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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 433 records · Page 24
All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

From Prevention to Disease Perturbations: A Multi-Omic Assessment of Exercise and Myocardial Infarctions

While a molecular assessment of the perturbations and injury arising from diseases is essential in their diagnosis and treatment, understanding changes due to preventative strategies is also imperative. Currently, complex diseases such as cardiovascular disease (CVD), the leading cause of death worldwide, suffer from a limited understanding of how the molecular mechanisms taking place following preventive measures (e.g., exercise) differ from changes occurring due to the injuries caused from the disease (e.g., myocardial infarction (MI)). Therefore, this manuscript assesses lipidomic changes before and one hour after exercise treadmill testing (ETT) and before and one hour after a planned myocardial infarction (PMI) in two separate patient cohorts. Strikingly, unique lipidomic perturbations were observed for these events, as could be expected from their vastly different stresses on the body. The lipidomic results were then combined with previously published metabolomic characterizations of the same patients. This integration provides complementary insights into the exercise and PMI events, thereby giving a more holistic understanding of the molecular changes associated with each.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1997

Pre-exercise hypervolemia and cycle ergometer endurance in men

Time to exhaustion at 87-91% of peak VO2 was measured in 5 untrained men (age: 31 +/- 8 years, body mass: 74.20 +/- 16.50 kg, body surface area: 1.90 +/- 0.24 m2, peak VO2: 2.87 +/- 0.40 l min-1, plasma volume: 3.21 +/- 0.88 l; means +/-SD) after consuming nothing (N) or two fluid formulations (10 ml kg-1, 743 +/- 161 ml): Performance 1 (P1), a multi-ionic carbohydrate drink, containing 55 mEq l-1 Na+, 4.16 g l-1 citrate, 20.49 g l-1 glucose, and 365 mOsm kg-1 H2O, and AstroAde (AA), a sodium chloride-sodium citrate hyperhydration drink, containing 164 mEq l-1 Na+, 8.54 g l-1 citrate, <5 mg l-1 glucose, and 253 mOsm kg-1 H2O. Mean (+/-SE) endurance for N, P1 and AA was 24.68 +/- 1.50, 24.55 +/- 1.09, and 30.50 +/- 3.44 min respectively. Percent changes in plasma volume (PV) from -105 min of rest to zero min before exercise were -1.5 +/- 3.2% (N), 0.2 +/- 2.2% (P1), and 4.8 +/- 3.0% (AA; P < 0.05). The attenuated endurance for N and P1 could not be attributed to differences in exercise metabolism (VE, RE, VO2) from the carbohydrate or citrate, terminal heart rate, levels of perceived exertion, forehead or thigh skin blood flow velocity, changes or absolute termination levels of rectal temperature. Thus, the higher level of resting PV for AA just before exercise, as well as greater acid buffering and possible increased energy substrate from citrate, may have contributed to the greater endurance.

NASA Center ARC↗
NASA NTRS1997

Resistance exercise prevents plantar flexor deconditioning during bed rest

Because resistance exercise (REX) and unloading induce opposing neuromuscular adaptations, we tested the efficacy of REX against the effects of 14 d of bed rest unloading (BRU) on the plantar flexor muscle group. Sixteen men were randomly assigned to no exercise (NOE, N = 8) or REX (N = 8). REX performed 5 sets x 6-10 repetitions to failure of constant resistance concentric/eccentric plantar flexion every other day during BRU. One-repetition maximum (1RM) strength was tested on the training device. The angle-specific torque-velocity relationship across 5 velocities (0, 0.52, 1.05, 1.75, and 2.97 rad.s-1) and the full range-of-motion power-velocity relationship were assessed on a dynamometer. Torque-position analyses identified strength changes at shortened, neutral, and stretched muscle lengths. Concentric and eccentric contractile work were measured across ten repetitions at 1.05 rad.s-1. Maximal neural activation was measured by surface electromyography (EMG). 1RM decreased 9% in NOE and improved 11% in REX (P < 0.05). Concentric (0.52 and 1.05 rad.s-1), eccentric (0.52 and 2.97 rad.s-1), and isometric angle-specific torques decreased (P < 0.05) in NOE, averaging 18%, 17%, and 13%, respectively. Power dropped (P < 0.05) in NOE at three eccentric (21%) and two concentric (14%) velocities. REX protected angle-specific torque and average power at all velocities. Concentric and eccentric strength decreased at stretched (16%) and neutral (17%) muscle lengths (P < 0.05) in NOE while REX maintained or improved strength at all joint positions. Concentric (15%) and eccentric (11%) contractile work fell in NOE (P < 0.05) but not in REX. Maximal plantar flexor EMG did not change in either group. In summary, constant resistance concentric/eccentric REX completely prevented plantar flexor performance deconditioning induced by BRU. The reported benefits of REX should prove useful in prescribing exercise for astronauts in microgravity and for patients susceptible to functional decline during bed- or chair-bound hospital stays.

