Superconductor Electronics and the International Roadmap for Devices and Systems.
Abstract not provided.
Holmes, D. Scott↗
SEARCH · Engineering Papers
Results for “Roadmap”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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A roadmap for improving the representation of photosynthesis in Earth System Models
Accurate representation of photosynthesis in terrestrial biosphere models (TBMs) is essential for robust projections of global change. However, current representations vary markedly between TBMs, contributing uncertainty projections of global carbon fluxes.
54 ENVIRONMENTAL SCIENCES↗
A roadmap to understanding and anticipating microbial gene transfer in soil communities
Engineered microbes are being programmed using synthetic DNA for applications in soil to overcome global challenges related to climate change, energy, food security, and pollution. However, we cannot yet predict gene transfer processes in soil to assess the frequency of unintentional transfer of engineered DNA to environmental microbes when applying synthetic biology technologies at scale. This challenge exists because of the complex and heterogeneous characteristics of soils, which contribute to the fitness and transport of cells and the exchange of genetic material within communities. Here, we describe knowledge gaps about gene transfer across soil microbiomes. Here, we propose strategies to improve our understanding of gene transfer across soil communities, highlight the need to benchmark the performance of biocontainment measures in situ, and discuss responsibly engaging community stakeholders. We highlight opportunities to address knowledge gaps, such as creating a set of soil standards for studying gene transfer across diverse soil types and measuring gene transfer host range across microbiomes using emerging technologies. By comparing gene transfer rates, host range, and persistence of engineered microbes across different soils, we posit that community-scale, environment-specific models can be built that anticipate biotechnology risks. Such studies will enable the design of safer biotechnologies that allow us to realize the benefits of synthetic biology and mitigate risks associated with the release of such technologies.
bioccontainment↗
Semantic Technologies in Practical Demand Response: An Information Requirement-based Roadmap
Explore the source record for details and available documents.
Mulayim, Ozan Baris↗
STREAM: Strategic Technology Roadmapping and Energy, Environmental, and Economic Analysis Model
This is the implementation of the framework for the planning of the technological makeup of the industrial sector. Motivated by the efforts to achieve carbon neutrality, the model of this framework modifies the portfolio of technologies over time for the sector of interest such that, - Net Present Value (NPV) is minimized - Constraint on Greenhouse Emissions (GHG), e.g. carbon dioxide, is satisfied - Demand of the underlying commodity is satisfied - The current implementation reflects a case study for the electric power sector. The for a given initial set of capacities of different vintages, the space of decisions include, - Retirement of the existing capacities. - Retrofitting the existing capacities to alternative characteristics. - Creation of new capacities from a technology portfolio. All the associated quantities with the deployments, e.g. CO2, heat requirement, etc.
Thiery, David↗
A Roadmap for the Future of Systems Biology in Cancer Research
Cancer systems biology seeks to understand how cancer arises as a system of interconnected molecules, cells, and tissues, with the goal of understanding, predicting, and controlling the disease. In the last decade, the field has rapidly grown as advances in experimental, computational, and analytic technologies have improved our ability to capture and recapitulate the complexities of cancer at multiple scales. However, the field’s promise to understand how specific molecular changes give rise to altered cancer outcomes remains incompletely fulfilled. Fortunately, an opportunity exists to accelerate progress by better coordinating modeling and data-gathering efforts across the cancer systems biology community. This will create the foundation for building accurate, multiscale cancer models that can better predict and identify improved therapeutic interventions. Here, in this study, we outline some of the current challenges in cancer systems biology research, how they can be addressed, and actions that the community can take to accelerate progress in the field.
Modeling & Simulation↗
HUMAN-ARTIFICIAL INTELLIGENCE TEAMING FOR THE U.S. NAVY: DEVELOPING A HOLISTIC RESEARCH ROADMAP
With the ever-increasing deluge of data and demand for warfighters to make decisions upon its analysis, U.S. defense strategy has prioritized the development of artificial intelligence (AI)/machine learning (ML) systems that can analyze multi-source data streams and suggest courses of action. However, there is a history of systems that have failed to be adopted by the warfighter due not only to unsolved technical challenges, but also a lack of usability or contributions to mission effectiveness, perceived or otherwise. To avoid this, research into human-AI teaming shows promise for developing AI systems that work with frontline operators. A recent National Academies of Sciences, Engineering, and Medicine report (NASEM, 2022) presented 57 research objectives in this area; however, the U.S. Navy requires a more-focused set of priorities, as it is impossible to tackle every priority. A workshop involving 23 human factors scientists, computer scientists, and active-duty sailors was organized at the Naval Information Warfare Center Pacific, resulting in a set of five research priorities spanning near-, mid-, and far-term time frames. This panel will summarize the results of this workshop, with a focus on the big questions both going into this workshop and coming out of it. The panel participants come from government, academia, and industry, providing perspective from the different kinds of organizations required to accomplish these research goals.
