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At least 433 records · Page 24

Decision Framework for Classifying the State of Knowledge for Pharmaceutical Stability in Spaceflight

The currently approved medication formulary for exploration-class spaceflight missions presently exceeds 200pharmaceuticals. However, these medications' physical and chemical stability during long-term exposure to the spaceflight environment remains uncharacterized. A multi-disciplinary team of pharmacy and spaceflight subject matter experts (SMEs) collaborated to develop a decision framework that will prioritize medications for future stability research. This framework prioritizes the physical stability, drug quality, and safety of the active pharmaceutical ingredient of finished drug products selected for specific design reference mission (DRM) drug formularies. The United States Pharmacopeia (USP) defines drug stability as "the extent to which a drug product retains, within specified limits, and throughout its period of storage and use, the same properties and characteristics that it possessed at the time of its manufacture.1"The candidate medication is assessed by applying a sequence of drug agnostic questions to evaluate the limits of stability information pertinent to spaceflight. The answers to these questions ultimately lead to one of three characterizations: green (not prioritized for further research for this DRM), yellow (requires further literature review/additional studies), or red (not suitable for this DRM based on current knowledge). The decision framework will rely on several information resources to inform the ultimate decision, including the ExMC Pharmacy Information Database, published literature, FDA/drug manufacturer monographs, and USP. The results of this framework will be used to classify the state of knowledge for pharmaceutical stability for any specified DRM and guide future research efforts accordingly. This presentation will provide an overview of how this decision framework was developed, detail the challenges and limitations of the pathways, and discuss how researchers can apply the lessons learned from this project to future work

S Kurian↗

Thermodynamics of grain-boundary phases

The past decade has seen a significant increase in research efforts aimed at understanding the thermodynamics of low-dimensional phases existing in many materials systems, ranging from two-dimensional materials to core regions of extended defects in crystalline solids. We review the current status of theoretical, computational, and experimental research on the “defect phases,” focusing on grain boundaries (GBs) in elemental and multicomponent polycrystalline materials. After reviewing the generalized concept of a phase of any dimensionality, we discuss recent progress in atomistic computer simulations of GB phase transformations and phase coexistences, including the observation of one-dimensional defects separating GB phases (defects in defects). Computational predictions compare well with experimental observations of multiple GB phases and segregation-induced phase transformations. An intriguing open question of GB thermodynamics is whether the GB free energy can be driven to a zero value by increasing solute segregation. We review recent efforts to understand this ultimate thermodynamic stabilization of GB phases and the possible polycrystalline microstructures that may arise. An outlook for future research in the field is discussed.

Materials science↗

Ecosystems and Networks Integrated with Genes and Molecular Assemblies (Final Scientific/Technical Report)

The ENIGMA science focus area (SFA) is a multi-disciplinary, multi-institutional research effort focused on addressing foundational knowledge gaps in environmental microbial communities by studying groundwater and sediment microbiomes in the shallow subsurface at the contaminated Oak Ridge Field Research Site (FRC). We seek to discover and characterize the reciprocal interactions between the microbial communities and the geochemical and geophysical parameters of the shallow subsurface within the contamination plume. The goal of the Fields lab is to help manage and conduct laboratory experiments informed by field observations using ecological and physiological approaches to study microbial populations in situ as well as ex situ (in the laboratory). In particular, we aim to study and characterize the impact of hydrological constraints on free-living and biofilm biomass and activity with increasing spatial and temporal resolution under static and flow conditions. We also aim to help characterize novel microbial groups that are present and active under relevant field conditions, including the development of molecular techniques for in situ detection as well as metabolic interactions that underlie pertinent physiology and ecology.

59 BASIC BIOLOGICAL SCIENCES↗

Computational methods and software systems for dynamics and control of large space structures

The deployment, assembly and mission-oriented maneuvering of space structures in orbit will trigger large motions of flexible, truss-type structures. In addition, the presence of on-board controls both for attitude stabilization and specified vibration tolerance requirements may further complicate the dynamic behavior of the orbiting structures. Because of safety and cost considerations, the dynamic response of the combined structural and control systems must be predicted reliably. This need can only be met through the development of reliable and efficient simulation capabilities, since there is general agreement that on-orbit experiments should be limited because of cost, time and facility constraints. The long-term objective of this research effort is to develop a next-generation computer simulator for the dynamics and control of large space structures. The simulator will be based on integrating four research thrusts: a new multibody dynamics formulation methodology, modeling capabilities in long/slender truss-beam components with realistic joints, efficient computational procedures that can be implemented either in sequential or concurrent computers, and prototype simulation modules that can be easily processed into a modern large-scale engineering software system such as the NASA/Computational Structural Mechanics (CSM) testbed.

