Summary of the Nuclear Risk Assessment 2019 Update for the Mars 2020 Mission Environmental Impact Statement.
Abstract not provided.
Clayton, Daniel↗
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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Building a Computational and Experimental Rapid Response Pipeline to Counter the Coronavirus Disease 2019 Outbreak and Emerging Biothreats
The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs, especially where protective candidates can be rapidly identified or developed for emerging biothreats and escape variants. Current cutting-edge technologies for this purpose still rely on pathogen-exposed convalescent volunteers and a large screening effort to find a proverbial needle in a haystack. Computational design of protective antibodies based on pre-existing templates skips those requirements and allows for greater control over the breadth and target epitope, while also co-optimizing for potency and developability or other biophysical characteristics. We approached this problem by building and expanding an in vitro experimental rapid antibody production and characterization pipeline to support development of an autonomous, closed loop, active learning software system based on structural simulation and ground truth experimental data to design and evaluate antibody antigen interactions. Starting from early in the pandemic, we targeted SARS-CoV-2, the causative agent of COVID-19, by re-purposing neutralizing antibodies against SARS-CoV-1 that had been identified in the wake of that outbreak in the early 2000’s. We successfully re-targeted three different anti-SARS-CoV-1 antibodies to neutralize SARS-CoV-2 in vitro, where the antibodies were generated externally and tested through conventional binding and neutralization assays internally or with collaborators. As antibodies were identified from the blood of humans infected with SARS-CoV-2, we shifted to collaborate with academic partners to develop improved versions of their human-derived antibodies. This work reached its most important stage in rapid response to the emergence of the Omicron variant of concern (VOC) in late 2021. In a matter of weeks, enabled by on demand innovation to our screening pipeline, we computationally designed and experimentally characterized derivative antibodies of COV2-2130, one of two antibodies from Vanderbilt that form the basis of the AstraZeneca Evusheld prophylactic drug product. This drug product suffers a serious loss of efficacy against Omicron BA.1 and BA.1.1, the first Omicron strains. Due to tight integration of computational design and experimental evaluation, we were able to identify a pair of designs with potent neutralization of the main targets Omicron BA.1 and BA.1.1; but also the earlier Delta variant, and subsequent Omicron strains including BA.2, BA.4, BA.5, and BA.2.75, demonstrating that our multi-target design process can, by its nature, produce robust antibody designs that strictly improve over the parental antibody. These results, recognized by a 2022 Director’s Science and Technology award, have enabled the follow-on GUIDE program, to commence in FY23. While earlier design campaigns were substantially outsourced, we have engineered better and faster processes internally to better compliment, calibrate, and speed computational designs. As part of the follow-on GUIDE program, we will stand up a rapid and high-throughput antibody production and characterization facility staffed with the expertise and capabilities to foster our current collaboration across PLS and ENG as well as other partnerships toward computational design of biologics.
59 BASIC BIOLOGICAL SCIENCES↗
2019 Groundwater Monitoring Report Project Shoal Area: Subsurface Corrective Action Unit 447
The Project Shoal Area is a site in Nevada where an underground nuclear test was conducted in 1963. It later came to be known as the Shoal, Nevada, Site. Surface contamination at the site has been remediated, but investigation of groundwater contamination resulting from the test is still in the corrective action process. Annual sampling and water-level monitoring are conducted as part of the subsurface corrective action strategy, which has focused on revising the site conceptual model and evaluating the adequacy of the monitoring well network. It has also included enhancements to the monitoring well network to address uncertainties in the groundwater flow direction and the cause of rising water levels in site wells west of the shear zone since the first hydrologic characterization (HC) wells were installed in 1996. Revisions to the site conceptual model and enhancements to the monitoring strategy were provided to Nevada Division of Environmental Protection (NDEP) in the Addendum to: Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) for the Subsurface Corrective Action Unit 447 Shoal, Nevada, Site. NDEP approved the addendum to the CADD/CAP, which included an expanded contaminant boundary and compliance boundary for the site.
