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At least 433 records · Page 24

Gantry-Based 5-Fraction Elective Nodal Irradiation in Unfavorable-Risk Prostate Cancer: Outcomes From 2 Prospective Studies Comparing SABR Boost With MR Dose-Painted HDR Brachytherapy Boost

Guidelines from the American Society of Clinical Oncology and Cancer Care Ontario recommend brachytherapy boost for patients with intermediate-risk or high-risk prostate cancer. SABR is an emerging technique for prostate cancer, but its use in high-risk disease is limited. Efficacy, toxic effects, and quality of life (QoL) were compared in patients treated on 2 prospective protocols that used SABR boost or magnetic resonance–guided high-dose-rate brachytherapy (HDR-BT) boost with 6 to 18 months of androgen deprivation therapy (ADT).

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Experiment K-6-24, K-6-25, K-6-26. Radiation dosimetry and spectrometry

Radiation experiments flown by the University of San Francisco on the Cosmos 1887 spacecraft were designed to measure the depth dependence of both total dose and heavy particle flux, dose and dose equivalent, down to very thin shielding. Three experiments were flown and were located both inside and outside the Cosmos 1887 spacecraft. Tissue absorbed dose rates of 264 to 0.028 rad d(-1) under shielding of 0.013 to 3.4 g/sq cm of (7)LiF were found outside the spacecraft and 0.025 rad d(-1) inside. Heavy particle fluxes of 3.43 to 1.03 x 10 to the minus 3rd power cm -2 sub s -1 sub sr -1 under shielding of 0.195 to 1.33 g/sq cm plastic were found outside the spacecraft and 4.25 times 10 to the minus 4th power cm -2 sub s -1 sub sr -1 inside (LET infinity H2O greater than or equal to 4 keV/micron m). The corresponding heavy particle dose equivalent rates outside the spacecraft were 30.8 to 19.8 mrem d(-1) and 11.4 mrem d(-1) inside. The large dose and particle fluxes found at small shielding thicknesses emphasize the importance of these and future measurements at low shielding, for predicting radiation effects on space materials and experiments where shielding is minimal and on astronauts during EVA. The Cosmos 1887 mission contained a variety of international radiobiological investigations to which the measurements apply. The high inclination orbit (62 degrees) of this mission provided a radiation environment which is seldom available to U.S. investigators. The radiation measurements will be compared with those of other research groups and also with those performed on the Shuttle, and will be used to refine computer models employed to calculate radiation exposures on other spacecraft, including the Space Station.

Benton, E. V.↗

Characterization of Radiation Hardened Bipolar Linear Devices for High Total Dose Missions

Radiation hardened linear devices are characterized for performance in combined total dose and displacement damage environments for a mission scenario with a high radiation level. Performance at low and high dose rate for both biased and unbiased conditions is compared and the impact to hardness assurance methodology is discussed.

Enhanced Low Dose Rate Sensitivity (ELDRS)↗

Avalanche ASV016204 (Pre-Production Samples) 40nm MRAM Total Ionizing Dose Test Report

The purpose of this test was to characterize the Avalanche Technology ASV016204’s total dose response. In the test, the device was exposed to high dose rate (HDR) irradiations using gamma radiation. Device functionality (in terms of memory cell upsets and read/write ability) as well as power supply currents during various modes of operations were recorded.

