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At least 451 records · Page 25

Linking age, survival, and transit time distributions

Abstract Although the concepts of age, survival, and transit time have been widely used in many fields, including population dynamics, chemical engineering, and hydrology, a comprehensive mathematical framework is still missing. Here we discuss several relationships among these quantities by starting from the evolution equation for the joint distribution of age and survival, from which the equations for age and survival time readily follow. It also becomes apparent how the statistical dependence between age and survival is directly related to either the age dependence of the loss function or the survival‐time dependence of the input function. The solution of the joint distribution equation also allows us to obtain the relationships between the age at exit (or death) and the survival time at input (or birth), as well as to stress the symmetries of the various distributions under time reversal. The transit time is then obtained as a sum of the age and survival time, and its properties are discussed along with the general relationships between their mean values. The special case of steady state case is analyzed in detail. Some examples, inspired by hydrologic applications, are presented to illustrate the theory with the specific results.

Calabrese, Salvatore↗

A comparative study between real-world and laboratory accelerated aging of Cu/SSZ-13 SCR catalysts

Elucidating aging mechanisms in real-world applications is a critical component for developing and maintaining Cu/SSZ-13 SCR catalysts. To reveal gaps between laboratory accelerated aging and real-world aging, herein we report thorough comparative studies between 6 representative catalysts. Here, we apply a wide range of catalyst characterization methods, including surface area/porosity analysis, X-ray diffraction (XRD), H 2 -temperature programmed reduction, NH3-temperaure programmed desorption, solid-state nuclear magnetic resonance (NMR), in situ X-ray photoelectron (XPS) and electron paramagnetic resonance (EPR) spectroscopies, to gain atomic-level knowledge on Cu transformation under different aging protocols. We then correlate such knowledge to SCR, NH 3 /NO oxidation kinetic behavior of the catalysts. We found that sulfur aging plays the most important role in interpreting catalyst degradation during real-world application, including direct sulfur poisoning of isolated Cu II SCR active species to CuSO 4 -like species, the agglomeration of such species to multinuclear CuSO 4 clusters, and eventually, CuO formation during desulfation treatments. Such chemistries convert SCR active Cu to SCR inert Cu moieties without severely deteriorating catalyst support integrity. These characteristics are partially replicated by hydrothermal aging in the presence of SOx but are poorly mimicked by hydrothermal aging alone.

36 MATERIALS SCIENCE↗

A Bayesian Modeling Approach for Estimation of a Shape-Free Groundwater Age Distribution using Multiple Tracers

The mixing of groundwaters with different ages in aquifers, groundwater age is more appropriately represented by a distribution rather than a scalar number. To infer a groundwater age distribution from environmental tracers, a mathematical form is often assumed for the shape of the distribution and the parameters of the mathematical distribution are estimated using deterministic or stochastic inverse methods. We found that the prescription of the mathematical form limits the exploration of the age distribution to the shapes that can be described by the selected distribution. In this paper, the use of freeform histograms as groundwater age distributions is evaluated. A Bayesian Markov Chain Monte Carlo approach is used to estimate the fraction of groundwater in each histogram bin. This method was able to capture the shape of a hypothetical gamma distribution from the concentrations of four age tracers. The number of bins that can be considered in this approach is limited based on the number of tracers available. The histogram method was also tested on tracer data sets from Holten (The Netherlands; 3 H, 3 He, 85 Kr, 39 Ar) and the La Selva Biological Station (Costa-Rica; SF 6 , CFCs, 3 H, 4 He and 14 C), and compared to a number of mathematical forms. According to standard Bayesian measures of model goodness, the best mathematical distribution performs better than the histogram distributions in terms of the ability to capture the observed tracer data relative to their complexity. Among the histogram distributions, the four bin histogram performs better in most of the cases. The Monte Carlo simulations showed strong correlations in the posterior estimates of bin contributions, indicating that these bins cannot be well constrained using the available age tracers. The fact that mathematical forms overall perform better than the freeform histogram does not undermine the benefit of the freeform approach, especially for the cases where a larger amount of observed data is available and when the real groundwater distribution is more complex than can be represented by simple mathematical forms.

