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At least 451 records · Page 25

SU-G-JeP1-15: Sliding Window Prior Data Assisted Compressed Sensing for MRI Lung Tumor Tracking

Purpose: Prior Data Assisted Compressed Sensing (PDACS) is a partial k-space acquisition and reconstruction method for mobile tumour (i.e. lung) tracking using on-line MRI in radiotherapy. PDACS partially relies on prior data acquired at the beginning of dynamic scans, and is therefore susceptible to artifacts in longer duration scan due to slow drifts in MR signal. A novel sliding window strategy is presented to mitigate this effect. Methods: MRI acceleration is simulated by retrospective removal of data from the fully sampled sets. Six lung cancer patients were scanned (clinical 3T MRI) using a balanced steady state free precession (bSSFP) sequence for 3 minutes at approximately 4 frames per second, for a total of 650 dynamics. PDACS acceleration is achieved by undersampling of k-space in a single pseudo-random pattern. Reconstruction iteratively minimizes the total variations while constraining the images to satisfy both the currently acquired data and the prior data in missing k-space. Our novel sliding window technique (SW-PDACS), uses a series of distinct pseudo-random under-sampling patterns of partial k-space – with the prior data drawn from a sliding window of the most recent data available. Under-sampled data, simulating 2 – 5x acceleration are reconstructed using PDACS and SW-PDACS. Three quantitative metrics: artifact power, centroid error and Dice’s coefficient are computed for comparison. Results: Quantitively metric values from all 6 patients are averaged in 3 bins, each containing approximately one minute of dynamic data. For the first minute bin, PDACS and SW-PDACS give comparable results. Progressive decline in image quality metrics in bins 2 and 3 are observed for PDACS. No decline in image quality is observed for SW-PDACS. Conclusion: The novel approach presented (SW-PDACS) is a more robust for accelerating longer duration (>1 minute) dynamic MRI scans for tracking lung tumour motion using on-line MRI in radiotherapy. B.G. Fallone is a co-founder and CEO of MagnetTx Oncology Solutions (under discussions to license Alberta bi-planar linac MR for commercialization).

60 APPLIED LIFE SCIENCES↗

Two-fluid electromagnetic simulations of plasma-jet acceleration with detailed equation-of-state

We describe a new particle-based two-fluid fully electromagnetic algorithm suitable for modeling high density (n{sub i} {approx} 10{sup 17} cm{sup -3}) and high Mach number laboratory plasma jets. In this parameter regime, traditional particle-in-cell (PIC) techniques are challenging due to electron timescale and lengthscale constraints. In this new approach, an implicit field solve allows the use of large timesteps while an Eulerian particle remap procedure allows simulations to be run with very few particles per cell. Hall physics and charge separation effects are included self-consistently. A detailed equation of state (EOS) model is used to evolve the ion charge state and introduce non-ideal gas behavior. Electron cooling due to radiation emission is included in the model as well. We demonstrate the use of these new algorithms in 1D and 2D Cartesian simulations of railgun (parallel plate) jet accelerators using He and Ar gases. The inclusion of EOS and radiation physics reduces the electron temperature, resulting in higher calculated jet Mach numbers in the simulations. We also introduce a surface physics model for jet accelerators in which a frictional drag along the walls leads to axial spreading of the emerging jet. The simulations demonstrate that high Mach number jets can be produced by railgun accelerators for a variety of applications, including high energy density physics experiments.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Anomaly detection with flow-based fast calorimeter simulators

Recently, several normalizing flow-based deep generative models have been proposed to accelerate the simulation of calorimeter showers. Using caloflow as an example, we show that these models can simultaneously perform unsupervised anomaly detection with no additional training cost. As a demonstration, we consider electromagnetic showers initiated by one (background) or multiple (signal) photons. The caloflow model is designed to generate single-photon showers, but it also provides access to the shower likelihood. We use this likelihood as an anomaly score and study the showers tagged as being unlikely. As expected, the tagger struggles when the signal photons are nearly collinear but is otherwise effective. This approach is complementary to a supervised classifier trained on only specific signal models using the same low-level calorimeter inputs. While the supervised classifier is also highly effective at unseen signal models, the unsupervised method is more sensitive in certain regions, and, thus, we expect that the ultimate performance will require a combination of these approaches.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

