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At least 451 records · Page 25

SU-F-T-550: Radiochromic Plastic Thin Sheet Dosimeter: Initial Performance

Purpose: Thin sheets, of a high sensitivity formulation of radiochromic dosimeter, Presage were prepared and evaluated for optical readout. Methods: Sheets of radiochromic polyurethane, 12 cm long, 10 cm wide and 0.2 cm thick were prepared with leuco crystal violet as the reporter molecule. Sample transmission was evaluated at a wavelength of 590 nm with in-house constructed instruments: optical cone beam laser CT scanner, fixed and scanning spot densitometers. Sample sequential irradiations to a total dose of 40 Gy were conducted with a modified, Theratron 60, cobalt radiotherapy machine at dose rates of 1 or 0.25 Gy per minute. Exposure to ambient and readout light was minimized to limit background photochromic signals. Samples were stored at 4°C. Optical activity was assessed from linearly polarized transmission images. Comparison sensitivity measurements with EBT3 film were conducted. Results: Samples were transparent, smooth and pale purple before irradiation. Radiochromic reaction was completed in less than 5 minutes. A linear dose response with a sensitivity of 0.5 cm-1Gy-1 was observed. Micrometer measurements found sheet thickness variations up to 20%. Uniform dose, 2 Gy attenuation images, correlated with local sheet thicknesses. Comparable measurements with EBT3 film were 3 times more sensitive at 1 Gy but above 15 Gy, EBT3 film had lower sensitivity than 0.2 cm thick Presage sheet dosimeter due to its non-linear response. Conclusion: Dose sensitivity provided a 10% decrease in transmission for a 1 Gy dose. Improvements in mold design are expected to allow production of sheets with less than 5% variation in thickness. Above, 10 Gy, Presage sheet dosimeter performance expected to exceed EBT3 film based on linearity, sensitivity, transparency and smoothness of samples. J Adamovics is owner of Heuris Inc.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

SU-G-IeP1-15: Towards Accurate Cerebral Blood Flow Quantification with Distortion- Corrected Pseudo-Continuous Arterial Spin Labeling

Purpose: Traditional arterial spin labeling (ASL) acquisitions with echo planar imaging (EPI) readouts suffer from image distortion due to susceptibility effects, compromising ASL’s ability to accurately quantify cerebral blood flow (CBF) and assess disease-specific patterns associated with CBF abnormalities. Phase labeling for additional coordinate encoding (PLACE) can remove image distortion; our goal is to apply PLACE to improve the quantitative accuracy of ASL CBF in humans. Methods: Four subjects were imaged on a 3T Philips Ingenia scanner using a 16-channel receive coil with a 21/21/10cm (frequency/phase/slice direction) field-of-view. An ASL sequence with a pseudo-continuous ASL (pCASL) labeling scheme was employed to acquire thirty dynamics of single-shot EPI data, with control and label datasets for all dynamics, and PLACE gradients applied on odd dynamics. Parameters included a post-labeling delay = 2s, label duration = 1.8s, flip angle = 90°, TR/TE = 5000/23.5ms, and 2.9/2.9/5.0mm (frequency/phase/slice direction) voxel size. “M0” EPI-reference images and T1-weighted spin-echo images with 0.8/1.0/3.3mm (frequency/phase/slice directions) voxel size were also acquired. Complex conjugate image products of pCASL odd and even dynamics were formed, a linear phase ramp applied, and data expanded and smoothed. Data phase was extracted to map control, label, and M0 magnitude image pixels to their undistorted locations, and images were rebinned to original size. All images were corrected for motion artifacts in FSL 5.0. pCASL images were registered to M0 images, and control and label images were subtracted to compute quantitative CBF maps. Results: pCASL image and CBF map distortions were removed by PLACE in all subjects. Corrected images conformed well to the anatomical T1-weighted reference image, and deviations in corrected CBF maps were evident. Conclusion: Eliminating pCASL distortion with PLACE can improve CBF quantification accuracy using minimal pulse sequence modifications and no additional scan time, improving ASL’s clinical applicability.

