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At least 451 records · Page 25

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NASA NTRSDate not supplied

Monocular Ranging for Small Unmanned Aerial Systems in the Far-Field

Recent proliferation of small Unmanned Aerial Systems (sUAS) applications requires onboard collision avoidance systems to mitigate the risk of collision with non-cooperative aircraft and manned aircraft, which may not see sUAS in time to perform an avoidance maneuver. An attractive avenue for onboard collision avoidance is the utilization of machine vision cameras due to their low size, weight and power (SWaP) requirements. In this paper, we characterize the range performance of a machine vision system developed in-house and mounted onto an sUAS. The technique was designed to estimate the performance of a sense-and-avoid system to ensure that the sensing components meet the well-clear requirements for the chosen platform and avoidance strategy. Experimental flight-test data was acquired from test-flights flown along multiple collision geometries for two intruders: a general Aviation (GA) aircraft and a fixed-wing sUAS. The ownship and both intruders were instrumented with inertial navigation systems (INS) recording position and attitude information. The range at first detection, 𝑹𝟎, was extracted from in-flight imagery of head-on collision course geometry synchronized with INS data from both aircraft and ground-truth values extracted from the raw imagery. This initial detection distance, 𝑹𝟎, scales with atmospheric attenuation. Therefore, under clear sky conditions, the derived 𝑹𝟎 value represents the upper bound on the detection range achievable by the test configuration of the detector. Results indicate that the maximum initial detection distance for a 4k resolution action camera fitted with a 41º Field of View (FOV) lens is 2.763 ± 0.037 km for a GA aircraft and 0.881 ± 0.061 km for a fixed-wing sUAS, respectively. The in results this study suggest that a vision-based detect and track system may be analyzed using the sensor characterization and contextualized within aircraft well-clear volumes.

Chester V. Dolph↗

NASA NTRS2020

Hawai'i Water Resources: Utilizing NASA Earth Observations to Assess Ocean Conditions Leading to the Spread of the Nuisance Red Algae (Chondria tumulosa) in Papahānaumokuākea Marine National Monument, Hawai’i

Chondria tumulosa, a newly discovered red alga, was observed in low abundance in 2016 but has since proliferated and is now smothering and decimating vast expanse of coral reefs in Manawai, located in Papahānaumokuākea Marine National Monument (PMNM). If the spread persists, the outbreak of this cryptogenic species could potentially cause region-wide ecosystem degradation. In coordination with the U.S. Fish and Wildlife Service, Marine National Monuments of the Pacific and the National Oceanographic and Atmospheric Administration (NOAA) Office of National Marine Sanctuaries’ Papahānaumokuākea Marine National Monument, this project created a tool to analyze oceanographic conditions (sea surface temperature (SST), chlorophyll-a, water velocity, salinity, turbidity) across the Monument that could potentially be driving the algal spread. The Google Earth Engine tool enabled the partners to visualize oceanographic conditions and gather time-series graphs utilizing Aqua and Terra Moderate Resolution Imaging Spectroradiometer (MODIS), Suomi National Polar-orbiting Partnership (NPP) Visible Infrared Imaging Radiometer Suite (VIIRS), Sentinel-3 Ocean and Land Colour Instrument (OLCI), Hybrid Coordinate Ocean Model (HYCOM) and NOAA's Climate Data Record in a user-friendly interface. The team used in situ SST data from subsurface temperature recorders provided by the partners to validate the tool's accuracy. Preliminary statistical analysis of MODIS data found warming trends in SST in Manawai as well as increased chlorophyll-a levels during the summer months in contrast to the control (non-infected) Lalo atoll. The tool did not aim to classify algal presence due to limited availability of higher resolution satellite imagery but instead enabled PMNM managers to monitor conditions that may be conducive to algal growth around the monument to make informed decisions and mitigation practices.

DEVELOP Project Summary↗

NASA NTRS1994

A New Generation of Intelligent Trainable Tools for Analyzing Large Scientific Image Databases

In a variety of scientific disciplines two-dimensional digital image data is now relied on as a basic component of routine scientific investigation. The proliferation of image acquisition hardware such as multi-spectral remote-sensing platforms, medical imaging sensors, and high-resolution cameras have led to the widespread use of image data in fields such as atmospheric studies, planetary geology, ecology, agriculture, glacielogy, forestry, astronomy, diagnostic medicine, to name but a few.

