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NASA NTRS1994

Light-Hydrocarbon Bearing Solids on Planetesimal 5145 Pholus

Object 5145 Pholus (=1992 AD) is a planetesimal in an orbit that crosses those of Saturn, Uranus, and Neptune (period 92.7 years). It is particularly notable because of its extreme red color, corroborated by several observing teams. A spectrum of Pholus obtained in 1992 shows a strong absorption band with a characteristic shape at 2.27 micrometers, plus a weaker band at 1.7 micrometers. A better spectrum of the 2.0-2.5 micrometer region in 1993 confirms the position and shape of the 2.27-micrometer band. The color and spectral bands are identified with the aliphatic-rich and high H/C organic solid called asphaltite, which in a terrestrial setting originates from thermal processing of products of biological activity. In Pholus, this material is attributed to formation from radiation processing of ices on grains in the interstellar medium. Laboratory spectra of asphaltite and related materials have been published by Moroz et al., while Cloutis showed similar bands in comparable materials and identified them as the overtone and combination bands of C-H stretching and bending modes in CH2 and CH3 groups. Asphaltites, kerites, and anthraxolites are solid non-graphite members of a sequence ranging from oil to graphite; diffuse reflectance spectra of suites of these intermediate materials show color characteristics similar to those of the low-albedo asteroids (C,P,D), although specific identifications have not been made because of the lack of distinct absorption bands in the spectra of most low-albedo solar system bodies. In the case of Pholus, however, the primary band is strong; its wavelength and its shape, plus the match of the extremely red color, leads us to the identification of aliphatic-rich, asphaltite-like organic solid. The C, P, and D-type asteroids vary in degree of "redness", but are all less red than Pholus. Pholus and the Ctype asteroids are the end members of a sequence that represents the radiation processing of hydrocarbons, with Pholus being the least processed. Solar irradiation processes and heating reduce the H/C and aliphatic content of hydrocarbons preserved from the interstellar medium, and in the end produce opaque solids of neutral reflectance, including the kerogens (similar to anthraxolites) found in profusion in the carbonaceous meteorites.

Cruikshank, Dale P.↗
NASA NTRS1994

Light-Hydrocarbon Bearing Solids on Planetesimal 5145 Pholus

Object 5145 Pholus (=1992 AD) is a planetesimal in an orbit that crosses those of Saturn, Uranus, and Neptune (period 92.7 years). It is particularly notable because of its extreme red color, corroborated by several observing teams. A spectrum of Pholus obtained in 1992 shows a strong absorption band with a characteristic shape at 2.27 micron, plus a weaker band at 1.7 microns. A better spectrum of the 2.0-2.5 micron region in 1993 confirms the position and shape of the 2.27 micron band. The color and spectral bands are identified with the aliphatic-rich and high H/C organic solid called asphaltite, which in a terrestrial setting originates from thermal processing of products of biological activity. In Pholus, this material is attributed to formation from radiation processing of ices on grains in the interstellar medium. Laboratory spectra of asphaltite and related materials have been published by Moroz et al., while Cloutis showed similar bands in comparable materials and identified them as the overtone and combination bands of C-H stretching and bending modes in CH2 and CH3 groups. Asphaltites, kerites, and anthraxolites are solid non-graphite members of a sequence ranging from oil to graphite; diffuse reflectance spectra of suites of these intermediate materials show color characteristics similar to those of the low-albedo asteroids (C,P,D), although specific identifications have not been made because of the lack of distinct absorption bands in the spectra of most low-albedo solar system bodies. In the case of Pholus, however, the primary band is strong; its wavelength and its shape, plus the match of the extremely red color, leads us to the identification of aliphatic-rich, asphaltite-like organic solid. The C, P, and D-type asteroids vary in degree of 'redness', but are all less red than Pholus. Pholus and the C-type asteroids are the end members of a sequence that represents the radiation processing of hydrocarbons, with Pholus being the least processed. Solar irradiation processes and heating reduce the H/C and aliphatic content of hydrocarbons preserved from the interstellar medium, and in the end produce opaque solids of neutral reflectance, including the kerogens (similar to anthraxolites) found in profusion in the carbonaceous meteorites.

