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At least 433 records · Page 24

Selected contribution: a three-dimensional model for assessment of in vitro toxicity in balaena mysticetus renal tissue

This study established two- and three-dimensional renal proximal tubular cell cultures of the endangered species bowhead whale (Balaena mysticetus), developed SV40-transfected cultures, and cloned the 61-amino acid open reading frame for the metallothionein protein, the primary binding site for heavy metal contamination in mammals. Microgravity research, modulations in mechanical culture conditions (modeled microgravity), and shear stress have spawned innovative approaches to understanding the dynamics of cellular interactions, gene expression, and differentiation in several cellular systems. These investigations have led to the creation of ex vivo tissue models capable of serving as physiological research analogs for three-dimensional cellular interactions. These models are enabling studies in immune function, tissue modeling for basic research, and neoplasia. Three-dimensional cellular models emulate aspects of in vivo cellular architecture and physiology and may facilitate environmental toxicological studies aimed at elucidating biological functions and responses at the cellular level. Marine mammals occupy a significant ecological niche (72% of the Earth's surface is water) in terms of the potential for information on bioaccumulation and transport of terrestrial and marine environmental toxins in high-order vertebrates. Few ex vivo models of marine mammal physiology exist in vitro to accomplish the aforementioned studies. Techniques developed in this investigation, based on previous tissue modeling successes, may serve to facilitate similar research in other marine mammals.

Whales/genetics/physiology↗

Cellular Responses to Mechanical Stress Selected Contribution: A Three-Dimensional Model for Assessment of in Vitro Toxicity in Balaena Mysticetus Renal Tissue

This study established two- and three-dimensional renal proximal tubular cell cultures of the endangered species bowhead whale (Balaena mysticetus), developed SV40-transfected cultures, and cloned the 61-amino acid open reading frame for the metallothionein protein, the primary binding site for heavy metal contamination in mammals. Microgravity research, modulations in mechanical culture conditions (modeled microgravity), and shear stress have spawned innovative approaches to understanding the dynamics of cellular interactions, gene expression, and differentiation in several cellular systems. These investigations have led to the creation of ex vivo tissue models capable of serving as physiological research analogs for three-dimensional cellular interactions. These models are enabling studies in immune function, tissue modeling for basic research, and neoplasia. Three-dimensional cellular models emulate aspects of in vivo cellular architecture and physiology and may facilitate environmental toxicological studies aimed at elucidating biological functions and responses at the cellular level. Marine mammals occupy a significant ecological niche (72% of the Earth's surface is water) in terms of the potential for information on bioaccumulation and transport of terrestrial and marine environmental toxins in high-order vertebrates. Few ex vivo models of marine mammal physiology exist in vitro to accomplish the aforementioned studies. Techniques developed in this investigation, based on previous tissue modeling successes, may serve to facilitate similar research in other marine mammals.

Goodwin, T. J.↗

Regression Model Optimization for the Analysis of Experimental Data

A candidate math model search algorithm was developed at Ames Research Center that determines a recommended math model for the multivariate regression analysis of experimental data. The search algorithm is applicable to classical regression analysis problems as well as wind tunnel strain gage balance calibration analysis applications. The algorithm compares the predictive capability of different regression models using the standard deviation of the PRESS residuals of the responses as a search metric. This search metric is minimized during the search. Singular value decomposition is used during the search to reject math models that lead to a singular solution of the regression analysis problem. Two threshold dependent constraints are also applied. The first constraint rejects math models with insignificant terms. The second constraint rejects math models with near-linear dependencies between terms. The math term hierarchy rule may also be applied as an optional constraint during or after the candidate math model search. The final term selection of the recommended math model depends on the regressor and response values of the data set, the user s function class combination choice, the user s constraint selections, and the result of the search metric minimization. A frequently used regression analysis example from the literature is used to illustrate the application of the search algorithm to experimental data.

Ulbrich, N.↗

Decay of Far-Flowfield in Trailing Vortices

Methods for reduction of velocities in trailing vortices of large aircraft are of current interest for the purpose of shortening the waiting time between landings at central airports. We have made finite-difference calculations of the flow in turbulent wake vortices as an aid to interpretation of wind-tunnel and flight experiments directed toward that end. Finite-difference solutions are capable of adding flexibility to such investigations if they are based on an adequate model of turbulence. Interesting developments have been taking place in the knowledge of turbulence that may lead to a complete theory in the future. In the meantime, approximate methods that yield reasonable agreement with experiment are appropriate. The simplified turbulence model we have selected contains features that account for the major effects disclosed by more sophisticated models in which the parameters are not yet established. Several puzzles are thereby resolved that arose in previous theoretical investigations of wake vortices.