54 ENVIRONMENTAL SCIENCES↗
Models for Incorporating Equity in Transportation Electrification Considerations for Public Utility Regulators, An addendum to the NARUC report, Electric Vehicles: Key Trends, Issues, and Considerations for State Regulators (2019)
Momentum for the electric vehicle (EV) transition is well underway, and the utility sector plays an important role in supporting its success. For frontline communities, the transition offers a promising solution to improve environmental and public health outcomes, economic development, affordability, and transit equity. However, the transition will need to involve care and intention to ensure that the needs of underserved communities are prioritized throughout the planning, decision-making, and implementation processes. States have taken the lead in some cases, as profiled in Box 6. Whether driven by state commissions or utilities themselves, utilities have a range of options available to ensure equity is central in their transportation electrification plans and programs by drawing from a variety of existing and emerging experiences, as summarized in Table 1.
29 ENERGY PLANNING, POLICY, AND ECONOMY↗
Understanding Water Controls on Shale Gas/Oil Mobilization into Fractures (FY 2019-2021(FY2022, No Cost Extension), Final Report)
The large volumes of injected and produced water, and costs associated with both hydraulic fracturing fluids and produced water treatment motivate development of hydraulic fracturing strategies that use water more efficiently. The overall objective of this project is to improve understanding on how water is distributed within unconventional shales during and after hydraulic fracturing in order to provide a more rational basis for reservoir stimulation strategies that increase hydrocarbon recovery per unit of water used. The strong capillary imbibition of water into shale matrix pores and immiscibility with hydrocarbons makes it highly desirable to reduce water use during reservoir development. Given the importance, and competing influences of capillarity and gravity in controlling water in fractured porous media, this project also seeks to understand how these factors interact to obstruct or allow gas flow.
04 OIL SHALES AND TAR SANDS↗
2019 Budget Request for the DOE Computational Science Graduate Fellowship (CSGF) Grant
The Department of Energy Computational Science Graduate Fellowship (DOE CSGF) is necessary to meet the continual challenging national workforce needs that arise as computational science and engineering problems continue to grow in scope and complexity. Computational science and engineering (CSE) is a multidisciplinary approach that uses scientific computing to solve practical problems methods and to supply technical tools across the scientific discovery spectrum. In particular, the DOE CSGF emphasizes high-performance computing (HPC) that enables CSE that advances science and engineering in directions important to the DOE and the economy in general. Over the past half-century, HPC has been an essential tool for DOE’s success. During this period, important missions, such as nuclear stockpile stewardship, have turned to HPC as an essential technology. Entire science disciplines, such as biology and cosmology, have been transformed through the augmentation of scientific observation via HPC. At government laboratories and in industry, DOE CSGF alumni are helping push traditional HPC boundaries while contributing to discoveries in high-energy physics, renewable energy, fusion-reactor design, additive manufacturing, nanomaterials for next-generation batteries and transistors, and turbine and advanced nuclear reactor modeling. In addition, HPC is used to address national health needs that will eventually point to cures both by helping cancer researchers manage and analyze huge troves of data, by simulating biological mechanisms, and by accelerating drug development — including continuing to rise to the challenge of pandemic-related research. A 2023 report from the ASCAC Subcommittee on American Competitiveness and Innovation to the ASCR office, “Can the United States Maintain Its Leadership in High-Performance Computing?” says of the Program, “The CSGF program provides a barometer for disciplines that will be of interest to future DOE computing.” An explosion in scientific and technological data has driven the need for increasingly sophisticated HPC to transform those data into scientific understanding. With access to more and more data and the proliferation of HPC, Machine Learning and Artificial Intelligence are experiencing a renaissance, complementing the now well-established use of computational simulation. Indeed, in its September 2020 subcommittee report on “AI/ML, Data Intensive Science and High-Performance Computing”, the DOE Advanced Scientific Computing Advisory Committee (ASCAC) explicitly called for a fellowship program to train computational and data scientists to tackle exascale and data-intensive computing challenges. This collaboration of empirical and theory-based modeling will increasingly inform federal policymakers whose decisions affect American society and future generations, and it requires highly skilled and intellectually agile computational scientists who can support the fast-moving DOE National Laboratory research environment. In fact, the DOE CSGF program has explicitly and consistently addressed this need.
