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At least 433 records · Page 24

Proton Pumps: Mechanism of Action and Applications

Recent progress in understanding molecular structures and mechanisms of action of proton pumps has paved the way to their novel applications in biotechnology. Proton pumps, in particular bacteriorhodopsin and ATP synthases, are capable of continuous, renewable conversion of light to chemical, mechanical or electrical energy, which can be used in macro- or nano-scale devices. The capability of protein systems incorporated into liposomes to generate ATP, which can be further used to drive chemical reactions, and to act as molecular motors has been already demonstrated. Other possible applications of such biochemical devices include targeted drug delivery and biocatalytic re actors. All these devices might prove superior to their inorganic alternatives.

Lanyi, Janos K.↗

Is Animal Age a Factor In the Response of Bone to Spaceflight?

The rodent bone response to spaceflight may be influenced by a multitude of actors including flight duration, strain, and housing. Review of bone formation rates during spaceflight suggests that age may also play a role in the response. Weanling rats show fewer bone changes than older rats. To determine if the long bones of weanling rats were insensitive to weight-bearing, a hindlimb unloading experiment was conducted simultaneously with a 9d shuttle flight in 34d old group-housed male rats. All animals were injected with bone markers 7d and 1d before flight and euthanized at landing, 24hr, and 72hr following recovery. If no differences in body weight, bone length, or bone formation at the tibiofibular junction were noted at the different time points, data were combined for each group. No significant differences in body weight were found at any time period among the groups. The humerus, tibia, and femur elongated significantly during the flight period with no difference in lengths between groups at the end of the flight period. The group-housed flight rats showed no change in cortical bone formation rate compared to preflight values, flight controls, or vivarium controls. However, the hindlimb unloading group showed a significant 30% decrease in bone formation rate compared to all other groups. Individually-housed 38d old animals flown for 14d showed approx. 10% suppression of cortical growth. We speculate that the mechanical threshold required for cross-sectional bone growth is reached in group-house weanling rats during spaceflight, perhaps, through physical interactions, and that the weanling animals are sensitive to loading. However, the threshold is not fully reached in either singly-housed flight or hindlimb unloaded weanling rats. Older singly-housed flight animals appear to show equal or greater bone changes compared to hindlimb unloaded rats. We conclude that age, flight duration, strain, and housing have important roles in rodent skeletal responses to spaceflight.

Morey-Holton, E. R.↗

An Application of the Methodology for Assessment of the Sustainability of Air Transport System

An assessment and operationalization of the concept of sustainable air transport system is recognized as an important but complex research, operational and policy task. In the scope of the academic efforts to properly address the problem, this paper aims to assess the sustainability of air transport system. It particular, the paper describes the methodology for assessment of sustainability and its potential application. The methodology consists of the indicator systems, which relate to the air transport system operational, economic, social and environmental dimension of performance. The particular indicator systems are relevant for the particular actors such users (air travellers), air transport operators, aerospace manufacturers, local communities, governmental authorities at different levels (local, national, international), international air transport associations, pressure groups and public. In the scope of application of the methodology, the specific cases are selected to estimate the particular indicators, and thus to assess the system sustainability under given conditions.

Janic, Milan↗

Knowledge Representation Standards and Interchange Formats for Causal Graphs

In many domains, automated reasoning tools must represent graphs of causally linked events. These include fault-tree analysis, probabilistic risk assessment (PRA), planning, procedures, medical reasoning about disease progression, and functional architectures. Each of these fields has its own requirements for the representation of causation, events, actors and conditions. The representations include ontologies of function and cause, data dictionaries for causal dependency, failure and hazard, and interchange formats between some existing tools. In none of the domains has a generally accepted interchange format emerged. The paper makes progress towards interoperability across the wide range of causal analysis methodologies. We survey existing practice and emerging interchange formats in each of these fields. Setting forth a set of terms and concepts that are broadly shared across the domains, we examine the several ways in which current practice represents them. Some phenomena are difficult to represent or to analyze in several domains. These include mode transitions, reachability analysis, positive and negative feedback loops, conditions correlated but not causally linked and bimodal probability distributions. We work through examples and contrast the differing methods for addressing them. We detail recent work in knowledge interchange formats for causal trees in aerospace analysis applications in early design, safety and reliability. Several examples are discussed, with a particular focus on reachability analysis and mode transitions. We generalize the aerospace analysis work across the several other domains. We also recommend features and capabilities for the next generation of causal knowledge representation standards.