machine↗

NASA NTRSDate not supplied

Launch Vehicle and Spacecraft Transmitter Electromagnetic Compatibility

The Launch Services Program at NASA’s Kennedy Space Center (KSC) is the primary gate for acquiring commercial vehicles to provide a cost effective ride to space for NASA spacecraft. With the lunar Gateway, more human tended elements are planned for launch. One challenge facing the space industry is the proliferation of communication and science transmitters at frequencies beyond the qualification of space avionics and instruments. Studies have ensued to examine the intricacies of performing radiated susceptibility testing and analysis above 18 GHz. Changes in the launch vehicle communications interface to the range have also lead to new launch vehicle antenna systems and more reliance on GPS and telemetry systems. Finally, research initiated at KSC in the area of predicted electric field distributions in launch vehicle payload fairings have spawned Small Business Technology Transfer initiatives for industry to investigate statistical algorithm and computational improvements in large payload fairing modeling of transmitters at frequencies in the GHz range. These topics, along with electromagnetic compatibility testing for launch vehicles will be discussed.

Electromagnetic Testing Cavity Statistics↗

NASA NTRS2021

Predicting the Functional State of Protein Kinases Using Interpretable Graph Neural Networks

Kinases are a family of proteins that function as molecular switches, regulating several essential cellular activities such as cell proliferation. Dysfunctional kinases are implicated in several types of cancers and hence they are actively pursued as drug targets. Given the vast number of complex kinase structures that are available in the protein data bank (PDB), there is a necessity to develop methodologies that can identify structurally important moieties of the kinases in an automated fashion, for such techniques can be instrumental in identifying novel drug targets. In this work, we develop a graph neural network (GNN) based deep learning framework for classifying the functionally active and inactive states of a large set of eukaryotic protein kinases, making use of their 3D structure from the PDB. We show that GNN based machine learning models can classify protein states with an accuracy greater than 97%. We further use the GNN models to automatically identify regions of the kinases that are important for its function. For this purpose, Gradient-weighted Class Activation Mapping (Grad-CAM) was implemented on the protein graphs. Remarkably, Grad-CAM consistently identifies the highly conserved DFG motif as the most important part of the protein across the entire kinome, without any prior input. Other regions of the hydrophobic core such as the HRD motif were also identified by the interpretable GNN framework, consistent with the literature. We discuss the significance of each of these regions in detail.

Ashwin Ravichandran↗

NASA NTRS2021

Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma

Metabolic dysfunctions enabling increased nucleotide biosynthesis are necessary for supporting malignant proliferation. Our investigations indicate that upregulation of fatty acid synthase (FASN) and de novo lipogenesis, commonly observed in many cancers, are associated with nucleotide metabolic dysfunction in lymphoma. The results from our experiments showed that ribonucleotide and deoxyribonucleotide pool depletion, suppression of global RNA/DNA synthesis, and cell cycle inhibition occurred in the presence of FASN inhibition. Subsequently, we observed that FASN inhibition caused metabolic blockade in the rate-limiting step of the oxidative branch of the pentose phosphate pathway (oxPPP) catalyzed by phosphogluconate dehydrogenase (PGDH). Furthermore, we determined that FASN inhibitor treatment resulted in NADPH accumulation and inhibition of PGDH enzyme activity. NADPH is a cofactor utilized by FASN, also a known allosteric inhibitor of PGDH. Through cell-free enzyme assays consisting of FASN and PGDH, we delineated that the PGDH-catalyzed ribulose-5-phosphate synthesis is enhanced in the presence of FASN and is suppressed by increasing concentrations of NADPH. Additionally, we observed that FASN and PGDH were colocalized in the cytosol. The results from these experiments led us to conclude that NADP–NADPH turnover and the reciprocal stimulation of FASN and PGDH catalysis are involved in promoting oxPPP and nucleotide biosynthesis in lymphoma. Finally, a transcriptomic analysis of non-Hodgkin’s lymphoma (n = 624) revealed the increased expression of genes associated with metabolic functions interlinked with oxPPP, while the expression of genes participating in oxPPP remained unaltered. Together we conclude that FASN–PGDH enzymatic interactions are involved in enabling oxPPP and nucleotide metabolic dysfunction in lymphoma tumors.