97 MATHEMATICS AND COMPUTING↗
Hanford Site Roadside Bird Surveys Report for Calendar Year 2019
The U.S. Department of Energy, Richland Operations Office (DOE-RL) conducts ecological monitoring on the Hanford Site to collect and track data needed to ensure compliance with an array of environmental laws, regulations, and policies governing DOE-RL activities. Ecological monitoring data provide baseline information about the plants, animals, and habitats under DOE-RL stewardship at Hanford which is required for decision-making under the National Environmental Policy Act (NEPA) and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). The Hanford Site Comprehensive Land Use Plan (CLUP, DOE/EIS- 0222-F), which is the Environmental Impact Statement for Hanford Site activities, helps ensure that DOE-RL, its contractors, and other entities conducting activities on the Hanford Site are in compliance with NEPA.
54 ENVIRONMENTAL SCIENCES↗
Hanford Reach Fall Chinook Salmon Redd Monitoring Report for Calendar Year 2019
The U.S. Department of Energy, Richland Operations Office (DOE-RL) conducts ecological monitoring on the Hanford Site to collect and track data needed to ensure compliance with an array of environmental laws, regulations, and policies governing DOE-RL activities. Ecological monitoring data provide baseline information about the plants, animals, and habitats under DOE-RL stewardship at the Hanford Site required for decision making under the National Environmental Policy Act (NEPA) and Comprehensive Environmental Response, Compensation, and Liability Act. DOE/EIS-0222, Final Hanford Comprehensive Land Use Plan Environmental Impact Statement (CLUP) evaluates the potential environmental impacts associated with implementing a comprehensive land-use plan for the Hanford Site for at least the next 50 years, and ensures that DOE-RL, its contractors, and other entities conduct activities on the Hanford Site in compliance with NEPA.
54 ENVIRONMENTAL SCIENCES↗
Hanford Site Bee Nest Box Monitoring Report for Calendar Year 2019
This report summarizes the results of the first year of monitoring bee nest boxes on the Hanford Site. Twenty bee nest boxes were installed as a component of compensatory mitigation for the installation of the L-894 water line between the 200-East and 200-West Areas of the Hanford Site. The goal of this compensatory mitigation is to replace lost nesting habitat for above-ground nesting bees in a mature sagebrush ecosystem. Annual monitoring will track the condition and occupation of the bee nest boxes to determine if the compensatory mitigation was successful and to identify best practices when replacing nesting habitat for native bees.
54 ENVIRONMENTAL SCIENCES↗
Evaluating Movement Patterns of the Rattlesnake Hills Elk Herd on Hanford for Calendar Years 2019-2024
Biologists first documented elk on the Hanford Site in 1972; since then, the elk herd known as the Rattlesnake Hills Elk Herd (RHEH) has grown substantially (PNNL-13331, Population Characteristics and Seasonal Movement Patterns of the Rattlesnake Hills Elk Herd: Status Report 2000). Through the 1990s, the core range of the RHEH was focused on the portion of the Hanford Reach National Monument known as the Fitzner-Eberhardt Arid Lands Ecology (ALE) Reserve. More recently, larger numbers of elk have been occupying the U.S. Department of Energy (DOE), Hanford Field Office (HFO), formerly the DOE, Richland Operations Office managed portion- of the Hanford Site, known as central Hanford (Figure 1-1). This began with bachelor groups of bulls occupying the site intermittently, and the herd has grown to resident herds, including bulls, cows, and calves. The Washington Department of Fish and Wildlife (WDFW) established a target herd size for the RHEH of less than 350 animals to minimize damages on adjacent private agricultural lands (Washington State Elk Herd Plan–Yakima Elk Herd [WDFW 2002]). Attempts to control the RHEH population through hunting on private lands and a relocation effort during 2000 have failed to limit growth of the population toward the WDFW target, and the herd exceeds 1,600 according to recent counts (PNNL-13331; DOE/RL- 2023-20, Hanford Annual Site Environmental Report for Calendar Year 2022). Although elk are present on central Hanford year-round, they continue to move between areas offsite, the ALE Reserve, and central Hanford throughout the year, and it is these movements that result in many of the elk-vehicle collisions (EVC) that occur along Hanford Site roads and on the Washington State highways bordering the site. In addition, changes in management strategies on the ALE Reserve, including recent and potential future tribal elk hunts, may alter herd behavior and result in additional animals transiting onto and off central Hanford.