NASA Discipline Musculoskeletal↗
NASA NTRS2025

Astronaut Physiological Deconditioning and Exercise Prescription Countermeasures in Spaceflight

The human skeletal muscular and cardiovascular systems are adapted to the upright posture of Earth’s gravitational environment. Astronauts experience an altered gravity environment in spaceflight that leads to a number of physiological changes and decrements to these systems that can decrease overall crew performance. Countermeasures, including prescribed exercise during spaceflight, is vital for astronauts to maintain optimal health and performance. The degree of physiological deconditioning is dependent on a multitude of factors such as sex, age, mission duration, fitness level, and gravity environments experienced. Deconditioning begins immediately upon entering an altered gravity environment and physiological decrements of the skeletal muscular and cardiovascular systems are measurable among astronauts within a few days. Thus, to maintain their physical fitness, ability to perform mission duties, and be able to egress vehicles when needed, it is imperative that astronauts participate in exercise during all phases of flight. This is especially important for long duration flights where deconditioning effects can be more deleterious. The NASA Office of the Chief Health and Medical Officer 3001 Standards Team develops requirements utilized by commercial and international partners to better understand spaceflight-induced physiological changes and countermeasures and expected outcomes with or without exercise.

exercise physiology↗
DOE OSTI2025

Summary Report Of The FY25 Reactor Physics Verification And Validation Exercises In The Advanced Reactor Technologies - Gas-cooled Reactor Program

Valdiation and verification of numerical tools is critical for ensuring reasonable predictions for design scoping, licensing, and safety analsyis. In this report, two reactor physics verification and validation exercises are presented. The first of these exercises focuses on burnup analysis with data from the Advanced Gas Reactor (AGR) program. Simulations are performed with Monte Carlo N-Particle (MCNP) and are compared with the experimental measurements for the AGR 1 and 2 experiments that utilize both UCO and UO2 fuel. The second exercises utilizes data from the HTR-Proteus experiments to perform reactor physics validation. Specifications of the experimental facility are provdied, along with a demonstration of initial modeling efforts in Serpent for one of the determistic packing experiments. Both cases are part of the Generation-IV international forum (GIF) Very High-Temperature Reactor (VHTR) Computational Methods, Validation, and Benchmarking (CMVB) program, an international collaborative organization dedicated to the verification and validation of High-Temperature Gas-Cooled Reactor (HTGR) analysis. Participation in the CMVB allows the US Department of Energy (DOE) to leverage these existing validation activities to provide extra value through benchmarking activities with other CMVB members.

and Benchmarking (CMVB) program↗
DOE OSTI2018

Fourth Collaborative Materials Exercise of the Nuclear Forensics International Technical Working Group

Abstract The Nuclear Forensics International Technical Working Group is a community of nuclear forensic practitioners who respond to incidents involving nuclear and other radioactive material out of regulatory control. The Group is dedicated to advancing nuclear forensic science in part through periodic participation in materials exercises. The Group completed its fourth Collaborative Materials Exercise in 2015 in which laboratories from 15 countries and one multinational organization analyzed three samples of special nuclear material in support of a mock nuclear forensic investigation. This special section of the Journal for Radioanalytical and Nuclear Chemistry is devoted to summarizing highlights from this exercise.