Cruikshank, Dale P.↗
DOE OSTI2024

Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes

Abstract Background Type 2 diabetes mellitus (T2DM) is a major risk factor for heart failure with preserved ejection fraction and cardiac arrhythmias. Precursors of these complications, such as diabetic cardiomyopathy, remain incompletely understood and underdiagnosed. Detection of early signs of cardiac deterioration in T2DM patients is critical for prevention. Our goal is to quantify T2DM-driven abnormalities in ECG and cardiac imaging biomarkers leading to cardiovascular disease. Methods We quantified ECG and cardiac magnetic resonance imaging biomarkers in two matched cohorts of 1781 UK Biobank participants, with and without T2DM, and no diagnosed cardiovascular disease at the time of assessment. We performed a pair-matched cross-sectional study to compare cardiac biomarkers in both cohorts, and examined the association between T2DM and these biomarkers. We built multivariate multiple linear regression models sequentially adjusted for socio-demographic, lifestyle, and clinical covariates. Results Participants with T2DM had a higher resting heart rate (66 vs. 61 beats per minute,p < 0.001), longer QTc interval (424 vs. 420ms,p < 0.001), reduced T wave amplitude (0.33 vs. 0.37mV,p < 0.001), lower stroke volume (72 vs. 78ml,p < 0.001) and thicker left ventricular wall (6.1 vs. 5.9mm,p < 0.001) despite a decreased Sokolow-Lyon index (19.1 vs. 20.2mm,p < 0.001). T2DM was independently associated with higher heart rate (beta = 3.11, 95% CI = [2.11,4.10],p < 0.001), lower stroke volume (beta = −4.11, 95% CI = [−6.03, −2.19],p < 0.001) and higher left ventricular wall thickness (beta = 0.133, 95% CI = [0.081,0.186],p < 0.001). Trends were consistent in subgroups of different sex, age and body mass index. Fewer significant differences were observed in participants of non-white ethnic background. QRS duration and Sokolow-Lyon index showed a positive association with the development of cardiovascular disease in cohorts with and without T2DM, respectively. A higher left ventricular mass and wall thickness were associated with cardiovascular outcomes in both groups. Conclusion T2DM prior to cardiovascular disease was linked with a higher heart rate, QTc prolongation, T wave amplitude reduction, as well as lower stroke volume and increased left ventricular wall thickness. Increased QRS duration and left ventricular wall thickness and mass were most strongly associated with future cardiovascular disease. Although subclinical, these changes may indicate the presence of autonomic dysfunction and diabetic cardiomyopathy. Graphical Abstract

Cardiovascular System & Cardiology↗
NASA NTRS1992

Wavefront sensing, control, and pointing

A majority of future NASA astrophysics missions from orbiting interferometers to 16-m telescopes on the Moon have, as a common requirement, the need to bring light from a large entrance aperture to the focal plane in a way that preserves the spatial coherence properties of the starlight. Only by preserving the phase of the incoming wavefront, can many scientific observations be made, observations that range from measuring the red shift of quasi-stellar objects (QSO's) to detecting the IR emission of a planet in orbit around another star. New technologies for wavefront sensing, control, and pointing hold the key to advancing our observatories of the future from those already launched or currently under development. As the size of the optical system increases, either to increase the sensitivity or angular resolution of the instrument, traditional technologies for maintaining optical wavefront accuracy become prohibitively expensive or completely impractical. For space-based instruments, the low mass requirement and the large temperature excursions further challenge existing technologies. The Hubble Space Telescope (HST) is probably the last large space telescope to rely on passive means to keep its primary optics stable and the optical system aligned. One needs only look to the significant developments in wavefront sensing, control, and pointing that have occurred over the past several years to appreciate the potential of this technology for transforming the capability of future space observatories. Future developments in space-borne telescopes will be based in part on developments in ground-based systems. Telescopes with rigid primary mirrors much larger than 5 m in diameter are impractical because of gravity loading. New technologies are now being introduced, such as active optics, that address the scale problem and that allow very large telescopes to be built. One approach is a segmented design such as that being pioneered by the W.M. Keck telescope now under construction at the Mauna Kea Observatory. It consists of 36 hexagonal mirror segments, supported on a framework structure, which are positioned by actuators located between the structure and the mirrors. The figure of the telescope is initialized by making observations of a bright star using a Shack Hartmann sensor integrated with a white light interferometer. Then, using sensed data from the mirror edges to control these actuators, the figure of the mosaic of 36 segments is maintained as if it were a rigid primary mirror. Another active optics approach is the use of a thin meniscus mirror with actuators. This technique was demonstrated on the European Southern Observatory's New Technology Telescope (NTT) and is planned for use in the Very Large Telescope (consists of four 8-m apertures), which is now entering the design phase.

Pitts, Thomas↗
DOE OSTI2020

Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease

Importance: Better understanding is needed of the degree to which individuals tolerate Alzheimer disease (AD)-like pathological tau with respect to brain structure (brain resilience) and cognition (cognitive resilience). Objective: To examine the demographic (age, sex, and educational level), genetic (APOE-ε4 status), and neuroimaging (white matter hyperintensities and cortical thickness) factors associated with interindividual differences in brain and cognitive resilience to tau positron emission tomography (PET) load and to changes in global cognition over time. Design, setting, an participants: In this cross-sectional, longitudinal study, tau PET was performed from June 1, 2014, to November 30, 2017, and global cognition monitored for a mean [SD] interval of 2.0 [1.8] years at 3 dementia centers in South Korea, Sweden, and the United States. The study included amyloid-β-positive participants with mild cognitive impairment or AD dementia. Data analysis was performed from October 26, 2018, to December 11, 2019. Exposures: Standard dementia screening, cognitive testing, brain magnetic resonance imaging, amyloid-β PET and cerebrospinal fluid analysis, and flortaucipir (tau) labeled with fluor-18 (18F) PET. Main outcomes and measures: Separate linear regression models were performed between whole cortex [18F]flortaucipir uptake and cortical thickness, and standardized residuals were used to obtain a measure of brain resilience. The same procedure was performed for whole cortex [18F]flortaucipir uptake vs Mini-Mental State Examination (MMSE) as a measure of cognitive resilience. Bivariate and multivariable linear regression models were conducted with age, sex, educational level, APOE-ε4 status, white matter hyperintensity volumes, and cortical thickness as independent variables and brain and cognitive resilience measures as dependent variables. Linear mixed models were performed to examine whether changes in MMSE scores over time differed as a function of a combined brain and cognitive resilience variable. Results: A total of 260 participants (145 [55.8%] female; mean [SD] age, 69.2 [9.5] years; mean [SD] MMSE score, 21.9 [5.5]) were included in the study. In multivariable models, women (standardized β = -0.15, P = .02) and young patients (standardized β = -0.20, P = .006) had greater brain resilience to pathological tau. Higher educational level (standardized β = 0.23, P < .001) and global cortical thickness (standardized β = 0.23, P < .001) were associated with greater cognitive resilience to pathological tau. Linear mixed models indicated a significant interaction of brain resilience × cognitive resilience × time on MMSE (β [SE] = -0.235 [0.111], P = .03), with steepest slopes for individuals with both low brain and cognitive resilience. Conclusions and relevance: Results of this study suggest that women and young patients with AD have relative preservation of brain structure when exposed to neocortical pathological tau. Interindividual differences in resilience to pathological tau may be important to disease progression because participants with both low brain and cognitive resilience had the most rapid cognitive decline over time.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2014