BiRD (BioReactorDesign) [SWR-24-35]

Numerical simulations can accelerate scale up and optimization of bioreactors. This project provides a toolbox to facilitate such numerical simulations in OpenFOAM. The tool box contains 1) mesh generations tools for several typical bio reactor types in OpenFOAM 2) Inverse modeling tools to calibrate models using available experimental data 3) post processing tools that accelerate and streamline the analysis of the numerical simulations.

Hassanaly, Malik↗

The extent of non-thermal particle acceleration in relativistic, electron-positron reconnection

Reconnection is studied as an explanation for high-energy flares from the Crab Nebula. The production of synchrotron emission >100 MeV challenges classical models of acceleration. 3D simulation shows that reconnection, converting magnetic energy to kinetic energy, can accelerate beyond γ rad . The power-law index and high-energy cutoff are important for understanding the radiation spectrum dN/dγ = f(γ) ∝ γ -α . α and cutoff were measured vs. L and σ, where L is system (simulation) size and σ is upstream magnetization (σ = B 2 /4πnmc 2 ). α can affect the high-energy cutoff. In conclusion, for collisionless relativistic reconnection in electron-positron plasma, without guide field, n b /n d =0.1: (1) relativistic magnetic reconnection yields power-law particle spectra, (2) the power law index decreases as σ increases, approaching ≈1.2. (3) the power law is cut off at an energy related to acceleration within a single current layer, which is proportional to the current layer length (for small systems, that length is the system length, yielding γ c2 ≈ 0.1 L/ρ 0 ; for large systems, the layer length is limited by secondary tearing instability, yielding γ c1 ≈ 4σ; the transition from small to large is around L/ρ 0 = 40σ.). (4) although the large-system energy cutoff is proportional to the average energy per particle, it is significantly higher than the average energy per particle.

79 ASTRONOMY AND ASTROPHYSICS↗

Advanced Klystrons for High Efficiency Accelerator Systems (Final Report)

This program explored tailoring of RF pulses used to drive accelerator cavities. Simulations indicated that properly shaping the pulse risetime to match accelerator cavity characteristics reduced reflected power and increased total efficiency. Tailoring the pulse requires a high power, gridded, klystron to shape the risetime while also controlling the beam current. The Phase I program generated a preliminary design of a gridded electron gun for a klystron producing 5-10 MW of RF power. This required design of a segmented cathode using Controlled Porosity Reservoir cathodes to limit power deposition on the grid. The program was successful in computationally designing a gun producing a high quality electron beam with grid control. Additional analysis of pulse tailoring indicated that technique would only be useful for cavity drive pulses that were less than approximately 2-3 times the risetime. Otherwise, the efficiency gained during the risetime of the pulse became insignificant when considering the efficiency over the entire pulse. Consequently, it was determined that a Phase II program would not provide sufficient return to justify the cost. Never the less, other applications for a high power gridded gun are currently being pursued. This klystron, for example, would facilitate development inverse Comptom x-ray sources by providing a high repetition rate (10 -100 kHz) RF source.

43 PARTICLE ACCELERATORS↗

Simulations of laser-wakefield acceleration with external electron-bunch injection for REGAE experiments at DESY

We present particle-in-cell simulations for future laser-plasma wakefield experiments with external bunch injection at the REGAE accelerator facility at DESY, Hamburg, Germany. Two effects have been studied in detail: emittance evolution of electron bunches externally injected into a wake, and longitudinal bunch compression inside the wakefield. Results show significant transverse emittance growth during the injection process, if the electron bunch is not matched to its intrinsic betatron motion inside the wakefield. This might introduce the necessity to include beam-matching sections upstream of each plasma-accelerator section with fundamental implications on the design of staged laser wakefield accelerators. When externally injected at the zero-field crossing of the laser-driven wake, the electron bunch may undergo significant compression in longitudinal direction and be accelerated simultaneously due to the gradient in the acting force. The mechanism would allow for production of single high-energy, ultra-short (on the order of one femtosecond) bunches at REGAE. The optimal conditions for maximal bunch compression are discussed in the presented studies.