Park, K. C.↗

Onyx-Advanced Aeropropulsion Simulation Framework Created

The Numerical Propulsion System Simulation (NPSS) project at the NASA Glenn Research Center is developing a new software environment for analyzing and designing aircraft engines and, eventually, space transportation systems. Its purpose is to dramatically reduce the time, effort, and expense necessary to design and test jet engines by creating sophisticated computer simulations of an aerospace object or system (refs. 1 and 2). Through a university grant as part of that effort, researchers at the University of Toledo have developed Onyx, an extensible Java-based (Sun Micro-systems, Inc.), objectoriented simulation framework, to investigate how advanced software design techniques can be successfully applied to aeropropulsion system simulation (refs. 3 and 4). The design of Onyx's architecture enables users to customize and extend the framework to add new functionality or adapt simulation behavior as required. It exploits object-oriented technologies, such as design patterns, domain frameworks, and software components, to develop a modular system in which users can dynamically replace components with others having different functionality.

Reed, John A.↗

A Study of Future Communications Concepts and Technologies for the National Airspace System-Part III

The National Aeronautics and Space Administration (NASA) Glenn Research Center (GRC) is investigating current and anticipated wireless communications concepts and technologies that the National Airspace System (NAS) may need in the next 50 years. NASA has awarded three NASA Research Announcements (NAR) studies with the objective to determine the most promising candidate technologies for air-to-air and air-to-ground data exchange and analyze their suitability in a post-NextGen NAS environment. This paper will present progress made in the studies and describe the communications challenges and opportunities that have been identified as part of the study. NASA's NextGen Concepts and Technology Development (CTD) Project integrates solutions for a safe, efficient and high-capacity airspace system through joint research efforts and partnerships with other government agencies. The CTD Project is one of two within NASA's Airspace Systems Program and is managed by the NASA Ames Research Center. Research within the CTD Project is in support the 2011 NASA Strategic Plan Sub-Goal 4.1: Develop innovative solutions and advanced technologies, through a balanced research portfolio, to improve current and future air transportation. The focus of CTD is on developing capabilities in traffic flow management, dynamic airspace configuration, separation assurance, super density operations and airport surface operations. Important to its research is the development of human/automation information requirements and decisionmaking guidelines for human-human and human-machine airportal decision-making. Airborne separation, oceanic intrail climb/descent and interval management applications depend on location and intent information of surrounding aircraft. ADS-B has been proposed to provide the information exchange, but other candidates such as satellite-based receivers, broadband or airborne internet, and cellular communications are possible candidate's.

Navigation↗

The International Satellite Cloud Climatology Project - Preliminary results and its potential aspects

The ISCCP (International Satellite Cloud Climatology Project) began its operational data collection phase on July 1, 1983. Considerable research efforts ensured that the compression of basic satellite data did not reduce the information content on cloudiness. At present an operational algorithm has been developed and tested with data from several months, whereas a target for very intensive use by the research community the data from April 1985 are selected. These concur with a simultaneous data set of the ERBE. Special efforts are now underway to map also clouds over both polar regions and may lead to the development of new specific algorithms. Several preliminary results are presented in this paper.

Raschke, E.↗

Researcher-driven Campaigns Engage Nature's Notebook Participants in Scientific Data Collection

One of the many benefits of citizen science projects is the capacity they hold for facilitating data collection on a grand scale and thereby enabling scientists to answer questions they would otherwise not been able to address. Nature's Notebook, the plant and animal phenology observing program of the USA National Phenology Network (USA-NPN) suitable for scientists and non-scientists alike, offers scientifically-vetted data collection protocols and infrastructure and mechanisms to quickly reach out to hundreds to thousands of potential contributors. The USA-NPN has recently partnered with several research teams to engage participants in contributing to specific studies. In one example, a team of scientists from NASA, the New Mexico Department of Health, and universities in Arizona, New Mexico, Oklahoma, and California are using juniper phenology observations submitted by Nature's Notebookparticipants to improve predictions of pollen release and inform asthma and allergy alerts. In a second effort, researchers from the University of Maryland Center for Environmental Science are engaging Nature's Notebookparticipants in tracking leafing phenophases of poplars across the U.S. These observations will be compared to information acquired via satellite imagery and used to determine geographic areas where the tree species are most and least adapted to predicted climate change. Researchers in these partnerships receive benefits primarily in the form of ground observations. Launched in 2010, the juniper pollen effort has engaged participants in several western states and has yielded thousands of observations that can play a role in model ground validation. Periodic evaluation of these observations has prompted the team to improve and enhance the materials that participants receive, in an effort to boost data quality. The poplar project is formally launching in spring of 2013 and will run for three years; preliminary findings from 2013 will be presented. Participants in these special campaigns benefit through direct engagement in science. This form of researcher partnership has now been successfully pilot-tested and implemented in several instances, and provides a template for future research project campaigns.