Non-Hodgkin lymphoma↗

NASA NTRSDate not supplied

Analysis of the Electrical Grid for UAM

A wide range of challenges must be overcome to conduct Urban Air Mobility (UAM) operations at scale with electric vertical takeoff and landing aircraft. This presentation is on an initial analysis of one potential infrastructure challenge for UAM: available electrical grid capacity. The success of UAM is dependent upon the availability of electricity, which will be increasingly impacted by the proliferation of ground electric vehicles over time. Under the best-case assumption that electricity can be transmitted and distributed as needed within each major interconnection (i.e., electrical grid), it is estimated that the maximum number of UAM aircraft that can charge simultaneously in the continental United States will decrease by 20% from 594,878 today to 475,177 in the year 2050.

electrical grid↗

NASA NTRSDate not supplied

The Application of Remote Sensing and Machine Learning to Improve Early Warning Systems for Harmful Algal Events in the Highland Lake Chain, TX

Beginning in 2019, harmful algal events have caused canine deaths in both Lady Bird Lake and Lake Travis located near Austin, Texas. These two reservoirs are part of the larger Highland Lakes chain, managed by the City of Austin Department of Watershed Protection (COA DWP) and the Lower Colorado River Authority (LCRA), which fulfill municipal, commercial, and agricultural water demands. Given the recent increase in favorable environmental conditions for algal events in central Texas, NASA DEVELOP partnered with LCRA and COA DWP to improve monitoring and early detection of algal events, utilizing satellite remote sensing and machine learning. Spatially and temporally varied chlorophyll a concentrations, cyanobacteria detections, turbidity, and water surface temperature products are used as environmental proxies. Landsat 8 Operational Land Imager (OLI) and the Sentinel-2 MultiSpectral Instrument (MSI) data were used to provide a combined revisit time of up to ~3 days and < 30 m per pixel products. Chlorophyll a concentrations were estimated using a pre-trained Mixture Density Network, and cyanobacteria detection was accomplished using the Broad Wavelength Algae Index, which can differentiate algal blooms from algal proliferations (mats). In situ data were used to validate remotely sensed measurements and quantify uncertainties. Preliminary results show a good fit between the modeled output and in situ observations, suggesting that remote sensing data can be used to retrieve biogeochemical properties and/or inherent optical properties (IOPs) of water columns in these inland human-made lakes. Uncertainties were introduced from the sensitivity to atmospheric correction, inherent mismatch between satellite and sampling data, and a relatively lower signal-to-noise ratio over water. The resulting products enable near real-time monitoring of environmental proxies relevant to algal event presence in the Highland Lakes chain, and will ultimately support water management, decision making, and risk communication.

Shuyu Chang↗

NASA NTRS2022

Lattice Confinement Fusion and Fusion-Fast-Fission Energy Source Development

NASA and the US Navy have demonstrated Lattice Confinement Fusion (LCF) and the Fusion-Fast-Fission of natural uranium and thorium. Both methods build upon decades of research, and the latter benefits from conventional nuclear fission and fusion results. However, this nascent technology doesn’t require fissile isotopes and avoids nuclear weapons proliferation concerns from uranium 235U isotopic enrichment or plutonium 239Pu separation. Of particular note, LCF doesn’t need power hungry magnets, lasers, or particle beams. Potentially, it could provide watts to hundreds of kilowatts of electrical power and process heat suitable for space power and high Isp nuclear electric propulsion (NEP) as well as distributed terrestrial power. Finally, there are indications that LCF fast-fission products are more benign than those of conventional fission reactors. Our goal is to scale the reactions and increase the power output through higher temperature operation and increased material masses.

lattice confinement fusion↗

NASA NTRSDate not supplied

Differential Responses to Mechanostimulation in Embryonic Stem Cells Versus the Embryoid Body Model of Development Assessed at Single Cell RNA-Seq Resolution

Mechanicalforces generated by gravity have shaped life on Earth and impact gene expression and morphogenesis during early development. In contrast disuse canreduce normal mechanical loading, resulting in altered cell and tissue function. Although loading in adult mammals is known to promote increased cell proliferation and differentiation, little is known about how cells respondto this stimulusduring early development. In this study we sought to understand, with single cell RNA-sequencing resolution, how a 60-minute pulse of 50xg hypergravity-generated 5kPa hydrostatic pressure, influences transcriptomic regulation of developmental processes in the Embryoid Body (EB) model. Our study included both day-9 EBs and progenitor mouse embryonic stem cells (ESCs) with or without the hydrostatic pressurepulse. Single cell tSNE mapping shows limited transcriptome shifts in response to thispulse in either ESCs or EBs; this pulse,however, induces greater positional shifts in EB mapping compared to ESCs, indicating the influence of mechanotransduction is more pronounced in later states of cell commitment within the developmental program.We assessed ESCs and EBs for differentially expressed (DE) genes with hydrostatic pressurepulse and found approximately 1/3 DE genes were shared. However, gene ontology (GO) pathway analysis show that EBs have choreographed responses associated with upregulation ofpathways formulticellular development, mechanical signal transduction, and DNA damage repair. Cluster transcriptome analysis of the EBs showsmechanostimulationpromotes maintenance of transitory cell phenotypes in early development,including EB cluster co-expression of markers for progenitor, post-implant epiblast and primitive endoderm phenotypes versus expression exclusivity in the non-pulsed clusters. Pseudotime analysisidentified three branching cell types susceptible tohydrostatic pressureinduction of cell fate decisions. In summary, this study provides novel evidence that ESC maintenance and EB development can be regulated by mechanostimulation,and that stem cells committed to a differentiation program are more sensitive to force-induced changes to their transcriptome.