Alaska: Glaciers of Kenai Fjords National Park and Katmai National Park and Preserve

There are hundreds of glaciers in Kenai Fjords National Park (KEFJ) and Katmai National Park and Preserve (KATM) covering over 2,276 sq km of park land (ca. 2000). There are two primary glacierized areas in KEFJ (the Harding Icefield and the Grewingk-Yalik Glacier Complex) and three primary glacierized areas in KATM (the Mt. Douglas area, the Kukak Volcano to Mt. Katmai area, and the Mt. Martin area). Most glaciers in these parks terminate on land, though a few terminate in lakes. Only KEFJ has tidewater glaciers, which terminate in the ocean. Glacier mapping and analysis of the change in glacier extent has been accomplished on a decadal scale using satellite imagery, primarily Landsat data from the 1970s, 1980s, and from2000. Landsat Multispectral Scanner (MSS),Thematic Mapper (TM), and Enhanced Thematic Mapper Plus (ETM) imagery was used to map glacier extent on a park-wide basis. Classification of glacier ice using image-processing software, along with extensive manual editing, was employed to create Geographic Information System (GIS)outlines of the glacier extent for each park. Many glaciers that originate in KEFJ but terminate outside the park boundaries were also mapped. Results of the analysis show that there has been a reduction in the amount of glacier ice cover in the two parks over the study period. Our measurements show a reduction of approximately 21 sq km, or 1.5(from 1986 to 2000), and 76 sq km, or 7.7 (from19861987 to 2000), in KEFJ and KATM, respectively. This work represents the first comprehensive study of glaciers of KATM. Issues that complicate the mapping of glacier extent include debris cover(moraine and volcanic ash), shadows, clouds, fresh snow, lingering snow from the previous season, and differences in spatial resolution between the MSS,TM, or ETM sensors. Similar glacier mapping efforts in western Canada estimate mapping errors of 34. Measurements were also collected from a suite of glaciers in KEFJ and KATM detailing terminus positions and rates of recession using datasets including 15 min USGS quadrangle maps(19501951), Landsat imagery (19861987, 2000,2006), and 2005 IKONOS imagery (KEFJ only).

Kenai Fjords↗
DOE OSTI2022

Evaluation of Oak Ridge National Laboratory Health Physics Research Reactor Operation Data for Critical Benchmark Creation [Abstract]

The Oak Ridge National Laboratory (ORNL) Health Physics Research Reactor (HPRR) was a research reactor designed and built at ORNL in 1961. The critical assembly was using a highly enriched uranium and molybdenum alloy as the fuel, and it could be operated in steady-state or burst modes. The reactor was used for about 25 years to produce a lot of publications related to dosimetry, radiobiology and radiation detectors testing before its decommissioning in 1987. In recent years, the idea of using legacy operation data from the to create a valuable critical accident alarm system shielding benchmark arose. Such a benchmark has been submitted to the International Criticality Safety Benchmark Experiment Project (ICSBEP) Technical Review Group for a potential inclusion in the 2022 version of the handbook. Another way to use the valuable data from the operation of the HPRR is to evaluate the feasibility of the creation of a subcritical or prompt supercritical benchmark for inclusion in the ICSBEP or the International Reactor Physics Experiments Evaluation Project (IRPhEP) handbooks. To initiate a burst, the HPRR had to be operated in a slightly subcritical state for a few minutes. Then, the insertion of the burst control rod would greatly increase the reactivity of the system and start the burst. No critical configuration of the HPRR critical assembly could be located. The only information available concerns stable subcritical and prompt supercritical states, found in a burst experiments’ logbook. In the recovered logbook pages, information about 8 different bursts is available. The information includes the rods positions before and during a burst, the recorded subcritical reactor period and reactivity, and the burst fission yield derived from the temperature elevation sulfur pellet irradiation analysis. By using the HPRR logbook information and the as-built drawings of the critical assembly, a highly detailed model of the HPRR was created with SCALE 6.2.4/KENO-VI. Eight KENO-VI models were created to replicate the sub-critical assembly configurations described in the eight bursts from the recovered logbook pages. KENO-VI calculates k eff and it can be linked to a reactivity value in cents by using the delayed neutron fraction B eff , also calculated by KENO-VI. KENO-VI can also be used to model the prompt super-critical configurations of the HPRR and to assess the similarity with the burst measurements by comparing the calculated k eff and the measured fission yields between each burst. Unfortunately, high uncertainty exist and the obtained discrepancies between experiments and calculation results are high, compromising the creation of a valuable critical benchmark from HPRR operation data. The reasons of the discrepancies and potential ways to solve them are explored.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗
NASA NTRS2011