Baldwin, B. S.↗

Response Surface Modeling Using Multivariate Orthogonal Functions

A nonlinear modeling technique was used to characterize response surfaces for non-dimensional longitudinal aerodynamic force and moment coefficients, based on wind tunnel data from a commercial jet transport model. Data were collected using two experimental procedures - one based on modem design of experiments (MDOE), and one using a classical one factor at a time (OFAT) approach. The nonlinear modeling technique used multivariate orthogonal functions generated from the independent variable data as modeling functions in a least squares context to characterize the response surfaces. Model terms were selected automatically using a prediction error metric. Prediction error bounds computed from the modeling data alone were found to be- a good measure of actual prediction error for prediction points within the inference space. Root-mean-square model fit error and prediction error were less than 4 percent of the mean response value in all cases. Efficacy and prediction performance of the response surface models identified from both MDOE and OFAT experiments were investigated.

Morelli, Eugene A.↗

A New Model of the Crustal Magnetic Field of Mars Using MGS and MAVEN

While devoid of an active magnetic dynamo field today, Mars possesses a remanent magnetic field that may reach several thousand nanoteslas locally. The exact origin and the events that have shaped the crustal magnetization remain largely enigmatic. Three magnetic field data sets from two spacecraft collected over 13 cumulative years have sampled the Martian magnetic field over a range of altitudes from 90 up to 6,000 km: (a) Mars Global Surveyor (MGS) magnetometer (1997–2006), (b) MGS Electron Reflectometer (1999–2006), and (c) Mars Atmosphere and Volatile EvolutioN (MAVEN) magnetometer (2014 to today). In this paper we combine these complementary data sets for the first time to build a new model of the Martian internal magnetic field. This new model improves upon previous ones in several aspects: comprehensive data coverage, refined data selection scheme, modified modeling scheme, discrete-to-continuous transformation of the model, and increased model resolution. The new model has a spatial resolution of ∼160 km at the surface, corresponding to spherical harmonic degree 134. It shows small scales and well-defined features, which can now be associated with geological signatures.

Magnetic↗

Development of an Open Rotor Cycle Model in NPSS Using a Multi-Design Point Approach

NASA's Environmentally Responsible Aviation Project and Subsonic Fixed Wing Project are focused on developing concepts and technologies which may enable dramatic reductions to the environmental impact of future generation subsonic aircraft (Refs. 1 and 2). The open rotor concept (also referred to as the Unducted Fan or advanced turboprop) may allow the achievement of this objective by reducing engine emissions and fuel consumption. To evaluate its potential impact, an open rotor cycle modeling capability is needed. This paper presents the initial development of an open rotor cycle model in the Numerical Propulsion System Simulation (NPSS) computer program which can then be used to evaluate the potential benefit of this engine. The development of this open rotor model necessitated addressing two modeling needs within NPSS. First, a method for evaluating the performance of counter-rotating propellers was needed. Therefore, a new counter-rotating propeller NPSS component was created. This component uses propeller performance maps developed from historic counter-rotating propeller experiments to determine the thrust delivered and power required. Second, several methods for modeling a counter-rotating power turbine within NPSS were explored. These techniques used several combinations of turbine components within NPSS to provide the necessary power to the propellers. Ultimately, a single turbine component with a conventional turbine map was selected. Using these modeling enhancements, an open rotor cycle model was developed in NPSS using a multi-design point approach. The multi-design point (MDP) approach improves the engine cycle analysis process by making it easier to properly size the engine to meet a variety of thrust targets throughout the flight envelope. A number of design points are considered including an aerodynamic design point, sea-level static, takeoff and top of climb. The development of this MDP model was also enabled by the selection of a simple power management scheme which schedules propeller blade angles with the freestream Mach number. Finally, sample open rotor performance results and areas for further model improvements are presented.