43 PARTICLE ACCELERATORS↗

Performance of an optical TPC Geant4 simulation with opticks GPU-accelerated photon propagation

We investigate the performance of Opticks, a NVIDIA OptiX API 7.5 GPU-accelerated photon propagation tool compared with a single-threaded Geant4 simulation. We compare the simulations using an improved model of the NEXT-CRAB-0 gaseous time projection chamber. Performance results suggest that Opticks improves simulation speeds by between 58.47 ± 0.02 and 181.39 ± 0.28 times relative to a CPU-only Geant4 simulation and these results vary between different types of GPU and CPU. A detailed comparison shows that the number of detected photons, along with their times and wavelengths, are in good agreement between Opticks and Geant4.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

The role of the spatial heterogeneity and correlation length of surface wettability on two-phase flow in a CO 2 -water-rock system

This study characterized and modeled heterogeneous surface wettability in sandstone and investigated the role of spatial heterogeneity and correlation length of surface wettability on relative permeability in a supercritical CO 2 (scCO 2 )-brine-rock system. Understanding the role of wettability heterogeneity on relative permeability is essential to geological CO 2 sequestration, oil and gas recovery, and contaminated groundwater remediation. Although numerous studies have attempted to understand the influences of surface wettability, capillary number (Ca), and viscosity ratio, the role of the spatial variation and correlation length of surface wettability on two-phase flow in three-dimensional (3D) porous media has not been unraveled due to the challenges in the measurement and representation of realistic rock surface wettability. In this work, we conducted in-situ measurements of surface contact angle (CA) in a Bentheimer sandstone after CO 2 flooding using micro-computed tomography (micro-CT), and found that the pore-scale CA distribution on rock surfaces followed a log-normal distribution associated with a spatial correlation length. Based on the statistical information from CT scanning, a Gaussian random field was used to model CA distributions that had desired standard deviations and spatial correlation lengths, which were then adjusted within a certain range of values for sensitivity analyses to study their combined effects on the two-phase flow in the porous medium using the lattice Boltzmann (LB) method. The LB two-phase flow simulation was accelerated using hybrid, multicore parallel computing to overcome the challenges in simulating multiphase flow in a large 3D domain having 800 × 800 × 600 nodes. The simulation results showed that the surface wettability heterogeneity (i.e., standard deviation of CA) had a lesser effect on the relative permeability of the wetting fluid (water) but a more significant impact on the relative permeability of the non-wetting fluid (scCO 2 ). The Corey model was used to fit the LB-simulated relative permeability curves of water and scCO 2 and showed that the variations in the relative permeability curves for both water and scCO 2 increased as the standard deviation and spatial correlation length of CA increased. This study illustrated that the assumption of homogeneous surface wettability may cause errors in multiphase flow simulations. Furthermore, the impacts of both the standard deviation and spatial correlation length of CAs should be accounted for. This is the first study that explored the spatial correlation lengths associated with CA distributions on sandstone surfaces and comprehensively investigated the roles of both spatial variation and correlation length of CA on two-phase flow properties in 3D porous media. The optimized LB multiphase flow model was proved a powerful tool to study the interplays and combined effects of these statistical parameters, which had critical applications in numerous natural and engineering processes that involved multiphase flow in porous media.

58 GEOSCIENCES↗

Essential Signal Simulation Enabled by Netlist Transforms (ESSENT) v1.0

Hardware simulation is an indispensable tool for designing chips as well as researching future architectures. Unfortunately, the slow rate of simulation can often bottleneck the design process, as designers must wait to see the results of a simulation before changing the design and starting a new simulation. The Essential Signal Simulation Enabled by Netlist Transforms (ESSENT) is a tool designed to accelerate hardware simulations. ESSENT takes in a design, uses graph algorithms to identify opportunities for conditional execution, and generates a simulator that leverages these opportunities. The generated simulator produces the exact same simulation results that would be returned by an unoptimized simulator, but in substantially less time. For input, ESSENT takes in designs formatted in FIRRTL (an open format).