Alaska: Glaciers of Kenai Fjords National Park and Katmai and Lake Clark National Parks and Preserve

There are hundreds of glaciers in Kenai Fjords National Park (KEFJ) and Katmai National Park and Preserve (KATM) covering over 2276 sq km of park land (circa 2000). There are two primary glacierized areas in KEFJ -- the Harding Icefield and the Grewingk-Yalik Glacier Complex, and three primary glacierized areas in KATM - the Mt. Douglas area, the Kukak Volcano to Mt. Katmai area and the Mt. Martin area. Most glaciers in these parks terminate on land, though a few terminate in lakes. Only KEFJ has tidewater glaciers, which terminate in the ocean. Glacier mapping and analysis of the change in glacier extent has been accomplished on a decadal scale using satellite imagery, primarily Landsat data from the 1970s, 1980s, and from 2000. Landsat Multispectral Scanner (MSS), Thematic Mapper (TM) and Enhanced Thematic Mapper Plus (ETM+) imagery was used to map glacier extent on a park-wide basis. Classification of glacier ice using image processing software, along with extensive manual editing, was employed to create Geographic Information System (GIS) outlines of the glacier extent for each park. Many glaciers that originate in KEFJ but terminate outside the park boundaries were also mapped. Results of the analysis show that there has been a reduction in the amount of glacier ice cover in the two parks over the study period. Our measurements show a reduction of approximately 21 sq km, or -1.5% (from 1986 to 2000), and 76 sq km, or -7.7% (from 1986/87 to 2000), in KEFJ and KATM, respectively. This work represents the first comprehensive study of glaciers of KATM. Issues that complicate the mapping of glacier extent include: debris-cover (moraine and volcanic ash), shadows, clouds, fresh snow, lingering snow from the previous season, and differences in spatial resolution between the MSS and TM or ETM+ sensors. Similar glacier mapping efforts in western Canada estimate mapping errors of 3-4%. Measurements were also collected from a suite of glaciers in KEFJ and KATM detailing terminus positions and rates of recession using datasets including the 15-minute USGS quadrangle maps (1950/1951), Landsat imagery (1986/1987, 2000, 2006) and 2005 Ikonos imagery (KEFJ only).

Giffen, bruce A.↗
NASA NTRS1994

Fluid Redistribution and Heart Rate in Humans During Whole-Body Tilting, G(z) Centrifugation, and Lower Body Negative Pressure

Gravity creates blood pressure gradients which redistribute body fluids towards the feet. Positive G(z) centrifugation and lower body negative pressure (LBNP) have been proposed to simulate these and other effects of gravity during long-term existence in microgravity. We hypothesized that the magnitude of upper-to-lower body fluid redistribution would increase according to the following order: short-arm centrifugation (SAC), long-arm centrifugation (LAC), head-up tilt (HUT), and LBNP. To test this hypothesis, we employed strain gauge plethysmography of the neck, thigh and calf during HUT and supine SAC and LAC up to lG(z) at the feet, and during supine LBNP to 100 mm Hg. Supine 100 mm Hg LBNP generates footward force and produces transmural blood pressures in the foot approximately equal to 1 G(z) (90 deg) HUT. Heart rate was measured via cardiotachometry. Control measurements were made while supine. SAC and LAC elicited similar increases in thigh volume at 1 G(z) (2.3 +/- 0.4 and 2.1 +/- 0.1%, respectively; mean +/- se, n greater than or equal to 7). At 100 mm Hg LBNP, thigh volume increased (3.4 +/- 0.3%) significantly more than during l G(z) centrifugation (p less than 0.05). Surprisingly, due to a paradoxical 0.6% reduction of thigh volume between 0.8 and 1.0 G(z) HUT, thigh volume was increased only 0.6 +/- 0.3% at 1 G(z) HUT. The calf demonstrated similar, although less definitive, responses to the various gravitational stimuli. Neck volume tended to decrease less during HUT than during the other stimuli. Heart rate increased similarly during HUT (18 +/- 2 beats/min) and LAC (12 +/- 2 beats/min), and exhibited still greater elevation during LBNP (29 +/- 4 beats/min), yet did not increase during SAC. These results suggest upright posture activates mechanisms that counteract footward fluid redistribution which are not activated during supine applications of simulated gravity. LAC more closely approximated effects of normal gravity (HUT) than LBNP. Therefore, when considering LBNP to simulate gravity, these findings support efforts to reduce the cardiovascular stress imposed by LBNP, while preserving the gravity-like force generated by LBNP.

Watenpaugh, D. E.↗
DOE OSTI2022

NSRC New Hire Orientation: Resources and What to Expect

Hello, New Hire! Right now, you are likely very excited to begin your position at the Laboratory. We are happy you are here! This document will walk you through different facets of your pre-security clearance interval at the Lab. This is a general guide not firm documentation. Its contents were compiled by National Security Research Center (NSRC) team members to make your transition easier. To begin, you will need a security clearance to do your job. A security clearance is essentially an extremely detailed background check. After you complete and turn in your security paperwork, the clearance process can take as little as three months or as long as one year. You may wonder, “If I can’t do my job until after I receive a clearance, what will I be doing?” There is plenty of unclassified work and professional development to be done. Waiting for a clearance can be trying, but we are here to help. This guide details what to expect during pre-clearance, resources to stay industrious, entry points to Lab networking and culture, and tips for success. Patience, flexibility, and productivity are key. Your workday responsibilities and priorities will vary depending on the self-study, assigned duties, and client-driven projects designated by your manager. This guide is here to help, and so are your NSRC colleagues.