Schwantes, J. M.↗
DOE OSTI2018

Lack of O-GlcNAcylation enhances exercise-dependent glucose utilization potentially through AMP-activated protein kinase activation in skeletal muscle

Highlights: • Ogt deletion enhances exercise-dependent glucose utilization in skeletal muscle. • Ogt depletion enhances glucose uptake and oxidation in C2C12 myotubes. • Lack of O-GlcNAcylation increases AMPKα protein expression both in vivo and in vitro. • Ogt deletion in skeletal muscle reverses HFD-induced obesity and insulin resistance. O-GlcNAcylation is a post-translational modification that is characterized by the addition of N-acetylglucosamine (GlcNAc) to proteins by O-GlcNAc transferase (Ogt). The degree of O-GlcNAcylation is thought to be associated with glucotoxicity and diabetic complications, because GlcNAc is produced by a branch of the glycolytic pathway. However, its role in skeletal muscle has not been fully elucidated. In this study, we created skeletal muscle-specific Ogt knockout (Ogt-MKO) mice and analyzed their glucose metabolism. During an intraperitoneal glucose tolerance test, blood glucose was slightly lower in Ogt-MKO mice than in control Ogt-flox mice. High fat diet-induced obesity and insulin resistance were reversed in Ogt-MKO mice. In addition, 12-month-old Ogt-MKO mice had lower adipose and body mass. A single bout of exercise significantly reduced blood glucose in Ogt-MKO mice, probably because of higher AMP-activated protein kinase α (AMPKα) protein expression. Furthermore, intraperitoneal injection of 5-aminoimidazole-4-carboxamide ribonucleotide, an AMPK activator, resulted in a more marked decrease in blood glucose levels in Ogt-MKO mice than in controls. Finally, Ogt knockdown by siRNA in C2C12 myotubes significantly increased protein expression of AMPKα, glucose uptake and oxidation. In conclusion, loss of O-GlcNAcylation facilitates glucose utilization in skeletal muscle, potentially through AMPK activation. The inhibition of O-GlcNAcylation in skeletal muscle may have an anti-diabetic effect, through an enhancement of glucose utilization during exercise.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2021

Dietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise

Whether dietary antioxidants are effective for alleviating oxidative costs associated with energy-demanding life events first requires they are successfully absorbed in the digestive tract and transported to sites associated with reactive species production (e.g. the mitochondria). Flying birds are under high energy and oxidative demands, and although birds commonly ingest dietary antioxidants in the wild, the bioavailability of these consumed antioxidants is poorly understood. We show for the first time that an ingested lipophilic antioxidant, α-tocopherol, reached the mitochondria in the flight muscles of a songbird but only if they regularly exercise (60 min of perch-to-perch flights two times in a day or 8.5 km day -1 ). Deuterated α-tocopherol was found in the blood of exercise-trained zebra finches within 6.5 hrs and in isolated mitochondria from pectoral muscle within 22.5 hrs, but never reached the mitochondria in caged sedentary control birds. This rapid pace (within a day) and extent of metabolic routing of a dietary antioxidant to muscle mitochondria means that daily consumption of such dietary sources can help to pay the inevitable oxidative costs of flight muscle metabolism, but only when combined with regular exercise.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2014

Final Design for an International Intercomparison Exercise for Nuclear Accident Dosimetry at the DAF Using Godiva-IV: IER-148 CED-2 Report

This document is the Final Design (CED-2) Report for IER-148, “International Inter-comparison Exercise for Nuclear Accident Dosimetry at the DAF Using Godiva-IV.” The report describes the structure of the exercise consisting of three irradiations; identifies the participating laboratories and their points of contact; provides the details of all dosimetry elements and their placement in proximity to Godiva-IV on support stands or phantoms ; and lists the counting and spectroscopy equipment each laboratory will utilize in the Mercury NAD Lab. The exercise is tentatively scheduled for one week in August 2015.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2016

International Intercomparison Exercise for Nuclear Accident Dosimetry at the DAF Using GODIVA-IV