60 APPLIED LIFE SCIENCES↗

TH-AB-201-04: Clinical Protocol for Reuse of Optically Stimulated Luminescence Detectors

Purpose: OSLDs made of Al2O3:C have many useful dosimetric characteristics including their ability to be reused. The signal on an OSLD can be removed through heat or light. The objective of this study was to characterize the change in sensitivity associated with annealing OSLDs with light and in doing so define a range through which reuse is viable. Methods: Four groups of nanoDot OSLDs were repeatedly irradiated and bleached to create accumulated dose history. Each group’s repeated irradiation remained constant at either 50, 100, 200, or 500 cGy. Before both irradiation and bleaching the OSLDs were read out, giving the dose reading and ensuring that ample bleaching had occurred, respectively. New and used OSLDs were compared in several clinical situations to verify accuracy. One final test involved correcting the readout dose based on the loss of sensitivity seen in the accumulated dose data. Results: In the first 40 Gy of accumulated dose the sensitivity can be broken into two regions: a region of sensitivity change and a region of no sensitivity change. From 0 cGy to an average of 1080 cGy the sensitivity does not change. After 1080 cGy the sensitivity begins to decrease linearly with an average slope of 0.00456 cGy lost per cGy accumulated after the cutoff point. The slope and cutoff point were used to correct readings in the final test, reducing the error from 6.8% to 3.9%. Conclusion: In the region of no sensitivity change OSLDs can be reused without concern to the validity of their result. Readings must be corrected if OSLDs are to be used in the region of sensitivity change, above 1080 cGy. After 40 Gy OSLDs must be retired because the sensitivity change reverses, making linear correction no longer feasible.

60 APPLIED LIFE SCIENCES↗

TH-CD-201-06: Experimental Characterization of Acoustic Signals Generated in Water Following Clinical Photon and Electron Beam Irradiation

Purpose: Previous work has demonstrated the detectability of acoustic waves induced following the irradiation of high density metals with radiotherapy linac photon beams. This work demonstrates the ability to experimentally detect such acoustic signals following both photon and electron irradiation in a more radiotherapy relevant material. The relationship between induced acoustic signal properties in water and the deposited dose distribution is explored, and the feasibility of exploiting such signals for radiotherapy dosimetry is demonstrated. Methods: Acoustic waves were experimentally induced in a water tank via the thermoacoustic effect following a single pulse of photon or electron irradiation produced by a clinical linac. An immersion ultrasound transducer was used to detect these acoustic waves in water and signals were read out on an oscilloscope. Results: Peaks and troughs in the detected acoustic signals were found to correspond to the location of gradients in the deposited dose distribution following both photon and electron irradiation. Signal amplitude was linearly related to the dose per pulse deposited by photon or electron beams at the depth of detection. Flattening filter free beams induced large acoustic signals, and signal amplitude decreased with depth after the depth of maximum dose. Varying the field size resulted in a temporal shift of the acoustic signal peaks and a change in the detected signal frequency. Conclusion: Acoustic waves can be detected in a water tank following irradiation by linac photon and electron beams with basic electronics, and have characteristics related to the deposited dose distribution. The physical location of dose gradients and the amount of dose deposited can be inferred from the location and magnitude of acoustic signal peaks. Thus, the detection of induced acoustic waves could be applied to photon and electron water tank and in vivo dosimetry. This work was supported in part by CIHR grants MOP-114910 and MOP-136774. S.H. acknowledges support by the NSERC CREATE Medical Physics Research Training Network grant 432290.

60 APPLIED LIFE SCIENCES↗

TH-CD-BRA-11: Implementation and Evaluation of a New 3D Dosimetry Protocol for Validating MRI Guided Radiation Therapy Treatments

Purpose: To develop, evaluate and apply a novel high-resolution 3D remote dosimetry protocol for validation of MRI guided radiation therapy treatments (MRIdian by ViewRay™). We demonstrate the first application of the protocol (including two small but required new correction terms) utilizing radiochromic 3D plastic PRESAGE™ with optical-CT readout. Methods: A detailed study of PRESAGE™ dosimeters (2kg) was conducted to investigate the temporal and spatial stability of radiation induced optical density change (ΔOD) over 8 days. Temporal stability was investigated on 3 dosimeters irradiated with four equally-spaced square 6MV fields delivering doses between 10cGy and 300cGy. Doses were imaged (read-out) by optical-CT at multiple intervals. Spatial stability of ΔOD response was investigated on 3 other dosimeters irradiated uniformly with 15MV extended-SSD fields with doses of 15cGy, 30cGy and 60cGy. Temporal and spatial (radial) changes were investigated using CERR and MATLAB’s Curve Fitting Tool-box. A protocol was developed to extrapolate measured ΔOD readings at t=48hr (the typical shipment time in remote dosimetry) to time t=1hr. Results: All dosimeters were observed to gradually darken with time (<5% per day). Consistent intra-batch sensitivity (0.0930±0.002 ΔOD/cm/Gy) and linearity (R2=0.9996) was observed at t=1hr. A small radial effect (<3%) was observed, attributed to curing thermodynamics during manufacture. The refined remote dosimetry protocol (including polynomial correction terms for temporal and spatial effects, CT and CR) was then applied to independent dosimeters irradiated with MR-IGRT treatments. Excellent line profile agreement and 3D-gamma results for 3%/3mm, 10% threshold were observed, with an average passing rate 96.5%± 3.43%. Conclusion: A novel 3D remote dosimetry protocol is presented capable of validation of advanced radiation treatments (including MR-IGRT). The protocol uses 2kg radiochromic plastic dosimeters read-out by optical-CT within a week of treatment. The protocol requires small corrections for temporal and spatially-dependent behaviors observed between irradiation and readout.