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗
DOE OSTI2025

PMDT: AI-Enabled Predictive Maintenance Digital Twins for Advanced Nuclear Reactors

Our team made substantial technical progress on various fronts during the course of the program. Multiple milestones were geared towards demonstrating the feasibility of machine learning based predictive maintenance digital twins towards reducing O&M costs, whereas some other milestones actually focused on identifying technical gaps and developing technologies such as humble AI to provide necessary robustness to the ML-based models. We were able to demonstrate in many cases that Machine learning-based methods can be successfully adapted for Nuclear plant environments especially for remote monitoring applications. Detailed analyses were carried out with plant and full scope simulation data along with capabilities of enhanced analytics to assess and set realistic expectations on cost reductions in O&M. These assessments are paving the way for investments towards reactor design improvements as well project planning for SMR projects as they develop and mature in the next few years. Technology developed under this program got direct visibility to GE Hitachi and their utility customers and resulted in positive intents to deploy some of the elements from design phase. The project additionally resulted in several reports, publications, software and data generation that will be useful in deployment and O&M services for BWRX300 fleets.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗
DOE OSTI2025

Determination of Scale Bar for AGHCF Metallography Data

The DOE Nuclear Energy Advanced Reactor Technologies (ART) Fast Reactor Program (FRP) has supported the development of several databases containing information on the safety performance of fast reactors, components, and fuels. This growing collection of legacy experimental data, operating data, and analysis is available online to registered users. Metallography data represents one of the most critical types of post-irradiation examination (PIE) data being collected, organized, and archived in several ART Fast Reactor Databases (https://frdb.ne.anl.gov), including the Metallic Fuels Irradiation & Physics Database (FIPD), Out-of-Pile Transient Database (OPTD), and TREAT (the Transient Reactor Test Facility) Experimental Relational Database (TREXR). These databases contain three principal sets of metallography data. The first set comprises metallography data from Experimental Breeder Reactor-II (EBR-II) and Fast Flux Test Facility (FFTF) irradiated fuel pins examined in the Hot Fuel Examination Facility (HFEF). The second set consists of metallography data from EBR-II irradiated fuel pins examined in the Alpha-Gamma Hot Cell Facility (AGHCF). The third set includes metallography data from transient-tested fuel pins (including both out-of-pile furnace tests and TREAT tests) examined in AGHCF. Since both the second and third sets were generated in AGHCF, they are governed by identical specifications. The metallography data in the databases consist of digital images scanned from either positive or negative photographic films. To analyze the microstructure of a fuel pin, a series of preparatory steps are required, including sectioning, epoxy mounting, mechanical grinding and polishing, and etching. Following sample preparation, specimens are transferred for metallographic examination. The AGHCF and HFEF metallography data were generated using optical microscopes manufactured by Leitz and Bausch and Lomb (B&L). Images were recorded on Polaroid film at preset magnifications. Magnification verification for the Leitz and B&L metallographs was conducted every two months prior to 1989 and at least every six months from 1989 through the conclusion of the IFR program. Magnifications determined from imaging of microslide standards were compared to the instrument settings for magnifications ranging from 50× to 500×. If the magnifications determined from standards deviated from the instrument settings, adjustments were made to the bellows extension until agreement was achieved. The specifications for AGHCF and HFEF legacy metallography data have been established based on available hard-copy and digital records, most of which have been incorporated into the data repositories associated with FIPD, OPTD, and TREXR. Detailed specifications including hard-copy records, digitized records, cutting diagrams and sectioning schemes, high-magnification photographs, photomosaics (composites), information tags, scale bars, and magnification verification procedures can be found in a separate report.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗
DOE OSTI2020