The Nuclear Criticality Safety Program operated under the direction of Dr. Jerry McKamy completed the first NNSA Nuclear Accident Dosimetry exercise on May 27, 2016. Participants in the exercise were from Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Sandia National Laboratory (SNL), Savanah River Site (SRS), Pacific Northwest National Laboratory (PNNL), US Navy, the Atomic Weapons Establishment (United Kingdom) under the auspices of JOWOG 30, and the Institute for Radiological Protection and Nuclear Safety (France) by special invitation and NCSP memorandum of understanding. This exercise was the culmination of a series of Integral Experiment Requests (IER) that included the establishment of the Nuclear Criticality Experimental Research Center, (NCERC) the startup of the Godiva Reactor (IER-194), the establishment of a the Nuclear Accident Dosimetry Laboratory (NAD LAB) in Mercury, NV, and the determination of reference dosimetry values for the mixed neutron and photon radiation field of Godiva within NCERC.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2019

IAEA Coordinated Research Project on HTGR Physics, Thermal Hydraulics, and Depletion Uncertainty Analysis: PHISICS/RELAP5-3D Results for the Phase III Coupled Core Exercises

This report details the Parallel and Highly Innovative Simulation for INL Code System (PHISICS)/Reactor Excursions and Leak Analysis Program (RELAP5)-3D results obtained for the neutronics stand-alone core exercises defined for Phase II of the International Atomic Energy Agency (IAEA) Coordinated Research Project (CRP) on high-temperature gas cooled reactor (HTGR) uncertainty analysis in modeling (UAM). The Phase II models and results are linked to the earlier Standardized Computer Analyses for Licensing Evaluation (SCALE)/Sampler/New ESC-based Weighting Transport (NEWT) data generated for the lattice physics (lattice) stage Phase I of the CRP. The focus of this report is the propagation of cross-section uncertainties from the lattice to the core calculation (core) phase of the prismatic 350 megawatt (MW) General Atomics (GA) Modular HTGR (MHTGR). The Phase II neutronics exercises consist of two sub-cases (II-2a and II-2b) specified for the fresh and mixed core loading of the MHTGR-350 prismatic high-temperature reactor design. Exercises II-2a and II-2b are performed without temperature feedback using isothermal temperature profiles. For the nominal lattice physics (i.e., best-estimate) model, a series of fresh and depleted single block and super cell SCALE/KENO and SCALE/NEWT models were developed at Idaho National Laboratory (INL) to assess the impact of spectral effects on the few-group cross sections. A combination of these lattice cells were used in a super cell calculation to construct 8-group cross-section libraries for use in the INL-developed PHISICS/RELAP5-3D code suite. The block-level homogenized libraries were assigned to the 220 fuel zones utilized in the MHTGR-350 PHISICS core model, according to the fresh and mixed fresh/depleted core loading pattern. In order to evaluate the effect of uncertainty propagation, several sets consisting of 1,000 perturbed NEWT lattice and PHISICS/RELAP5-3D core calculations were performed using the SCALE 6.2 ENDF/B-VII.1 cross-section co-variance data and the stochastic sampling module Sampler in SCALE 6.2.0. The Figures of Merit (FOM) investigated include the mean and standard deviation uncertainty values obtained for the eigenvalues, control rod worth values, block-averaged power profiles, power axial offsets, and isothermal temperature feedback coefficients. A sensitivity study on the main nuclide reaction contributors to the FOM uncertainties has not yet been performed since the SCALE/PHISICS/RAVEN coupling with ENDF/B-VII co-variance data is still being developed. It was found that uncertainties in the cross sections lead to uncertainties in the local power values of up to 1.5%. The variances between the fresh and mixed/depleted core models are not as large as the axial variations between the top and bottom within each core model. The core eigenvalue uncertainty is approximately 0.5%, which is significant in comparison to typical eigenvalue difference targets (less than ~0.1% for LWRs). The power peaking and axial offset uncertainties are smaller (0.10% – 0.15%) and probably below the level of significance in typical core design metrics. The use of an 8-group energy structure slightly under-estimates some of the uncertainties, but in absolute terms, the uncertainty results are reasonably close to the 26-group results. The 26- and 8-group mean and nominal results differ by a larger degree, and if it can be afforded in terms of calculation resources, the 26-group structure should be used for HTGR calculations. The 8-group structure can, however, still be useful for reasonably accurate uncertainty assessments of transient cases where computational time is important. It was furthermore found that the use of a super cell during the cross-section generation process for better representation of the spectral environment at the core periphery did not lead to significant changes in the core eigenvalues, axial offset, and power peaking uncertainties. The impact of the super cell cross sections on the nominal and mean eigenvalues is, however, important enough (0.6% – 1.1% lower) to justify the use of these super cells for HTGR core simulation to represent the softer spectral environment in the core peripheral regions for nominal best-estimate calculations. The use of super cells for HTGR uncertainty studies is, therefore, not strictly necessary, but the improvements in nominal results could justify their use.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗
DOE OSTI2020