Wong, Jason↗
A metagenomics roadmap to the uncultured genome diversity in hypersaline soda lake sediments
Not Available
Candidate PhylaRadiation↗
Roadmap for the future of extreme wildfire events
Background Extreme wildfire events (EWEs) represent a growing threat globally, posing substantial risks to ecosystems, human communities, and infrastructure. Despite increased recognition of their ecological, social, and economic significance, current definitions of EWEs vary widely, reflecting disciplinary biases and regional contexts. This article emerges from an interdisciplinary workshop convened to reassess and refine the definition of EWEs, examine their impacts across ecological and social dimensions, and identify critical knowledge gaps impeding our understanding of these infrequent but important events. Results Our synthesis highlights significant limitations with existing definitions, particularly their reliance on subjective thresholds and their emphasis on extreme fire behavior alone. EWEs encompass a spectrum of complex, multi-dimensional phenomena that extend beyond immediate biophysical characteristics to include cumulative social, economic, and ecological impacts. These impacts often manifest over extended timeframes and include hazardous environmental contamination, severe geomorphic disturbances, ecosystem transformations, and unintended consequences of post-fire management actions. Current wildfire modeling frameworks inadequately capture these compounding factors, particularly the interactions among social systems, ecological conditions, and extreme fire behavior. To overcome these issues, we advocate for an interdisciplinary and context-sensitive approach to defining and studying EWEs. This revised definition emphasizes wildfires exhibiting anomalies in fire behavior, ecological outcomes, or social impacts relative to historically observed baselines, accommodating variability across different geographic regions and ecological settings. Conclusions Adopting an interdisciplinary framework that integrates biophysical and social sciences will enhance the predictive capability of wildfire models and improve resilience planning and response strategies. Filling identified knowledge gaps—such as limited high-quality empirical fire behavior data and insufficient integration of social dynamics into modeling—will better prepare communities and ecosystems to cope with and adapt to EWEs. This inclusive approach underscores the necessity for collaboration across disciplines and sectors, essential to managing extreme wildfires in an era of increasing climatic and ecological uncertainty.
54 ENVIRONMENTAL SCIENCES↗
Biophysical characterization and a roadmap towards the NMR solution structure of G0S2, a key enzyme in non-alcoholic fatty liver disease
In the United States non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, affecting an estimated 80 to 100 million people. It occurs in every age group, but predominantly in people with risk factors such as obesity and type 2 diabetes. NAFLD is marked by fat accumulation in the liver leading to liver inflammation, which may lead to scarring and irreversible damage progressing to cirrhosis and liver failure. In animal models, genetic ablation of the protein G0S2 leads to alleviation of liver damage and insulin resistance in high fat diets. The research presented in this paper aims to aid in rational based drug design for the treatment of NAFLD by providing a pathway for a solution state NMR structure of G0S2. Here we describe the expression of G0S2 in an E. coli system from two different constructs, both of which are confirmed to be functionally active based on the ability to inhibit the activity of Adipose Triglyceride Lipase. In one of the constructs, preliminary NMR spectroscopy measurements show dominant alpha-helical characteristics as well as resonance assignments on the N-terminus of G0S2, allowing for further NMR work with this protein. Additionally, the characterization of G0S2 oligomers are outlined for both constructs, suggesting that G0S2 may defensively exist in a multimeric state to protect and potentially stabilize the small 104 amino acid protein within the cell. This information presented on the structure of G0S2 will further guide future development in the therapy for NAFLD.
59 BASIC BIOLOGICAL SCIENCES↗
Material Protection, Accounting, and Control Technologies (MPACT) Advanced Integration Roadmap
The development of sustainable advanced nuclear fuel cycles is a long-term goal of the Office of Nuclear Energy’s (DOE-NE) Fuel Cycle Technologies program. The Material Protection, Accounting, and Control Technologies (MPACT) campaign is supporting research and development (R&D) of advanced instrumentation, analysis tools, and integration methodologies to meet this goal (Miller, 2015). This advanced R&D is intended to facilitate safeguards and security by design of fuel cycle facilities. The lab-scale demonstration of a virtual facility, distributed test bed, that connects the individual tools being developed at National Laboratories and university research establishments, is a key program milestone for 2020. These tools will consist of instrumentation and devices as well as computer software for modeling, simulation and integration.