54 ENVIRONMENTAL SCIENCES↗

Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1

Highlights: • Aging impaired beige adipocyte differentiation of AT-MSC by induction of senescence. • The induced senescence in elderly AT-MSC caused by reduction of Sirt1 and Sirt3. • Sirt1 activated beige adipocyte differentiation of elderly AT-MSC via p53/p21 pathway. In the body, different types of adipose tissue perform different functions, with brown and beige adipose tissues playing unique roles in dissipating energy. Throughout life, adipocytes are regenerated from progenitors, and this process is impaired by aging. One of the progenitors of adipocytes are mesenchymal stem cells (MSCs), which have recently become a promising tool for stem cell therapy. However, whether or not aging impairs the brown/beige adipocyte differentiation of adipose tissue-derived MSCs (AT-MSCs) remains unclear. In the present study, we isolated AT-MSCs from two different age groups of donors (infants and elderly subjects) and examined the effects of aging on the AT-MSC brown/beige adipocyte differentiation ability. We found that none of the AT-MSCs expressed Myf5, which indicated the beige (not brown) differentiation ability of cells. Of note, an inverse correlation was noted between the beige adipocyte differentiation ability and age, with AT-MSCs derived from elderly donors showed the most severely reduced function due to induced cellular senescence. The impaired expression of Sirtuin 1 (Sirt1) and Sirt3 proved to be responsible for the induction of senescence in elderly AT-MSCs; however, only Sirt1 was directly involved in the regulation of beige adipocyte differentiation. The overexpression of Sirt1 impaired the p53/p21 pathway, thereby preventing elderly AT-MSCs from entering senescence and restoring the beige differentiation ability. Thus, our study represents the important role of Sirt1 and senescence in the regulation of beige adipocyte differentiation during aging.

60 APPLIED LIFE SCIENCES↗

Effect of aging on lignin content, composition and enzymatic saccharification in Corymbia hybrids and parental taxa between years 9 and 12

Corymbia (a eucalypt) is an important forestry genus and a potential lignocellulosic bioenergy feedstock. The composition of the lignocellulosic cell wall significantly impacts pretreatment efficiency and conversion to biofuel but is variable and changes with age. In this study, we estimated Klason lignin content, composition, and monosaccharide (glucose and xylose) release after enzymatic saccharification of untreated and hydrothermally pretreated biomass from Corymbia parental species Corymbia torelliana (CT), Corymbia citriodora subsp. variegata (spotted gum; CCV), and interspecific F1 hybrids (CT x CCV) at ages 9 and 12 years from planting. Analysis of lignin composition derived from syringyl/guaiacyl monolignols (S/G) found significant differences among taxa, with CT S/G ratios (2.2 and 2.0) being significantly lower than CCV (2.6 and 2.3) or hybrids (2.5 and 2.3) at ages 9 and 12 respectively. In general, enzymatic saccharification yields from untreated biomass were significantly different among taxa, with CT (113 and 75 mg g -1 ) and hybrids (108 and 81 mg g -1 ) yielding significantly higher glucose from untreated biomass than CCV (82 and 56 mg g -1 ) at ages 9 and 12 respectively. Comparison of traits within taxa between ages 9 and 12 found S/G ratios and glucose yields from untreated biomass were significantly lower in CT, CCV and hybrid taxa. As a result, the formation of lignocellulosic cell walls is complex, influenced by genetics and age of material, requiring optimization of rotation age for biofuel production and other industrial processes.

09 BIOMASS FUELS↗

Investigating rapid alpha-decay induced aging of 238 PuO 2 by Raman Spectroscopy

Investigating alpha-decay induced aging in PuO 2 is useful in nuclear forensics; helping to determine the time since last calcination. This was previously investigate by monitoring the damage to 240 PuO 2 over the course of a few years. The rate of alpha-decay induced aging has long been assumed to scale only with the decay rate of other isotopes without direct verification. This article reports the first alpha-decay aging study of 238 PuO 2 by Raman spectroscopy. Contrary to the expected 10 days for 238 PuO 2 to reach steady state based on 240 PuO 2 studies, the alpha aging curve reached an approximate steady state ∼24–30 h after laser annealing. While the cause of the order of magnitude decrease is unknown, it is speculated that dynamic annealing could contribute to the differences in rate of induced aging. The Raman spectra of annealed and aged 238 PuO 2 matched the expected features in 239 PuO 2 and 240 PuO 2 spectra; showing no formation of new stable chemical species in the material such as secondary Pu oxide phases (e.g., Pu 4 O 9 ). In conclusion, results indicate that 238 Pu could be leveraged for rapid alpha-decay aging studies to characterize alpha-decay induced features and better understand matrix temperatures and the annealing of Frankel pair defects.