TA-55 Forensic Support Operations Cross-Training Exercise

As part of the annual FBI/LANL training schedule, a joint training exercise was conducted during the week of 10FEB2020 with FBI HEAT members and LANL Fissile Material Handlers (FMHs). The joint training exercise was conducted in a non-radiological area to reduce cost and ensure the test object would not be contaminated. The exercise test object was fabricated by LANL using surrogate materials to represent an object containing Special Nuclear Material (SNM). Working with Jim Blankenship and Kevin Swearingen, functional requirements of the test object included the following: unclassified, disassembly (to include screws), and moderately heavy. To meet the objectives, the test object was fabricated by welding a custom aluminum box (8” x 8” x 12”) with a lid which was secured by four (4) screws. The custom box housed a track and field shot put (16 lbs.) that was anchored by a hose clamp. The intent of the training was to disassemble the test object and conduct traditional forensic determinations on the parts. This lessons learned report documents all of the associated aspects related to the joint training effort.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2022

Experiment Logistics for an International Blind Intercomparison Exercise for Nuclear Accident Dosimetry at Godiva-IV

This document is the Experimental Set-up and Design (CED-3A) Report for IER-538, “Full Dosimetry Exercise Around Godiva Reactors” The report discusses the structure of the exercise consisting of two critical excursions, identifying the participating laboratories and their points of contact. The report also includes details of all dosimetry each laboratory will submit to be placed in proximity to Godiva-IV on aluminum plates or BOMAB phantoms. Each laboratory list the counting and spectroscopy equipment to be utilized at the LLNL NAD Laboratory in Mercury. The exercise is tentatively scheduled for one week in fiscal year 2022.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2023

Godiva-IV Dosimetry Exercise 2022 (IER-538 CED4A Report)

This report presents the final results of IER 538, The International Nuclear Accident Dosimeter (NAD) Intercomparison Exercise with Godiva-IV. The purpose of the exercise, held in August of 2022, was to test participants’ NADs and dosimetry personnel to the dose estimation requirements established by ANSI/HPS-N13.3 Dosimetry for Criticality Accidents and DOE-STD-1098-2017, Radiological Control. Two prompt critical bursts of the Godiva critical assembly were used to simulate criticality accidents, and NADs from participating laboratories were placed at known locations around Godiva, mounted on either BOttle Manikin ABsorptions (BOMABs) phantoms (to simulate doses received by people) or plates (to simulate doses in free air). Similar exercises have been held in 2016 and 2018 using National Criticality Experiments Research Center’s (NCERC’s) Flattop and Godiva assemblies.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2022

HERA M&S Exercise Problem Description Report

The Nuclear Energy Agency (NEA) Framework for Irradiation Experiments (FIDES) program includes the High burnup Experiments for Reactivity initiated Accident (HERA) Joint Experimental Program (JEEP). The HERA project is focused on studying Light Water Reactor (LWR) fuel behavior during Reactivity Initiated Accident (RIA) conditions. The HERA experiment plan includes analytical integral experiments using test specimens tailored to investigate specific conditions of relevance as well as prototypic integral experiments focused on irradiated fuel from prototypic origin. Modeling & simulation (M&S) is a key component of any experiment program, and the HERA JEEP is coordinating a M&S exercise. The purpose of this document is to provide problem descriptions to support the HERA M&S exercise based on fuel performance modeling. The HERA M&S exercise is expected to evolve into multiple efforts in outyears. This document may be revised and expanded to incorporate those evolutions.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2026