Total Ionizing Dose (TID)↗

Analysis of Material Properties of Aged Rigid Polyurethane Foam

Foams are classified as either rigid or flexible and are commonly used in applications such as pipe insulation, carpet fibers, and chair foam cushions. Polyurethane foams are excellent thermal insulators, have excellent mechanical properties, and are chemically inert. With the addition of fire protective additives, polyurethane foams have the ability to intumescence when exposed to high temperatures. For the future storage of the 9977 nuclear shipping packages, the material properties of the General Plastics 3716 rigid polyurethane foam were evaluated for long term performance by comparing aged samples to unaged samples. General Plastics 3716 rigid polyurethane foam was aged from November 2014 to June 2019 at varying temperatures of: 160 deg. F, 160 deg. F + 50% relative humidity (RH), 185 deg. F, 215 deg. F, and 250 deg. F. The foam was then analyzed via Fourier Transform Infrared Spectroscopy (FTIR), 3D Optical Microscope, Thermal Gravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC). FTIR and Optical Microscope: No significant change to chemical or physical structure was evident by FTIR or optical microscope analysis. DSC: Decrease of heat capacity over time for all oven temperatures except a slight increase for the 185 deg. F conditioned foams. Largest decrease evident with foams conditioned at 250 deg. F. A slight increase in heat capacity for humid samples. Similar trends in heat capacities at 71 deg. C and 102 deg. C. TGA: As conditioning temperature increased, a decline was evident in the average percent weight loss, onset temperature, and first derivative peak temperature. No significant effect due to humidity except for a decrease in first derivative peak temperature. Unaged samples exhibited strong intumescence. Foams conditioned at 160 deg. F exhibited slight intumescence. Results suggest fire protective additives decomposed at higher temperatures, which contributed to a lower average percent mass loss in higher temperature conditioning. Further thermal degradation testing would be beneficial to evaluate the ability of the conditioned foams to intumesce. Evaluate irradiation dose rate effects on conditioned foam. Possible conditioning in an environment with a known humidity or analyzing a new aliquot of sample for each trial to achieve a more representative heat capacity calculation.

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HSYE-117RH Voltage Linear Regulator Total Ionizing Dose Test Report

The purpose of this test was to validate the Intersil HSYE-117RH-Q flight lot for use in the fabrication of Europa Clipper Propulsion subsystem flight hardware. This test shall serve as the radiation lot acceptance test (RLAT) for the flight lot date with wafer lot number G3X3CQC and lot date code (LDC) 1830. Low dose rate (LDR) irradiations have been performed by the manufacturer, but only to 100 krad(Si). This test was a follow-on to the original Radiation Lot-Specific Acceptance Testing (RLAT) performed on this LDC. Application-specific load currents were used for the line regulation and load regulation measurements. All other parameters were measured with standard bias conditions as specified in the datasheet.

Total Ionizing Dose (TID)↗

A Streamlined, Open Source Neutronics Toolkit for Fusion Reactor Design (Final Report)

Final report for the DOE Fusion Energy Sciences project titled "A Streamlined, Open Source Neutronics Toolkit for Fusion Reactor Design". This project developed unstructured mesh tracking capabilities in OpenMC as well as two shutdown dose rate methodologies, and performed extensive performance improvements and validation of the open source Monte Carlo code, OpenMC.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Multicellular Spheroids as In Vitro Models of Oxygen Depletion During FLASH Irradiation

The differential response of normal and tumor tissues to ultrahigh-dose-rate radiation (FLASH) has raised new hope for treating solid tumors but, to date, the mechanism remains elusive. One leading hypothesis is that FLASH radiochemically depletes oxygen from irradiated tissues faster than it is replenished through diffusion. The purpose of this study was to investigate these effects within hypoxic multicellular tumor spheroids through simulations and experiments.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

A Data Processing Workflow for Fixed-wing Drone Based Radiation Mapping in the Chornobyl Exclusion Zone (CEZ) - 20119

April 2020 marks the 34. anniversary of the high-profile radiological release from the Chornobyl Nuclear Power Plant (ChNPP). The release of radioactive material from reactor number four began on the 26 April 1986 and continued over a period of about 10 days, releasing approximately 1700 PBq of radioactive material (including 85 PBq of 137-Cs) into the environment. To this day, the accident remains the most significant release of radioactive material since civil nuclear power generation began. In the years since the accident, automated and remote radiation monitoring technologies have advanced significantly in their capabilities. One such example of this is the use of unmanned aerial vehicles (UAVs) in radiation mapping investigations. In April 2019, a team of scientists from the University of Bristol showcased a novel radiation mapping system within the CEZ, specifically aiming to map radiation over a large portion of the area immediately surrounding the ChNPP. Over six days of data collection, the system flew a total distance of 583.8 km, covering an area of 14.6 sq.km with an exceptional spatial resolution (sub 20 m/pixel). The work presented herein outlines and explains the data processing procedure to convert the raw data into 137-Cs activity (kBq/sq.m) and cesium-equivalent dose-rate (CED) at 1 m above ground level (μSv/hr). A demonstration of the validity of the method is demonstrated through the successful reduction of the raw data into a single linear relationship between the measured {sup 137}Cs net peak intensity and the {sup 137}Cs activity. (authors)