Actinide↗

Mechanical behavior and texture development of over-aged and solution treated Al-Cu-Mg alloy during multi-directional forging

The effects of initial heat treatments, i.e. solution treating and over ageing, on deformation behavior of an age hardenable Al-Cu-Mg alloy, including mechanical properties and texture evolution, during multi-directional forging (MDF) are investigated. Hardness measurements, electron back scatter diffraction (EBSD) maps, and differential scanning calorimetry (DSC) are carried out. Mechanical behaviors of the alloy in terms of compressive stress and hardness test after MDF are investigated. In both solution treated and over-aged alloys, the compressive stress during MDF shows an increase up to the second pass, and by further straining the flow stress is decreased. However, shear and deformation bands are formed in both solution treated and over-aged alloys, the density of these instabilities in the solution treated alloy is higher than that in over-aged alloy. In the solution treated alloy, not only large particles induce deformation bands, but also the dynamically formed GPB zones/Cu-Mg co-clusters. Texture analysis shows that the shear component of C {001}<110> (Φ{sub 1} = 90°, Φ = 0°, Φ{sub 2} = 45°) is developed with 18 mrd during MDF of the over-aged alloy. In the solution treated alloy, due to the high density of deformation bands and different microchemistry of the matrix in comparison with that of the over-aged alloy, the Copper type texture component {112}<111> (Φ{sub 1} = 90°, Φ = 35°, Φ{sub 2} = 45°) is developed with 11 mrd.

36 MATERIALS SCIENCE↗

Metabolic brain networks in aging and preclinical Alzheimer's disease

Metabolic brain networks can provide insight into the network processes underlying progression from healthy aging to Alzheimer's disease. We explore the effect of two Alzheimer's disease risk factors, amyloid-β and ApoE ε4 genotype, on metabolic brain networks in cognitively normal older adults (N = 64, ages 69–89) compared to young adults (N = 17, ages 20–30) and patients with Alzheimer's disease (N = 22, ages 69–89). Subjects underwent MRI and PET imaging of metabolism (FDG) and amyloid-β (PIB). Normal older adults were divided into four subgroups based on amyloid-β and ApoE genotype. Metabolic brain networks were constructed cross-sectionally by computing pairwise correlations of metabolism across subjects within each group for 80 regions of interest. We found widespread elevated metabolic correlations and desegregation of metabolic brain networks in normal aging compared to youth and Alzheimer's disease, suggesting that normal aging leads to widespread loss of independent metabolic function across the brain. Amyloid-β and the combination of ApoE ε4 led to less extensive elevated metabolic correlations compared to other normal older adults, as well as a metabolic brain network more similar to youth and Alzheimer's disease. This could reflect early progression towards Alzheimer's disease in these individuals. Altered metabolic brain networks of older adults and those at the highest risk for progression to Alzheimer's disease open up novel lines of inquiry into the metabolic and network processes that underlie normal aging and Alzheimer's disease.

Neurosciences & Neurology↗

Adhesion and Contact Aging of Acrylic Pressure-Sensitive Adhesives to Swollen Elastomers

Fluid-infused (or swollen) elastomers are known for their antiadhesive properties. The presence of excess fluid at their surface is the main contributor to limiting contact formation and minimizing adhesion. Despite their potential, the mechanisms for adhesion and contact aging to fluid-infused elastomers are poorly understood beyond contact with a few materials (ice, biofilms, glass). This study reports on adhesion to a model fluid-infused elastomer, poly(dimethylsiloxane) (PDMS), swollen with silicone oil. The effects of oil saturation, contact time, and the opposing surface are investigated. Specifically, adhesion to two different adherents with comparable surface energies but drastically different mechanical properties is investigated: a glass surface and a soft viscoelastic acrylic pressure-sensitive adhesive film (PSA, modulus ~25 kPa). Adhesion between the PSA and swollen PDMS [with 23% (w/w) silicone oil] retains up to 60% of its value compared to contact with unswollen (dry) PDMS. In contrast, adhesion to glass nearly vanishes in contact with the same swollen elastomer. Adhesion to the PSA also displays stronger contact aging than adhesion to glass. Contact aging with the PSA is comparable for dry and unsaturated PDMS. Moreover, load relaxation when the PSA is in contact with the PDMS does not correlate with contact aging for contact with the dry or unsaturated elastomer, suggesting that contact aging is likely caused by chain interpenetration and polymer reorganization within the contact region. Closer to full saturation of the PDMS with oil, adhesion to the PSA decreases significantly and shows a delay in the onset of contact aging that is weakly correlated to the poroelastic relaxation of the elastomer. Additional confocal imaging suggests that the presence of a layer of fluid trapped at the interface between the two solids could explain the delayed (and limited) contact aging to the oil-saturated PDMS.