11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
A Bottom-up Energy Efficiency Improvement Roadmap for China’s Iron and Steel Industry up to 2050
Iron and steel manufacturing is energy intensive in China and in the world. China is the world largest steel producer accounting for around half of the world steel production. In this study, we use a bottom-up energy consumption model to analyze four steel-production and energy-efficiency scenarios and evaluate the potential for energy savings from energy-efficient technologies in China’s iron and steel industry between 2010 and 2050. The results show that China’s steel production will rise and peak in the year 2020 at 860 million tons (Mt) per year for the base-case scenario and 680 Mt for the advanced energy-efficiency scenario. From 2020 on, production will gradually decrease to about 510 Mt and 400 Mt in 2050, for the base-case and advanced scenarios, respectively. Energy intensity will decrease from 21.2 gigajoules per ton (G/t) in 2010 to 12.2 GJ/t and 9.9 GJ/t in 2050 for the base-case and advanced scenarios, respectively. In the near term, decreases in iron and steel industry energy intensity will come from adoption of energy-efficient technologies. In the long term, a shift in the production structure of China’s iron and steel industry, reducing the share of blast furnace/basic oxygen furnace production and increasing the share of electric-arc furnace production while reducing the use of pig iron as a feedstock to electric-arc furnaces will continue to reduce the sector’s energy consumption. We discuss barriers to achieving these energy-efficiency gains and make policy recommendations to support improved energy efficiency and a shift in the nature of iron and steel production in China.
32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
DOE OE Energy Storage Systems Safety Roadmap.
Foster confidence in the safety and reliability of energy storage systems.
25 ENERGY STORAGE↗
Roadmap for disposal of Electrorefiner Salt as Transuranic Waste.
The experimental breeder reactor (EBR-II) used fuel with a layer of sodium surrounding the uranium-zirconium fuel to improve heat transfer. Disposing of EBR-II fuel in a geologic repository without treatment is not prudent because of the potentially energetic reaction of the sodium with water. In 2000, the US Department of Energy (DOE) decided to treat the sodium-bonded fuel with an electrorefiner (ER), which produces metallic uranium product, a metallic waste, mostly from the cladding, and the salt waste in the ER, which contains most of the actinides and fission products. Two waste forms were proposed for disposal in a mined repository; the metallic waste, which was to be cast into ingots, and the ER salt waste, which was to be further treated to produce a ceramic waste form. However, alternative disposal pathways for metallic and salt waste streams may reduce the complexity. For example, performance assessments show that geologic repositories can easily accommodate the ER salt waste without treating it to form a ceramic waste form. Because EBR-II was used for atomic energy defense activities, the treated waste likely meets the definition of transuranic waste. Hence, disposal at the Waste Isolation Pilot Plant (WIPP) in southern New Mexico, may be feasible. This report reviews the direct disposal pathway for ER salt waste and describes eleven tasks necessary for implementing disposal at WIPP, provided space is available, DOE decides to use this alternative disposal pathway in an updated environmental impact statement, and the State of New Mexico grants permission.
12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
Energy Storage Financing: A Roadmap for Accelerating Market Growth
Project financing is emerging as the linchpin for the future health, direction, and momentum of the energy storage industry. Market leaders have so far relied on self-funding or captive lending arrangements to fund projects. New lenders are proceeding hesitantly as they lack a full understanding of the technology, business, and credit risks involved in this rapidly changing market. The U.S. Department of Energy is poised to play a critical role in expanding access to capital by reducing the barriers to entry for new lenders, and providing trusted analytical benchmarks to better judge and price the risk in systematic ways.
29 ENERGY PLANNING, POLICY, AND ECONOMY↗
Reducing Energy Burden with Solar: Colorado's Strategy and Roadmap for States
The Colorado Energy Office (CEO) recently implemented a multi-pronged strategy to reduce energy burden for low-income (LI) Colorado residents through the deployment of solar electricity generation. Due to these efforts, approximately 20 MW of photovoltaic (PV) solar may be deployed in Colorado by the end of 2019 specifically for low-income households. Relying on interviews with ten subject-matter experts and other research, this report outlines the details of the CEO strategy including why the agency pursued this strategy, how it was carried out, and lessons learned from implementation. Though CEO's strategy is unique and tailored to the needs of Colorado, it is possible that other states might learn from CEO's experiences when designing their own LI strategies. As a result, the report concludes by outlining six primary steps for designing a comprehensive low-income solar strategy.
14 SOLAR ENERGY↗
DOE OE Energy Storage Systems Safety Roadmap Focus on Proposed Changes to the ICC International Codes Special Briefing Paper — Unofficial Hearing Results April 2018
The goal of the DOE OE ESS Safety Roadmap1 is to foster confidence in the safety and reliability of energy storage systems (ESSs). Three interrelated objectives support the realization of that goal: research, codes and standards, and communication/coordination. The objective focused on codes and standards is - To apply research and development (R&D) to support efforts that are focused on ensuring that codes and standards are available to enable the safe implementation of ESSs in a comprehensive, non-discriminatory and science-based manner. The purpose of this special briefing paper is to support the above objective by providing information about current and upcoming efforts being conducted by U.S. standards developing organizations, specifically code changes associated with the 2018 Group A International Codes (I-Codes) of the International Code Council (ICC) that are relevant to ESSs.
25 ENERGY STORAGE↗