Beamer, Scott↗

Overcoming timestep limitations in boosted-frame particle-in-cell simulations of plasma-based acceleration

Explicit electromagnetic Particle-In-Cell (PIC) codes are typically limited by the Courant- Friedrichs-Lewy (CFL) condition, which implies that the timestep multiplied by the speed of light must be smaller than the smallest cell size. In the case of boosted-frame PIC simulations of plasma-based acceleration, this limitation can be a major hinderance as the cells are often very elongated along the longitudinal direction and the timestep is thus limited by the small, transverse cell size. This entails many small-timestep PIC iterations, and can limit the potential speed-up of the boosted-frame technique. Here, by using a CFL-free analytical spectral solver, and by mitigating additional numerical instabilities that arise at large timestep, we show that it is possible to overcome traditional limitations on the timestep and thereby realize the full potential of the boosted-frame technique over a much wider range of parameters.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

SHarD: A beam dynamics simulation code for dielectric laser accelerators based on spatial harmonic field expansion

In order to demonstrate acceleration of electrons to relativistic scales by an on chip dielectric laser accelerator (DLA), a ponderomotive focusing scheme capable of capturing and transporting electrons through nanometer-scale apertures over extended interaction lengths has been proposed. Here we present a Matlab-based numerical code (SHarD) utilizing a spatial harmonic expansion of the fields within the dielectric structure to simulate the evolution of the beam phase space distribution in this scheme. The code can be used to optimize key-parameters for the accelerator performance such as the final energy, transverse spot size evolution and total number of electrons accelerated through currently fabricated structures. Eventually, the simulation model will be applied to inform the phase mask profile to be added to a pulse front tilt drive laser pulse using a liquid crystal mask in the experimental setup being assembled at UCLA Pegasus Laboratory.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Beam dynamics and wakefield simulations of the double grating accelerating structure

Laser-driven acceleration in dielectric structures can provide gradients on the order of GeV/m. The small transverse dimension and tiny feature sizes introduce challenges in design, fabrication, and simulation studies of these structures. In this paper we present the results of beam dynamic simulation and short range longitudinal wakefield simulation of the double grating structure. We show the linear trend of acceleration in a dielectric accelerator design and calculate the maximum achievable gradient equal to 0.47E{sub 0} where E0 is maximum electric field of the laser excitation. On the other hand, using wakefield simulations, we show that the loss factor of the structure with 400nm gap size will be 0.12GV/m for a 10fC, 100as electron bunch which is an order of magnitude less than expected gradient near damage threshold of the device.

43 PARTICLE ACCELERATORS↗

Experiments in sensing transient rotational acceleration cues on a flight simulator

Results are presented for two transient motion sensing experiments which were motivated by the identification of an anomalous roll cue (a 'jerk' attributed to an acceleration spike) in a prior investigation of realistic fighter motion simulation. The experimental results suggest the consideration of several issues for motion washout and challenge current sensory system modeling efforts. Although no sensory modeling effort is made it is argued that such models must incorporate the ability to handle transient inputs of short duration (some of which are less than the accepted latency times for sensing), and must represent separate channels for rotational acceleration and velocity sensing.

Parrish, R. V.↗

Flight simulation testing of advanced composites for supersonic cruise aircraft applications

The goal of this program is to characterize advanced composite systems before and after exposures to simulated supersonic cruise environments for real times of up to 50,000 hours. Fatigue data for specimens tested at various temperatures and stress ratios are presented. The changes in properties and the degradation mechanisms during high temperature aging are discussed and illustrated using metallographic and fractographic techniques. Initial results of long term flight simulation tests are presented and compared with wearout model predictions based on accelerated flight simulation exposures.

Haskins, J. F.↗