36 MATERIALS SCIENCE↗

Landscape Age as a Major Control on the Geography of Soil Weathering

Global-scale models of rock-derived nutrient availability often assume that physical erosion drives soils toward an approximate “steady state” over geologic timescales. By definition, steady-state models do not represent landscape age—that is, the time elapsed since soil formation is initiated by major erosional or depositional events. We hypothesize that this steady-state assumption has large consequences on estimates of soil fertility because landscape age can mediate the retention of mobile elements in soil, particularly in low-relief landscapes and humid climates. We quantified the effect of landscape age on soil fertility by estimating Na retention in soils across the United States and explicitly resolving landscape age in regions that experienced significant deposition or glacial retreat after the Last Glacial Maximum (LGM). We then used a simple one-compartment model to simulate soil formation and weathering, comparing predictions that incorporated landscape age with those based on the steady-state assumption. We found that soils formed in LGM deposits in low-relief, humid settings generally retain 10 times more Na than soils formed outside of LGM deposits. Furthermore, the model that accounted for landscape age outperformed a steady-state model across the United States and increased globally averaged estimates of Na retention by 17%. These results reinforce the idea that landscape age is a major control on weathering and should not be ignored in simulations of nutrient cycling.

58 GEOSCIENCES↗

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice

Pharmaceutical intervention of aging requires targeting multiple pathways, thus there is rationale to test combinations of drugs targeting different but overlapping processes. In order to determine if combining drugs shown to extend lifespan and healthy aging in mice would have greater impact than any individual drug, a cocktail diet containing 14 ppm rapamycin, 1000 ppm acarbose, and 1000 ppm phenylbutyrate was fed to 20-month-old C57BL/6 and HET3 4-way cross mice of both sexes for three months. Mice treated with the cocktail showed a sex and strain-dependent phenotype consistent with healthy aging including decreased body fat, improved cognition, increased strength and endurance, and decreased age-related pathology compared to mice treated with individual drugs or control. The severity of age-related lesions in heart, lungs, liver, and kidney was consistently decreased in mice treated with the cocktail compared to mice treated with individual drugs or control, suggesting an interactive advantage of the three drugs. This study shows that a combination of three drugs, each previously shown to enhance lifespan and health span in mice, is able to delay aging phenotypes in middle-aged mice more effectively than any individual drug in the cocktail over a 3-month treatment period.

60 APPLIED LIFE SCIENCES↗

THE AGES OF HIGH-MASS X-RAY BINARIES IN NGC 2403 AND NGC 300

We have examined resolved stellar photometry from HST imaging surrounding 18 high-mass X-ray binary (HMXB) candidates in NGC 300 and NGC 2403 as determined from combined Chandra/HST analysis. We have fit the color-magnitude distribution of the surrounding stars with stellar evolution models. All but one region in NGC 300 and two in NGC 2403 contain a population with an age between 20 and 70 Myr. One of the candidates is the ultraluminous X-ray source in NGC 2403, which we associate with a 60 {+-} 5 Myr old population. These age distributions provide additional evidence that 16 of these 18 candidates are HMXBs. Furthermore, our results suggest that the most common HMXB age in these galaxies is 40-55 Myr. This preferred age is similar to observations of HMXBs in the Small Magellanic Cloud, providing new evidence of this formation timescale, but in higher metallicity populations. We suggest that this preferred HMXB age is the result of the fortuitous combination of two physical effects. First, this is the age of a population when the greatest rate of core-collapse events should be occurring, maximizing neutron star production. Second, this is the age when B stars are most likely to be actively losing mass. We also discuss our results in the context of HMXB feedback in galaxies, confirming HMXBs as a potentially important source of energy for the interstellar medium in low-mass galaxies.

