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At least 433 records · Page 24

Letting Our Cells Do the Fighting: Flight-Induced Changes in the Immune Response

The organisms that make us ill, such as bacteria, viruses, and fungi, are like attacking armies. We now know a great deal more about this unseen world of microscopic invaders. Fortunately for us, the human immune system is ever vigilant against them. Microorganisms such as bacteria, viruses, and fungi occupy almost every corner of the Earth, and even parts of the human body. Some organisms are beneficial to us, helping to produce milk, cheese or yogurt. Others are potentially harmful, yet we don#t always develop illnesses from them; they are kept in check by the sentinels of our immune system. Our immune system is routinely challenged by these organisms every day. When the immune response is diminished, our ability to fight off these "bugs" is lowered. And that's when we become ill. Space flight presents a challenge to the immune system. Scientists believe that the stressful conditions of space flight - launch into orbit, adapting to microgravity, heavy workloads, and isolation from family and friends, to name but a few - reduce the astronauts' immunity. This immune suppression makes them more susceptible to common illnesses from bacteria and to re-infections from latent viruses in the body. In addition, risk of spreading illness in the confined environment of the Space Shuttle is high. Understanding changes in immune function will help scientists develop ways to keep astronauts healthy in space. This knowledge can also benefit earthbound populations. This experiment will give scientists insight into the immune system by comparing how certain cells of astronauts' innate immune system - the first line of defense against invaders - function after flight compared to before flight.

Pierson, Duane↗

High-Resolution and Analytical TEM Investigation of Space Radiation Processing Effects in Primitive Solar System Materials and Airless Planetary Surface Environments

Energetic ions present in the diverse plasma conditions in space play a significant role in the formation and modification of solid phases found in environments ranging from the interstellar medium (ISM) to the surfaces of airless bodies such as asteroids and the Moon. These effects are often referred to as space radiation processing, a term that encompasses changes induced in natural space-exposed materials that may be only structural, such as in radiation-induced amorphization, or may involve ion-induced nanoscale to microscale chemical changes, as occurs in preferential sputtering and ion-beam mixing. Ion sputtering in general may also be responsible for partial or complete erosion of space exposed materials, in some instances possibly bringing about the complete destruction of free-floating solid grains in the ISM or in circumstellar nebular dust clouds. We report here on two examples of the application of high-resolution and analytical transmission electron microscopy (TEM) to problems in space radiation processing. The first problem concerns the role of space radiation processing in controlling the overall fate of Fe sulfides as hosts for sulfur in the ISM. The second problem concerns the known, but as yet poorly quantified, role of space radiation processing in lunar space weathering.

Christoffersen, R.↗

Thermal and solutal convection with conduction effects inside a rectangular enclosure

We numerically investigate the effects of various boundary conditions on the flow field characteristics of the physical vapor transport process. We use a prescribed temperature profile as boundary condition on the enclosure walls, and we consider parametric variations applicable to ground-based and space microgravity conditions. For ground-based applications, density gradients in the fluid phase generate buoyancy-driven convection which in turn disrupts the uniformity of the mass flux at the interface depending on the orientation. Heat conduction in the crystal can affect the fluid flow near the interface of the crystal. When considering isothermal source and sink at the interfaces, we observe a diffusive mode and three modes (i.e., thermal, solutal, and thermo-solutal). The convective modes show opposing flow field trends between thermal and solutal convection; theoretically, these trends can be used to achieve a uniform mass flux near the crystal. However, under the physical conditions chosen, the mathematical condition necessary for uniform mass flux cannot be satisfied because of thermodynamic restrictions. When a longitudinal thermal gradient is prescribed on the boundary of the crystal, a non-uniform interface temperature results, which induces a symmetrical fluid flow near the interface for the vertical case. For space microgravity applications, we show that the flow field is dominated by the Stefan wind and a uniform mass flux results at the interface.

Mennetrier, Christophe↗

Space environment considerations for perovskite solar cell operations: A review

Designing new technology for extraterrestrial applications certainly presents unique challenges. The environmental stressors perovskite-based photovoltaics must overcome will vary with the environment in which they are deployed. One must consider mission requirements when designing photovoltaic devices and packaging. Different space "theaters" can have dramatically different stressors needing consideration for designing panels for solar power generation. Here, in this article, we review the relevant space environmental conditions that must be considered when designing perovskite-based photovoltaic devices for implementation in space. We specifically consider thermal, radiation, gaseous, weather, and other phenomena most relevant to photovoltaic operation for specific theaters such as Low Earth Orbit, Geosynchronous Orbit, Lunar surface, Mars (orbit and surface), and interplanetary exploration pathways.