Logistics for the 2026 International Nuclear Accident Dosimetry Intercomparison Exercise

The purpose of this exercise is to test participants’ nuclear accident dosimeters (NADs) and personnel to the requirements established by American National Standards Institute (ANSI), Health Physics Society (HPS) standard ANSI/HPS-N13.3-2013 (R2025) Dosimetry for Criticality Accidents. IER-634 is the second nuclear accident dosimetry exercise taking place at the Armed Forces Radiobiology Research Institute (AFRRI) in Bethesda, MD, a Department of Defense (DOD) facility. This effort continues use of the high-dose neutron exposure test bed maintained by the DOD and represents the continued collaboration between the DOD and Department of Energy (DOE). Previous work at AFRRI included a reactor characterization (IER 484) in 2023 and a nuclear accident intercomparison exercise (IER-602) in 2024.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2023

The comparison between effects of Taichi and conventional exercise on functional mobility and balance in healthy older adults: a systematic literature review and meta-analysis

Background Taichi is beneficial for functional mobility and balance in older adults. However, such benefits of Taichi when comparing to conventional exercise (CE) are not well understood due to large variance in study protocols and observations. Methods We reviewed publications in five databases. Eligible studies that examined the effects of Taichi on the outcomes of functional mobility and balance in healthy older adults as compared to CE were included. Subgroup analyses compared the effects of different types of CE (e.g., single and multiple-type exercise) and different intervention designs (e.g., Taichi types) on those outcomes (Registration number: CRD42022331956). Results Twelve studies consisting of 2,901 participants were included. Generally, compared to CE, Taichi induced greater improvements in the performance of Timed-Up-and-Go (SMD = −0.18, [−0.33 to −0.03], p = 0.040, I 2 = 59.57%), 50-foot walking (MD = −1.84 s, [−2.62 to −1.07], p < 0.001, I 2 = 0%), one-leg stance with eyes open (MD = 6.00s, [2.97 to 9.02], p < 0.001, I 2 = 83.19%), one-leg stance with eyes closed (MD = 1.65 s, [1.35 to 1.96], p < 0.001, I 2 = 36.2%), and functional reach (SMD = 0.7, [0.32 to 1.08], p < 0.001, I 2 = 86.79%) tests. Subgroup analyses revealed that Taichi with relatively short duration (<20 weeks), low total time (≤24 h), and/or using Yang-style, can induce significantly greater benefits for functional mobility and balance as compared to CE. Uniquely, Taichi only induced significantly greater improvements in Timed-Up-and-Go compared to single- (SMD = −0.40, [−0.55 to −0.24], p < 0.001, I 2 = 6.14%), but not multiple-type exercise. A significant difference between the effects of Taichi was observed on the performance of one-leg stance with eyes open when compared to CE without balance (MD = 3.63 s, [1.02 to 6.24], p = 0.006, I 2 = 74.93%) and CE with balance (MD = 13.90s, [10.32 to 17.48], p < 0.001, I 2 = 6.1%). No other significant difference was shown between the influences of different CE types on the observations. Conclusion Taichi can induce greater improvement in functional mobility and balance in older adults compared to CE in a more efficient fashion, especially compared to single-type CE. Future studies with more rigorous design are needed to confirm the observations here.

Li, Yiting↗
NASA NTRS1971

Cardiocirculatory responses to exercise - Physiologic study by noninvasive techniques.

The changes from rest to exercise were determined for certain phases of the cardiac cycle in ten healthy male subjects who underwent submaximal, physiologically paced bicycle ergometry. ECGs, phonocardiograms, and carotid pu lse tracings were recorded. The preejection period and isovolumic contraction time decreased with exercise. Changes in left ventricular ejection time appeared to depend on the severity or the duration of stress. Pulse transmission time did not change significantly. The data obtained in the study and comparison of these results to those obtained by invasive methods indicate that noninvasive techniques, when used in the manner suggested, are appropriate means for detecting a variety of cardiocirculatory changes during exercise.

Pigott, V. M.↗