79 ASTRONOMY AND ASTROPHYSICS↗

A BAYESIAN APPROACH TO DERIVING AGES OF INDIVIDUAL FIELD WHITE DWARFS

We apply a self-consistent and robust Bayesian statistical approach to determine the ages, distances, and zero-age main sequence (ZAMS) masses of 28 field DA white dwarfs (WDs) with ages of approximately 4-8 Gyr. Our technique requires only quality optical and near-infrared photometry to derive ages with <15% uncertainties, generally with little sensitivity to our choice of modern initial-final mass relation. We find that age, distance, and ZAMS mass are correlated in a manner that is too complex to be captured by traditional error propagation techniques. We further find that the posterior distributions of age are often asymmetric, indicating that the standard approach to deriving WD ages can yield misleading results.

79 ASTRONOMY AND ASTROPHYSICS↗

Not-so-simple stellar populations in the intermediate-age Large Magellanic Cloud star clusters NGC 1831 and NGC 1868

Using a combination of high-resolution Hubble Space Telescope/Wide-Field and Planetary Camera-2 observations, we explore the physical properties of the stellar populations in two intermediate-age star clusters, NGC 1831 and NGC 1868, in the Large Magellanic Cloud based on their color-magnitude diagrams. We show that both clusters exhibit extended main-sequence turn offs. To explain the observations, we consider variations in helium abundance, binarity, age dispersions, and the fast rotation of the clusters' member stars. The observed narrow main sequence excludes significant variations in helium abundance in both clusters. We first establish the clusters' main-sequence binary fractions using the bulk of the clusters' main-sequence stellar populations ≳ 1 mag below their turn-offs. The extent of the turn-off regions in color-magnitude space, corrected for the effects of binarity, implies that age spreads of order 300 Myr may be inferred for both clusters if the stellar distributions in color-magnitude space were entirely due to the presence of multiple populations characterized by an age range. Invoking rapid rotation of the population of cluster members characterized by a single age also allows us to match the observed data in detail. However, when taking into account the extent of the red clump in color-magnitude space, we encounter an apparent conflict for NGC 1831 between the age dispersion derived from that based on the extent of the main-sequence turn off and that implied by the compact red clump. We therefore conclude that, for this cluster, variations in stellar rotation rate are preferred over an age dispersion. For NGC 1868, both models perform equally well.

79 ASTRONOMY AND ASTROPHYSICS↗

The panchromatic Hubble Andromeda Treasury. V. Ages and masses of the year 1 stellar clusters

We present ages and masses for 601 star clusters in M31 from the analysis of the six filter integrated light measurements from near-ultraviolet to near-infrared wavelengths, made as part of the Panchromatic Hubble Andromeda Treasury (PHAT). We derive the ages and masses using a probabilistic technique, which accounts for the effects of stochastic sampling of the stellar initial mass function. Tests on synthetic data show that this method, in conjunction with the exquisite sensitivity of the PHAT observations and their broad wavelength baseline, provides robust age and mass recovery for clusters ranging from ∼10{sup 2} to 2 × 10{sup 6} M {sub ☉}. We find that the cluster age distribution is consistent with being uniform over the past 100 Myr, which suggests a weak effect of cluster disruption within M31. The age distribution of older (>100 Myr) clusters falls toward old ages, consistent with a power-law decline of index –1, likely from a combination of fading and disruption of the clusters. We find that the mass distribution of the whole sample can be well described by a single power law with a spectral index of –1.9 ± 0.1 over the range of 10{sup 3}-3 × 10{sup 5} M {sub ☉}. However, if we subdivide the sample by galactocentric radius, we find that the age distributions remain unchanged. However, the mass spectral index varies significantly, showing best-fit values between –2.2 and –1.8, with the shallower slope in the highest star formation intensity regions. We explore the robustness of our study to potential systematics and conclude that the cluster mass function may vary with respect to environment.