Hendricks, Eric S.↗

Topology-selective jamming of fully-connected, code-division random-access networks

The purpose is to introduce certain models of topology selective stochastic jamming and examine its impact on a class of fully-connected, spread-spectrum, slotted ALOHA-type random access networks. The theory covers dedicated as well as half-duplex units. The dominant role of the spatial duty factor is established, and connections with the dual concept of time selective jamming are discussed. The optimal choices of coding rate and link access parameters (from the users' side) and the jamming spatial fraction are numerically established for DS and FH spreading.

Polydoros, Andreas↗

An Innovative Structural Mode Selection Methodology: Application for the X-33 Launch Vehicle Finite Element Model

An innovative methodology for determining structural target mode selection and mode selection based on a specific criterion is presented. An effective approach to single out modes which interact with specific locations on a structure has been developed for the X-33 Launch Vehicle Finite Element Model (FEM). We presented Root-Sum-Square (RSS) displacement method computes resultant modal displacement for each mode at selected degrees of freedom (DOF) and sorts to locate modes with highest values. This method was used to determine modes, which most influenced specific locations/points on the X-33 flight vehicle such as avionics control components, aero-surface control actuators, propellant valve and engine points for use in flight control stability analysis and for flight POGO stability analysis. Additionally, the modal RSS method allows for primary or global target vehicle modes to also be identified in an accurate and efficient manner.

Hidalgo, Homero, Jr.↗

Modification and updating of the Manned Activity Scheduling System (MASS) for shuttle and shuttle payloads analysis. Volume 2: Space shuttle sortie payload analysis

Space shuttle operations include a significant number of launches with a sortie laboratory serving as a facility for manned experimentation in space. Planning a program of space experiments for a facility of this type requires that both the composition of the laboratory payload and the schedule of experiment operations for each payload be carefully selected. Experiment operations are investigated using the manned activity scheduling system (MASS). Schedules provided by these models assist in selecting experiment groups that efficiently use the laboratory resources and yield the desired experiment accomplishment at the program level. An alternate use of the MASS models provides for establishing the time-dependent supporting resources required for a specified candidate payload. A procedure for defining and analyzing shuttle sortie payloads was developed. This procedure was then applied to the definition of mixed-discipline experiment payloads for an advanced technology laboratory (ATL) supported by two-and three-man crews. The ATL payloads, including schedules of experiment operations, were defined to realize a high percentage of experiment accomplishment. The study considers the sensitivity of experiment accomplishment rate to variations of system parameters such as crew cross training, crew operations, shuttle and laboratory resources, ground target systems, and operational orbits.

Huyett, R. C.↗

An integrated and modular digital modeling approach for the space station electrical power system development

An electrical power system for the Space Station was designed, developed and built. This system provides for electrical power generation, conditioning, storage, and distribution. The initial configuration uses photovoltaic power generation. The power system control is based on a hierarchical architecture to support the requirements of automation. In the preliminary design and technology development phase of the program, various modeling techniques and software tools were evaluated for the purpose of meeting the Space Station power system modeling requirements. Rocketdyne and LeRC jointly selected the EASY5 simulation software, developed by Boeing Computer Services, as a system level modeling tool. The application of the selected analytical modeling approach to represent the entire power system is described. Typical results of model predictions are also summarized. The equipment modeled includes solar arrays, dc to ac converters, resonant inverters, battery storage system, alternator, transmission line, switch gear, and system level microprocessor controls. During the advanced development phase of this program, several models were developed using this approach.

Gombos, Frank J.↗

An integrated and modular digital modeling approach for the Space Station electrical power system development

An electrical power system for the Space Station was designed, developed and built. This system provides for electrical power generation, conditioning, storage, and distribution. The initial configuration uses photovoltaic power generation. The power system control is based on a hierarchical architecture to support the requirements of automation. In the preliminary design and technology development phase of the program, various modeling techniques and software tools were evaluated for the purpose of meeting the Space Station power system modeling requirements. Rocketdyne and LeRC jointly selected the EASY5 simulation software, developed by Boeing Computer Services, as a system level modeling tool. The application of the selected analytical modeling approach to represent the entire power system is described. Typical results of model predictions are also summarized. The equipment modeled includes solar arrays, dc to ac converters, resonant inverters, battery storage system, alternator, transmission line, switch gear, and system level microprocessor controls. During the advanced development phase of this program, several models were developed using this approach.