Throop, David R.↗

Intelligent Motion and Interaction Within Virtual Environments

What makes virtual actors and objects in virtual environments seem real? How can the illusion of their reality be supported? What sorts of training or user-interface applications benefit from realistic user-environment interactions? These are some of the central questions that designers of virtual environments face. To be sure simulation realism is not necessarily the major, or even a required goal, of a virtual environment intended to communicate specific information. But for some applications in entertainment, marketing, or aspects of vehicle simulation training, realism is essential. The following chapters will examine how a sense of truly interacting with dynamic, intelligent agents may arise in users of virtual environments. These chapters are based on presentations at the London conference on Intelligent Motion and Interaction within a Virtual Environments which was held at University College, London, U.K., 15-17 September 2003.

Ellis, Stephen R.↗

Constraint, Intelligence, and Control Hierarchy in Virtual Environments

This paper seeks to deal directly with the question of what makes virtual actors and objects that are experienced in virtual environments seem real. (The term virtual reality, while more common in public usage, is an oxymoron; therefore virtual environment is the preferred term in this paper). Reality is difficult topic, treated for centuries in those sub-fields of philosophy called ontology- "of or relating to being or existence" and epistemology- "the study of the method and grounds of knowledge, especially with reference to its limits and validity" (both from Webster s, 1965). Advances in recent decades in the technologies of computers, sensors and graphics software have permitted human users to feel present or experience immersion in computer-generated virtual environments. This has motivated a keen interest in probing this phenomenon of presence and immersion not only philosophically but also psychologically and physiologically in terms of the parameters of the senses and sensory stimulation that correlate with the experience (Ellis, 1991). The pages of the journal Presence: Teleoperators and Virtual Environments have seen much discussion of what makes virtual environments seem real (see, e.g., Slater, 1999; Slater et al. 1994; Sheridan, 1992, 2000). Stephen Ellis, when organizing the meeting that motivated this paper, suggested to invited authors that "We may adopt as an organizing principle for the meeting that the genesis of apparently intelligent interaction arises from an upwelling of constraints determined by a hierarchy of lower levels of behavioral interaction. "My first reaction was "huh?" and my second was "yeah, that seems to make sense." Accordingly the paper seeks to explain from the author s viewpoint, why Ellis s hypothesis makes sense. What is the connection of "presence" or "immersion" of an observer in a virtual environment, to "constraints" and what types of constraints. What of "intelligent interaction," and is it the intelligence of the observer or the intelligence of the environment (whatever the latter may mean) that is salient? And finally, what might be relevant about "upwelling" of constraints as determined by a hierarchy of levels of interaction?

Sheridan, Thomas B.↗

Workflow Agents vs. Expert Systems: Problem Solving Methods in Work Systems Design

During the 1980s, a community of artificial intelligence researchers became interested in formalizing problem solving methods as part of an effort called "second generation expert systems" (2nd GES). How do the motivations and results of this research relate to building tools for the workplace today? We provide an historical review of how the theory of expertise has developed, a progress report on a tool for designing and implementing model-based automation (Brahms), and a concrete example how we apply 2nd GES concepts today in an agent-based system for space flight operations (OCAMS). Brahms incorporates an ontology for modeling work practices, what people are doing in the course of a day, characterized as "activities." OCAMS was developed using a simulation-to-implementation methodology, in which a prototype tool was embedded in a simulation of future work practices. OCAMS uses model-based methods to interactively plan its actions and keep track of the work to be done. The problem solving methods of practice are interactive, employing reasoning for and through action in the real world. Analogously, it is as if a medical expert system were charged not just with interpreting culture results, but actually interacting with a patient. Our perspective shifts from building a "problem solving" (expert) system to building an actor in the world. The reusable components in work system designs include entire "problem solvers" (e.g., a planning subsystem), interoperability frameworks, and workflow agents that use and revise models dynamically in a network of people and tools. Consequently, the research focus shifts so "problem solving methods" include ways of knowing that models do not fit the world, and ways of interacting with other agents and people to gain or verify information and (ultimately) adapt rules and procedures to resolve problematic situations.