60 APPLIED LIFE SCIENCES↗

Searches for a sterile-neutrino admixture in detecting tritium decays in a proportional counter: New possibilities

An experiment aimed at searches for an admixture of a sterile neutrino whosemass is 1 to 8 keV via detecting electrons from tritium decay in a proportional counter is proposed. The admixture in question can be discovered by a specific distortion of the energy spectrum of these electrons. For the above masses, the distortion extends over the whole spectrum; therefore, use can bemade of detectors that have a relatively low energy resolution (about 10 to 15%). A classic proportional counter is a simple and natural choice of detector for the decays of a gaseous tritium. The approach that we propose is novel in two respects. On one hand, the proportional counter used is made as a discrete unit in the form of a fully fused quartz tube. This permits a readout of current signals directly from the anode filament and ensures a high stability in the case of long-term measurements. At the same time, the application of state-of-the-art digital data-acquisition methods will make it possible to perform measurements under conditions of high counting rates—up to 10{sup 6} Hz. As a result, the energy spectrum of electrons from tritium decays that is formed by 10{sup 12} counts could be accumulated within about a month. This data sample would make it possible to set an upper limit in the range of 10{sup −3}–10{sup −5} on a sterile-neutrino admixture at a confidence level of three standard deviations (3σ) for m{sub s} in the range of 1–8 keV, this being one to two orders of magnitude more stringent than present-day limits.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Digital optical module electronics of KM3NeT

The KM3NeT neutrino telescope is being built on the Mediterranean sea and, once completed, it will be composed by tens of thousands of glass spheres (nodes) including each 31 of small photocathode (3”). The readout and data acquisition system of KM3NeT has to collect, treat and send to shore, in an economic way, the enormous amount of data produced by the photomultipliers and at the same time to provide time synchronization between each node at the level of 1 ns. It is described in the present article all the electronics developed for achieving this goal.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

New CHOD detector for the NA62 experiment at CERN

The New CHOD is a scintillation hodoscope with a pad structure featuring a total of 148 counters. The signal from each pad is read out using wavelength-shifting fibers and two or four SensL SiPMs with a sensitive area of 3 × 3 mm{sup 2}. This photodetector has 4774 pixels 35 × 35 μm{sup 2} in size. The key parameters (photon detection efficiency, dark current, crosstalk, and gain) were measured for 500 SiPMs.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

The beam test of muon detector parameters for the SHiP experiment at CERN

Scintillation detectors based on extruded plastics have been tested in a 10 GeV/c beam at CERN. The scintillation signal readout was provided using optical wavelength shifting fibers Y11 Kuraray and Hamamatsu MPPC micropixel avalanche photodiodes. The light yield was scanned along and across the detectors. Time resolution was found by fitting the MPPC digitized pulse rise and other methods.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Design and Prototyping of a High Granularity Scintillator Calorimeter

A novel approach for constructing fine-granularity scintillator calorimeters, based on the concept of an Integrated Readout Layer (IRL) was developed. The IRL consists of a printed circuit board inside the detector which supports the directly-coupled scintillator tiles, connects to the surface-mount SiPMs and carries the necessary front-end electronics and signal/bias traces. Prototype IRLs using this concept were designed, prototyped and successfully exposed to test beams. Concepts and implementations of an IRL carried out with funds associated with this contract promise to result in the next generation of scintillator calorimeters.

Direct coupling↗

Research and Development for the Mu2e Extinction Monitor

Mu2e is a planned experiment to search for flavor-violating conversion from a muon to an electron. The experiment will use a pulsed 8 GeV proton beam to produce muons which will then stop in an aluminum target. Mu2e will search for the $\mu^- + Al \rightarrow e^- + Al$ process. For Mu2e, an extinction rate of 10$^{-10}$ is required to reduce the backgrounds to an acceptable level. Extinction is the ratio of the amount of protons striking the production target between beam pulses to the number striking it during the beam pulse. One of the backgrounds, off-target interactions, was simulated using G4beamline and Fermilab's Grid setup to confirm that an extinction rate of 10$^{-10}$ is possible. The extinction level will be measured by the extinction monitor which will include scintillation counters read out by photomultiplier tubes. In order to build a beam time profile, low fake responses (after pulses) are needed in the photomultiplier tubes. This thesis determines the best combination of resistors, voltage, and other components that provide the lowest after pulse rate.