Ambient Mass Spectrometry Rapid Analysis Methods for Trace Inorganics

The ability to rapidly detect and characterize the chemistry of trace quantities of inorganic species has multiple potential applications, including nuclear safeguards, nuclear forensics, and environmental monitoring. Some mass spectrometric methods currently exist, but they are costly and time-intensive, often destroying chemical information in the process of ionization. Ambient mass spectrometry is a relatively new analytical method in which samples are introduced to the mass spectrometer from atmospheric pressure, rather than from high vacuum. Ambient MS can operate with gentler ionization methods such as electrospray ionization (ESI) and paper-spray ionization (PSI), reducing fragmentation and preserving the chemical information of the analyte. This may be useful for determining the intended purpose of material in a sample. Strontium, part of nuclear fallout, is analyzed here to test these new analytical methods for viability. Electrospray ionization mass spectrometry functions by spraying the sample as a solution through a needle charged to a few kV. A nebulizing gas flows out along with the sample to create the spray before droplets enter a drying chamber with heated drying gas to remove the solvent molecules. From there bare analyte ions enter the mass spectrometer. This method has the advantage of relatively fast sample preparation and stable ionization. More stable ionization produces higher-quality data. Paper-spray ionization mass spectrometry operates by applying sample to a paper triangle. The paper triangle is then electrified in a metal clamp to a few kV before spray solvent is applied. The spray solvent transports analyte in the sample to the tip, where it is ionized and enters the mass spectrometer. One advantage of this method is reduced sample preparation - an analyst can even swipe a surface and cut a triangle directly from the swipe. The data analysis serves to rapidly process tens of samples all at once. The mass spectrometer outputs a file containing a few hundred spectra for each sample. The pipeline processes each one to identify peaks of interest. A full palette of data analysis metrics are generated, including plots of the raw data and plots of calculated values such as isotopic ratios. The pipeline filters the raw data to remove noise and background peaks, as well as peaks representing detector saturation. A heat map is generated to show the overall spectrum in mass-time- intensity space. Post-processing, we obtained the desired calibration curves, demonstrating that both ESI-MS and PSI-MS are viable methods for quantifying trace amounts of inorganics while retaining their chemical speciation information. ESI-MS demonstrated a linear response region of 100 ppb to 20 ppm, with a limit-of-detection of around 100 ppb. At top left is an example spectrum with the {sup 88}SrNO{sub 3} peak identified to show the retention of chemical speciation. PSI-MS showed a linear response region of around 1 ppb to 1 ppm, with a limit-of-detection of near 1 ppb. PSI-MS produced more erratic results than ESI-MS, likely due to the variability in ionization resulting from manual positioning of the paper triangle near the MS inlet. Future efforts will focus on improving the repeatability of PSI-MS as well as analyzing other species of interest such as cerium and uranium. Improvements will also be made to create more reliable data extraction and intelligent data filtering.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
NASA NTRS2014

Search for Fluid Inclusions in a Carbonaceous Chondrite Using a New X-Ray Micro-Tomography Technique Combined with FIB Sampling

Early solar system aqueous fluids are preserved in some H chondrites as aqueous fluid inclusions in halite (e.g., [1]). Although potential fluid inclusions are also expected in carbonaceous chondrites [2], they have not been surely confirmed. In order to search for these fluid inclusions, we have developped a new X-ray micro-tomography technique combined with FIB sampling and applied this techniqu to a carbanaceous chondrite. Experimental: A polished thin section of Sutter's Mill meteorite (CM) was observed with an optical microscope and FE-SEM (JEOL 7001F) for chosing mineral grains of carbonates (mainly calcite) and sulfides (FeS and ZnS) 20-50 microns in typical size, which may have aqueous fluid inclusions. Then, a "house" similar to a cube with a roof (20-30 microns in size) is sampled from the mineral grain by using FIB (FEI Quanta 200 3DS). Then, the house was atached to a thin W-needle by FIB and imaged by a SR-based imaging microtomography system with a Fresnel zone plate at beamline BL47XU, SPring-8, Japan. One sample was imaged at two X-ray energies, 7 and 8 keV, to identify mineral phases (dual-enegy microtomography: [3]). The size of voxel (pixel in 3D) was 50-80 nm, which gave the effective spatial resolution of approx. 200 nm. A terrestrial quartz sample with an aqueous fluid inclusion with a bubble was also examined as a test sample by the same method. Results and discussion: A fluid inclusion of 5-8 microns in quartz was clearly identified in a CT image. A bubble of approx. 4 microns was also identified as refraction contrast although the X-ray absorption difference between fluid and bubble is small. Volumes of the fluid and bubble were obtained from the 3D CT images. Fourteen grains of calcite, two grains of iron sulfide and one grain of (Zn,Fe)S were examined. Ten calcite, one iron sulfide and one (Zn,Fe)S grains have inclusions >1 micron in size (the maximum: approx. 5 microns). The shapes are spherical or irregular. Tiny inclusions (<1 micron) are also present in all the grains examined. These results show that mineral grains have more inclusions than expected from 2D observations. The X-ray absorption of the inclusions shows that they are not solid inclusions. No bubbles were observed inside, indicating that we cannot determine whether they are really aqueous fluids or merely voids. One calcite grain has an inclusion approx. 2 microns in size, which seems to have a bubble and a tiny solid daughter crystal inside (three-phase inclusion). As we know the exact 3D position of the inclusion, we will anlyze the inclusion by SIMS after freezing the sample as has been done for a halite sample [3]. The present technique is useful for finding small inclusions not only in carbonaceous chondrites but also for terrestrial materials.