Clancey, William J.↗

Using Satellite Remote Sensing and Modelling for Insights into N02 Air Pollution and NO2 Emissions

Nitrogen oxides (NO(x)) are key actors in air quality and climate change. Satellite remote sensing of tropospheric NO2 has developed rapidly with enhanced spatial and temporal resolution since initial observations in 1995. We have developed an improved algorithm and retrieved tropospheric NO2 columns from Ozone Monitoring Instrument. Column observations of tropospheric NO2 from the nadir-viewing satellite sensors contain large contributions from the boundary layer due to strong enhancement of NO2 in the boundary layer. We infer ground-level NO2 concentrations from the OMI satellite instrument which demonstrate significant agreement with in-situ surface measurements. We examine how NO2 columns measured by satellite, ground-level NO2 derived from satellite, and NO(x) emissions obtained from bottom-up inventories relate to world's urban population. We perform inverse modeling analysis of NO2 measurements from OMI to estimate "top-down" surface NO(x) emissions, which are used to evaluate and improve "bottom-up" emission inventories. We use NO2 column observations from OMI and the relationship between NO2 columns and NO(x) emissions from a GEOS-Chem model simulation to estimate the annual change in bottom-up NO(x) emissions. The emission updates offer an improved estimate of NO(x) that are critical to our understanding of air quality, acid deposition, and climate change.

Lamsal, L. N.↗

Establishment of a Spaceport Network Architecture

Since the beginning of the space age, the main actors in space exploration have been governmental agencies, enabling a privileged access to space, but with very restricted and rare missions. The last decade has seen the rise of space tourism, and the founding of ambitious private space mining companies, showing the beginnings of a new exploration era, that is based on a more generalized and regular access to space and which is not limited to the Earth's vicinity. However, the cost of launching sufficient mass into orbit to sustain these inspiring challenges is prohibitive, and the necessary infrastructures to support these missions is still lacking. To provide easy and affordable access into orbital and deep space destinations, there is the need to create a network of spaceports via specific waypoint locations coupled with the use of natural resources, or In Situ Resource Utilization (ISRU), to provide a more economical solution. As part of the International Space University Space Studies Program 2012, the international and intercultural team of Operations and Service Infrastructure for Space (OASIS) proposes an interdisciplinary answer to the problem of economical space access and transportation. This paper presents a summary of a detailed report [1] of the different phases of a project for developing a network of spaceports throughout the Solar System in a timeframe of 50 years. The requirements, functions, critical technologies and mission architecture of this network of spaceports are outlined in a roadmap of the important steps and phases. The economic and financial aspects are emphasized in order to allow a sustainable development of the network in a public-private partnership via the formation of an International Spaceport Authority (ISPA). The approach includes engineering, scientific, financial, legal, policy, and societal aspects. Team OASIS intends to provide guidelines to make the development of space transportation via a spaceports logistics network feasible, and believes that this pioneering effort will revolutionize space exploration, science and commerce, ultimately contributing to permanently expand humanity into space.

Larson, Wiley J.↗

Cognitive Systems Modeling and Analysis of Command and Control Systems

Military operations, counter-terrorism operations and emergency response often oblige operators and commanders to operate within distributed organizations and systems for safe and effective mission accomplishment. Tactical commanders and operators frequently encounter violent threats and critical demands on cognitive capacity and reaction time. In the future they will make decisions in situations where operational and system characteristics are highly dynamic and non-linear, i.e. minor events, decisions or actions may have serious and irreversible consequences for the entire mission. Commanders and other decision makers must manage true real time properties at all levels; individual operators, stand-alone technical systems, higher-order integrated human-machine systems and joint operations forces alike. Coping with these conditions in performance assessment, system development and operational testing is a challenge for both practitioners and researchers. This paper reports on research from which the results led to a breakthrough: An integrated approach to information-centered systems analysis to support future command and control systems research development. This approach integrates several areas of research into a coherent framework, Action Control Theory (ACT). It comprises measurement techniques and methodological advances that facilitate a more accurate and deeper understanding of the operational environment, its agents, actors and effectors, generating new and updated models. This in turn generates theoretical advances. Some good examples of successful approaches are found in the research areas of cognitive systems engineering, systems theory, and psychophysiology, and in the fields of dynamic, distributed decision making and naturalistic decision making.