14 SOLAR ENERGY↗

Atomic-Scale Behavior of Radiation-Resistant ZnO under High-Energy Electron Bombardment

Understanding the atomic structure and defect characteristics of ZnO thin films is crucial for optimizing their electronic properties and performance in advanced applications. Here, we investigate the atomic structure and defect characteristics of atomic layer deposition (ALD)-grown ZnO thin films by using aberration-corrected scanning transmission electron microscopy (STEM). Atomic-resolution imaging identifies prevalent stacking faults, dipole disorder, and various grain boundary types, which are believed to influence the electronic properties of ZnO. Additionally, real-time electron beam exposure experiments demonstrate structural transformations, including crystal growth and surface rearrangements. These findings provide insights into the growth mechanisms of ALD ZnO under high-energy electron irradiation conditions, an important finding for the use of polycrystalline ZnO wide bandgap semiconductors in space-like conditions. In conclusion, our results underscore the capability of STEM in directly visualizing and quantifying atomic-scale defects and beam-induced transformations in radiation-resistant ZnO.

Defects↗

General Bohm and Langmuir conditions for a strong double layer in space plasmas

The appropriate Bohm and Langmuir conditions when there are three beam-type particles passing through the double layer in addition to the usual two species of trapped particles are derived. It is shown that the Langmuir conditions, which normally imply a net current through the double layer, are consistent with zero net current when the class of accreting ions is included. It is also found that the Bohm criterion is quite different from its usual form, and that it has nothing to do with instabilities of the plasma at some critical level, as is believed to be true.

Williams, A. C.↗

Fertilization of sea urchin eggs and sperm motility are negatively impacted under low hypergravitational forces significant to space flight

Sperm and other flagellates swim faster in microgravity (microG) than in 1 G, raising the question of whether fertilization is altered under conditions of space travel. Such alterations have implications for reproduction of plant and animal food and for long-term space habitation by man. We previously demonstrated that microG accelerates protein phosphorylation during initiation of sperm motility but delays the sperm response to the egg chemotactic factor, speract. Thus sperm are sensitive to changes in gravitational force. New experiments using the NiZeMi centrifugal microscope examined whether low hypergravity (hyperG) causes effects opposite to microG on sperm motility, signal transduction, and fertilization. Sperm % motility and straight-line velocity were significantly inhibited by as little as 1.3 G. The phosphorylation states of FP130, an axonemal phosphoprotein, and FP160, a cAMP-dependent salt-extractable flagellar protein, both coupled to motility activation, showed a more rapid decline in hyperG. Most critically, hyperG caused an approximately 50% reduction in both the rate of sperm-egg binding and fertilization. The similar extent of inhibition of both fertilization parameters in hyperG suggests that the primary effect is on sperm rather than eggs. These results not only support our earlier microG data demonstrating that sperm are sensitive to small changes in gravitational forces but more importantly now show that this sensitivity affects the ability of sperm to fertilize eggs. Thus, more detailed studies on the impact of space flight on development should include studies of sperm function and fertilization.

NASA Discipline Developmental Biology↗

Space Weather: What is it, and Why Should a Meteorologist Care?

"Space weather" is a term coined almost 15 years ago to describe environmental conditions ABOVE Earth's atmosphere that affect satellites and astronauts. As society has become more dependent on technology, we nave found that space weather conditions increasingly affect numerous commercial and infrastructure sectors: airline operations, the precision positioning industry, and the electric power grid, to name a few. Similar to meteorology where "weather" often refers to severe conditions, "space weather" includes geomagnetic storms, radiation storms, and radio blackouts. But almost all space weather conditions begin at the Sun--our middle-age, magnetically-variable star. At NASA, the science behind space weather takes place in the Heliophysics Division. The Space Weather Prediction Center in Boulder, Colorado, is manned jointly by NCAA and US Air Force personnel, and it provides space weather alerts and warnings for disturbances that can affect people and equipment working in space and on Earth. Organizationally, it resides in NOAA's National Weather Service as one of the National Centers for Environmental Prediction. In this seminar we hope to give the audience a brief introduction to the causes of space weather, discuss some of the effects, and describe the state of the art in forecasting. Our goal is to highlight that meteorologists are increasingly becoming the "first responders" to questions about space weather causes and effects.