Tsuchiyama, A.↗
NASA NTRS2012

Analyses of Cometary Silicate Crystals: DDA Spectral Modeling of Forsterite

Comets are the Solar System's deep freezers of gases, ices, and particulates that were present in the outer protoplanetary disk. Where comet nuclei accreted was so cold that CO ice (approximately 50K) and other supervolatile ices like ethane (C2H2) were preserved. However, comets also accreted high temperature minerals: silicate crystals that either condensed (greater than or equal to 1400 K) or that were annealed from amorphous (glassy) silicates (greater than 850-1000 K). By their rarity in the interstellar medium, cometary crystalline silicates are thought to be grains that formed in the inner disk and were then radially transported out to the cold and ice-rich regimes near Neptune. The questions that comets can potentially address are: How fast, how far, and over what duration were crystals that formed in the inner disk transported out to the comet-forming region(s)? In comets, the mass fractions of silicates that are crystalline, f_cryst, translate to benchmarks for protoplanetary disk radial transport models. The infamous comet Hale-Bopp has crystalline fractions of over 55%. The values for cometary crystalline mass fractions, however, are derived assuming that the mineralogy assessed for the submicron to micron-sized portion of the size distribution represents the compositional makeup of all larger grains in the coma. Models for fitting cometary SEDs make this assumption because models can only fit the observed features with submicron to micron-sized discrete crystals. On the other hand, larger (0.1-100 micrometer radii) porous grains composed of amorphous silicates and amorphous carbon can be easily computed with mixed medium theory wherein vacuum mixed into a spherical particle mimics a porous aggregate. If crystalline silicates are mixed in, the models completely fail to match the observations. Moreover, models for a size distribution of discrete crystalline forsterite grains commonly employs the CDE computational method for ellipsoidal platelets (c:a:b=8.14x8.14xl in shape with geometrical factors of x:y:z=1:1:10, Fabian et al. 2001; Harker et al. 2007). Alternatively, models for forsterite employ statistical methods like the Distribution of Hollow Spheres (Min et al. 2008; Oliveira et al. 2011) or Gaussian Random Spheres (GRS) or RGF (Gielen et al. 200S). Pancakes, hollow spheres, or GRS shapes similar to wheat sheaf crystal habit (e.g., Volten et al. 2001; Veihelmann et al. 2006), however, do not have the sharp edges, flat faces, and vertices seen in images of cometary crystals in interplanetary dust particles (IDPs) or in Stardust samples. Cometary forsterite crystals often have equant or tabular crystal habit (J. Bradley). To simulate cometary crystals, we have computed absorption efficiencies of forsterite using the Discrete Dipole Approximation (DDA) DDSCAT code on NAS supercomputers. We compute thermal models that employ a size distribution of discrete irregularly shaped forsterite crystals (nonspherical shapes with faces and vertices) to explore how crystal shape affects the shape and wavelength positions of the forsterite spectral features and to explore whether cometary crystal shapes support either condensation or annealing scenarios (Lindsay et al. 2012a, b). We find forsterite crystal shapes that best-fit comet Hale-Bopp are tetrahedron, bricks or brick platelets, essentially equant or tabular (Lindsay et al. 2012a,b), commensurate with high temperature condensation experiments (Kobatake et al. 2008). We also have computed porous aggregates with crystal monomers and find that the crystal resonances are amplified. i.e., the crystalline fraction is lower in the aggregate than is derived by fitting a linear mix of spectral features from discrete subcomponents, and the crystal resonances 'appear' to be from larger crystals (Wooden et al. 2012). These results may indicate that the crystalline mass fraction in comets with comae dominated by aggregates may be lower than deduced by popular methods that only emoy ensembles of discrete crystals.

Wooden, Diane↗
NASA NTRS2014

Use of Semi-Autonomous Tools for ISS Commanding and Monitoring

As the International Space Station (ISS) has moved into a utilization phase, operations have shifted to become more ground-based with fewer mission control personnel monitoring and commanding multiple ISS systems. This shift to fewer people monitoring more systems has prompted use of semi-autonomous console tools in the ISS Mission Control Center (MCC) to help flight controllers command and monitor the ISS. These console tools perform routine operational procedures while keeping the human operator "in the loop" to monitor and intervene when off-nominal events arise. Two such tools, the Pre-positioned Load (PPL) Loader and Automatic Operators Recorder Manager (AutoORM), are used by the ISS Communications RF Onboard Networks Utilization Specialist (CRONUS) flight control position. CRONUS is responsible for simultaneously commanding and monitoring the ISS Command & Data Handling (C&DH) and Communications and Tracking (C&T) systems. PPL Loader is used to uplink small pieces of frequently changed software data tables, called PPLs, to ISS computers to support different ISS operations. In order to uplink a PPL, a data load command must be built that contains multiple user-input fields. Next, a multiple step commanding and verification procedure must be performed to enable an onboard computer for software uplink, uplink the PPL, verify the PPL has incorporated correctly, and disable the computer for software uplink. PPL Loader provides different levels of automation in both building and uplinking these commands. In its manual mode, PPL Loader automatically builds the PPL data load commands but allows the flight controller to verify and save the commands for future uplink. In its auto mode, PPL Loader automatically builds the PPL data load commands for flight controller verification, but automatically performs the PPL uplink procedure by sending commands and performing verification checks while notifying CRONUS of procedure step completion. If an off-nominal condition occurs during procedure execution, PPL Loader notifies CRONUS through popup messages, allowing CRONUS to examine the situation and choose an option of how PPL loader should proceed with the procedure. The use of PPL Loader to perform frequent, routine PPL uplinks offloads CRONUS to better monitor two ISS systems. It also reduces procedure performance time and decreases risk of command errors. AutoORM identifies ISS communication outage periods and builds commands to lock, playback, and unlock ISS Operations Recorder files. Operation Recorder files are circular buffer files of continually recorded ISS telemetry data. Sections of these files can be locked from further writing, be played back to capture telemetry data that occurred during an ISS loss of signal (LOS) period, and then be unlocked for future recording use. Downlinked Operation Recorder files are used by mission support teams for data analysis, especially if failures occur during LOS. The commands to lock, playback, and unlock Operations Recorder files are encompassed in three different operational procedures and contain multiple user-input fields. AutoORM provides different levels of automation for building and uplinking the commands to lock, playback, and unlock Operations Recorder files. In its automatic mode, AutoORM automatically detects ISS LOS periods, then generates and uplinks the commands to lock, playback, and unlock Operations Recorder files when MCC regains signal with ISS. AutoORM also features semi-autonomous and manual modes which integrate CRONUS more into the command verification and uplink process. AutoORMs ability to automatically detect ISS LOS periods and build the necessary commands to preserve, playback, and release recorded telemetry data greatly offloads CRONUS to perform more high-level cognitive tasks, such as mission planning and anomaly troubleshooting. Additionally, since Operations Recorder commands contain numerical time input fields which are tedious for a human to manually build, AutoORM's ability to automatically build commands reduces operational command errors. PPL Loader and AutoORM demonstrate principles of semi-autonomous operational tools that will benefit future space mission operations. Both tools employ different levels of automation to perform simple and routine procedures, thereby offloading human operators to perform higher-level cognitive tasks. Because both tools provide procedure execution status and highlight off-nominal indications, the flight controller is able to intervene during procedure execution if needed. Semi-autonomous tools and systems that can perform routine procedures, yet keep human operators informed of execution, will be essential in future long-duration missions where the onboard crew will be solely responsible for spacecraft monitoring and control.