54 ENVIRONMENTAL SCIENCES↗
Hanford Site Mule Deer Monitoring Report for Fiscal Year 2019
The U.S. Department of Energy, Richland Operations Office (DOE-RL) conducts ecological monitoring on the Hanford Site to collect and track data needed to ensure compliance with environmental laws, regulations, and policies governing Department of Energy activities. Ecological monitoring data provide baseline information about the plants, animals, and habitats under DOE-RL stewardship at the Hanford Site required for decision-making under the National Environmental Policy Act of 1969 (NEPA) and Comprehensive Environmental Response, Compensation, and Liability Act of 1980. The Hanford Site Comprehensive Land Use Plan (CLUP, DOE 1999), which is the Environmental Impact Statement that evaluates the potential environmental impacts associated with implementing a comprehensive land-use plan for the Hanford Site, ensures that DOE-RL, its contractors, and other entities conduct activities on the Hanford Site in compliance with NEPA.
54 ENVIRONMENTAL SCIENCES↗
Updated Commercial Aviation Non-Airport Crash Density Values Using Data Obtained from the U.S. National Transportation Safety Board for 2000 through 2019
This report documents the calculation of the commercial aviation (CA) non-airport crash density for Air Route Traffic Control Center (ARTCC) area associated with the Contiguous United States (CONUS) using the methodology outlined in the Department of Energy (DOE) Standard 3014-2006, Accident Analysis for Aircraft Crash Into Hazardous Facilities. For analytical purposes, the CA aircraft fleet is comprised of aircraft engaged in operations under Title 14 of the Code of Federal Regulations (CFR) Part 121 (i.e., Air Carrier) and Part 135 (i.e., Air Taxi).
99 GENERAL AND MISCELLANEOUS↗
Updated General Aviation Non-Airport Crash Density Values Using Data Obtained from the U.S. National Transportation Safety Board for 2000 through 2019
This report documents the calculation of the General Aviation (GA) non-airport crash density for Department of Energy (DOE) sites and power generating facilities licensed by the Nuclear Regulatory Commission (NRC) using the methodology outlined in DOE-STD-3014-2006, Accident Analysis for Aircraft Crash Into Hazardous Facilities. The results of this report will be used by the American Nuclear Society (ANS) for the development of ANS standard 2.36, Accident Analysis for Aircraft Crash into Reactor and Nonreactor Nuclear Facilities.
99 GENERAL AND MISCELLANEOUS↗
Addendum: Zhang, C., et al. Pulsed Laser-Assisted Helium Ion Nanomachining of Monolayer Graphene—Direct-Write Kirigami Patterns. Nanomaterials 2019, 9, 1394
The authors wish to make the following corrections to this paper [1]: The funding section needs to be corrected.
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
2019 Performance Assessment Calculations for the Recertification of the Waste Isolation Pilot Plant.
Abstract not provided.
Zeitler, Todd↗
Orthomosaic Images and Digital Elevation Models for the 2019 SALVO Campaign
The springtime, surface-albedo transition in the Alaskan Arctic and the forcings that determine the duration and nature of that transition are the focus of our Snow ALbedo eVOlution (SALVO I & II) campaign. The SALVO team are assessing the “whys” and “how longs” of the stages of the spring melt during which albedo values drop from 0.8 to 0.1, the largest and most significant change of the year. The near-shore location of the ARM NSA observatory makes this an ideal place to investigate these melt stages.
54 ENVIRONMENTAL SCIENCES↗
Magnaprobe Snow Depths for the 2019 SALVO Campaign
The springtime, surface-albedo transition in the Alaskan Arctic and the forcings that determine the duration and nature of that transition are the focus of our Snow ALbedo eVOlution (SALVO I & II) campaign. The SALVO team are assessing the “whys” and “how longs” of the stages of the spring melt during which albedo values drop from 0.8 to 0.1, the largest and most significant change of the year. The near-shore location of the ARM NSA observatory makes this an ideal place to investigate these melt stages.
54 ENVIRONMENTAL SCIENCES↗
Snow-substrate interface temperature and air temperature for the SALVO 2019 Campaign
The springtime, surface-albedo transition in the Alaskan Arctic and the forcings that determine the duration and nature of that transition are the focus of our Snow ALbedo eVOlution (SALVO I & II) campaign. The SALVO team are assessing the “whys” and “how longs” of the stages of the spring melt during which albedo values drop from 0.8 to 0.1, the largest and most significant change of the year. The near-shore location of the ARM NSA observatory makes this an ideal place to investigate these melt stages.
54 ENVIRONMENTAL SCIENCES↗