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Challenges and Solutions in Operation and Lay-Up of the Modular Caustic- Side Solvent Extraction Unit - 20078

The Modular Caustic-Side Solvent Extraction (CSSX) Unit (MCU) was designed and constructed to provide interim salt waste processing so that the Liquid Waste Disposition Program (LWDP) could continue waste removal and tank closure until start-up of the Salt Waste Processing Facility (SWPF). MCU processes Clarified Salt Solution (CSS), or salt solution (SS) that has undergone actinide removal/filtration, to produce two waste streams: the cesium laden Strip Effluent (SE), which is incorporated into glass at the Defense Waste Processing Facility (DWPF), and the cesium depleted Decontaminated SS (DSS), which is incorporated into grout at the Saltstone Production Facility (SPF). MCU completed start-up in 2008 with an initial operating life of 3 years and design life of 5 years. Prior to reaching the end of the design life, multiple critical components were upgraded and/or replaced to mitigate risks associated with any delays in SWPF start-up. During the remainder of operation (until June 2019), MCU was challenged to maximize processing with minimal additional modifications to repair/improve aging infrastructure, while maintaining low levels of risk to workers and the environment. Notable challenges during the extended operating life of the facility involved both mechanical and operational issues. Two of the most significant issues were the increased frequency of Process Vessel Ventilation (PVV) High Efficiency Particulate Air (HEPA) filter change-outs and the biofouling of the SE coalescer (SEC). The major impacts of both issues were that replacement of these components 1) resulted in high exposure to workers, and 2) required substantial downtime, thus hindering achievement of processing goals. PVV HEPA filter replacements are required based on dose rate and differential pressure (dP) limits. After introducing a higher-curie feed to MCU, the operating time between change outs was reduced by approximately half. SEC replacements are required based on dP limits. After restarting from an extended outage, the operating life of the SEC was significantly reduced by more than half due to biofouling. As a result of extensive troubleshooting and process improvements, the facility was able to recover performance and extend the operating life of the PVV HEPA filters and the SEC media. Through troubleshooting both of these issues, the facility was also able to learn from prior experience and adapt in order to minimize down time and maintain throughput. Although the facility took advantage of short periods of downtime to perform nonintrusive troubleshooting and minor corrective/preventative maintenance activities, longer outages were periodically required for corrective maintenance involving process cell entry. During these outages, remote tools and specialized shield plates were employed to minimize dose to workers. Mock-ups of non-routine maintenance activities were critical to early identification of potential issues and improvements, which shortened outage duration. Consistent with the facility's operational strategy, evolutions needed for MCU layup were identified and sequenced to ensure safe conditions within the facility, meet pre-defined criteria for lay-up configuration, and protect workers, while minimizing the impact to SWPF integration. De-inventory and flushing of process areas was prioritized so that the total residual inventory was reduced as efficiently as possible. This paper discusses lessons learned and best practices from troubleshooting unique issues, performing complex maintenance activities, and implementing a layup strategy that best supports the overall system mission. (authors)

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Quantification of Oxygen Depletion During FLASH Irradiation In Vitro and In Vivo

Delivery of radiation at ultrahigh dose rates (UHDRs), known as FLASH, has recently been shown to preferentially spare normal tissues from radiation damage compared with tumor tissues. However, the underlying mechanism of this phenomenon remains unknown, with one of the most widely considered hypotheses being that the effect is related to substantial oxygen depletion upon FLASH, thereby altering the radiochemical damage during irradiation, leading to different radiation responses of normal and tumor cells. Testing of this hypothesis would be advanced by direct measurement of tissue oxygen in vivo during and after FLASH irradiation.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