Cassandra Juran↗

NASA NTRSDate not supplied

Conserved Function of RNA Binding Motif Protein48 (RBM48) and Armadillo Repeat Containing 7 (ARMC7) in Maize and Human U12 Splicing

Splicing of pre-mRNA is fundamental for genes containing introns. Emerging data points to a deeply conserved role of this process in eukaryotic cell differentiation and proliferation. The vast majority of introns termed U2-type introns are spliced by a major spliceosome; however, there also exist rare and more conserved U12-type introns that are spliced by a minor spliceosome. Mutations that disrupt U12 splicing inhibit cell differentiation in both maize endosperm and human blood cells. However, the mechanism underlying this process is not well understood. The maize RNA Binding Motif Protein 48 (RBM48) plays an essential role as a U12 splicing factor and is required for proper maize kernel development. Using human cell lines, CRISPR-Cas9 knockdown of RBM48 demonstrated a conserved function in human U12 intron splicing. RBM48 and Armadillo Repeat Containing 7 (ARMC7) protein interact in both maize and human as part of the activated minor spliceosome. Here we show RBM48 and ARMC7 co-localization in the nucleus of human cell lines. Vertebrate ARMC7 is normally localized in the cytosol, whereas RBM48 is found in the nucleus. Our data suggests that the interaction plays a role in regulating ARMC7 localization or the efficiency of U12 intron splicing. We also performed comprehensive transcriptome profiling and identified a common subset of conserved Minor Intron Containing Genes (MIGs) impacted in both human and maize RBM48 knockout mutants. Of importance, the vast majority of these MIGs are associated with developmental defects in both plants and animals. This suggests that aberrant splicing of these targets has a high likelihood of mediating abnormal cell phenotypes. These data support evolutionarily conserved U12 splicing mechanisms between maize and humans with both RBM48 and ARMC7 having roles in the activated spliceosome.

maize↗

NASA NTRSDate not supplied

Microbial Characterization of Heat Melt Compaction for Treatment of Space Generated Solid Wastes

One treatment process in development for solid waste management in space has been the Trash Compaction Processing System (TCPS). Human space mission wastes typically contain large percentages of contaminated wet solid waste. The Heat Melt Compactor (HMC) is being developed to be a multi-function means of water recovery, volume reduction, and the making safe of contaminant-rich trash with the potential for waste stabilization and/or sterilization. To determine the efficacy of the HMC treatment to kill microorganisms in solid waste and remain biologically stable, testing was conducted on three tiles produced by HMC-Gen 2 at Ames Research Center. Samples were shipped to Kennedy Space Center to test for microbial viability after compaction, determine the bio-stability of the HMC disks during storage (43 days), and assess potential airborne contaminate microbial growth on surfaces at low and high humidity conditions. In addition to the products of solid waste processing technologies, there is a concern that the crew might come into contact with hardware surfaces that have been contaminated by microorganisms during waste processing. The extent of microbial surface contamination of waste processing hardware was determined by surface sample swabbing and analysis for total bacterial and yeast counts and cultivable counts of aerobic and anaerobic bacteria, spore-forming bacteria, and fungi. Results indicate that trash processing increased bacterial counts on the surfaces of the compacter. All but one biological indicator spore strip imbedded in the HMC produced tiles were negative for growth after incubation for five days indicating effective sterilization through the heat melt compaction process. Analysis of core samples as well as surface growth of tiles inoculated with Aspergillus niger fungal spores incubated at three levels of humidity indicate that HMC created tiles did not support the proliferation of bacterial and fungal growth.