Crimmins, Theresa M.↗

Researcher-driven Campaigns Engage Nature's Notebook Participants in Scientific Data Collection

One of the many benefits of citizen science projects is the capacity they hold for facilitating data collection on a grand scale and thereby enabling scientists to answer questions they would otherwise not been able to address. Nature's Notebook, the plant and animal phenology observing program of the USA National Phenology Network (USA-NPN) suitable for scientists and non-scientists alike, offers scientifically-vetted data collection protocols and infrastructure and mechanisms to quickly reach out to hundreds to thousands of potential contributors. The USA-NPN has recently partnered with several research teams to engage participants in contributing to specific studies. In one example, a team of scientists from NASA, the New Mexico Department of Health, and universities in Arizona, New Mexico, Oklahoma, and California are using juniper phenology observations submitted by Nature's Notebookparticipants to improve predictions of pollen release and inform asthma and allergy alerts. In a second effort, researchers from the University of Maryland Center for Environmental Science are engaging Nature's Notebookparticipants in tracking leafing phenophases of poplars across the U.S. These observations will be compared to information acquired via satellite imagery and used to determine geographic areas where the tree species are most and least adapted to predicted climate change. Results/Conclusions Researchers in these partnerships receive benefits primarily in the form of ground observations. Launched in 2010, the juniper pollen effort has engaged participants in several western states and has yielded thousands of observations that can play a role in model ground validation. Periodic evaluation of these observations has prompted the team to improve and enhance the materials that participants receive, in an effort to boost data quality. The poplar project is formally launching in spring of 2013 and will run for three years; preliminary findings from 2013 will be presented. Participants in these special campaigns benefit through direct engagement in science. This form of researcher partnership has now been successfully pilot-tested and implemented in several instances, and provides a template for future research project campaigns.

Crimmins, Theresa M.↗

Concrete Structure Health Monitoring Using Vibro-acoustic Testing and Machine Learning

Assessment and management of aging concrete structures in nuclear power plants require a more systematic approach than simple reliance on margins of safety in existing codes. Research is required to deploy online monitoring capability to assess the health of concrete structures in nuclear power plants and perform predictive analytics based on heterogeneous measurements, in order to reduce the operation and maintenance costs. The research effort described in this report focuses on the health monitoring of concrete slabs containing reactive aggregates using the vibro-acoustic modulation (VAM) technique and predictive modeling. The research is developing an approach to enable detection, localization, and estimation of the extent of degradation in concrete slabs due to alkali-silica reaction (ASR). The project outcomes are generic and extendable to other degradation modes in concrete. A concrete slab without reinforcements was cast at Vanderbilt University and cured in aggressive conditions to accelerate ASR degradation. In this report, we develop a methodology for the automation of VAM testing, and the construction of machine learning models to facilitate damage localization in concrete structures. We investigate how machine learning models based on physics simulation data can be effectively utilized for damage localization (damage location and depth) and estimation in a concrete slab specimen. Our study indicates that these models could potentially support damage localization and estimation for NPP structures.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Dual Purpose – Heating & Cooling – Thermal Battery for Flexible and Energy-Efficient Heat Pump Systems

The integration of heat pumps with thermal energy storage (HP-TES) systems is gaining attention as a viable solution for managing peak building demand driven by immense cooling and heating loads. With growing reliance on renewable energy sources, thermal energy storage offers an excellent opportunity to mitigate mismatches in thermal load between energy supply and demand. The use of phase-change material (PCM) TES is especially promising, as PCMs offer significant latent energy storage capacity with smaller temperature glides in smaller volumes compared to other TES technologies. However, challenges arise because current HP-TES architectures can load-shift only cooling or heating, not both, requiring two systems and thus doubling cost, weight, and footprint. Furthermore, current research efforts lack specific tools and techniques to advance integrated systems from concept design to end-user application, focusing on only discharge performance. To address these challenges, this research proposes a dual-mode (heating and cooling) integrated HP-TES system that uses room-temperature PCM-TES as a high-temperature heat source in heating mode and a low-temperature heat sink in cooling mode, thereby reducing temperature lifts and compressor power. Design criteria for PCM-TES heat exchangers were developed, balancing thermal-hydraulic performance with practical constraints such as available building space and weight requirements along with PCM selection considerations such as shipping conditions, moisture exposure, and number of available cycles. A detailed transient model for HP-TES systems was developed to enable rapid annual performance assessments in any US climate zone.