43 PARTICLE ACCELERATORS↗

Developing novel techniques for readout, calibration and event selection in the NOvA long-baseline neutrino experiment

The NOvA long-baseline neutrino experiment uses a fine-grained, low-Z, fully active detector that offers unprecedented electron neutrino identification capabilities for a detector of its scale. In this award’s proposal, the PI outlined the development and implementation of novel techniques for channel readout, detector calibration, and event reconstruction that make full use of the strengths of the NOvA detector technology. In particular, this included designing custom event reconstruction algorithms that utilize the rich information available in the substructure of hadronic and electromagnetic showers. Exploiting this information provides not only substantial improvement in background rejection for the electron neutrino search but also better shower energy resolution (improving the precision on measured oscillation parameters) and a high-energy electromagnetic calibration source (through neutral pion events). The PI further proposed developing and deploying a new electronics readout scheme compatible with the existing hardware that can reduce near detector event pile-up and can offer powerful timing information to the reconstruction, allowing for cosmic ray muon tagging via track direction determination, among other things. In conjunction with the above, the PI proposed leading the calibration of the NOvA detectors, including characterizing individual electronics channels, correcting for spatial variations across the detector, and establishing absolute event energy scales. All three of these lines of effort have been successfully completed, feeding directly into the NOvA’s recent exciting neutrino oscillation results. The techniques developed under this award are detailed in this final technical report.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Test of New Readout Electronics for the BONuS12 Experiment

For decades, electron-proton scattering experiments have been providing a large amount of data on the proton structure function. However, because of the instability of free neutrons, fewer experiments have been able to study the neutron structure function. The BONuS collaboration at Jefferson Laboratory addresses this challenge by scattering electrons off a deuterium target, using a RTPC capable of detecting the low-momentum spectator protons near the target. Events of electrons scattering on almost free neutrons are selected by constraining the spectator protons to very low momenta and very backward scattering angles. In 2005, BONuS successfully measured the neutron structure with scattering electrons of up to 5.3 GeV energy. An extension of this measurement has been approved using the newly upgraded 12 GeV electron beam and CLAS12 (CEBAF Large Acceptance Spectrometer). For this new set of measurements, a new RTPC detector using GEM trackers is being developed to allow measurements of spectator protons with momenta as low as 70 MeV/c. The new RTPC will use a new readout electronic system, which is also used by other trackers in CLAS12. This thesis will present the first tests of this electronics using a previously built RTPC of similar design.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

JWST Noise Floor. I. Random Error Sources in JWST NIRCam Time Series

James Webb Space Telescope (JWST) transmission and emission spectra will provide invaluable glimpses of transiting exoplanet atmospheres, including possible biosignatures. This promising science from JWST, however, will require exquisite precision and understanding of systematic errors that can impact the time series of planets crossing in front of and behind their host stars. Here, we provide estimates of the random noise sources affecting JWST Near-Infrared Camera (NIRCam) time-series data on the integration-to-integration level. We find that 1/f noise can limit the precision of grism time series for two groups (230–1000 ppm depending on the extraction method and extraction parameters), but will average down like the square root of N frames/reads. The current NIRCam grism time-series mode is especially affected by 1/f noise because its GRISMR dispersion direction is parallel to the detector fast-read direction, but could be alleviated in the GRISMC direction. Care should be taken to include as many frames as possible per visit to reduce this 1/f noise source: thus, we recommend the smallest detector subarray sizes one can tolerate, four output channels, and readout modes that minimize the number of skipped frames (RAPID or BRIGHT2). We also describe a covariance-weighting scheme that can significantly lower the contributions from 1/f noise as compared to sum extraction. We evaluate the noise introduced by pre-amplifier offsets, random telegraph noise, and high dark current resistor capacitor (RC) pixels and find that these are correctable below 10 ppm once background subtraction and pixel masking are performed. We explore systematic error sources in a companion paper.

79 ASTRONOMY AND ASTROPHYSICS↗

Optics used to measure torque at high rotational speeds

In measuring torque transmitted by a high speed rotation shaft, an apparatus has been devised which includes a shaft, an optical system and readout servomechanism. This highly accurate method uses only optical contact with moving part and is statically calibrated.

Krsek, A., Jr.↗

PLZT block data composers operated in differential phase mode

The use of a PLTZ block data composer as a matrix type phase modulator to record and process digital data by the differential phase mode in a holographic recording/processing system was investigated. The system has readout contrast ratios of between 10 and 15 to 1. The differential phase mode has the advantage that strain bias is not required and thickness and strain variations in the PLZT are cancelled out.

Drake, M. D.↗