79 ASTRONOMY AND ASTROPHYSICS↗

The metallicity spread and the age-metallicity relation of ω Centauri

ω Centauri is a peculiar globular cluster formed by a complex stellar population. To investigate it, we studied 172 stars belonging to the five SGBs that we can identify in our photometry, in order to measure their [Fe/H] content as well as estimate their age dispersion and the age-metallicity relation. The first important result is that all of these SGBs have a distribution in metallicity with a spread that exceeds the observational errors and typically displays several peaks that indicate the presence of several subpopulations. We were able to identify at least six of them based on their mean [Fe/H] content. These metallicity-based subpopulations are seen to varying extents in each of the five SGBs. Taking advantage of the age sensitivity of the SGB, we showed that, first of all, at least half of the subpopulations have an age spread of at least 2 Gyr. Then, we obtained an age-metallicity relation that is the most complete to date for this cluster. Interpretation of the age-metallicity relation is not straightforward, but it is possible that the cluster (or what we can call its progenitor) was initially composed of two populations with different metallicities. Because of their age, it is very unlikely that the most metal-rich derives from the most metal-poor by some kind of chemical evolution process, so they can be assumed to be two independent primordial objects, or perhaps two separate parts of a single larger object, that merged in the past to form the present-day cluster.

79 ASTRONOMY AND ASTROPHYSICS↗

Declines in Pneumonia and Meningitis Hospitalizations in Children Under 5 Years of Age After Introduction of 10-Valent Pneumococcal Conjugate Vaccine in Zambia, 2010–2016

Background: Pneumococcus is a leading cause of pneumonia and meningitis. Zambia introduced a 10-valent pneumococcal conjugate vaccine (PCV10) in July 2013 using a 3-dose primary series at ages 6, 10, and 14 weeks with no booster. We evaluated the impact of PCV10 on meningitis and pneumonia hospitalizations. Methods: Using hospitalization data from first-level care hospitals, available at the Ministry of Health, and from the largest pediatric referral hospital in Lusaka, we identified children aged <5 years who were hospitalized with pneumonia or meningitis from January 2010–December 2016. We used time-series analyses to measure the effect of PCV10 on monthly case counts by outcome and age group (<1 year, 1–4 years), accounting for seasonality. We defined the pre- and post-PCV10 periods as January 2010–June 2013 and July 2014–December 2016, respectively. Results: At first-level care hospitals, pneumonia and meningitis hospitalizations among children aged <5 years accounted for 108 884 and 1742 admissions in the 42 months pre-PCV10, respectively, and 44 715 and 646 admissions in the 30 months post-PCV10, respectively. Pneumonia hospitalizations declined by 37.8% (95% confidence interval [CI] 21.4–50.3%) and 28.8% (95% CI 17.7–38.7%) among children aged <1 year and 1–4 years, respectively, while meningitis hospitalizations declined by 72.1% (95% CI 63.2–79.0%) and 61.6% (95% CI 50.4–70.8%), respectively, in these age groups. In contrast, at the referral hospital, pneumonia hospitalizations remained stable and a smaller but significant decline in meningitis was observed among children aged 1–4 years (39.3%, 95% CI 16.2–57.5%). Conclusions: PCV10 introduction was associated with declines in meningitis and pneumonia hospitalizations in Zambia, especially in first-level care hospitals.

59 BASIC BIOLOGICAL SCIENCES↗

Measuring M31 globular cluster ages and metallicities using both photometry and spectroscopy

ABSTRACT The ages and metallicities of globular clusters play an important role not just in testing models for their formation and evolution but also in understanding the assembly history of their host galaxies. Here, we use a combination of imaging and spectroscopy to measure the ages and metallicities of globular clusters in M31, the closest massive galaxy to our own. We use the strength of the near-infrared calcium triplet spectral feature to provide a relatively age-insensitive prior on the metallicity when fitting stellar population models to the observed photometry. While the age–extinction degeneracy is an issue for globular clusters projected on to the disc of M31, we find generally old ages for globular clusters in the halo of M31 and in its satellite galaxy NGC 205 in line with previous studies. We measure ages for a number of outer halo globular clusters for the first time, finding that globular clusters associated with halo substructure extend to younger ages and higher metallicities than those associated with the smooth halo. This is in line with the expectation that the smooth halo was accreted earlier than the substructured halo.

Usher, Christopher (ORCID:0000000273837106)↗