Gombos, Frank J.↗

Simulation Framework to Estimate the Performance of CO2 and O2 Sensing from Space and Airborne Platforms for the ASCENDS Mission Requirements Analysis

The Active Sensing of CO2 Emissions over Nights Days and Seasons (ASCENDS) mission recommended by the NRC Decadal Survey has a desired accuracy of 0.3% in carbon dioxide mixing ratio (XCO2) retrievals requiring careful selection and optimization of the instrument parameters. NASA Langley Research Center (LaRC) is investigating 1.57 micron carbon dioxide as well as the 1.26-1.27 micron oxygen bands for our proposed ASCENDS mission requirements investigation. Simulation studies are underway for these bands to select optimum instrument parameters. The simulations are based on a multi-wavelength lidar modeling framework being developed at NASA LaRC to predict the performance of CO2 and O2 sensing from space and airborne platforms. The modeling framework consists of a lidar simulation module and a line-by-line calculation component with interchangeable lineshape routines to test the performance of alternative lineshape models in the simulations. As an option the line-by-line radiative transfer model (LBLRTM) program may also be used for line-by-line calculations. The modeling framework is being used to perform error analysis, establish optimum measurement wavelengths as well as to identify the best lineshape models to be used in CO2 and O2 retrievals. Several additional programs for HITRAN database management and related simulations are planned to be included in the framework. The description of the modeling framework with selected results of the simulation studies for CO2 and O2 sensing is presented in this paper.

Plitau, Denis↗

Application of an Optimal Tuner Selection Approach for On-Board Self-Tuning Engine Models

An enhanced design methodology for minimizing the error in on-line Kalman filter-based aircraft engine performance estimation applications is presented in this paper. It specific-ally addresses the under-determined estimation problem, in which there are more unknown parameters than available sensor measurements. This work builds upon an existing technique for systematically selecting a model tuning parameter vector of appropriate dimension to enable estimation by a Kalman filter, while minimizing the estimation error in the parameters of interest. While the existing technique was optimized for open-loop engine operation at a fixed design point, in this paper an alternative formulation is presented that enables the technique to be optimized for an engine operating under closed-loop control throughout the flight envelope. The theoretical Kalman filter mean squared estimation error at a steady-state closed-loop operating point is derived, and the tuner selection approach applied to minimize this error is discussed. A technique for constructing a globally optimal tuning parameter vector, which enables full-envelope application of the technology, is also presented, along with design steps for adjusting the dynamic response of the Kalman filter state estimates. Results from the application of the technique to linear and nonlinear aircraft engine simulations are presented and compared to the conventional approach of tuner selection. The new methodology is shown to yield a significant improvement in on-line Kalman filter estimation accuracy.

Simon, Donald L.↗

Acoustic Model Testing Chronology

Scale models have been used for decades to replicate liftoff environments and in particular acoustics for launch vehicles. It is assumed, and analyses supports, that the key characteristics of noise generation, propagation, and measurement can be scaled. Over time significant insight was gained not just towards understanding the effects of thruster details, pad geometry, and sound mitigation but also to the physical processes involved. An overview of a selected set of scale model tests are compiled here to illustrate the variety of configurations that have been tested and the fundamental knowledge gained. The selected scale model tests are presented chronologically.

Nesman, Tom↗

Jet V/STOL wind-tunnel simulation and groundplane effects

The pretest preparation necessary to define the objectives of an appropriate investigation into the jet V/STOL wind tunnel simulation and ground plane effects were examined. Low speed wind tunnel testing of V/STOL aircraft concepts to determine the aerodynamic propulsion interaction effects during the transition between hover and wingborne flight is a necessary step in the development cycle of this type of aircraft. Powered models are normally used to determine the aerodynamic performance characteristics. Several factors which influence the selection of the model concept and the engine simulator are discussed. Some of the test techniques important for this class of aircraft model are examined. Wind tunnel wall effects important to this aircraft testing with special emphasis on groundplane effects are reviewed.

Margason, R. J.↗

Orbital transfer vehicle concept definition and system analysis study, 1985. Volume 3: System and program trades

The key system and program trade studies performed to arrive at a preferred Orbital Transfer Vehicle (OTV) system concept and evolutionary approach to the acquisition of the requisite capabilites is documented. These efforts were expanded to encompass a Space Transportation Architecture Study (STAS) mission model and recommended unmanned cargo vehicle. The most important factors affecting the results presented are the mission model requirements and selection criteria. The reason for conducting the OTV concept definition and system analyses study is to select a concept and acquisition approach that meets a delivery requirement reflected by the mission model.

Nelson, James H.↗