The Galactic Cosmic Ray Simulator at the NASA Space Radiation Research Laboratory

With NASA’s new Artemis plan for a sustainable return to the moon, astronauts will once again leave Earth’s protective magnetosphere only to endure higher levels of radiation from galactic cosmic radiation (GCR). The ever penetrating GCR will continue to pose significant health risks especially as lunar missions increase in duration and as NASA sets its aspirations on Mars. The primary risks of concern include carcinogenesis, central nervous system (CNS) effects resulting in potential in-mission cognitive or behavioral impairment and/or late neurological disorders, and degenerative tissue effects including circulatory and heart disease. Characterization and mitigation of these risks requires a significant reduction in the large biological uncertainties of chronic (low-dose rate) heavy ion exposures and the validation of countermeasures in a relevant space environment. Historically, most research on understanding space radiation-induced health risks has been performed using acute exposures of monoenergetic single-ion beams. However, the space radiation environment consists of a wide variety of ion species over a broad energy range. Using the fast beam switching and controls systems technology recently developed at the NASA Space Radiation Laboratory at Brookhaven National Laboratory, a new era in radiobiological research is possible. NASA has developed the “GCR simulator” to generate a spectrum of ion beams that approximates the primary and secondary GCR field experienced at human organ locations within a deep-space vehicle.

NASA Space Radiation Laboratory↗

HBU R and D Cask Transportation Options - 20436

The TN-32B HBU Demonstration Cask was successfully loaded in November 2017 with 32 high burnup (HBU) fuel assemblies at Dominion's North Anna Nuclear Plant and is collecting thermal data as intended. The first two phases of this very successful project sponsored by DOE and EPRI was designed to collect thermal data of HBU fuel to support extended storage. The next phase of the project requires the cask be licensed for transportation so the cask can be relocated to a site (to be determined by DOE) to facilitate long term monitoring and additional research on the fuel. This is a unique challenge given the constraints that exist for this particular bolted metal cask. The TN-32B cask is a 234,288 lb. (storage configuration) dry storage system that was selected for this project and it was modified to provide thermal data and the ability to collect gas samples after loading. Several major issues must be addressed to obtain the transport license including protecting the seven lid penetrations that were made to allow for the insertion of the thermocouples into the selected fuel assemblies after the cask was loaded. In order to protect the integrity of the research, the payload must remain as is. Therefore, the cask system must be placed into the transportation configuration without rewetting the fuel, replacing the lid and without removing the thermocouple instrumentation that is currently installed. A critical portion of the design and engineering that was performed in the first two phases of the project was to ensure that future transportation of the cask was integrated into the approach. Efforts were made to accommodate requirements such as containment boundary leakage testing, installation of impact limiter brackets and lid bolts suitable for transportation. Due to the science requirements of the project, the fuel selected was intended to yield the highest payload temperatures permitted to provide the greatest value for the researchers. This resulted in higher than usual external dose rates and surface temperatures that warranted performing as much preparatory work prior to cask loading to ensure ALARA and personnel safety to the greatest extent practical rather than working on a loaded cask. In addition to the work performed prior to cask load, there are remaining challenges such as protecting the modified lid, design and fabrication of impact limiters that accommodate the modified cask lid and preserving the thermocouple connections for continued monitoring. The project team is currently performing the necessary calculations, engineering, and design to support the licensing as required by the US NRC. Pre-application meetings have been held to inform the regulator of the planned technical approach to ensure compliance with the applicable regulations. The current plan is to obtain the transportation C of C by the end of 2021. (authors)

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Initial Testing of Alkaline Earth Metal Ion Absorption on Crystalline Silicotitanate - 20440