Mary E Hummerick↗

NASA NTRSDate not supplied

Analysis of the Electrical Grid for UAM

A wide range of challenges must be overcome to conduct Urban Air Mobility (UAM) operations at scale with electric vertical takeoff and landing aircraft as envisioned. This presentation is on an analysis of one potential infrastructure challenge for UAM: available electrical grid power capacity. The success of UAM depends on the availability of electricity, which will be increasingly impacted by the proliferation of ground electric vehicles over time. Under the best-case assumption that electricity can be transmitted and distributed as needed within each interconnection (i.e., electrical grid), it is estimated that the maximum number of UAM aircraft that can charge simultaneously in the continental United States will decrease by 20% from about 595 thousand in the year 2021 to about 475 thousand in the year 2050 due to the projected increase in ground electric vehicles.

electrical grid; urban air mobility; electric vehi↗

NASA NTRSDate not supplied

Analysis of Electrical Grid Capacity by Interconnection for Urban Air Mobility

A wide range of challenges must be overcome to conduct Urban Air Mobility (UAM)operations at scale with electric vertical take-off and landing aircraft as envisioned. This paper documents an analysis of one potential infrastructure challenge for UAM: available electrical grid power capacity. The success of UAM depends on the availability of electricity, which will be increasingly impacted by the proliferation of ground electric vehicles(EVs) over time. Under the best-case assumption that electricity can be transmitted and distributed as needed within each interconnection (i.e., electrical grid), it is estimated that the maximum number of UAM aircraft that can charge simultaneously in the continental United States will decrease by 20% from about 595 thousand in the year 2021 to about 475 thousand in the year 2050due to the projected increase in ground EVs.

electrical grid↗

NASA NTRSDate not supplied

Analysis of Electrical Grid Capacity by Interconnection for Urban Air Mobility

electrical grid↗

NASA NTRS2023

An MBSE Approach for Developing an Autonomous Rover Platform

The proliferation of increasingly autonomous systems calls for new ways to address how safety is assured. As these systems become more advanced and complex, it becomes more important to model and prototype autonomous functions at the systems level and the functions that assure they are operating safely and as expected. To that effect, researchers at the National Aeronautics and Space Administration (NASA) 's Robust Software Engineering (RSE) group are working on prototyping a Research Autonomous Vehicle, commonly referred to as R-RAV. The R-RAV is an autonomous rover platform designed to act as a case study for assured autonomy research. Moreover, an overarching goal is for the R-RAV to serve as a training ground for other mission projects. In this paper, we will detail how we have used a Model-Based Systems Engineering (MBSE) approach to model a prototype of the R-RAV and test and verify its different functionalities.

MBSE↗

NASA NTRSDate not supplied

NASA’s Goddard Space Flight Center’s Distributed Systems Missions Architecture

Space and Earth Science are being transformed by applying a distributed approach to missions, where the fusion of data from components, systems, instruments, models, and observation locations works in concert with timely responses and feedback mechanisms to multiply the knowledge obtained. Additionally, a disaggregated approach allows for a distributed cost and schedule that can be shared across multiple organizations to enable the greater mission. With the advances in reduced size, weight, and power for space-worthy components leading to the revolution in smaller spacecraft, the cost and timeliness proposition for launching multiple space assets has also greatly improved. Thus, the aerospace industry is undergoing a paradigm shift toward a proliferation of small satellites as a networked approach to meet mission objectives. This paper will describe the impetus, goal, and path to provide an openly available framework as a unifying catalyst for broad-ranging Distributed Systems Missions (DSMs) contributors.

Distributed Systems↗

NASA NTRS2022

The Space Superhighway: Systems Analysis of an In-Space Logistics Delivery Network

The number of assets in cislunar space is anticipated to dramatically increase in the coming decades. Many of these newer spacecraft are being designed to take advantage of capabilities currently in development like In-Space Servicing Assembly and Manufacturing (ISAM). Additionally, the National Aeronautics and Space Administration (NASA) intends to develop and maintain a human-lunar presence that will then serve as a steppingstone for human missions to Mars. With continued growth in space operations, the combined demand for payload and propellant delivery in cislunar space could exceed 1,000 t annually in the next decade. The Space Superhighway principally consists of a logistics network and is intended to both use and proliferate ISAM in order to meet projected payload demands. Several architecture and vehicle-level trade studies are explored in order to better understand what in-space logistics networks may be feasible. The network consists of commercial launch vehicles, resupply tankers, orbital depots, and in-space tugs. This work specifically analyzes high-level trades such as: launch and in-space vehicle propulsion systems, vehicle size, staging orbit, level of vehicle reuse, reuse method, and propellant management strategy. Each of the trades are analyzed across several destination orbits such as Low-Earth Orbit (LEO) and Near-Rectilinear Halo Orbit (NRHO). Several payload types are also considered such as storable and cryogenic chemical propellants, electric propellants, crew logistics, spares, smallsats, and satellite piece parts.

Daniel J Tiffin↗