Norlander, Arne↗

Impact of NO2 Profile Shape in OMI Tropospheric NO2 Retrievals

Nitrogen oxides (NOx NO + NO2) are key actors in air quality and climate change. Tropospheric NO2 columns from the nadir-viewing satellite sensors have been widely used to understand sources and chemistry of NOx. We have implemented several improvements to the operational algorithm developed at NASA GSFC and retrieved tropospheric NO2 columns. We present tropospheric NO2 validation studies of the new OMI Standard Product version 2.1 using ground-based and in-situ aircraft measurements. We show how vertical profile of scattering weight and a-priori NO2 profile shapes, which are taken from chemistry-transport models, affect air mass factor (AMF) and therefore tropospheric NO2 retrievals. Users can take advantage of scattering weights information that is made available in the operational NO2 product. Improved tropospheric NO2 data retrieved using thoroughly evaluated high spatial resolution NO2 profiles are helpful to test models.

OMI↗

Playing a 3-Stringed Violin: Innovation via the Joint Evolution of People, Process, and Knowledge Management System

Users continuously evaluate the value and performance of their Knowledge Management Systems (KMS). As suggested by a punctuated socio-technical system process model, today's success can quickly become tomorrow's failure should the KMS fail to meet evolving needs and expectations. The more deeply a tool is embedded in the actual work process, the more vulnerable it is to emergent changes and perturbations. This paper uses the metaphor of a "3-stringed violin" to explore how differing levels of user knowledge about tools and processes can lead to system perturbations and how the active involvement of other actors can dampen the impact of perturbations, i.e., help the system survive the operational equivalent of a broken string. Recommendations suggest ways to increase system resiliency and contribute to incremental innovation.

Socio-technical systems↗

Absorption and Scattering by Molecules and Particles

The Earth's atmosphere absorbs, scatters, and emits electromagnetic radiation. Although air molecules are the primary actors in these processes, aerosol particles are also present ubiquitously and modify the radiation field. In fact, this modification constitutes the very physical basis of aerosol remote sensing. Whenever clouds are present, they have a much larger influence on radiation which largely overshadows the aerosol impact. Therefore, in aerosol remote sensing, one often has to limit observations to cloudless conditions and screen cloudy pixels. In the solar part of the spectrum, molecular absorption is mostly limited to ultraviolet (UV; ozone) and near-infrared (near-IR; carbon dioxide, water vapor) wavelengths and is characterized by strong and narrow oxygen bands. A brief description of atmospheric molecular absorption is presented in Section 2.2. Shortwave aerosol remote sensing is usually performed outside the absorption bands, but some instruments also have channels capturing absorption bands with the objective of quantifying gaseous components.

remote sensing↗

Spot: A Programming Language for Verified Flight Software

The C programming language is widely used for programming space flight software and other safety-critical real time systems. C, however, is far from ideal for this purpose: as is well known, it is both low-level and unsafe. This paper describes Spot, a language derived from C for programming space flight systems. Spot aims to maintain compatibility with existing C code while improving the language and supporting verification with the SPIN model checker. The major features of Spot include actor-based concurrency, distributed state with message passing and transactional updates, and annotations for testing and verification. Spot also supports domain-specific annotations for managing spacecraft state, e.g., communicating telemetry information to the ground. We describe the motivation and design rationale for Spot, give an overview of the design, provide examples of Spot's capabilities, and discuss the current status of the implementation.

validation↗

Human Factors Virtual Analysis Techniques for NASA's Space Launch System Ground Support using MSFC's Virtual Environments Lab (VEL)