42 ENGINEERING↗

Exobiology experiment concepts for space station

The exobiology discipline uses ground based and space flight resources to conduct a multidiscipline research effort dedicated to understanding fundamental questions about the origin, evolution, and distribution of life and life related molecules throughout the universe. Achievement of this understanding requires a methodical research strategy which traces the history of the biogenic elements from their origins in stellar formation processes through the chemical evolution of molecules essential for life to the origin and evolution of primitive and, ultimately, complex living species. Implementation of this strategy requires the collection and integration of data from solar system exploration spacecraft and ground based and orbiting observatories and laboratories. The Science Lab Module (SLM) of the Space Station orbiting complex may provide an ideal setting in which to perform certain classes of experiments which form the cornerstone of exobiology research. These experiments could demonstrate the pathways and processes by which biomolecules are synthesized under conditions that simulate the primitive Earth, planetary atmospheres, cometary ices, and interstellar dust grains. Exobiology experiments proposed for the Space Station generally fall into four classes: interactions among gases and grains (nucleation, accretion, gas-grain reactions), high energy chemistry for the production of biomolecules, physical and chemical processes occurring on an artificial comet, and tests of the theory of panspermia.

Griffiths, L. D.↗

Exobiology experiment concepts for Space Station

The exobiology discipline uses ground based and space flight resources to conduct a multidiscipline research effort dedicated to understanding fundamental questions about the origin, evolution, and distribution of life and life related molecules throughout the universe. Achievement of this understanding requires a methodical research strategy which traces the history of the biogenic elements from their origins in stellar formation processes through the chemical evolution of molecules essential for life to the origin and evolution of primitive and, ultimately, complex living species. Implementation of this strategy requires the collection and integration of data from solar system exploration spacecraft and ground based and orbiting observatories and laboratories. The Science Lab Module (SLM) of the Space Station orbiting complex may provide an ideal setting in which to perform certain classes of experiments which form the cornerstone of exobiology research. These experiments could demonstrate the pathways and processes by which biomolecules are synthesized under conditions that stimulate the primitive earth, planetary atmospheres, cometary ices, and interstellar dust grains. Exobiology experiments proposed for the Space Station generally fall into four classes: interactions among gases and grains (nucleation, accretion, gas-grain reactions), high energy chemistry for the production of biomolecules, physical and chemical processes occurring on an artificial comet, and tests of the theory of panspermia.

Griffiths, Lynn D.↗

Schools of the Pacific rainfall climate experiment

The SPaRCE program is a cooperative rainfall climate field project involving high school and college level students and teachers from various Pacific island and atoll nations. The goals of the SPaRCE program are: (1) to foster interest and increase understanding among Pacific-area students and teachers of climate and climate change; (2) to educate the students and teachers as to the importance of rainfall in the Pacific area to climate studies; (3) to provide the students and teachers an opportunity of making a major contribution to the global climate research effort by collecting and analyzing Pacific rainfall data; and (4) to incorporate collected rainfall observations into a comprehensive Pacific daily rainfall data base to be used for climate research purposes. Schools participating in SPaRCE have received standard raingauges with which to measure rainfall at their sites. Students learned to site and use their raingauges by viewing a video produced at the University of Oklahoma. Four more videos will be produced which will include information on Earth's atmosphere, global climate and climate change, regional climate and implications of climate change, and how to analyze and use the rainfall data they are collecting. The videos are accompanied by workbooks which summarize the main points of each video, and contain concrete learning activities to help the student better understand climate and climate change. Following each video, interactive sessions are held with the students using the PEACESAT (Pan-Pacific Education And Communication Experiments by Satellite) satellite radio communication system.

