from Apollo missions 8, 12, 15, and 16, and Lunar Orbiters 1, 2, 3, 4, and 5, and laser ranging data to the lunar surface. To compensate for the irregular selenographic distribution of these data, the solution algorithm has also incorporated a semi-empirical a priori covariance function. Maps of the free-air gravity disturbance and its formal error are presented, as are free-air anomaly and Bouguer anomaly maps. The lunar gravitational variance spectrum has the form V(G; n) = O(n to the -4th power), as do the corresponding terrestrial and martian spectra. The variance spectra of the Bouguer corrections (topography converted to equivalent gravity) for these bodies have the same basic form as the observed gravity; and, in fact, the spectral ratios are nearly constant throughout the observed spectral range for each body. Despite this spectral compatibility, the correlation between gravity and topography is generally quite poor on a global scale.

Bills, B. G.↗

Method for predicting impulsive noise generated by wind turbine rotors

Large wind turbines can generate both broad band and impulsive noises. These noises can be controlled by proper choice of rotor design parameters such as rotor location with respect to the supporting tower, tower geometry and tip speed. A method was developed to calculate the impulsive noise generated when the wind turbine blade experiences air forces that are periodic functions of the rotational frequency. This phenomenon can occur when the blades operate in the wake of the support tower and the nonuniform velocity field near the ground due to wind shear. Results from this method were compared with measured sound spectra taken at locations of one to two rotor diameters from the DOE/NASA Mod-1 wind turbine. The calculated spectra generally agreed with the measured data in both the amplitude of the predominant harmonics and the roll of rate with frequency. Measured sound pressure levels far from the Mod-1 (15 rotor diameters), however, were higher than predicted. Simultaneous measurements in the near and far field indicated that the propagation effects could enhance the sound levels by more than 10 dB above that expected by spherical dispersion. These propagation effects are believed to be due to terrain and atmospheric characteristics of the Mod-1 site.

Viterna, L. A.↗

Accuracy and resolution of Earth Radiation Budget Estimates

A numerical filter inversion technique that reduces wide-angle satellite measurements to top-of-the-atmosphere radiant exitances has been proposed for the Earth Radiation Budget Experiment (ERBE). The matrix formulation of this technique is presented, and the design of the numerical filter is discussed. The filter is smoothed with a singular value decomposition. The inversion process is simulated by generating synthetic measurements from a 24 degree spherical harmonic radiation field derived from Nimbus 6 ERB data. The numerical filter is applied to these measurements after they are corrupted with instrument error. The results are curves of expected error versus resolution area.

Green, R. N.↗

Plasma waves and continuum radiation in planetary magnetospheres

Voyager data on whistler mode waves and electron cyclotron harmonic emissions are analyzed to understand the interaction of the waves with the dynamics of the electrons. The occurrence and characteristics of Jovian whistler mode chorus and the interactions with the plasma in and near the Io torus are emphasized. Bernstein waves, especially those near the upper hybrid or plasma frequency are discussed to provide insight into an important plasma diagnostic tool and to compare the relevant portions of the electron distribution function at Earth, Jupiter, and Saturn. The nonthermal continuum radiation common to the magnetospheres of Earth, Jupiter, and Saturn is considered. Because of the very low frequency of these radio waves and their close association with upper hybrid resonance emissions, continuum radiation is often associated more closely with the plasma wave spectrum of a planetary magnetosphere than with the planet's radio spectrum.

Kurth, W. S.↗

Search for evidence of a clock related to the solar 154 day complex of periodicities

Evidence indicates that the 154-day periodicity in solar activity may be part of a complex of periodicities that are approximate multiples of 25.8 d, which suggests that the sun contains a 'clock' with frequency in the range 440-463 nHz. To search for evidence of this clock, the daily Greenwich sunspot areas and daily Zurich sunspot numbers have been Fourier-analyzed. The Zurich data show a strong peak that may clearly be identified with the fundamental frequency, while the Greenwich data show a peak that may be the harmonic of the fundamental frequency. A model is discussed which provides a kinematical interpretation of the sunspot spectrum.

Sturrock, P. A.↗