The Tank Closure Cesium Removal process at the Savannah River Site (SRS) has processed aqueous tank waste using the inorganic ion exchange media IONSIV{sup TM} R9120-Ba (which is also known as Crystalline Silicotitanate (CST)). Salt-cake in Tank 10H at SRS was dissolved and processed through filters and ion exchange columns. The primary purpose of the process is to remove Cs-137 from the aqueous waste so that it can be disposed as low level waste. It is known that this inorganic media also absorbs strontium from solution, and that strontium competes with cesium ions for absorption sites. The strontium ion is actually more strongly absorbed than the cesium ion from typical tank waste. However, strontium is typically present in low concentrations so does not normally cause a significant impact. Strontium is present as both non-radioactive isotopes and the radioactive Sr-90 isotope; with the non-radioactive isotopes being much more abundant. Although the total strontium solubility is usually much lower than cesium, some tank waste compositions can have a high enough soluble strontium concentration to decrease the cesium absorption. Relatedly, some testing at SRS suggested that another alkaline earth metal, calcium, may also absorb onto CST and may decrease cesium absorption. Barium is also an important species in treatment of tank waste, but is also usually present at low concentrations. However, after the Cs-137 is absorbed onto CST, it emits a beta particle and converts to Ba-137m, which then decays to non-radioactive Ba-137 by emission of a gamma ray. If the Ba-137m were to desorb quickly, it could impact the dose rate in down-stream equipment. In order to understand the impact of these alkaline earth metals on CST, SRNL performed testing using simulants of SRS tank waste that contain soluble barium, strontium, and calcium. Testing examined both removal of the alkaline earth metals and their impact on removal of cesium. Testing involved first developing realistic waste simulant formulations and dissolving the alkaline earth metals to high enough concentrations to potentially impact the Cs absorption. Once the formulations were developed and prepared, computer modeling was used to calculate the expected Cs absorption behavior to determine if the alkaline earth metals impact the performance. Measurements of the alkaline earth metals absorption by the media is also important for disposition of spent media because of the added radionuclide inventory from the Sr-90. These initial tests are examining the general impact and will be used to determine if further testing or measurements are needed. (authors)

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Test for Reconditioning RA Waste with Simulated Bitumen and Concrete in a 1,2 MW Plasma Test Facility - 20092

The operation and maintenance of nuclear power plants, the non nuclear fuel cycle, etc generate low-level radioactive waste which, along with the historical radioactive waste from past nuclear activities, needs to be treated and stored, awaiting final disposal. Plasma technology offers a very effective way of treating this waste with a high volume reduction factor (VRF), free from organics, liquids and moisture, and meets without a doubt the acceptance criteria for safe storage and disposal. By means of a plasma beam of approximately 5000 deg. C, the inorganic materials are melted into a glassy slag, containing most of the radioactive isotopes while the organic material is gasified, oxidized and purified in an off-gas cleaning system. First the paper describes the new full-scale Plasma Melting Facility (PMF) at the Kozloduy Nuclear Power Plant in Bulgaria which was taken in nuclear operation In May 2018. The plant has a capacity of 250 tons per year and the maximum contact dose rates of the incoming waste is 2 mSv/h. Different mixtures of radioactive waste packed in 200 l drums were successfully treated resulting in a glassy slag free from liquids and organic material with an important volume reduction factor (VRF). The Project was co-financed through a grant by Kozloduy International Decommissioning fund (KIDSF) administrated by the EBRD through Bulgarian national funding. Plasma is a suitable technology for treatment of problematic waste or even reconditioning waste so Belgoprocess was contracted to do plasma tests with simulated conditioned waste types. One can do tests on a laboratory scale on smaller samples and torch capacities of e.g. 50 kW but Belgoprocess wanted to do more realistic and reliable tests. So Belgoprocess contracted Phoenix Solutions Co who has a full-scope test facility equipped with a 1200 kW plasma torch for full-scope treatment of simulated conditioned waste. For a first confidential contract simulated 200 l (55 gallon) bitumen drums were treated. The drums contained different pucks of compacted waste such as rags, used filters, granulates, etc. The pucks were stacked in the 200 l drums and subsequently embedded with bitumen. A total of 6 drums were treated in the plasma facility. For a second contract simulated homogeneous 200 l (55 gallon) concrete drums with on the one hand concentrates and on the other hand spent resins were selected. A total of 6 drums with concrete and spent resins were treated and melted in the plasma testing facility. The paper describe the test facility, volume reduction factor (VRF) of different waste streams and most important parameters. (authors)

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