Postawko, S. E.↗

Making the Most of Waste Energy

The Thermo-Mechanical Systems Branch at NASA s Glenn Research Center is responsible for planning and conducting research efforts to advance thermal systems for space, aerospace, and non-aerospace applications. Technological areas pertain to solar and thermal energy conversion. For example, thermo-mechanical systems researchers work with gas (Stirling) and liquid/vapor (Rankine) systems that convert thermal energy to electrical power, as well as solar dynamic power systems that concentrate sunlight to electrical power. The branch s development of new solar and thermal energy technologies is propelling NASA s missions deep into unfamiliar territories of space. Solar dynamic power systems are actively improving the health of orbiting satellites, giving them longer life and a stronger radiation tolerance, thus, creating less need for on-orbit maintenance. For future missions, NASA may probe even deeper into the mysterious cosmos, with the adoption of highly efficient thermal energy converters that have the potential to serve as the source of onboard electrical power for satellites and spacecraft. Research indicates that these thermal converters can deliver up to 5 times as much power as radioisotope thermoelectric generators in use today, for the same amount of radioisotope. On Earth, energy-converting technologies associated with NASA s Thermo-Mechanical Systems Branch are being used to recover and transform low-temperature waste heat into usable electric power, with a helping hand from NASA.

Source record↗

Conceptual Design of Environmentally Friendly Rotorcraft - A Comparison of NASA and ONERA Approaches

In 2011, a task was initiated under the US-French Project Agreement on rotorcraft studies to collaborate on design methodologies for environmentally friendly rotorcraft. This paper summarizes the efforts of that collaboration. The French and US aerospace agencies, ONERA and NASA, have their own software toolsets and approaches to rotorcraft design. The first step of this research effort was to understand how rotorcraft impact the environment, with the initial focus on air pollution. Second, similar baseline helicopters were developed for a passenger transport mission, using NASA and ONERA rotorcraft design software tools. Comparisons were made between the designs generated by the two tools. Finally, rotorcraft designs were generated targeting reduced environmental impact. The results show that a rotorcraft design that targets reduced environmental impact can be significantly different than one that targets traditional cost drivers, such as fuel burn and empty weight.

Conceptual Design↗

NASA’s Geospace Dynamics Constellation—Providing the first Systematic Measurements of Global Magnetospheric Energy Inputs and Ionosphere-Thermosphere Responses

The Geospace Dynamics Constellation (GDC) is NASA's next strategic Living With a Star mission. GDC's goals are: 1) Understand how the high-latitude ionosphere-thermosphere system responds to variable solar wind/magnetosphere forcing; and 2) Understand how internal processes in the global ionosphere-thermosphere system redistribute mass, momentum, and energy. Planned for launch by the end of the decade, GDC will use six identical observatories, each identically instrumented to fully characterize the magnetospheric drivers of the I-T system as well as the global response of the ionized and neutral gases. GDC will do this with a series of orbital configurations that will enable it to study the widest range of spatial and temporal scales to date, ranging from hundreds of kilometers and several seconds to tens of minutes, and extending through the regional to the global scale. This talk presents GDC's current status, measurement capabilities, sampling scheme, and model development efforts and show how GDC will fit into the larger Heliophysics ecosystem, by 1) obtaining critically needed scientific observations; 2) providing a source for real-time space weather and situational awareness, as well as retrospective studies to further the science of space weather; 3) serving as a "strategic hub" for other space-based and ground-based efforts that want to leverage GDC to perform complementary science. To get the most benefit from GDC’s observations, it will be critical to identify partnerships with other research efforts in the ITM and Geospace arenas, including those utilizing space-based, ground-based, or theoretical investigations. We particularly would like to discuss with groups who are planning or considering observational campaigns during the GDC era, to find ways to leverage GDC observations to do synergistic science that could not be done otherwise.

Douglas E Rowland↗

Magnetic field waves at Uranus

The proposed research efforts funded by the UDAP grant to the BRI involve the study of magnetic field waves associated with the Uranian bow shock. This is a collaborative venture bringing together investigators at the BRI, Southwest Research Institute (SwRI), and Goddard Space Flight Center (GSFC). In addition, other collaborations have been formed with investigators granted UDAP funds for similar studies and with investigators affiliated with other Voyager experiments. These investigations and the corresponding collaborations are included in the report. The proposed effort as originally conceived included an examination of waves downstream from the shock within the magnetosheath. However, the observations of unexpected complexity and diversity within the upstream region have necessitated that we confine our efforts to those observations recorded upstream of the bow shock on the inbound and outbound legs of the encounter by the Voyager 2 spacecraft.

Smith, Charles W.↗