Brzezinski, Amy S.↗
DOE OSTI2024

Dynamic and Responsive Distributed Energy Resource Education Solutions for Building, Fire, and Safety Department Officials (Final Technical Report)

From April 2021 through March 2024, the Interstate Renewable Energy Council (IREC) led a collaborative project to develop a free online clearinghouse of educational resources about solar photovoltaics (PV), energy storage systems (ESS), electric vehicle supply equipment (EVSE), and grid-interactive efficient building (GEB) technologies. Two websites—the Clean Energy Clearinghouse and CleanEnergyTraining.org—housed over 70 educational resources. Over the course of the three-year project, 154,272 unique visitors accessed the learning materials. Learner feedback was overwhelmingly positive. Even through the end of the project, there was sustained demand for education and communication. A primary innovation of the project was to drive multiple complementary audiences to the same place. Building owners, designers, installation contractors and developers, authorities having jurisdiction (AHJs), and fire service personnel all benefit from a shared understanding of clean energy technologies, including safety and code-related requirements. When considering the impact on the target audience, the project team worked with partners and advisors to inform resource creation and delivery in such a way as to address key motivational factors of the target audience and compel each user to seek additional information on the topic and return to the Clean Energy Clearinghouse website as their central location for more information. Resources were intentionally developed to be concise—five to 15 minutes—and accessible, meaning not overly technical. Providing basic information demystified the technologies and invited the professional to explore additional learning opportunities. Awardee and partner collaboration was key to project success. IREC facilitated collaboration among the other Topic 2 awardees, Southface and New Buildings Institute (NBI). The three awardees shared relevant information gained through discovery and validation questionnaires that informed product development and reduced duplication of effort by coordinating the development of complementary, and not competing, educational resources. Inspired by this collaboration, IREC brought on additional partners even in the final year of the project. Five regional energy efficiency organizations were part of the project, which expanded the connection between efficiency and distributed energy resources. We also included resources on the Clearinghouse that were developed through other federally funded projects, such as the Buildings Energy Efficiency Frontiers & Innovation Technologies (BENEFIT) program. The website was developed with the learner in mind, and not solely the funding source. Feedback from stakeholders throughout the project, and especially in its final year, indicated the need for continued education and facilitated communication among stakeholders to further the safe and widespread adoption of clean energy.

14 SOLAR ENERGY↗
DOE OSTI2025

DOME: Directional medical embedding vectors from Electronic Health Records

Motivation: The increasing availability of Electronic Health Record (EHR) systems has created enormous potential for translational research. Recent developments in representation learning techniques have led to effective large-scale representations of EHR concepts along with knowledge graphs that empower downstream EHR studies. However, most existing methods require training with patient-level data, limiting their abilities to expand the training with multi-institutional EHR data. On the other hand, scalable approaches that only require summary-level data do not incorporate temporal dependencies between concepts. Methods: We introduce a DirectiOnal Medical Embedding (DOME) algorithm to encode temporally directional relationships between medical concepts, using summary-level EHR data. Specifically, DOME first aggregates patient-level EHR data into an asymmetric co-occurrence matrix. Then it computes two Positive Pointwise Mutual Information (PPMI) matrices to correspondingly encode the pairwise prior and posterior dependencies between medical concepts. Following that, a joint matrix factorization is performed on the two PPMI matrices, which results in three vectors for each concept: a semantic embedding and two directional context embeddings. They collectively provide a comprehensive depiction of the temporal relationship between EHR concepts. Results: We highlight the advantages and translational potential of DOME through three sets of validation studies. First, DOME consistently improves existing direction-agnostic embedding vectors for disease risk prediction in several diseases, for example achieving a relative gain of 5.5% in the area under the receiver operating characteristic (AUROC) for lung cancer. Second, DOME excels in directional drug-disease relationship inference by successfully differentiating between drug side effects and indications, correspondingly achieving relative AUROC gain over the state-of-the-art methods by 10.8% and 6.6%. Finally, DOME effectively constructs directional knowledge graphs, which distinguish disease risk factors from comorbidities, thereby revealing disease progression trajectories. The source codes are provided at https://github.com/celehs/Directional-EHRembedding.

60 APPLIED LIFE SCIENCES↗