SaintCyr, Chris↗

Thin metal film and multilayers experiment (A0138-3)

The sources of degradation of in state of the art and newly developed components and testing the usefulness of the concept of storing experiment samples in dry nitrogen under launch and space vacuum conditions during reentry mission phase were investigated. Ultraviolet (UV) and extreme ultraviolet (EUV) experiments suffer degradations during space missions of even 1 month duration. It is suggested that the degradation is due to condensation of outgassing products, followed by solar induced polymerization, however, penetrating charged particles are also known to produce volume effects. Degradation may also start immediately after manufacturing of the component due to oxidation, moisture, or chemical corrosion by atmospheric constituents such as CO2 and SO2. When the filters are used as windows for gas absorption cells or gas filters, or when they define the instrumental bandwidth by themselves. The effects of mechanical degradation by thermal cycling and/or dust may cause a dramatic impact.

Delaboudiniere, J. P.↗

The HERMES Payload for Gateway: Heliophysics Enabled by Lunar Exploration

At launch, the first two modules of the Gateway space station will carry external payloads from NASA and ESA designed to observe the space environment. The NASA payload is the Heliophysics Environmental and Radiation Measurement Experiment Suite (HERMES). The HERMES instrumentation includes an ion mass spectrometer, an electron electrostatic analyzer, a proton and electron telescope for energetic particles, and a set of magnetometers. After an approximately one year transit to the Moon, HERMES will begin a science campaign that addresses heliophysics and space-weather objectives. Analyses of the in-situ measurements from HERMES will leverage observations from other Heliophysics spacecraft missions to enable multipoint studies of structure in the solar wind and in the magnetotail. Gateway’s polar lunar orbit is advantageous for this purpose. HERMES also is a pathfinder for future payloads on human-exploration vessels, for which there will be pragmatic interest in the variable radiation environment. Thus, with observations enabled by the ARTEMIS Program, HERMES is expected to be enabling of future exploration missions. Additionally, although HERMES objectives have a space-weather focus, the measurements also can be useful for studies of the Moon. Data, algorithms, calibrations, and related software produced by the project will be fully open and accessible through a Science Operations Center. In this presentation we provide an overview of science plans, including expectations for collaboration with other HSO missions and with international partners. Plain-Language Summary: The HERMES scientific payload will be attached to the HALO module of the Artemis Program's Gateway lunar outpost. HERMES will observe space weather conditions from lunar orbit. The data will be freely available for studies of the Moon and its space environment.

William R Paterson↗

Power conditioning for large dc motors for space flight applications

The design and performance of a prototype power-conditioning system for use with large brushless dc motors on NASA space missions are discussed in detail and illustrated with extensive diagrams, drawings, and graphs. The 5-kW 8-phase parallel module evaluated here would be suitable for use in the Space Shuttle Orbiter cargo bay. A current-balancing magnetic assembly with low distributed inductance permits high-speed current switching from a low-voltage bus as well as current balancing between parallel MOSFETs.

Veatch, Martin S.↗

Progress of manned space flight from Apollo to Space Shuttle

The technology employed for the Apollo lunar missions is examined, taking into account developments which represented, at the time, advances in the state of the art. Differences between the technology required for the Space Shuttle and Apollo are partly related to the fact that the Shuttle mission is 'more forgiving' than Apollo with its lunar landings. On the other side, the Orbiter is a much more complicated vehicle, and has to function as a launch vehicle, a spacecraft, and an aircraft. Technological advances needed in connection with the Shuttle development are described in detail, and requirements for a manned permanent presence in space are discussed. A manned orbital transfer vehicle which can go to geosynchronous orbit will have to be developed, while a regenerative life support system will be needed for the space station itself along with a power generation and energy storage system, and improvements related to living and working conditions in space.

Cohen, A.↗

Control of free-flying space robot manipulator systems

New control techniques for self contained, autonomous free flying space robots were developed and tested experimentally. Free flying robots are envisioned as a key element of any successful long term presence in space. These robots must be capable of performing the assembly, maintenance, and inspection, and repair tasks that currently require human extravehicular activity (EVA). A set of research projects were developed and carried out using lab models of satellite robots and a flexible manipulator. The second generation space robot models use air cushion vehicle (ACV) technology to simulate in 2-D the drag free, zero g conditions of space. The current work is divided into 5 major projects: Global Navigation and Control of a Free Floating Robot, Cooperative Manipulation from a Free Flying Robot, Multiple Robot Cooperation, Thrusterless Robotic Locomotion, and Dynamic Payload Manipulation. These projects are examined in detail.