Using virtual environments to assess complex large scale human tasks provides timely and cost effective results to evaluate designs and to reduce operational risks during assembly and integration of the Space Launch System (SLS). NASA's Marshall Space Flight Center (MSFC) uses a suite of tools to conduct integrated virtual analysis during the design phase of the SLS Program. Siemens Jack is a simulation tool that allows engineers to analyze human interaction with CAD designs by placing a digital human model into the environment to test different scenarios and assess the design's compliance to human factors requirements. Engineers at MSFC are using Jack in conjunction with motion capture and virtual reality systems in MSFC's Virtual Environments Lab (VEL). The VEL provides additional capability beyond standalone Jack to record and analyze a person performing a planned task to assemble the SLS at Kennedy Space Center (KSC). The VEL integrates Vicon Blade motion capture system, Siemens Jack, Oculus Rift, and other virtual tools to perform human factors assessments. By using motion capture and virtual reality, a more accurate breakdown and understanding of how an operator will perform a task can be gained. By virtual analysis, engineers are able to determine if a specific task is capable of being safely performed by both a 5% (approx. 5ft) female and a 95% (approx. 6'1) male. In addition, the analysis will help identify any tools or other accommodations that may to help complete the task. These assessments are critical for the safety of ground support engineers and keeping launch operations on schedule. Motion capture allows engineers to save and examine human movements on a frame by frame basis, while virtual reality gives the actor (person performing a task in the VEL) an immersive view of the task environment. This presentation will discuss the need of human factors for SLS and the benefits of analyzing tasks in NASA MSFC's VEL.

Searcy, Brittani↗

Unmanned Aircraft System Traffic Management (UTM) Research Transition Team (RTT) Concept Working Group - Concept & Use Cases Package #2 Addendum: Technical Capability Level 3

This document is a product of the joint NASA and FAA Research Transition Team's (RTT) Concept Working Group (CWG) as part of the UAS Traffic Management (UTM) project. The scope of the document covers Technical Capability Level (TCL) 3 of the UTM research path and presents the 1) Terms and Definitions, 2) Foundational Principles, 3) Concept Narratives, 4) Use Cases, 5) Operational Views (OVs), and 6) Roles and Responsibilities of actors interacting within a TCL3 environment. The document includes additional use cases to accompany the RTT CWG Package #2 document.

UTM↗

UTM RTT CWG Concept & Use Cases Package #2

The Concept & Use Cases Package #2: Technical Capability Level 3 document represents the collaborative research efforts between the FAA and NASA as joint members of the Unmanned Aircraft System Traffic Management (UTM) Research Transition Team (RTT). Contained in this document are the 1) Terms and Definitions, 2) Foundational Principles, 3) Concept Narratives, 4) Use Cases, 5) Operational Views, and 6) Roles and Responsibilities of actors interacting within what is considered to be encompassed by Technical Capability Level 3 UTM operating environments. The contents of Package #2 should NOT be considered established policy or construed as regulatory in nature. What is presented is meant to communicate the current, agreed upon understanding between the FAA and NASA on particular features of UTM as exemplified through use cases and concept narratives for the purposes of supporting joint NASA/Industry Demonstrations and the UTM Pilot Program. It is also meant to foster discussion and refinement of the concepts and approaches being pursued by the other RTT working groups.

RTT↗

Remote ID for Rapid Assessment of Flight and Vehicle Information

The ability to rapidly identify UAS (Unmanned Aircraft Systems) in the field has emerged as a critical need for the integration of small UASs into the national airspace and counter-UAS operations. This paper proposes an architecture for rapid retrieval of UAS information leveraging NASA's current Unmanned Aircraft System (UAS) Traffic Management (UTM) system. The proposed architecture utilizes UTM components: FIMS (Flight Information Management System), USS (UAS Service Supplier), and vehicle registration and model database in order to provide assessment of the UAS reported in the field including the ability to distinguish between participating and non- participating UTM actors. Detailed system descriptions are provided and preliminary results from field tests conducted during UTM TCL (Technical Capability Level) 3 are discussed. It is found that 94 percent of the remote ID look-ups were successful. The average time of a look-up is found to be 1.2 seconds. Failure cases are examined and recommendations on next steps to advance UAS remote identification are provided.

USS (UAS Service Supplier)↗