Cannon, Robert H., Jr.↗

Reproduction in the space environment: Part I. Animal reproductive studies

Mankind's exploration and colonization of the frontier of space will ultimately depend on men's and women's ability to live, work, and reproduce in the space environment. This paper reviews animal studies, from microorganisms to mammals, done in space or under space-simulated conditions, which identify some of the key areas which might interfere with human reproductive physiology and/or embryonic development. Those space environmental factors which impacted almost all species included: microgravity, artificial gravity, radiation, and closed life support systems. These factors may act independently and in combination to produce their effects. To date, there have been no studies which have looked at the entire process of reproduction in any animal species. This type of investigation will be critical in understanding and preventing the problems which will affect human reproduction. Part II will discuss these problems directly as they relate to human physiology.

Review, Tutorial↗

Development of Training Programs to Optimize Planetary Ambulation

Astronauts experience disturbances in functional mobility following their return to Earth due to adaptive responses that occur during exposure to the microgravity conditions of space flight. Despite significant time spent performing in-flight exercise routines, these training programs have not been able to mitigate postflight alterations in postural and locomotor function. Therefore, the goal of our two inter-related projects (NSBRI-ground based and ISS flight study, "Mobility") is to develop and test gait training programs that will serve to optimize functional mobility during the adaptation period immediately following space flight, thereby improving the safety and efficiency of planetary ambulation. The gait training program entails manipulating the sensory conditions of treadmill exercise to systematically challenge the balance and gait control system. This enhances the overall adaptability of locomotor function enabling rapid reorganization of gait control to respond to ambulation in different gravitational environments. To develop the training program, we are conducting a series of ground-based studies evaluating the training efficacy associated with variation in visual flow, body loading, and support surface stability during treadmill walking. We will also determine the optimal method to present training stimuli within and across training sessions to maximize both the efficacy and efficiency of the training procedure. Results indicate that variations in both visual flow and body unloading during treadmill walking leads to modification in locomotor control and can be used as effective training modalities. Additionally, the composition and timing of sensory challenges experienced during each training session has significant impact on the ability to rapidly reorganize locomotor function when exposed to a novel sensory environment. We have developed the capability of producing support surface variation during gait training by mounting a treadmill on a six-degree-of-freedom motion device. This hardware development will allow us to evaluate the efficacy of this type of training in conjunction with variation in visual flow and body unloading.

Bloomberg, J. J.↗

Dietary Formulas Fortify Antioxidant Supplements

The astronaut's life and work is so different from our own daily experiences that it s easy to forget that astronauts are people, too. Just like everyone else, astronauts have basic nutritional needs, such as five to nine servings of fruit and vegetables per day, in order to maintain optimal health. Here on Earth, it can be a challenge to incorporate the recommended amount of fruit and veggies into our diets, despite easy access to fresh produce. In space, it becomes even more difficult, as astronauts must take everything they need with them. And in the harsh conditions of space, many miles from medical assistance, proper nutrition takes on added importance. As NASA makes plans to send astronauts on missions that could take months and even years, the Agency explores new ways to provide astronauts with a daily dose of nutrition equivalent to that provided by fresh produce. These foods are critically important because they provide the essential vitamins, minerals, pigments, and other micronutrients (substances required in small amounts for human health) that promote everything from healthy skin to a strong heart.

Source record↗

Machine Learning for Extravehicular Mobility Unit (EMU) Glove Inspections

The Extravehicular Mobility Unit (EMU) Glove Machine Learning Inspection project utilizes machine learning to expedite the inspection, analysis, and recommendation for continued use of space suit gloves post spacewalks. Today, ISS glove photos are individually reviewed by a team of experts to determine the conditions of space suit gloves. For this project the Microsoft Azure platform is used to perform Automated Machine Learning (AutoML) to detect issues with tagged images from previous Extravehicular Activities (EVA’s) to build a predictive model. The model analyzes a test image and deems the glove GO or NO-GO for additional EVA’s. The goal for this ML project is to decrease the time spent reviewing images by ground personnel and crewmembers in high frequency EVA locations such as the Moon and Mars. For destinations such as the Moon and Mars the goal is to give crew autonomy in determining glove conditions with limited support from Earth. This paper will outline the results to date and future work needed to expand the capability for in-situ recommendations.

EVA↗